CN107526049B - Multi-core metabolic imaging double-frequency head coil for ultrahigh field - Google Patents

Multi-core metabolic imaging double-frequency head coil for ultrahigh field Download PDF

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CN107526049B
CN107526049B CN201710821697.2A CN201710821697A CN107526049B CN 107526049 B CN107526049 B CN 107526049B CN 201710821697 A CN201710821697 A CN 201710821697A CN 107526049 B CN107526049 B CN 107526049B
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microstrip line
organic glass
cylindrical frame
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voltage
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CN107526049A (en
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薛蓉
左真涛
燕新强
石磊
王喆
李志光
褚索达
卓彦
张笑良
周晓洪
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Institute of Biophysics of CAS
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34007Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • G01R33/287Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR involving active visualization of interventional instruments, e.g. using active tracking RF coils or coils for intentionally creating magnetic field inhomogeneities
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/343Constructional details, e.g. resonators, specially adapted to MR of slotted-tube or loop-gap type
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36Electrical details, e.g. matching or coupling of the coil to the receiver
    • G01R33/3642Mutual coupling or decoupling of multiple coils, e.g. decoupling of a receive coil from a transmission coil, or intentional coupling of RF coils, e.g. for RF magnetic field amplification
    • G01R33/3657Decoupling of multiple RF coils wherein the multiple RF coils do not have the same function in MR, e.g. decoupling of a transmission coil from a receive coil

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Abstract

The invention relates to a multi-core metabolic imaging double-frequency head coil for an ultra-high field, which is characterized by comprising a first organic glass cylindrical frame and a second organic glass cylindrical frame, wherein the second organic glass cylindrical frame is sleeved in the first organic glass cylindrical frame; the outer surface of the first organic glass cylindrical frame is fixedly provided with a 1H microstrip line multichannel array coil, and the 1H microstrip line multichannel array coil is used for positioning and shimming a sample and/or a tested sample to obtain a high-resolution structural image of the sample and/or the tested sample; the outer surface of the second organic glass cylindrical frame is fixedly provided with a heteronuclear nuclide coil, and the heteronuclear nuclide coil is used for carrying out heteronuclear nuclide imaging on a sample and/or a tested object to obtain physiological metabolism information of the sample and/or the tested object. The invention can realize in-situ simultaneous imaging of protons and heteronuclear nuclides and observe physiological and metabolic conditions of organisms in real time.

Description

Multi-core metabolic imaging double-frequency head coil for ultrahigh field
Technical Field
The invention relates to a multi-nuclear metabolic imaging double-frequency head coil for an ultra-high field, and relates to the technical field of Magnetic Resonance (MRI) ultra-high field imaging.
Background
In the existing magnetic resonance systems, magnetic resonance signals of 1H protons are mostly used as imaging nuclides. But from the viewpoint of human physiological metabolism, the protons carry little physiological information, and hardly provide any metabolic information. Some aprotic nuclides, such as 23Na sodium, 31P phosphorus and the like, reflect the electrolyte equilibrium concentration inside and outside cells and tissues, carry more physiological and metabolic information of human bodies, and can also provide magnetic resonance signals. The disadvantage is that the content of the aprotic nuclides in the organism is reduced by thousands of times compared with that of water molecules, so that the signal-to-noise ratio (SNR) of the obtained magnetic resonance image is very low, and the method has no practical significance in a low-field-intensity magnetic resonance imaging system.
With popularization and application of an ultra-high field strength (7T and 9.4T) magnetic resonance imaging system, the signal-to-noise ratio of the magnetic resonance image is enhanced along with the enhancement of the magnetic field strength, so that the imaging of the aprotic heteronuclear nuclides such as 23Na, 31P and the like is possible. Therefore, the research and development of the human brain dual-frequency coil capable of simultaneously carrying out in-situ imaging on protons and heteronuclei is a research hot spot in the international magnetic resonance radio frequency field at present, and a more mature multi-core metabolic imaging dual-frequency head coil does not exist at present.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a multi-core metabolic imaging double-frequency head coil for an ultrahigh field, which can be used for simultaneously imaging protons and heteronuclei in situ and can ensure a higher signal-to-noise ratio.
In order to achieve the above purpose, the present invention adopts the following technical scheme: the double-frequency head coil for ultra-high field multi-core metabolic imaging is characterized by comprising a first organic glass cylindrical frame and a second organic glass cylindrical frame, wherein the second organic glass cylindrical frame is sleeved in the first organic glass cylindrical frame, and the first organic glass cylindrical frame is fixedly connected with the second organic glass cylindrical frame; the outer surface of the first organic glass cylindrical frame is fixedly provided with a 1H microstrip line multichannel array coil, and the 1H microstrip line multichannel array coil is used for positioning and shimming a sample and/or a tested sample to obtain a high-resolution structural image of the sample and/or the tested sample; the outer surface of the second organic glass cylindrical frame is fixedly provided with a heteronuclear nuclide coil, and the heteronuclear nuclide coil is used for carrying out heteronuclear nuclide imaging on a sample and/or a tested sample to obtain physiological metabolism information of the sample and/or the tested sample.
Further, the 1H microstrip line multichannel array coil adopts 1*8 proton microstrip line loop units, eight proton microstrip line loop units are made of Teflon materials, eight proton microstrip line loop units are circumferentially and uniformly and fixedly arranged on the outer surface of the organic glass cylindrical frame, the structures of the eight proton microstrip line loop units are identical, the adjacent two proton microstrip line loop units are connected with a capacitor for decoupling, and each proton microstrip line loop unit respectively and independently transmits or receives magnetic resonance signals.
Further, a layer of high-purity rectangular copper sheet is laid on the top surface of each proton microstrip line loop unit, a gap is formed in the middle of each rectangular copper sheet, and two parts of copper sheets divided by the gap are connected through a high-voltage-resistant nano-method capacitor Cn; the bottom surface of each proton microstrip line loop unit is provided with 1-2 high-purity copper wires in parallel, one side surface of each proton microstrip line loop unit is provided with a nonmagnetic adjustable high-voltage-resistant capacitor Cf, and the other side surface of each proton microstrip line loop unit is provided with a nonmagnetic adjustable high-voltage-resistant capacitor Ct; one end of the rectangular copper sheet is connected with one end of the nonmagnetic adjustable high-voltage-resistant capacitor Cf, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Cf is connected with one end of the copper sheet, the other end of the copper sheet is connected with one end of the nonmagnetic adjustable high-voltage-resistant capacitor Ct, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Ct is connected with the other end of the rectangular copper sheet, and the other end of the copper sheet is also connected with a coaxial cable and a grounding end in parallel through the nonmagnetic adjustable high-voltage-resistant capacitor Cm.
Furthermore, the heteronuclear nuclide coil adopts a phased array loop array structure, eight phased array loops are respectively and fixedly arranged on the outer surface of the second organic glass cylindrical frame, and two non-magnetic adjustable high-voltage-resistant capacitors Cf1 are connected in parallel between two adjacent phased array loops for decoupling.
Further, each phased array loop comprises six nonmagnetic high voltage resistant capacitors which are distributed symmetrically up and down, and each loop top of the phased array loop is provided with a nonmagnetic adjustable high voltage resistant capacitor Cm1 for receiving or transmitting signals by impedance adjustment, the bottom end of each phased array loop is provided with a nonmagnetic adjustable high voltage resistant capacitor Ct1 for adjusting resonance frequency, and each left end and right end of the phased array loop are respectively symmetrically provided with a plurality of distributed fixed capacitors Cm, wherein the nonmagnetic adjustable high voltage resistant capacitor Cm1, the four distributed fixed capacitors Cm and the nonmagnetic adjustable high voltage resistant capacitor Ct1 are connected in series to form a phased array loop.
Further, the two ends of the first organic glass cylindrical frame are provided with threading holes.
Further, the thickness of the rectangular copper sheet is 1mm.
Due to the adoption of the technical scheme, the invention has the following advantages: 1. the invention provides an eight-channel inner and outer two-layer double-frequency multi-core metabolic imaging double-frequency head coil, which utilizes a 1H proton microstrip line multi-channel array coil to obtain a high-resolution structural image in an ultra-high field, and utilizes an aprotic nuclide 23Na or 31P coil to obtain a heteronuclear metabolic image of an organism, so that protons and heteronuclei can be imaged in situ simultaneously in real time to observe physiological and metabolic conditions of the organism, and a higher signal-to-noise ratio can be ensured. 2. Compared with the traditional single-nuclide coil design scheme, the invention does not need to reposition a sample or a tested object, and can simultaneously complete the magnetic resonance scanning of the proton and the heteronuclide in the same determined area and position. 3. The electromagnetic fields of the inner 8 phased array loop units and the outer 8 proton microstrip line loop units are distributed in an orthogonal mode (the current direction of the outer layer flows on four surfaces of the front top and the rear bottom to form a closed loop, the current direction of the inner layer flows on four surfaces of the left top and the right bottom to form a closed loop, the current direction is vertical, the generated magnetic field is vertical), so that resonance frequencies are several times different, and because a space is reserved between the inner and outer double-layer coils, coupling can be removed well between the inner and outer double-layer coil loop units, and proton structure images and heteronuclear metabolism images with high signal to noise ratio can be obtained. The invention adopts the double-layer double-frequency circular volume array coil to realize proton and multi-core imaging, and can be widely applied to magnetic resonance ultrahigh field imaging.
Drawings
FIG. 1 is a schematic diagram of a multi-nuclear metabolic imaging dual-frequency head coil structure of the invention;
fig. 2 is a three-dimensional physical simulation schematic diagram of a multi-core metabolic imaging double-frequency head coil, wherein fig. a is a schematic diagram of a 1H microstrip line multi-channel array coil structure, and fig. b is a schematic diagram of a heteronuclear nuclide coil structure;
FIG. 3 is a schematic diagram of a proton microstrip line loop unit of the present invention;
Fig. 4 is a schematic diagram of the phased array loop structure of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings. It is to be understood, however, that the drawings are designed solely for the purposes of providing a better understanding of the invention and are not to be construed as limiting the invention.
As shown in fig. 1 and 2, the invention provides a multi-core metabolic imaging double-frequency head coil for an ultra-high field, which comprises a first organic glass cylindrical frame 1 and a second organic glass cylindrical frame 2. The second organic glass cylindrical frame 2 is sleeved in the first organic glass cylindrical frame 1, and the first organic glass cylindrical frame 1 and the second organic glass cylindrical frame 2 are fixedly connected through plastic screws.
The outer diameter of the first plexiglas cylindrical frame 1 of the present invention is 30 cm, and the outer diameter of the second plexiglas cylindrical frame is 25 cm, which is exemplified, but not limited thereto, and may be selected according to actual needs. The outer layer of the first organic glass cylindrical frame 1 is fixedly provided with a 1H microstrip line multichannel array coil 3 which is used for positioning and shimming a sample and/or a tested object to obtain a high-resolution structural image; the outer layer of the second organic glass cylindrical frame 2 is fixedly provided with a heteronuclear nuclide (23 Na or 31P) coil 4, the heteronuclear nuclide coil 4 adopts a phased array structure for realizing heteronuclear nuclide imaging such as sodium or phosphorus and the like, and sample and/or tested physiological metabolism information is obtained so as to evaluate diseases and effectively intervene in treatment, and in addition, two ends of the first organic glass cylindrical frame 1 are provided with threading holes.
In a preferred embodiment, as shown in fig. 3, the 1H microstrip multi-channel array coil 3 adopts a 1*8 proton microstrip line loop unit array structure, and the 8 proton microstrip line loop units 31 are made of Teflon (Teflon) with a relatively low dielectric constant, and the dielectric constant of the Teflon is generally lower than 2.2. The 8 proton microstrip line loop units 31 are uniformly and fixedly arranged on the outer surface of the first organic glass cylindrical frame 1 in the circumferential direction. The structures of the 8 proton microstrip line loop units 31 are identical, the distribution characteristics of transverse electromagnetic waves (TEM) are met, the adjacent two proton microstrip line loop units 31 can be connected with a capacitor with a smaller capacitance value according to the distance of an actual distance to remove coupling, no obvious coupling influence exists among the proton microstrip line loop units 31, and magnetic resonance signals can be respectively and independently transmitted or received.
A rectangular copper sheet 310 of high purity (the high purity is nearly one hundred percent purity, and is accurate to the position 3 after the decimal point) with a thickness of about 1mm is laid on the top surface of each proton microstrip line loop unit 31. The rectangular copper sheet 310 serves as a low-resistance grounding end and plays a role of radio frequency shielding, a gap 311 with the width of about 1cm is formed in the middle of the rectangular copper sheet 310, two parts of copper sheets 310 divided by the gap 311 are connected through a high-voltage-resistant nano-meter-level capacitor Cn, and the high-voltage-resistant nano-meter-level capacitor Cn is used for removing eddy current effects between the two parts of copper sheets. The bottom surface of each proton microstrip line loop unit 31 is provided with 1 to 2 high purity copper lines 312 having a width of about 1cm in parallel. One side surface of each proton microstrip line loop unit 31 is provided with a non-magnetic adjustable high-voltage-resistant capacitor Cf, and the other side surface of each proton microstrip line loop unit 31 is provided with a non-magnetic adjustable high-voltage-resistant capacitor Ct. One end of the rectangular copper sheet 310 is connected with one end of a nonmagnetic adjustable high-voltage-resistant capacitor Cf, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Cf is connected with one end of a copper wire 312, the other end of the copper wire 312 is connected with one end of a nonmagnetic adjustable high-voltage-resistant capacitor Ct, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Ct is connected with the other end of the rectangular copper sheet 310, and the other end of the copper wire 312 is also connected with a coaxial cable 313 and a grounding end in parallel through the nonmagnetic adjustable high-voltage-resistant capacitor Cm. The three non-magnetic high-voltage-resistant capacitors Cf, ct and Cm and the copper wire 312 inductance form a resonant circuit, the proton microstrip line loop unit can resonate under proton frequency by adjusting the non-magnetic adjustable high-voltage-resistant capacitors Cf and Ct, the output resistance of the microstrip line circuit can be matched with a 50 ohm coaxial cable by adjusting the non-magnetic adjustable high-voltage-resistant capacitor Cm, the best magnetic resonance signal output effect is achieved, the coaxial cable 313 is used for receiving or transmitting signals, wherein the numerical values of the non-magnetic adjustable high-voltage-resistant capacitors Cf, ct and Cm can be determined according to simulation and actual debugging, and the method is not limited.
In a preferred embodiment, as shown in fig. 4, the heteronuclear species (23 Na or 31P) coil 4 adopts a phased array Loop array structure, and 8 phased array loops are uniformly fixed on the outer surface of the second plexiglas cylindrical frame 2. Each phased array loop of the invention comprises six nonmagnetic high-voltage-resistant capacitors which are symmetrically distributed up and down and left and right, two nonmagnetic adjustable high-voltage-resistant capacitors Cf1 are connected in parallel between two adjacent phased array loops, wherein the loop top end of each phased array loop is provided with nonmagnetic adjustable high-voltage-resistant capacitor Cm1 for receiving or transmitting signals by impedance adjustment, the bottom end of each phased array loop is provided with nonmagnetic adjustable high-voltage-resistant capacitor Ct1 for adjusting resonance frequency, two distributed fixed capacitors Cm are symmetrically arranged at the left and right ends of each phased array loop respectively (taking this as an example, the number of the fixed capacitors symmetrically arranged at the left and right ends of the phased array loop can be set according to actual needs, as long as the actually required capacitance value requirement is met), wherein the nonmagnetic adjustable high-voltage-resistant capacitor Cm1, the four distributed fixed capacitors Cm and the nonmagnetic adjustable high-voltage-resistant capacitor Ct1 are connected in series to form a loop, the numerical value of the nonmagnetic high-voltage-resistant capacitor Cm can be determined according to the actual needs, and the numerical value of the nonmagnetic high-resistant capacitor Cm can not be limited.
The specific use process of the multi-core metabolic imaging double-frequency head coil for the ultra-high field is described in detail below with reference to specific embodiments.
As shown in fig. 1 and 2, after the manufacturing of the multi-core metabolic imaging double-frequency head coil for the ultra-high field is completed, the human head is placed into a second organic glass cylindrical frame 2 during the magnetic resonance ultra-high field scanning.
Firstly, a 1H microstrip line multichannel array coil 3 is utilized to scan a positioning item to image protons of the head, and the position is determined to obtain a structural image of the head.
And then, carrying out heteronuclear nuclide metabolism imaging by using the heteronuclear nuclide coil 4 according to the obtained information, thereby obtaining the wanted physiological metabolism information.
In summary, the problem of repositioning can be avoided, and the invention can simultaneously image and observe the physiological and metabolic conditions of organisms on the basis of in-situ simultaneous imaging of protons and heteronuclear nuclides in real time.
The foregoing embodiments are only for illustrating the present invention, wherein the structures, connection modes, manufacturing processes, etc. of the components may be changed, and all equivalent changes and modifications performed on the basis of the technical solutions of the present invention should not be excluded from the protection scope of the present invention.

Claims (4)

1. The double-frequency head coil for ultra-high field multi-core metabolic imaging is characterized by comprising a first organic glass cylindrical frame and a second organic glass cylindrical frame, wherein the second organic glass cylindrical frame is sleeved in the first organic glass cylindrical frame, and the first organic glass cylindrical frame is fixedly connected with the second organic glass cylindrical frame;
The outer surface of the first organic glass cylindrical frame is fixedly provided with a 1H microstrip line multichannel array coil, and the 1H microstrip line multichannel array coil is used for positioning and shimming a sample and/or a tested sample to obtain a high-resolution structural image of the sample and/or the tested sample; threading holes are formed in two ends of the first organic glass cylindrical frame;
The outer surface of the second organic glass cylindrical frame is fixedly provided with a heteronuclear nuclide coil, and the heteronuclear nuclide coil is used for carrying out heteronuclear nuclide imaging on a sample and/or a tested sample to obtain physiological metabolism information of the sample and/or the tested sample;
The 1H microstrip line multichannel array coil adopts 1*8 proton microstrip line loop units, eight proton microstrip line loop units are made of Teflon materials, the eight proton microstrip line loop units are circumferentially and uniformly and fixedly arranged on the outer surface of the organic glass cylindrical frame, the structures of the eight proton microstrip line loop units are identical, the adjacent two proton microstrip line loop units are connected with a capacitor for decoupling, and each proton microstrip line loop unit respectively and independently transmits or receives magnetic resonance signals;
A layer of high-purity rectangular copper sheet is paved on the top surface of each proton microstrip line loop unit, a gap is formed in the middle of each rectangular copper sheet, and two parts of copper sheets divided by the gap are connected through a high-voltage-resistant nano-meter-level capacitor Cn; the bottom surface of each proton microstrip line loop unit is provided with 1-2 high-purity copper wires in parallel, one side surface of each proton microstrip line loop unit is provided with a nonmagnetic adjustable high-voltage-resistant capacitor Cf, and the other side surface of each proton microstrip line loop unit is provided with a nonmagnetic adjustable high-voltage-resistant capacitor Ct; one end of the rectangular copper sheet is connected with one end of the nonmagnetic adjustable high-voltage-resistant capacitor Cf, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Cf is connected with one end of the copper sheet, the other end of the copper sheet is connected with one end of the nonmagnetic adjustable high-voltage-resistant capacitor Ct, the other end of the nonmagnetic adjustable high-voltage-resistant capacitor Ct is connected with the other end of the rectangular copper sheet, and the other end of the copper sheet is also connected with a coaxial cable and a grounding end in parallel through the nonmagnetic adjustable high-voltage-resistant capacitor Cm.
2. The multi-core metabolic imaging double-frequency head coil for the ultra-high field according to claim 1, wherein the heteronuclear nuclide coil adopts a phased array loop array structure, eight phased array loops are fixedly arranged on the outer surface of the second organic glass cylindrical frame respectively, and two non-magnetic adjustable high-voltage-resistant capacitors Cf1 decoupling are connected in parallel between two adjacent phased array loops.
3. The multi-core metabolic imaging double-frequency head coil for the ultra-high field according to claim 2, wherein each phased array loop comprises six nonmagnetic high voltage resistant capacitors which are symmetrically distributed up and down, a nonmagnetic adjustable high voltage resistant capacitor Cm1 is arranged at the top end of each phased array loop and used for receiving or transmitting signals through impedance adjustment, a nonmagnetic adjustable high voltage resistant capacitor Ct1 is arranged at the bottom end of each phased array loop and used for adjusting resonance frequency, a plurality of distributed fixed capacitors Cm are symmetrically arranged at the left end and the right end of each phased array loop, and the nonmagnetic adjustable high voltage resistant capacitor Cm1, the four distributed fixed capacitors Cm and the nonmagnetic adjustable high voltage resistant capacitor Ct1 are connected in series to form one phased array loop.
4. The dual-head coil for ultra-high field multi-core metabolic imaging according to claim 1, wherein the rectangular copper sheet has a thickness of 1mm.
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