CN107519370B - Compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and preparation method thereof - Google Patents

Compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and preparation method thereof Download PDF

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CN107519370B
CN107519370B CN201710916858.6A CN201710916858A CN107519370B CN 107519370 B CN107519370 B CN 107519370B CN 201710916858 A CN201710916858 A CN 201710916858A CN 107519370 B CN107519370 B CN 107519370B
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spleen
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马力
王维蔚
齐燕松
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Tianjin Shanji Hongxing Technology Development Co ltd
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Abstract

A compound preparation for treating non-allergic purpura caused by spleen and kidney deficiency and its preparation method are provided. The preparation is prepared from the following medicinal raw materials in parts by weight: 18-48 parts of raw astragalus membranaceus, 6-15 parts of codonopsis pilosula, 9-24 parts of raw bighead atractylodes rhizome, 9-24 parts of poria cocos, 12-32 parts of prepared rehmannia root, 9-24 parts of Chinese yam, 6-15 parts of dogwood, 12-32 parts of semen cuscutae, 4-10 parts of schisandra chinensis, 9-24 parts of hairyvein agrimonia herb and bud, 6-15 parts of lithospermum and 9-24 parts of radix achyranthis bidentatae. The preparation of the invention adopts a water boiling extraction method to extract the effective components in the raw material medicaments and keep the activity of the effective components, thus not only greatly improving the dissolution rate of the effective components in the medicaments, but also being beneficial to the absorption of the medicaments, thereby improving the bioavailability of the medicaments. In addition, the medicine is a pure Chinese herbal compound preparation, so that no toxic or side effect is generated after the medicine is taken by a patient for a long time, and the safety is good. In addition, the preparation method of the invention has simple process and convenient operation.

Description

Compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a compound preparation which is prepared by taking traditional Chinese medicines as raw materials and is used for treating anaphylactoid purpura caused by deficiency of spleen and kidney and a preparation method thereof.
Background
Allergic purpura is a hemorrhagic disease characterized by abnormal blood vessels caused by various non-allergic causes and diseases, and is clinically manifested as: skin purpura or ecchymosis, mucosal or visceral hemorrhage (rare), capillary fragility test can be positive, and blood coagulation function, platelet count, platelet function, etc. are generally normal. Causes and diseases of non-allergic purpura are many, and are similar to the record of the myoepistaxis disease in the traditional Chinese medicine. Although the medicines for treating the non-allergic purpura clinically at present have more varieties, the medicines lack pertinence, the treatment course is relatively long, and part of the medicines have certain side effects or anaphylactic reactions because of multiple factors and multiple types of the non-allergic purpura, so the effect of treating the non-allergic purpura caused by spleen and kidney deficiency after the medicines are taken is not ideal.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and a preparation method thereof.
In order to achieve the aim, the compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney is prepared from the following medicinal raw materials in parts by weight:
Figure BDA0001425974100000011
the preparation method of the compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
The compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney is prepared by extracting the effective components in the raw material medicaments by a water boiling extraction method and keeping the activity of the effective components, so that the dissolution rate of the effective components in the medicaments is greatly improved, the absorption of the medicaments is facilitated, and the bioavailability of the medicaments is improved. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.
Detailed Description
The symptoms of the non-allergic purpura are complex, the course of disease is prolonged, and more complications are caused. Clinically, deficiency syndrome, excess syndrome and syndrome of intermingled deficiency and excess are common. The method is used for invigorating spleen and kidney. In the formula, raw astragalus is sweet and mild in nature, has the effects of tonifying spleen and middle energizer, raising yang and sinking, tonifying defensive qi and consolidating superficial resistance, inducing diuresis, expelling toxin and promoting granulation, and is a key medicine for tonifying middle-jiao and Qi, so that the astragalus is a monarch medicine. Radix Codonopsis is sweet and neutral, and has effects of invigorating spleen and lung qi, replenishing blood, and promoting fluid production; poria is sweet and mild, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, eliminating phlegm, calming heart, and tranquilizing mind; the Chinese yam is sweet and neutral, can tonify spleen and nourish stomach, and is a good product for regulating and tonifying spleen and stomach in chronic persistent diseases; dodder seed, semen cuscutae, pungent and sweet in flavor and capable of tonifying kidney and replenishing vital essence, nourishing liver and improving eyesight and stopping diarrhea; the agrimony is bitter and astringent, can astringe to stop bleeding and tonify deficiency, and the medicines have the effects of tonifying spleen and removing dampness, tonifying liver and kidney, and tonifying qi and nourishing blood and are used as ministerial medicines together. Raw rhizoma atractylodis macrocephalae is sweet, bitter and warm, has the effects of tonifying qi and strengthening spleen, eliminating dampness and promoting urination, and is the first important medicine for tonifying qi and strengthening spleen; radix rehmanniae Preparata is sweet and warm, and has effects of replenishing blood, nourishing yin, replenishing essence and nourishing marrow; cornus officinalis is sour, astringent and warm, has the effects of tonifying liver and kidney, astringing and inducing astringency, and is the essential drug for balancing yin and yang; the schisandra chinensis is sour, sweet and warm, astringes and astringes, benefits qi and generates body fluid, tonifies kidney and calms heart; the lithospermum is sweet and salty in flavor and cold in property, has the effects of clearing heat and cooling blood, activating blood, detoxifying and promoting eruption, and is an adjuvant drug for supplementing qi and strengthening spleen, nourishing yin and enriching blood, and clearing heat and detoxifying. Achyranthes root, radix Achyranthis bidentatae, bitter in taste and sweet in acid, promotes blood circulation, clears the meridians, tonifies liver and kidney, strengthens muscles and bones, induces diuresis, treats stranguria, and induces fire (blood) to descend as a guiding drug. The formula has the effects of strengthening spleen and tonifying kidney, and tonifying qi and controlling blood, so the traditional Chinese medicine is suitable for treating the non-allergic purpura caused by deficiency of spleen and kidney.
The following will explain the compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and the preparation method thereof provided by the invention in detail by combining the examples.
Example 1:
the compound preparation for treating non-allergic purpura caused by spleen and kidney deficiency provided by the embodiment is prepared from the following medicinal raw materials in parts by weight:
Figure BDA0001425974100000031
the preparation method of the compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to prepare the traditional Chinese medicine compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney.
In addition, the traditional Chinese medicine compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutical excipients.
Example 2:
the compound preparation for treating non-allergic purpura caused by spleen and kidney deficiency provided by the embodiment is prepared from the following medicinal raw materials in parts by weight:
Figure BDA0001425974100000032
the preparation method is the same as example 1.
Example 3:
the compound preparation for treating non-allergic purpura caused by spleen and kidney deficiency provided by the embodiment is prepared from the following medicinal raw materials in parts by weight:
Figure BDA0001425974100000041
the preparation method is the same as example 1.
The compound preparation for treating the non-allergic purpura caused by the deficiency of the spleen and the kidney is brown to tan; light smell, slightly bitter taste. In order to verify the treatment effect of the traditional Chinese medicine compound preparation, the inventor carries out systematic clinical observation on 420 patients suffering from spleen and kidney deficiency type non-allergic purpura by using the traditional Chinese medicine compound preparation, wherein 102 patients between 21 and 30 years old are 102 patients, 129 patients between 31 and 40 years old and 189 patients between 41 and 50 years old are treated by 150ml of the traditional Chinese medicine compound preparation each time, 3 times are taken every day, and 120 days are 1 treatment course. 198 cases are cured (bleeding symptoms basically disappear) after 1 course of treatment, accounting for 47.1 percent; 146 cases with effect (improvement of main symptoms) account for 34.8 percent; 76 cases of no effect (no improvement in the chief complaints), accounting for 18.1%; the total effective rate is 81.9%. 311 cases of the traditional Chinese medicine are cured after 2 courses of treatment, accounting for 74.0 percent; 79 effective cases account for 18.8 percent; 30 invalid cases account for 7.1%; the total effective rate is 92.9%.
Meanwhile, the inventor analyzes the relationship between the treatment effect and the age and the relationship between the treatment effect and the treatment course, and the analysis results are respectively shown in tables 1 and 2.
Table 1: the relation table between the treatment effect and the age of the traditional Chinese medicine compound preparation provided by the invention
Figure BDA0001425974100000042
The data in Table 1 above are expressed as x2The test method carries out calculation, and the result is 0.050 > P > 0.025, so that the effect of taking the traditional Chinese medicine compound preparation provided by the invention to treat spleen and kidney deficiency type non-allergic purpura can be proved to be not changed with age for the treatment effect of each age group.
Table 2: the relation table of the treatment effect and the treatment course of the traditional Chinese medicine compound preparation provided by the invention
Figure BDA0001425974100000051
The data in Table 2 above are expressed as x2The result of calculation by an inspection method is that P is less than 0.005, so that the traditional Chinese medicine compound preparation provided by the invention is proved to be taken to treat spleen and kidney deficiency type anaphylactoid purpura, and the cure rate and the effective rate are obviously improved along with the deep treatment.

Claims (3)

1. A compound preparation for treating non-allergic purpura caused by spleen and kidney deficiency is characterized in that: the traditional Chinese medicine compound preparation is prepared from the following raw materials in parts by weight:
radix astragali 18-48, radix Codonopsis 6-15, rhizoma Atractylodis Macrocephalae 9-24, Poria 9-24, radix rehmanniae Preparata 12-32
9-24 parts of yam, 6-15 parts of dogwood, 12-32 parts of dodder, 4-10 parts of schisandra chinensis, 9-24 parts of hairyvein agrimony
6-15 parts of lithospermum and 9-24 parts of achyranthes bidentata.
2. A method for preparing the compound preparation for treating the anaphylactoid purpura caused by the deficiency of spleen and kidney according to claim 1, which is characterized in that: the preparation method comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, filtering and removing slag to prepare the traditional Chinese medicine compound preparation for treating the non-allergic purpura caused by spleen and kidney deficiency.
3. The method of claim 2, wherein: the Chinese medicinal compound preparation and common pharmaceutical excipients are prepared into granules, tablets, capsules, syrups, oral liquid, pills or paste.
CN201710916858.6A 2017-09-30 2017-09-30 Compound preparation for treating non-allergic purpura caused by deficiency of spleen and kidney and preparation method thereof Active CN107519370B (en)

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