CN107550450A - A kind of fluorescence endoscopy system for bronchial disease early diagnosis - Google Patents
A kind of fluorescence endoscopy system for bronchial disease early diagnosis Download PDFInfo
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- CN107550450A CN107550450A CN201710824809.XA CN201710824809A CN107550450A CN 107550450 A CN107550450 A CN 107550450A CN 201710824809 A CN201710824809 A CN 201710824809A CN 107550450 A CN107550450 A CN 107550450A
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Abstract
The invention discloses a kind of fluorescence endoscopy system for bronchial disease early diagnosis, including master controller, light source cell, endoscopic unit, detection unit, Cloud Server and display unit, Cloud Server is connected by internet with master controller, display unit is connected by USB interface with master controller, master controller is connected with light source cell and detection unit respectively by cable, and light source cell and detection unit are connected by optical fiber with endoscopic unit respectively.The present invention realizes the high-resolution to bronchus position, high-precision light spectrum image-forming by spectral imaging technology, while is transmitted image information to Cloud Server by internet, realizes the Real-Time Sharing and auxiliary diagnosis of data.
Description
Technical field
The invention belongs in optical image technology field, more particularly to a kind of fluorescence for bronchial disease early diagnosis
Endoscope system.
Background technology
Endoscopic technique is that modern medical service diagnoses one of essential instrument, can be directly in human body by endoscope
Organ is observed, and the early diagnosis for diseases such as bronchuses is significant.
Clinical experience shows that, for diseases such as bronchuses, early diagnosis is extremely important, is then able to realize high-resolution spectra
The fluorescence endoscope technology of imaging is increasingly taken seriously.Spectral imaging technology is a kind of by spectral technique and optical image technology
Perfect adaptation and caused imaging technique, multi-optical spectrum imaging technology are a kind of one kind to grow up on light spectrum image-forming basis
New imaging technique, it can be had differences for principle, by object with absorption of the different objects to different wave length light
Change of the body to luminous intensity in the light of one group of different wave length is detected to target object to realize, the application such as distinguishes.In mesh
Multi-optical spectrum imaging technology is combined with clinical diagnosis in preceding clinical research, two are realized simultaneously by microscopy endoscopic imaging technique
The acquisition of person, detection sensitivity is not only drastically increased, and obtain molecular level sample biochemical information, be cancer
The clinical diagnosis of the diseases such as disease, bronchus provides important evidence.The drawbacks of existing diagnostic techniques, is on the one hand due to diagnostic device
The limitation of performance, on the other hand due to doctor subjective judgement error and medical level it is uneven.
CN102697449A discloses a kind of light source device for endoscope, is connected to or is installed on into body cavity and projects warp
The endoscope of light as derived from light guide, the light source device for endoscope possess：Laser light source portion, at least with
1 and the 2nd laser light source, the 1st laser light source produce the 1st laser, the 2nd laser light source produce centre wavelength with
The 2nd different laser of 1st laser；Wavelength conversion section, incident 1st and the 2nd laser is configured to, and the described 1st is swashed
Light is transformed into white light, and the illumination light for being mixed with the 2nd laser, the illumination light from the wavelength conversion section are projected to the white light
Incide the light guide.The device can not be selected the light of different wave length.
CN103315711B discloses a kind of medical include through endoscope Cherenkov's luminescence imaging system, the system：
Endoscope probe, hair is combined with probe for gathering targeting target inside detected object surface white light signal and/or detected object
The Cherenkov's fluorescence signal gone out；Optical fiber image transmission beam, one end are connected with the endoscope probe, for transmitting the white light signal
And/or Cherenkov's fluorescence signal；Detection device, be connected with the optical fiber image transmission beam other end, for by described through light
The white light signal and/or Cherenkov's fluorescence signal of fine coherent fiber bundle transmission are converted into electric signal；Calculate and imaging device, it is and described
Detection device connects, and for carrying out subsequent treatment to the electric signal after the conversion, obtains the white light structure on detected object surface
Targeting target is combined the Cherenkov's fluoroscopic image sent with probe inside image and/or detected object.This is medical through endoscope
Cherenkov's luminescence imaging system exist imaging nucleic it is few, image taking speed is slow, light signal strength is low, signal penetrability deficiency lack
Point.
And from the point of view of existing disclosed technology contents, synchronously carried out in the absence of the excitation of spectra and spectroscopic acquisition
Device.In addition, other all many deficiencies also be present in existing spectrum based endoscopic imaging technology, such as：Endoscopic imaging system is answered
It is miscellaneous, bulky, involve great expense, by medical personnel's experience, its degree of accuracy, stability, imaging precision can not all meet at present
Clinical demand.
The content of the invention
The present invention is to avoid above-mentioned the shortcomings of the prior art part, there is provided one kind is examined for bronchial disease early stage
Disconnected fluorescence endoscopy system, by spectral imaging technology, realize the high-resolution to bronchus position, high-precision spectrum into
Picture, while transmitted image information to Cloud Server by internet, realize the Real-Time Sharing and instrument auxiliary diagnosis of data.
The technical solution adopted in the present invention is：
A kind of fluorescence endoscopy system for bronchial disease early diagnosis, including master controller, light source cell, interior peep
Mirror unit, detection unit, Cloud Server and display unit, Cloud Server are connected by internet with master controller, display unit
It is connected by USB interface with master controller, master controller is connected with light source cell and detection unit respectively by cable, light source
Unit and detection unit are connected by optical fiber with endoscopic unit respectively, and master controller is used to control light source cell, endoscope
Unit and detection unit, light source cell are used to send excitation beam and conduct excitation beam to endoscopic unit, endoscope list
Member is used to transmit the fluorescence signal that excitation beam is directed at bronchial surface and sends bronchial surface to detection unit, detection
Unit is used to fluorescence signal is divided and gathered, and by the real-time data transmission collected to master controller, master controller
By the data transfer come from detection unit transmission to Cloud Server to carry out cloud storage, data maintenance and cloud computing.
The master controller include time-sequence control module, waveband selection module, synchronous trigger module, image capture module,
Spectral manipulation module and image processing module, waveband selection module are used for the waveband selection for carrying out excitation beam as needed, when
Sequence control module and synchronous trigger module are used to control light source cell and detection unit while work, and image capture module is used to connect
Receive the data from detection part and send data to spectral manipulation module, image processing module progress data processing, simultaneously
Display unit progress image is sent data to show.
The light source cell includes luminescent device, filtering device, entrance lens group and the incident optical coupling arranged successively
Device, luminescent device send excitation beam as light source, and filtering device is used for the gating for realizing different wave length excitation beam, incident saturating
Microscope group is with incident optical coupler the excitation beam for gating to obtain through filtering device to be coupled to be connected light source cell
With in the optical fiber of endoscopic unit and transmit to endoscopic unit.
The luminescent device includes xenon lamp, Halogen lamp LED, laser or light emitting diode；The filtering device includes the first filter
Mating plate group, the first acousto-optic tunable filter or the first liquid crystal tunable filter.
The endoscopic unit includes gathering the endoscope of image and to enter in subject to be detected in operating
The operation handle that sight glass stretches into.
The detection unit includes reception optical fiber coupler, receiving lens group, light-splitting device and the imager arranged successively
Part, reception optical fiber coupler and receiving lens group are used to receiving and exporting the fluorescence signal from endoscopic unit, light-splitting device
Light-splitting processing is carried out for the fluorescence signal come will to be transmitted, image device is used for fluorescence signal of the collection after light-splitting processing and gone forward side by side
Row IMAQ.
The light-splitting device includes the second filter set, the second acousto-optic tunable filter or the filtering of the second liquid crystal tunable
Device；The image device includes charge coupled cell sensor or complementary metal oxide semiconductor sensor.
The Cloud Server includes cloud storage module, data maintenance module and cloud computing module, and cloud storage module is used to suffer from
For the reliable memory of person's diagnostic data with reading at a high speed, data maintenance module is clear to realize the timing of data in cloud storage module
Reason, renewal and to realize the data sharing between different Cloud Servers, cloud computing module to realize spectrum split, background
Elimination and auxiliary diagnosis.
The display unit includes viewing hardware and operation software, to realize the behaviour of the display of image and endoscopic unit
Control.
The viewing hardware includes desktop computer, notebook computer, palm PC, tablet personal computer or smart mobile phone.
By adopting the above-described technical solution, having the beneficial effect that acquired by the present invention：
1st, it can be realized and excited and emission spectrum real time imagery, simple to operate, imaging resolution height, and master using the present invention
The external Cloud Server of controller, image and fluorescence signal are transmitted to Cloud Server by network, realize the common in real time of data
Enjoy and auxiliary diagnosis, improve the accuracy of judgement.
2nd, the present invention is simple in construction, and cost is relatively low, stable system performance, and doctor can easily select that multi-wavelength's is interior
Sight glass is imaged, and this is the early diagnosis of some diseases, the diagnosis of particularly early stage bronchial disease provide strong diagnosis according to
According to.
Brief description of the drawings
Fig. 1 is the operation principle schematic diagram of the present invention.
Wherein,
1st, master controller 2, light source cell 21, luminescent device 22, filtering device 23, entrance lens group 24, incident light
Fine coupler 3, endoscopic unit 4, detection unit 41, reception optical fiber coupler 42, receiving lens group 43, light-splitting device
44th, image device 5, display unit 6, Cloud Server
Embodiment
The present invention is described in further detail with specific embodiment below in conjunction with the accompanying drawings, but the present invention is not limited to
These embodiments.
As shown in figure 1, a kind of fluorescence endoscopy system for bronchial disease early diagnosis, including master controller 1, light
Source unit 2, endoscopic unit 3, detection unit 4, Cloud Server 6 and display unit 5.The Cloud Server 6 by internet with
Master controller 1 is connected.The display unit 5 is connected by USB interface with master controller 1.Master controller 1 by cable respectively with
Light source cell 2 is connected with detection unit 4.Light source cell 2 is connected by incident optical 7 with endoscopic unit 3.Detection unit
4 are connected by reception optical fiber 8 with endoscopic unit 3.
The master controller 1 is used to control light source cell 2, endoscopic unit 3 and detection unit 4.Specifically, it is described
Master controller 1 includes time-sequence control module, waveband selection module, synchronous trigger module, image capture module, spectral manipulation module
And image processing module.Waveband selection module is used for the waveband selection for carrying out excitation beam as needed, chooses corresponding ripple
Duan Hou, master controller 1 control light source cell 2 and detection unit 4 to work simultaneously by time-sequence control module and synchronous trigger module,
So as to ensure that the synchronism of the excitation of spectra and spectroscopic acquisition.Described image acquisition module, which is used to receive, comes from detection part
Data and send data to spectral manipulation module, image processing module carries out data processing, while send data to aobvious
Show that unit 5 carries out image and shown.
The light source cell 2 is used to send excitation beam and conduct excitation beam to endoscopic unit 3.Specifically come
Say, the light source cell 2 includes luminescent device 21, filtering device 22, entrance lens group 23 and the incident optical coupling arranged successively
Clutch 24.The luminescent device 21 sends excitation beam as light source.The luminescent device 21 includes xenon lamp, Halogen lamp LED, laser
Device or light emitting diode.The filtering device 22 is used for the gating for realizing different wave length excitation beam, and the filtering device 22 wraps
Include the first filter set, the first acousto-optic tunable filter or the first liquid crystal tunable filter.Entrance lens group 23 and incidence
Fiber coupler 24 is the excitation beam for gating to obtain through filtering device to be coupled in incident optical 7 and transmit to endoscope
Unit 3.
The one end of light source cell 2 connection master controller 1, one end connection endoscopic unit 3, luminescent device 21 obtain master control
The order of device 1 processed carries out the transmitting and shut-off of excitation beam, and the wave band that filtering device 22 selects according to master controller 1 carries out corresponding
The gating of wave band, by the light beam of filtering device 22 again through entrance lens group 23 and incident optical coupler 24 by excitation beam coupling
Close into incident optical 7, transmitted excitation beam to following endoscopes by incident optical 7.
The endoscopic unit 3 is used to believe the fluorescence that excitation beam is directed at bronchial surface and sends bronchial surface
Number transmit to detection unit 4.Specifically, the endoscopic unit 3 includes gathering figure in subject to be detected to enter
The endoscope of picture and to operate the operation handle that endoscope stretches into.Endoscopic imaging can be adjusted by manipulation operations handle
Position and angle, to find suitable observation position.
The detection unit 4 is used to fluorescence signal is divided and gathered, and by the real-time data transmission collected extremely
Master controller 1.Specifically, the detection unit 4 includes reception optical fiber coupler 41, the receiving lens group arranged successively
42nd, light-splitting device 43 and image device 44.The reception optical fiber coupler 41 and receiving lens group 42 are used to receive and export to come
From the fluorescence signal of endoscopic unit 3.The light-splitting device 43 is used to that the fluorescence signal progress light-splitting processing come will to be transmitted.Light splitting
Device 43 includes the second filter set, the second acousto-optic tunable filter or the second liquid crystal tunable filter.The imager
Part 44 is used to collect the fluorescence signal after light-splitting processing and carries out IMAQ.Image device 44 passes including charge coupled cell
Sensor or complementary metal oxide semiconductor sensor.
Transmitted from the fluorescence signal of endoscope output by reception optical fiber coupler 41 and receiving lens group 42 to optical splitter
Part 43, light-splitting device 43 are split according to the instruction of master controller 1 to fluorescence signal, then by image device 44 to fluorescence
Signal is acquired.
By detection unit 4 gather come spectroscopic data transmitted after the processing of master controller 1 to Cloud Server 6 to enter
Rack storage, data maintenance and cloud computing.Specifically, the Cloud Server 6 includes cloud storage module, data maintenance mould
Block and cloud computing module.The cloud storage module is made up of high-performance, large capacity disc array, and cloud storage module is examined for patient
The reliable memory of disconnected data is with reading at a high speed.The data maintenance module is clear to realize the timing of data in cloud storage module
Reason, update and to realize the data sharing between different Cloud Servers 6.The cloud computing module provides powerful fluorescence light
Imaging data analytic function is composed, to realize that spectrum is split, background eliminates and auxiliary diagnosis.
The display unit 5 includes viewing hardware and operation software, to realize the display of image and endoscopic unit
Operational control.The viewing hardware includes desktop computer, notebook computer, palm PC, tablet personal computer or smart mobile phone etc..
When carrying out the diagnosis of early stage bronchial disease using the fluorescence endoscope in the present invention, light that luminescent device 21 is sent
The light beam of suitable wave band is gated by filtering device 22, then passes through entrance lens group 23 and incident optical coupler 24
The wave band of selection is coupled into incident optical 7, by incident optical 7 by beam Propagation to endoscope, and entered by endoscope
Endobronchial surface.After excitation beam is irradiated to bronchial surface, tissue emissions fluorescence signal, the fluorescence signal of return leads to
Cross reception optical fiber 8 to transmit to detection unit 4, detection unit 4 realizes the light splitting and collection of the fluorescence signal to passing back, main control
Device 1 carries out the analysis and upload of data, and the operation software for the display unit 5 being connected with master controller 1 can control whole system
Normal operation, the spectroscopic data that master controller 1 collects detection unit analyzed, and is passed through the Internet transmission to cloud and taken
Business device 6, cloud storage, data maintenance and cloud computing are carried out to spectral signal by Cloud Server 6.
The part do not addressed in the present invention uses or used for reference prior art and can be achieved.
In addition, term " first ", " second " are only used for describing purpose, and it is not intended that indicating or implying relatively important
Property.
Specific embodiment described herein is only the spiritual example explanation to the present invention.Belonging to the present invention
Those skilled in the art can make various modifications or supplement to described specific embodiment or using similar
Mode substitutes, but without departing from the spiritual of the present invention or surmounts scope defined in appended claims.
Claims (10)
1. a kind of fluorescence endoscopy system for bronchial disease early diagnosis, it is characterised in that including master controller, light source
Unit, endoscopic unit, detection unit, Cloud Server and display unit, Cloud Server are connected by internet with master controller,
Display unit is connected by USB interface with master controller, master controller by cable respectively with light source cell and detection unit phase
Connection, light source cell and detection unit are connected by optical fiber with endoscopic unit respectively, and master controller is used to control light source list
Member, endoscopic unit and detection unit, light source cell are used to send excitation beam and conduct excitation beam to endoscopic unit,
Endoscopic unit is used to transmit the fluorescence signal that excitation beam is directed at bronchial surface and sends bronchial surface to detection
Unit, detection unit are used to fluorescence signal is divided and gathered, and by the real-time data transmission collected to master controller,
Master controller by from detection unit transmission come data transfer to Cloud Server in terms of carrying out cloud storage, data maintenance and cloud
Calculate.
2. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In, the master controller include time-sequence control module, waveband selection module, synchronous trigger module, image capture module, at spectrum
Module and image processing module are managed, waveband selection module is used for the waveband selection for carrying out excitation beam as needed, SECO
Module and synchronous trigger module are used to control light source cell and detection unit while work, and image capture module comes from for reception
The data of detection part simultaneously send data to spectral manipulation module, image processing module carries out data processing, while by data
Transmit to display unit progress image and show.
3. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In the light source cell includes luminescent device, filtering device, entrance lens group and the incident optical coupler arranged successively, hair
Optical device sends excitation beam as light source, and filtering device is used for the gating for realizing different wave length excitation beam, entrance lens group
With incident optical coupler being coupled to be connected light source cell and interior by the excitation beam for gating to obtain through filtering device
In the optical fiber of sight glass unit and transmit to endoscopic unit.
4. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 3, its feature exist
In the luminescent device includes xenon lamp, Halogen lamp LED, laser or light emitting diode；The filtering device includes the first optical filter
Group, the first acousto-optic tunable filter or the first liquid crystal tunable filter.
5. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In the endoscopic unit is included to be stretched into the endoscope of collection image in subject to be detected and to operate endoscope
The operation handle entered.
6. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In the detection unit includes reception optical fiber coupler, receiving lens group, light-splitting device and the image device arranged successively, connects
Receive fiber coupler and receiving lens group is used to receiving and exporting the fluorescence signal from endoscopic unit, light-splitting device is used for will
The fluorescence signal that transmission comes carries out light-splitting processing, and image device is used to collect the fluorescence signal after light-splitting processing and carries out image
Collection.
7. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 6, its feature exist
In the light-splitting device includes the second filter set, the second acousto-optic tunable filter or the second liquid crystal tunable filter；Institute
Stating image device includes charge coupled cell sensor or complementary metal oxide semiconductor sensor.
8. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In the Cloud Server includes cloud storage module, data maintenance module and cloud computing module, and cloud storage module diagnoses for patient
The reliable memories of data is with reading at a high speed, and data maintenance module is realizing the timing of data in cloud storage module cleaning, renewal
And to realize the data sharing between different Cloud Servers, cloud computing module spectrum is split, background eliminates realizing and
Auxiliary diagnosis.
9. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 1, its feature exist
In the display unit includes viewing hardware and operation software, to realize the operation control of the display of image and endoscopic unit
System.
10. a kind of fluorescence endoscopy system for bronchial disease early diagnosis according to claim 9, its feature exist
In the viewing hardware includes desktop computer, notebook computer, palm PC, tablet personal computer or smart mobile phone.
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| CN101125075A (en) * | 2007-09-26 | 2008-02-20 | 叶衍铭 | Fluoroscopic image early cancer diagnosis equipment |
| WO2013002350A1 (en) * | 2011-06-29 | 2013-01-03 | 京都府公立大学法人 | Tumor site identification device and method |
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Application publication date: 20180109 |