CN107536755A - The preparation method of oil-soluble Flos Osmanthi Fragrantis extract and its application in cosmetics - Google Patents
The preparation method of oil-soluble Flos Osmanthi Fragrantis extract and its application in cosmetics Download PDFInfo
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- CN107536755A CN107536755A CN201710798846.8A CN201710798846A CN107536755A CN 107536755 A CN107536755 A CN 107536755A CN 201710798846 A CN201710798846 A CN 201710798846A CN 107536755 A CN107536755 A CN 107536755A
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Abstract
The invention provides the preparation method of oil-soluble Flos Osmanthi Fragrantis extract; the preparation method using freeze-drying crush, be heated at reflux and extraction process combine by the way of; the natural oils containing high level in the oil-soluble Flos Osmanthi Fragrantis extract that is prepared can be made, wherein based on oleic acid and linoleic acid, there is efficient antimicrobial antiphlogistic; it is nontoxic to skin, non-stimulated; it is easily controllable and extraction process is simple, safety; cost is low, suitable for large-scale production antimicrobial antiphlogistic cosmetics.
Description
Technical field
The invention belongs to cosmetic field, a kind of preparation method more particularly to oil-soluble Flos Osmanthi Fragrantis extract and its changing
Application in cosmetic.
Background technology
Giving off a strong fragrance causes remote when sweet osmanthus blooms, its fragrance have clear dense two and the characteristics of, can cleanse clearly, it is dense to cause remote, therefore have
The laudatory title of " kamuning ", sweet osmanthus contain natural oils about 0.3%, contain tens of kinds of compounds in oil, be commonly used to fabricate cake, candy
Based food, there is cold dispelling to break knot, preventing phlegm from forming and stopping coughing and other effects, also have for making wine, the sweet and pure thickness of the aroma, there is appetizing inducing resuscitation, be good for
Spleen qi-restoratives and other effects, and sweet osmanthus is used to make the technologies of cosmetics, also mostly is production white-skinned face function class product, is produced used
Carbon dioxide supercritical extraction technique is highly vulnerable to breakage the natural oils in sweet osmanthus, and process conditions are difficult to control, equipment cost compared with
Height, it is unfavorable for large-scale production.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of preparation method of oil-soluble Flos Osmanthi Fragrantis extract and its changed
Application in cosmetic so that the cosmetics produced have preferable antimicrobial antiphlogistic effect.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
The preparation method of oil-soluble Flos Osmanthi Fragrantis extract, comprises the following steps：
（1）It will be freeze-dried after the removal of impurities of fresh sweet osmanthus, cleaning, then be ground into 40-80 mesh powder material；
（2）In 8-15mL/g ratio by powder materials the soak at room temperature 15-24h in ethanol solution, obtain immersion liquid；
（3）Immersion liquid is heated at reflux 2-5h at a temperature of 48-53 DEG C, is cooled to room temperature, filtering, concentration remove ethanol, obtained dense
Contracting liquid；
（4）Concentrate dichloromethane or chloroform are extracted 3-5 times, it is 1- that mass fraction is added in the solvent phase being collected into
2% activated carbon, 0.5-1.5h is stirred, filtering, concentration remove solvent, and obtained paste is oil-soluble Flos Osmanthi Fragrantis extract.
The step（2）In, the volumetric concentration of ethanol solution is 66-74%.
The step（4）In, activated carbon is 200-230 mesh.
Application of the oil-soluble Flos Osmanthi Fragrantis extract that the preparation method is prepared in antimicrobial antiphlogistic cosmetics.
The oil-soluble Flos Osmanthi Fragrantis extract accounts for the 1-5% of cosmetics gross weight.
The dosage form of the cosmetics is smoothing toner, gel, elite breast, shampoo or washing cream.
The advantage of the invention is that：The preparation method of the present invention is crushed using freeze-drying, is heated at reflux and extracts work
The mode that skill combines, the natural oils containing high level in the oil-soluble Flos Osmanthi Fragrantis extract that is prepared can be made, wherein with
Based on oleic acid and linoleic acid, there is efficient antimicrobial antiphlogistic, it is nontoxic to skin, non-stimulated, and extraction process is simple, is easy to control
System, safety, cost is low, suitable for large-scale production antimicrobial antiphlogistic cosmetics.
Embodiment：
The present invention is described in further details with reference to embodiments, but these embodiments are not limitation of the invention.
Embodiment 1
The preparation method of oil-soluble Flos Osmanthi Fragrantis extract, comprises the following steps：
（1）It will be freeze-dried after the removal of impurities of fresh sweet osmanthus, cleaning, then be ground into 40 mesh powder material；
（2）In 8mL/g ratio by powder materials volumetric concentration be 74% ethanol solution in soak at room temperature 16h, obtain immersion liquid；
（3）Immersion liquid is heated at reflux 2h at a temperature of 48 DEG C, is cooled to room temperature, filtering, concentration remove ethanol, obtain concentrate；
（4）Concentrate dichloromethane or chloroform are extracted 3 times, it is 1% that mass fraction is added in the solvent phase being collected into
200 mesh activated carbons, 0.8h is stirred, filtering, concentration remove solvent, and obtained paste is oil-soluble Flos Osmanthi Fragrantis extract.
Sampling detection paste, oleic acid content 1.57%, linoleic acid content 3.61%.
Embodiment 2
The preparation method of oil-soluble Flos Osmanthi Fragrantis extract, comprises the following steps：
（1）It will be freeze-dried after the removal of impurities of fresh sweet osmanthus, cleaning, then be ground into 60 mesh powder material；
（2）In 12mL/g ratio by powder materials volumetric concentration be 70% ethanol solution in soak at room temperature 20h, obtain immersion liquid；
（3）Immersion liquid is heated at reflux 3h at a temperature of 50 DEG C, is cooled to room temperature, filtering, concentration remove ethanol, obtain concentrate；
（4）Concentrate dichloromethane or chloroform are extracted 3 times, it is 2% that mass fraction is added in the solvent phase being collected into
200-230 mesh activated carbons, 1h is stirred, filtering, concentration remove solvent, and obtained paste is oil-soluble Flos Osmanthi Fragrantis extract.
Sampling detection paste, oleic acid content 1.72%, linoleic acid content 3.89%.
Embodiment 3
The preparation method of oil-soluble Flos Osmanthi Fragrantis extract, comprises the following steps：
（1）It will be freeze-dried after the removal of impurities of fresh sweet osmanthus, cleaning, then be ground into 80 mesh powder material；
（2）In 15mL/g ratio by powder materials volumetric concentration be 74% ethanol solution in soak at room temperature 24h, obtain immersion liquid；
（3）Immersion liquid is heated at reflux 4.5h at a temperature of 52 DEG C, is cooled to room temperature, filtering, concentration remove ethanol, must concentrated
Liquid；
（4）Concentrate dichloromethane or chloroform are extracted 5 times, it is 2% that mass fraction is added in the solvent phase being collected into
230 mesh activated carbons, 1h is stirred, filtering, concentration remove solvent, and obtained paste is oil-soluble Flos Osmanthi Fragrantis extract.
Sampling detection paste, oleic acid content 1.80%, linoleic acid content 4.12%.
The oil-soluble Flos Osmanthi Fragrantis extract that the embodiment of the present invention 3 is prepared with reference to embodiments, as main
Application of the active component in antimicrobial antiphlogistic cosmetics is described in further details, but these embodiments are nor to the present invention's
Limit.
Embodiment 4
Antimicrobial antiphlogistic elite emulsion formulation, its each component and content in being formulated are as shown in table 1 below：
Table 1.
Component A and B component are uniformly dissolved at a temperature of 75-80 DEG C respectively, emulsification is then mixed, filters, goes out
Bacterium, packaging.
Embodiment 5
Antimicrobial antiphlogistic hair washing water formulation, its each component and content in being formulated are as shown in table 2 below：
Table 2.
Component A and B component are uniformly dissolved at a temperature of 70-80 DEG C respectively, is then well mixed, is cooled to 40-45
Component C is added after DEG C to be well mixed, and is filtered, sterilizes, is packed.
Suppression of the cosmetics that detection embodiment 4 and embodiment 5 are prepared respectively to free radical and TYR enzyme activity
Situation：
1.5ml centrifuge tubes are taken, add TYR（0.3mg/ml）500 μ L, μ L of buffer solution 500, μ L of water 450, the μ L of enzyme 50 and change
At cosmetic 40 μ L, spectrophotometer wavelength 480nm, absorbance is as shown in table 3 below：
Table 3.
Wherein, comparative example 1 and comparative example 2 are formula when corresponding embodiment is not added with oil-soluble Flos Osmanthi Fragrantis extract.
Antibiotic property experiment is carried out to embodiment 3, it is as a result as shown in table 4 below：
Table 4.
Wherein, 30%BG is as positive control, the results showed that, the antibacterial effect of oil-soluble Flos Osmanthi Fragrantis extract is more preferable.
Anti-inflammatory experiment is carried out to embodiment 4：
Blank control, embodiment 4, the skin irritatin of three groups of pictures of control sample of 4 groups of participants are rubescent to eliminate phenomenon contrast,
30min results：Embodiment 4>=control sample>=blank control；1h results：Embodiment 4>=control sample>=blank control.
Wherein, blank control is as negative control, and control sample is as positive control, the results showed that, addition oil-soluble osmanthus
The antiphlogistic effects of embodiment 4 of flower extract are preferable.
Claims (6)
1. the preparation method of oil-soluble Flos Osmanthi Fragrantis extract, it is characterised in that comprise the following steps：
（1）It will be freeze-dried after the removal of impurities of fresh sweet osmanthus, cleaning, then be ground into 40-80 mesh powder material；
（2）In 8-15mL/g ratio by powder materials the soak at room temperature 15-24h in ethanol solution, obtain immersion liquid；
（3）Immersion liquid is heated at reflux 2-5h at a temperature of 48-53 DEG C, is cooled to room temperature, filtering, concentration remove ethanol, obtained dense
Contracting liquid；
（4）Concentrate dichloromethane or chloroform are extracted 3-5 times, it is 1- that mass fraction is added in the solvent phase being collected into
2% activated carbon, 0.5-1.5h is stirred, filtering, concentration remove solvent, and obtained paste is oil-soluble Flos Osmanthi Fragrantis extract.
2. preparation method according to claim 1, it is characterised in that the step（2）In, the volumetric concentration of ethanol solution
For 66-74%.
3. preparation method according to claim 1, it is characterised in that the step（4）In, activated carbon is 200-230 mesh.
4. the oil-soluble Flos Osmanthi Fragrantis extract that preparation method according to any one of claim 1 to 3 is prepared is in antibacterial
Application in anti-inflammatory cosmetics.
5. application according to claim 4, it is characterised in that the oil-soluble Flos Osmanthi Fragrantis extract accounts for cosmetics gross weight
1-5%.
6. application according to claim 4, it is characterised in that the dosage form of the cosmetics is smoothing toner, gel, essence
Magnificent breast, shampoo or washing cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787218A (en) * | 2019-11-14 | 2020-02-14 | 科丽思化妆品（上海）有限公司 | Extraction process of sweet osmanthus extract |
Citations (4)
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|---|---|---|---|---|
| CN103751284A (en) * | 2013-10-19 | 2014-04-30 | 华中科技大学 | Application of sweet osmanthus essential oil in resisting decayed tooth |
| CN105267306A (en) * | 2014-06-27 | 2016-01-27 | 三活水生物科技股份有限公司 | Preparation method of sweet osmanthus extract |
| CN105441193A (en) * | 2015-12-03 | 2016-03-30 | 李嘉 | Method for purifying sweet osmanthus essential oil |
| CN105559003A (en) * | 2015-12-30 | 2016-05-11 | 重庆市日用化学工业研究所 | Preparation method of sweet-scented osmanthus medicinal extract |
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2017
- 2017-09-07 CN CN201710798846.8A patent/CN107536755A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751284A (en) * | 2013-10-19 | 2014-04-30 | 华中科技大学 | Application of sweet osmanthus essential oil in resisting decayed tooth |
| CN105267306A (en) * | 2014-06-27 | 2016-01-27 | 三活水生物科技股份有限公司 | Preparation method of sweet osmanthus extract |
| CN105441193A (en) * | 2015-12-03 | 2016-03-30 | 李嘉 | Method for purifying sweet osmanthus essential oil |
| CN105559003A (en) * | 2015-12-30 | 2016-05-11 | 重庆市日用化学工业研究所 | Preparation method of sweet-scented osmanthus medicinal extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787218A (en) * | 2019-11-14 | 2020-02-14 | 科丽思化妆品（上海）有限公司 | Extraction process of sweet osmanthus extract |
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