CN107523598A - 一种提高多杀菌素产量的发酵方法 - Google Patents
一种提高多杀菌素产量的发酵方法 Download PDFInfo
- Publication number
- CN107523598A CN107523598A CN201710469688.1A CN201710469688A CN107523598A CN 107523598 A CN107523598 A CN 107523598A CN 201710469688 A CN201710469688 A CN 201710469688A CN 107523598 A CN107523598 A CN 107523598A
- Authority
- CN
- China
- Prior art keywords
- fermentation
- nitrogen source
- compound organic
- organic nitrogen
- pleocidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 85
- 230000004151 fermentation Effects 0.000 title claims abstract description 85
- 241000894006 Bacteria Species 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 235000012054 meals Nutrition 0.000 claims description 31
- 244000105624 Arachis hypogaea Species 0.000 claims description 18
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 18
- 235000012343 cottonseed oil Nutrition 0.000 claims description 18
- 235000003276 Apios tuberosa Nutrition 0.000 claims description 16
- 235000010744 Arachis villosulicarpa Nutrition 0.000 claims description 16
- 235000019198 oils Nutrition 0.000 claims description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 244000068988 Glycine max Species 0.000 claims description 9
- 235000010469 Glycine max Nutrition 0.000 claims description 9
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 9
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 9
- 240000008042 Zea mays Species 0.000 claims description 9
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 9
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 9
- 229940041514 candida albicans extract Drugs 0.000 claims description 9
- 235000005822 corn Nutrition 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 239000012138 yeast extract Substances 0.000 claims description 9
- 241000868102 Saccharopolyspora spinosa Species 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 238000009423 ventilation Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001477 organic nitrogen group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000002609 medium Substances 0.000 description 9
- 108010053950 Teicoplanin Proteins 0.000 description 8
- BJNLLBUOHPVGFT-QRZIFLFXSA-N teichomycin Chemical compound CCCCCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)OC=2C(=CC(=CC=2)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@H]2C(N[C@H](C3=CC(O)=CC(O[C@@H]4[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=C3C=3C(O)=CC=C(C=3)[C@@H](NC3=O)C(=O)N2)C(O)=O)=O)Cl)=C(OC=2C(=CC(C[C@H](C(N4)=O)NC(=O)[C@H](N)C=5C=C(O6)C(O)=CC=5)=CC=2)Cl)C=C1[C@H]3NC(=O)[C@@H]4C1=CC6=CC(O)=C1 BJNLLBUOHPVGFT-QRZIFLFXSA-N 0.000 description 8
- JFLRKDZMHNBDQS-UCQUSYKYSA-N CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C Chemical compound CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C JFLRKDZMHNBDQS-UCQUSYKYSA-N 0.000 description 6
- 239000005930 Spinosad Substances 0.000 description 6
- 229940014213 spinosad Drugs 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 241000187560 Saccharopolyspora Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 241000255925 Diptera Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710469688.1A CN107523598B (zh) | 2017-06-20 | 2017-06-20 | 一种提高多杀菌素产量的发酵方法 |
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CN201710469688.1A CN107523598B (zh) | 2017-06-20 | 2017-06-20 | 一种提高多杀菌素产量的发酵方法 |
Publications (2)
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CN107523598A true CN107523598A (zh) | 2017-12-29 |
CN107523598B CN107523598B (zh) | 2021-04-09 |
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CN201710469688.1A Expired - Fee Related CN107523598B (zh) | 2017-06-20 | 2017-06-20 | 一种提高多杀菌素产量的发酵方法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115261240A (zh) * | 2022-08-18 | 2022-11-01 | 黄河三角洲京博化工研究院有限公司 | 一种提高多杀菌素摇瓶发酵水平的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105441518A (zh) * | 2014-08-22 | 2016-03-30 | 牡丹江佰佳信生物科技有限公司 | 提高多杀菌素产量的发酵方法 |
CN105506038A (zh) * | 2014-09-26 | 2016-04-20 | 牡丹江佰佳信生物科技有限公司 | 利用刺糖多孢菌发酵生产多杀菌素的方法 |
WO2016074221A1 (zh) * | 2014-11-14 | 2016-05-19 | 浙江海正药业股份有限公司 | 多杀菌素异源表达菌株及其构建方法和应用 |
-
2017
- 2017-06-20 CN CN201710469688.1A patent/CN107523598B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105441518A (zh) * | 2014-08-22 | 2016-03-30 | 牡丹江佰佳信生物科技有限公司 | 提高多杀菌素产量的发酵方法 |
CN105506038A (zh) * | 2014-09-26 | 2016-04-20 | 牡丹江佰佳信生物科技有限公司 | 利用刺糖多孢菌发酵生产多杀菌素的方法 |
WO2016074221A1 (zh) * | 2014-11-14 | 2016-05-19 | 浙江海正药业股份有限公司 | 多杀菌素异源表达菌株及其构建方法和应用 |
Non-Patent Citations (2)
Title |
---|
THAVARA等: "Field evaluation in Thailand of spinosad, a larvicide derived from Saccharopolyspora spinosa (Actinomycetales) against Aedes aegypti (L.) larvae", 《SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE & PUBLIC HEALTH》 * |
蔡恒等: "刺糖多孢菌生产多杀菌素的研究进展", 《中国生物工程杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115261240A (zh) * | 2022-08-18 | 2022-11-01 | 黄河三角洲京博化工研究院有限公司 | 一种提高多杀菌素摇瓶发酵水平的方法 |
CN115261240B (zh) * | 2022-08-18 | 2023-09-29 | 黄河三角洲京博化工研究院有限公司 | 一种提高多杀菌素摇瓶发酵水平的方法 |
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Publication number | Publication date |
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CN107523598B (zh) | 2021-04-09 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A fermentation method for improving the yield of spinosad Effective date of registration: 20210930 Granted publication date: 20210409 Pledgee: Fengxian Branch of Shanghai Rural Commercial Bank Co.,Ltd. Pledgor: SHANGHAI NONG LE BIOLOGICAL PRODUCTS Co.,Ltd. Registration number: Y2021310000091 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230223 Granted publication date: 20210409 Pledgee: Fengxian Branch of Shanghai Rural Commercial Bank Co.,Ltd. Pledgor: SHANGHAI NONG LE BIOLOGICAL PRODUCTS CO.,LTD. Registration number: Y2021310000091 |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210409 |