CN107550810A - A kind of Chinese medicine composition and its preparation method and application - Google Patents
A kind of Chinese medicine composition and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition and its preparation method and application, the Chinese medicine composition is mainly prepared by the following raw material by mass percentage：Peony 5% 50%, the leaf of bamboo 5% 50%, common bombax flower 5% 50% and lotus 5% 40%, wherein, the mass percent sum of each raw material of the Chinese medicine composition is no more than 100%.The Traditional Chinese medicine composition formula of the present invention is reasonable, Multiple components Synergistic, and from natural, property safe to the human body is high and has the effect of antiallergic moisturizing.
Description
Technical field
The invention belongs to cosmetic field, is related to a kind of Chinese medicine composition and its preparation method and application.
Background technology
Cosmetics contact dermatitis, it is the most important type of cosmetic dermatosis.According to pathogenesis, two can be divided into
Class：One kind is the irritant contact dermatitis caused by chemical stimulation；One kind is the allergic contact as caused by immune response
Dermatitis.The original preservative of common sensitization, essence and flavoring agent and surfactant in cosmetics.Skin sensitivity problem becomes puzzlement
The subject matter of cosmetics consumer, the cosmetics with antiallergic effect are increasingly favored by market, are returned in cosmetic industry
Under natural trend, develop natural antiallergic additive and in industry seem and be even more important.
The Chinese herbal medicine resource in China is extremely abundant, and many Chinese herbal medicines not only have good antiallergic effect, and have and disappear
Scorching myogenic, moisturizing whitening and other effects.
The A of CN 103284915 disclose a kind of plant composition with whitening function and its in skin-lightening cosmetics
Using.The plant composition is extracted by mulberry bark extract, licorice, peony extract, Flos Bombacis Malabarici extract, Radix Angelicae Sinensis
Thing and Cortex Moutan extract compounding form.The plant composition of the invention can be used in whitening formula, has and suppresses tyrosine enzyme activity
Property, remove the function of free radical and skin whitening.The A of CN 105147584 are related to a kind of yeast product containing traditional Chinese medicine ingredients, institute
Stating traditional Chinese medicine powder includes：Selfheal dry powder, henon bamboo leaf dried powder, root bark of white mulberry dry powder, lotus dry powder and peony dry powder etc.；The invention is same
When possess yeast and active ingredients from traditional Chinese medicinal, both Synergistics, can strongly remove free radical, significantly inhibit tyrosinase
Activity, whitening effect skin.But above-mentioned composition does not have antiallergic effect, it is impossible to is used for antiallergic cosmetics as active ingredient
Preparation.
The A of CN 105147551 are specifically related to a kind of skin care item of active component containing tree peony, further relate to above-mentioned skin care item
Production method.The skin care item of the active component containing tree peony produced using the method for the invention, with the addition of tree peony active component, such as male
Red seed oil, peony essential oil and peony extract, good antioxidation can be played to human body skin, is advantageous to delaying skin
Aging, suppress color spot；These tree peony active components are combined with other compositions, can play synergy, and can increase
The antiallergic effect of skin care item.But the active ingredient for playing antiallergic function, which understands, intactly to be disclosed.
The A of CN 106420467 disclose a kind of plant antiallergic moisture-keeping composition and application.Said composition is by beautiful schizonepeta, thorn
Puncture vine, windproof, lophatherum gracile, the tuber of dwarf lilyturf, bamboo are made in CCCP.Said composition preparation method is：Weigh, sieve, mixing, add water or ethanol
Solution is as Extraction solvent, and after immersion, normal temperature extraction is carried out with high pressure homogenization method machine, extract solution is centrifuged, concentrate after,
With macroporous resin adsorption, repeatedly eluted with ethanol solution, collect eluent, added after concentration and be made with butanediol filtering.The group
Compound is designed according to the theory of traditional Chinese medical science of monarch, plurality of Chinese Synergistic, is had and is expelled pathogenic wind from the body surface well, only
Itch, invigorate blood circulation, moisturizing and the effect of anti-inflammatory, so as to reach skin antiallergic and moisturizing purpose.But said composition preparation method is cumbersome, group
Polymer component is complicated, and antiallergic effect is not notable.
Therefore it provides a kind of Chinese medicine composition with antiallergic effect using natural Chinese medicinal herb as primary raw material, is making up
Product field has great importance and wide market prospects.
The content of the invention
The present invention is directed to the deficiency of in the market antiallergic product, there is provided a kind of Chinese medicine composition and its preparation method and application,
The Chinese medicine composition only not antianaphylactic effect, also has the function that moisturizing, the group using natural Chinese medicinal herb as primary raw material
Compound is derived from natural plants, using 100% aqueous solution as Extraction solvent, possesses natural, environmentally friendly advantage.
In a first aspect, the invention provides a kind of Chinese medicine composition, the Chinese medicine composition by mass percentage mainly by
The following raw material is prepared：Peony 5%-50%, leaf of bamboo 5%-50%, common bombax flower 5%-50% and lotus 5%-40%；
Wherein, the mass percent sum of each raw material of the Chinese medicine composition is no more than 100%.
Chinese medicine composition combination Chinese medicine Chinese prescription principle provided by the invention and antiallergic moisturizing are theoretical, measure skin selection, have
Arrow is put, four kinds of components of the invention coordinate jointly, Synergistic, have antiallergic moisturizing and other effects, and four kinds of compositions of the invention exist
Under the proportioning of the present invention, antiallergic moistening effect is more notable.
Preferably, the mass percent of the peony is 5%-50%, for example, can be 5%, 8%, 10%, 15%,
20%th, 25%, 30%, 35%, 40%, 45% or 50%, preferably 10-40%, more preferably 30%.
Preferably, the mass percent of the leaf of bamboo is 5%-50%, for example, can be 5%, 8%, 10%, 15%,
20%th, 25%, 30%, 35%, 40%, 45% or 50%, preferably 10-40%, more preferably 20%.
Preferably, the mass percent of the common bombax flower is 5%-50%, for example, can be 5%, 8%, 10%, 15%,
20%th, 25%, 30%, 35%, 40%, 45% or 50%, preferably 20-40%, more preferably 30%.
Preferably, the mass percent of the lotus is 5%-40%, for example, can be 5%, 8%, 10%, 15%,
20%th, 25%, 30%, 35% or 40%, preferably 10-30%, more preferably 20%.
Preferably, the Chinese medicine composition is mainly prepared by the following raw material by mass percentage：Peony 10-
40%th, leaf of bamboo 10-40%, common bombax flower 20-40% and lotus 10-30%；Wherein, the quality of each raw material of the Chinese medicine composition
Percentage sum is no more than 100%.
Preferably, the Chinese medicine composition is mainly prepared by the following raw material by mass percentage：Peony 30%, bamboo
Leaf 20%, common bombax flower 30% and lotus 20%.
Second aspect, the invention provides a kind of method for preparing Chinese medicine composition as described in relation to the first aspect, including with
Lower step：
(1) coarse powder is obtained by the Chinese medicine material is dry, sieving by formula ratio；
(2) coarse powder that soaking step (1) obtains, obtains extract solution；
(3) extract solution for obtaining step (2) filters, and rotary evaporation concentration, freeze-drying, obtains the Chinese traditional medicine composition
Thing.
In addition, a kind of method of the Chinese medicine composition present invention also offers processing as described in relation to the first aspect, including it is following
Step：
(1) coarse powder is obtained by the Chinese medicine material is dry, sieving by formula ratio；
(2) coarse powder that soaking step (1) obtains, obtains extract solution；
(3) extract solution for obtaining step (2) filters, and rotary evaporation concentration, freeze-drying, obtains the Chinese traditional medicine composition
Thing.
Preferably, the mesh number of step (1) selection of sieving is 80-200 mesh, for example, can be 80 mesh, 90 mesh, 100 mesh,
120 mesh, 140 mesh, 170 mesh or 200 mesh, preferably 100 mesh.
Preferably, the solution that step (2) the immersion coarse powder uses is deionized water.
Preferably, the dosage of the deionized water is 5-8 times of the meal quality, such as can be 5 times, 6 times, 7 times
Or 8 times, preferably 6 times.
Preferably, the temperature of the immersion is 60-90 DEG C, for example, can be 60 DEG C, 61 DEG C, 62 DEG C, 63 DEG C, 65 DEG C, 68
DEG C, 70 DEG C, 75 DEG C, 80 DEG C, preferably 85 DEG C or 90 DEG C, 80 DEG C.
Preferably, the number of the immersion is 1-4 times, such as can be 1 time, 2 times, 3 times or 4 times, preferably 2 times.
Preferably, the time of the immersion is 1-2 hours, such as can be 1 hour, 1.5 hours or 2 hours, preferably 1
Hour.
Preferably, the filtering described in step (3) is filtered using microfiltration membranes.
Preferably, filter the aperture of the microfiltration membranes used as 0.1-0.65 μm, for example, can be 0.1 μm, 0.22 μm, 0.45
μm or 0.65 μm, preferably 0.22 μm.
The third aspect, it is used to prepare antiallergic cosmetics the invention provides a kind of Chinese medicine composition；
Preferably, the addition of the Chinese medicine composition is 1-30%, for example, can be 1%, 2%, 3%, 4%, 5%,
6%th, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 28% or 30%, preferably 7%.
Preferably, the formulation of the cosmetics includes：It is any in aqua, emulsion, spray, cream, elite or facial mask
It is a kind of or at least two combination, preferably cream agent and/or spray.
Compared with prior art, the present invention has the advantages that：
(1) Traditional Chinese medicine composition formula provided by the invention is simple, and from natural, green, four kinds of components coordinate jointly,
Synergistic, it can effectively suppress hyaluronidase enzymatic activity and tyrosinase enzymatic activity, effectively remove free radical, excitant is low,
Hyaluronidase enzymatic activity extracorporeal inhibiting rate is up to 96.66%, and free radical scavenging activity is up to 96.31%, tyrosinase enzymatic activity
Inhibiting rate reaches 98.94%；
(2) Chinese medicine composition prepared by the present invention, which is applied in cosmetics, has the effect of antiallergic moisturizing, and antiallergy is effective
Rate reaches 100%, and moisture-keeping function is lasting；
(3) preparation method of Chinese medicine composition provided by the present invention is succinctly efficient, is easy to industrially popularization and application.
Embodiment
For the present invention technological means and its effect taken is expanded on further, the present invention is made with reference to embodiments into
Illustrate to one step.It is understood that embodiment described herein is used only for explaining the present invention, rather than to this hair
Bright restriction.
In the examples where no specific technique or condition is specified, according to the technology or condition described by document in the art,
Or carried out according to product description.Agents useful for same or the unreceipted production firm person of instrument, be can be by regular channel commercially available from
The conventional products of acquisition.
The preparation of the Chinese medicine composition of embodiment 1 (I)
Peony 3g, leaf of bamboo 2g, common bombax flower 3g and lotus 2g are weighed respectively, sieving is dried, and mesh number is 100 mesh, is obtained
To coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 2 times of 6 times, i.e. 60g, 80 DEG C of meal quality, and 1 is small every time
When, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.22 μm of micro-filtrate membrane filtration, concentrate is freeze-dried,
Obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 2 (II)
Peony 4g, leaf of bamboo 3g, common bombax flower 2g and lotus 1g are weighed respectively, sieving is dried, and mesh number is 80 mesh, is obtained
Coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 1 time of 5 times, i.e. 50g, 60 DEG C of meal quality, and the time is 1 small
When, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.1 μm of micro-filtrate membrane filtration, concentrate is freeze-dried, obtained
To Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 3 (III)
Peony 3g, leaf of bamboo 1g, common bombax flower 4g and lotus 2g are weighed respectively, sieving is dried, and mesh number is 120 mesh, is obtained
To coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 2 times of 6 times, i.e. 60g, 65 DEG C of meal quality, and 1.5 is small every time
When, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.45 μm of micro-filtrate membrane filtration, concentrate is freeze-dried,
Obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 4 (IV)
Peony 1g, leaf of bamboo 4g, common bombax flower 2g and lotus 3g are weighed respectively, sieving is dried, and mesh number is 140 mesh, is obtained
To coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 3 times of 7 times, i.e. 70g, 70 DEG C of meal quality, and 2 is small every time
When, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.45 μm of micro-filtrate membrane filtration, concentrate is freeze-dried,
Obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 5 (V)
Peony 2g, leaf of bamboo 3g, common bombax flower 2g and lotus 3g are weighed respectively, sieving is dried, and mesh number is 200 mesh, is obtained
To coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 4 times of 8 times, i.e. 80g, 80 DEG C of meal quality, and 2 is small every time
When, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.65 μm of micro-filtrate membrane filtration, concentrate is freeze-dried,
Obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 6 (VI)
Peony 0.5g, leaf of bamboo 0.5g, common bombax flower 5g and lotus 4g are weighed respectively, and sieving, mesh number 100 is dried
Mesh, obtain coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 4 times of 8 times, i.e. 80g, 90 DEG C of meal quality, every time
2 hours, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.65 μm of micro-filtrate membrane filtration, concentrate is freezed dry
It is dry, obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 7 (VII)
Peony 5g, leaf of bamboo 0.5g, common bombax flower 0.5g and lotus 4g are weighed respectively, and sieving, mesh number 100 is dried
Mesh, obtain coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 4 times of 8 times, i.e. 80g, 90 DEG C of meal quality, every time
2 hours, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.65 μm of micro-filtrate membrane filtration, concentrate is freezed dry
It is dry, obtain Chinese medicine composition.
The preparation of the Chinese medicine composition of embodiment 8 (VIII)
Peony 0.5g, leaf of bamboo 5g, common bombax flower 4g and lotus 0.5g are weighed respectively, and sieving, mesh number 100 is dried
Mesh, obtain coarse powder.Coarse powder is added into deionized water, dosage is the closed immersion 4 times of 8 times, i.e. 80g, 90 DEG C of meal quality, every time
2 hours, obtain extract solution.By extract solution with rotary evaporation concentration is carried out after 0.65 μm of micro-filtrate membrane filtration, concentrate is freezed dry
It is dry, obtain Chinese medicine composition.
Comparative example 1
Compared with Example 1, in addition to Chinese medicine selects peony 10g, other conditions are same as Example 1.
Comparative example 2
Compared with Example 1, in addition to Chinese medicine selects leaf of bamboo 10g, other conditions are same as Example 1.
Comparative example 3
Compared with Example 1, in addition to Chinese medicine selects common bombax flower 10g, other conditions are same as Example 1.
Comparative example 4
Compared with Example 1, in addition to Chinese medicine only selects lotus 10g, other conditions are same as Example 1.
Comparative example 5
Compared with Example 1, in addition to traditional Chinese medicinal components are leaf of bamboo 6g, common bombax flower 2g and lotus 2g, other steps and embodiment 1
It is identical.
Comparative example 6
Compared with Example 1, in addition to traditional Chinese medicinal components are peony 6g, common bombax flower 2g and lotus 2g, other steps are with implementing
Example 1 is identical.
Comparative example 7
Compared with Example 1, in addition to traditional Chinese medicinal components are peony 2g, leaf of bamboo 2g and lotus 6g, other steps and embodiment 1
It is identical.
Comparative example 8
Compared with Example 1, in addition to traditional Chinese medicinal components are peony 2g, leaf of bamboo 2g and common bombax flower 6g, other steps are with implementing
Example 1 is identical.
The Chinese medicine composition test experience of embodiment 9
Embodiment 1-8 and comparative example 1-8 Chinese medicine composition are configured into the solution that concentration is 1g/L with deionized water to make
For sample, following experiment is carried out.
1st, hyaluronidase body outer suppressioning test
(1) preparation of reagents
Measure 1155 μ L glacial acetic acids and be diluted to 100mL, it is solution A to take 4.8mL, weigh 2.72g sodium acetates crystallization plus it is water-soluble
Solution is settled to 100mL, takes 45.2mL to be B solution, mixed solution A and B and be settled to 100mL with water, pH=5.6 acetic acid is made
Buffer solution；Preparing hyaluronidase solution and sodium hyaluronate solution by the use of the acetate buffer solution prepared as solvent, (two kinds molten
The final working concentration 1250u/mL and 0.5mg/mL of liquid)；The concentration of calcium chloride solution is formulated as 0.25mmol/L；Sodium hydroxide
Solution is configured to 0.4mol/L；Sodium carbonate liquor is configured to 1.0mol/L, and 3.5mL levulinics are added in 50mL sodium carbonate liquors
Ketone is configured to acetylacetone,2,4-pentanedione solution；Finally weigh the p- dimethylaminobenzaldehydes of 0.8g and be dissolved in 15mL concentrated hydrochloric acids and the anhydrous second of 15mL
Ehrlich's reagent is configured in alcohol.
(2) experimental procedure
Carried out using hyaluronidase body outer suppressioning test method, take 0.1mL calcium chloride solutions and hyaluronic acid enzyme liquid to be incubated
Cultivate 20min；Sample liquid 0.5mL is added, continues 37 DEG C of heat insulating culture 20min；Add the insulation of 0.5mL Sodium Hyaluronates liquid
30min, room temperature 5min；0.1mL0.4mol/L NaOH solutions and 0.5mL acetylacetone,2,4-pentanedione solution are added, puts in boiling water bath and adds
Cooling 5min is carried out after hot 15min with frozen water immediately；Add Ehrlich's reagent 1.0mL and carried out with 3.0mL absolute ethyl alcohols dilute
Release, 20min colour developings are placed, with its absorbance of spectrophotometric determination.
(3) result calculates
Hyaluronic acid enzyme inhibition rate is calculated as follows：
A is contrast solution absorbance (replacing sample solution with hac buffer), and B is control blank solution absorbance
(replacing sample solution and enzyme liquid with hac buffer), C are sample solution absorbance, and D is sample blank solution absorbance
(replacing enzyme liquid with hac buffer).Length scanning first is carried out to control group sample during experiment, to determine maximum absorption wavelength,
Then using deionized water as reference, absorbance measurement is carried out respectively at the maximum absorption wavelength.
2nd, erythrocyte hemolysis excitant testing experiment
(1) solution allocation
With sodium chloride preparing normal saline：Made with the lauryl sodium sulfate that normal saline mass concentration is 0.1%
For positive control solution, 2% sheep haemocyte of purchase saves backup in 4 DEG C of refrigerators.
Physiological saline is used as solvent, the Chinese medicine composition in embodiment and comparative example is diluted to 10% sample it is molten
Liquid.
(2) experimental procedure
In 1.5mL centrifuge tubes, the μ L of tested material 300 and the μ L of 2% sheep red blood cell (SRBC) suspension 300 (isometric mixing) are added,
Fully mix.Each tested material be respectively provided with 2 it is parallel.Using solvent (physiological saline) as negative control (i.e. fairly insoluble blood),
Positive control (i.e. complete hemolysis) is used as using 0.1%SDS solution.Be placed in after 37 DEG C of constant incubators are incubated 3h, 2000r/min from
Heart 3min, the μ L of Aspirate supernatant 10, (in advance per hole plus 90 μ L physiological saline or PBS) is added in ELISA Plate, is mixed, in enzyme mark
Absorbance (respective value A is determined at instrument 410nm, 540nm, 575nm410nm、A540nm、A575nm)。
(3) result calculates
Hemolysis rate is calculated as follows in haemolysis measure：
Hemolysis rate (%)=(A-C)/(B-C) × 100
In formula, A is mean light absorbency of each concentration of sample at 410nm, and B is average suction of the positive control at 410nm
Luminosity, C are mean light absorbency of the negative control at 410nm.
3rd, Hydroxyl radical-scavenging is tested
The addition of each solution first adds 9mmol/LFeSO successively according to shown in table 1 in colorimetric cylinder4, 9mmol/L second
Alcohol-salicylic acid, is subsequently added into appropriate amount of deionized water, is eventually adding 8.8mmol/LH2O2After shake up, 37 DEG C of heating water baths 15 minutes
After take out, survey its absorbance A0。A0During measure, reference solution is the system for being not added with hydrogen peroxide.As stated above, add such as the institute of table 1
Each solution shown, to determine absorbance Ax、Ax0。Ax、Ax0During measure, reference solution is deionized water.
Following formula is clearance rate of the prepare liquid to hydroxy radical (OH)：
OH clearance rates (%)=A0- (Ax- Ax0)/A0× 100%
Wherein A0For the light absorption value of blank control；AxTo be loaded the light absorption value of product；Ax0To be not added with developer H2O2Solution background
Absorption value.
Table 1
4th, the measure of tyrosinase vigor is suppressed
It is loaded according to table 2 below, is not added with tyrosinase, solution is placed in constant temperature 10 minutes in 37 DEG C of water-baths, adds tyrosine
Enzyme, after solution is placed in 37 DEG C of water-baths into constant temperature 10 minutes, its absorbance is measured under 475nm.
Table 2
Calculation formula：Inhibitory activity against tyrosinase=[1- (A2/A1)] × 100%
A1 is the absorbance of blank control in formula；A2 is the absorbance of sample.
Chinese medicine composition test result analysis
Test result is shown in Table 3：
Table 3
Embodiment 1-8 comparative analysis in table 3 is understood that embodiment 1-8 is by controlling peony, the leaf of bamboo, common bombax flower and lotus
Colored proportioning, improves inhibiting rate and clearance rate, is further reduced with the proportioning of peony, the leaf of bamboo, common bombax flower and lotus, effect
Fruit is further enhanced, and when peony 30%, the leaf of bamboo 20%, common bombax flower 30% and lotus 20%, effect is best, inhibiting rate
And clearance rate highest, hyaluronidase enzymatic activity extracorporeal inhibiting rate are up to 96.66%, erythrocyte hemolysis rate is only 7.76%, from
By base clearance rate up to 96.31%, tyrosinase enzymatic activity inhibiting rate reaches 98.94%.
Meanwhile comparative example 1-4 is compared with Example 1, independent any component is all unable to reach preferable technique effect, contrast
Example 5-8 compared with Example 1, lacks any of four kinds of components and is unable to reach preferable effect.Thus, it can be known that the application
In four kinds of components coordinate jointly, Synergistic is indispensable.In the condition and range that the application provides, preferable effect can reach
Fruit.
Embodiment 9
The Chinese medicine composition of embodiment 1 is applied in antiallergic toner, the toner formula containing Chinese medicine composition is
6% 1,3 butylene glycol, 3% glycerine, 0.02% EDETATE SODIUM, 0.1% xanthans, 0.5% panthenol, 0.05%
Sodium Hyaluronate, 7% Chinese medicine composition, 0.1% methyl hydroxybenzoate, 0.05% Nipasol and 0.2% Phenoxyethanol,
Surplus is supplemented with deionized water.The dosage of each material mass parts meter.
Preparation method is as follows：
(1) it is xanthans and Sodium Hyaluronate glycerine is pre-dispersed；
(2) 55 DEG C of stirring and dissolvings are heated to after methyl hydroxybenzoate, Nipasol and 1,3-BDO being simply mixed, are cooled to
30 DEG C standby；
(3) EDETATE SODIUM, panthenol, Chinese medicine composition and deionized water are mixed evenly, are warming up to 80 DEG C, Ran Houjia
Enter the solution of the xanthans handled through step (1), Sodium Hyaluronate and glycerine, cool after stirring 20min；
(4) after being cooled to 45 DEG C, the molten of the methyl hydroxybenzoate handled through step (2), Nipasol and 1,3-BDO is added
Liquid, Phenoxyethanol is then added, stirred, discharged after being cooled to 35 DEG C.
Embodiment 10
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 2, addition is other steps outside 1%
It is rapid same as Example 9.
Embodiment 11
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 3, addition is other steps outside 30%
It is rapid same as Example 9.
Embodiment 12
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 4, addition is other steps outside 5%
It is rapid same as Example 9.
Embodiment 13
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 5, addition is other steps outside 10%
It is rapid same as Example 9.
Embodiment 14
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 6, addition is other steps outside 20%
It is rapid same as Example 9.
Embodiment 15
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 7, addition is other steps outside 15%
It is rapid same as Example 9.
Embodiment 16
Compared with Example 9, except the Chinese medicine composition of addition is made for embodiment 8, addition is other steps outside 25%
It is rapid same as Example 9.
Comparative example 9
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 1, other steps and the phase of embodiment 9
Together.
Comparative example 10
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 2, other steps and the phase of embodiment 9
Together.
Comparative example 11
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 3, other steps and the phase of embodiment 9
Together.
Comparative example 12 compared with Example 9, except addition Chinese medicine composition for comparative example 4 be made in addition to, other steps with
Embodiment 9 is identical.
Comparative example 13
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 5, other steps and the phase of embodiment 9
Together.
Comparative example 14
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 6, other steps and the phase of embodiment 9
Together.
Comparative example 15
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 7, other steps and the phase of embodiment 9
Together.
Comparative example 16
Compared with Example 9, in addition to the Chinese medicine composition of addition is made for comparative example 8, other steps and the phase of embodiment 9
Together.
The cosmetics test experience of embodiment 17
1st, antiallergy is tested
Using antiallergic cosmetics made of embodiment 9-16 and comparative example 9-16 as laboratory sample, per 30 allergy of group selection
Patient (male 10, women 20) is used as human experimentation object, and after the daily morning and evening face cleaning of experimenter, experiment sample is used in full face
Product, result is observed after two weeks.
2nd, moisturizing is tested
Using antiallergic cosmetics made of embodiment 9-16 and comparative example 9-16 as laboratory sample, it is real to carry out moisturizing test
Test.Per 30 ages of group selection 20~55 years old, skin health, the volunteer without cosmetic allergic contact dermatitis history.Use CM825 skin water
Divide the cuticula moisture content at tester determination test position, take the average values of 5 measurements to be represented as test value with MMV.Experiment
Method is as follows：(1) the left and right inboard arm of subject is selected to mark 4cm × 4cm examination away from being Test sites at palm base portion 5cm
Test region.
(2) the cuticula moisture content at CM825 moisture of skin tester determination tests position is used, obtains blank value.
(3) sample is smeared in subject's arm, left arm is comparative example, and right arm is laboratory sample.
(4) subject determines cuticula after cosmetics 1h, 2h, 4h is used continuously using moisture of skin tester CM825
Moisture content.
(5) MMV rates of change are calculated.
MMV rates of change=(skin hydration degree-initial skin hydrauture during test)/initial skin hydrauture × 100%.
Cosmetics test result analysis
1st, antiallergy is tested, and the results are shown in Table 4
Table 4
2nd, moisturizing is tested, and the results are shown in Table 5
Table 5
From the data analysis of embodiment 9-16 in table 4 and table 5, the cosmetics antiallergic effect of embodiment 9 is best, up to
100%, moistening effect is most lasting, from comparative example 9-12 data analysis, cosmetics made by independent any component
Antiallergic moistening effect is all poor, and from comparative example 13-16 data analysis, four kinds of components lack either of which without
Method reaches preferable antiallergic moistening effect, thus, it can be known that four kinds of components coordinate jointly in the application, Synergistic is indispensable.
In the condition and range that the application provides, better effects are can reach.
In summary, the Chinese medicine composition that prepared by the present invention can effectively suppress hyaluronidase enzymatic activity and tyrosinase enzyme
Activity, effectively remove free radical.Wherein hyaluronidase enzymatic activity extracorporeal inhibiting rate is up to 96.66%, and erythrocyte hemolysis rate is only
For 7.76%, for free radical scavenging activity up to 96.31%, tyrosinase enzymatic activity inhibiting rate reaches 98.94%.By Chinese medicine composition
It is applied in cosmetics, antiallergy effective percentage reaches 100%, and moisture-keeping function is lasting.Four kinds of components coordinate jointly, Synergistic,
There is remarkable result in condition and range provided by the invention.Each comparative example compared with Example 1, lacks any or more
Kind is all unable to reach optimal effectiveness.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implemented.Art
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., within the scope of all falling within protection scope of the present invention and disclosing.
Claims (9)
1. a kind of Chinese medicine composition, it is characterised in that the Chinese medicine composition is mainly prepared by the following raw material by mass percentage
Obtain：Peony 5%-50%, leaf of bamboo 5%-50%, common bombax flower 5%-50% and lotus 5%-40%；
Wherein, the mass percent sum of each raw material of the Chinese medicine composition is no more than 100%.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition is main by mass percentage
It is prepared by the following raw material：Peony 10-40%, leaf of bamboo 10-40%, common bombax flower 20-40% and lotus 10-30%；
Wherein, the mass percent sum of each raw material of the Chinese medicine composition is no more than 100%.
3. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition is main by mass percentage
It is prepared by the following raw material：Peony 30%, the leaf of bamboo 20%, common bombax flower 30% and lotus 20%.
A kind of 4. method for preparing the Chinese medicine composition as any one of claim 1-3, it is characterised in that including following step
Suddenly：
(1) coarse powder is obtained by the Chinese medicine material is dry, sieving by formula ratio；
(2) coarse powder that soaking step (1) obtains, obtains extract solution；
(3) extract solution for obtaining step (2) filters, and rotary evaporation concentration, freeze-drying, obtains the Chinese medicine composition.
5. according to the method for claim 4, it is characterised in that the mesh number of step (1) selection of sieving is 80-200 mesh,
Preferably 100 mesh.
6. the method according to claim 4 or 5, it is characterised in that step (2) solution that uses of immersion coarse powder is goes
Ionized water；
Preferably, the dosage of the deionized water is 5-8 times, preferably 6 times of the meal quality；
Preferably, the temperature of the immersion is 60-90 DEG C, preferably 80 DEG C；
Preferably, the number of the immersion is 1-4 times, preferably 2 times；
Preferably, the time of the immersion is 1-2 hours, preferably 1 hour.
7. according to the method any one of claim 4-6, it is characterised in that the filtering described in step (3) uses micro-filtration
Film is filtered；
Preferably, the aperture of the microfiltration membranes used is filtered as 0.1-0.65 μm, preferably 0.22 μm.
8. a kind of Chinese medicine composition as any one of claim 1-3 is used to prepare antiallergic cosmetics；
Preferably, the addition of the Chinese medicine composition is 1-30%, preferably 7%.
9. cosmetics according to claim 8, it is characterised in that the formulation of the cosmetics includes：Aqua, emulsion, spray
In mist agent, cream, elite or facial mask any one or at least two combination, preferably cream agent and/or spray.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938493A (en) * | 2018-09-11 | 2018-12-07 | 广州环亚化妆品科技有限公司 | A kind of Chinese medicine composition and its preparation method and application |
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| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
| CN103284915A (en) * | 2013-05-31 | 2013-09-11 | 广州环亚化妆品科技有限公司 | Whitening plant extract combination and application thereof in cosmetics |
| CN104784069A (en) * | 2014-01-21 | 2015-07-22 | 广州环亚化妆品科技有限公司 | Aromatic plant composition with whitening and oxidation resisting efficacies, and its application in cosmetics |
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2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
| CN103284915A (en) * | 2013-05-31 | 2013-09-11 | 广州环亚化妆品科技有限公司 | Whitening plant extract combination and application thereof in cosmetics |
| CN104784069A (en) * | 2014-01-21 | 2015-07-22 | 广州环亚化妆品科技有限公司 | Aromatic plant composition with whitening and oxidation resisting efficacies, and its application in cosmetics |
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| CN108938493A (en) * | 2018-09-11 | 2018-12-07 | 广州环亚化妆品科技有限公司 | A kind of Chinese medicine composition and its preparation method and application |
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Address after: No.18, Nanyun 1st Road, Guangzhou Development Zone, Guangdong 510000 Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: No.18, Nanyun 1st Road, Guangzhou Development Zone, Guangdong 510000 Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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