CN107518004A - A kind of preparation method of Nanometer Copper antibacterial granule - Google Patents
A kind of preparation method of Nanometer Copper antibacterial granule Download PDFInfo
- Publication number
- CN107518004A CN107518004A CN201610452682.9A CN201610452682A CN107518004A CN 107518004 A CN107518004 A CN 107518004A CN 201610452682 A CN201610452682 A CN 201610452682A CN 107518004 A CN107518004 A CN 107518004A
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- China
- Prior art keywords
- preparation
- nanometer copper
- antibacterial granule
- copper antibacterial
- chitosan
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
This application discloses a kind of preparation method of Nanometer Copper antibacterial granule, including step：(1), carboxymethyl chitosan and copper sulfate solution are dissolved in distilled water, and are stirred；(2) mixed solution, is warming up to 40~50 DEG C, N is added under stirring2H4·H2O, continue to be stirred；(3), centrifugation, supersound washing and drying, Nanometer Copper antibacterial granule is obtained.Nanometer Copper antibacterial granule of the present invention has good antibacterial, bactericidal action, Durability of antimicrobial effect length to Escherichia coli, staphylococcus aureus.
Description
Technical field
The application is related to a kind of anti-biotic material, more particularly to a kind of preparation method of Nanometer Copper antibacterial granule.
Background technology
At present, the conventional inorganic antiseptic of in the market is silver system and zinc series antibacterial agent, though silver-series antibacterial agent is with higher
Sterilizing ability, but because it has higher 0.798 volt of chemical potential (25 DEG C), chemical stability is poor, is irradiated in ultraviolet
Lower or after being heated to certain temperature, silver ion is reduced to argent, and is immediately converts into silver oxide, makes that product is graying, blackening,
This not only lowers its commercial value, also reduces its anti-microbial property.In addition, silver-series antibacterial agent price is higher, fungal resistance
It is weaker.Though zinc series antibacterial agent is without discoloration problem, cheap, its anti-microbial property is low, it is impossible to meets antibacterial requirement.
The content of the invention
It is an object of the invention to provide a kind of preparation method of Nanometer Copper antibacterial granule, with overcome it is of the prior art not
Foot.
To achieve the above object, the present invention provides following technical scheme：
The embodiment of the present application discloses a kind of preparation method of Nanometer Copper antibacterial granule, including step：
(1), carboxymethyl chitosan and copper sulfate solution are dissolved in distilled water, and are stirred；
(2) mixed solution, is warming up to 40~50 DEG C, N is added under stirring2H4·H2O, continue to be stirred；
(3), centrifugation, supersound washing and drying, Nanometer Copper antibacterial granule is obtained.
Preferably, in the preparation method of above-mentioned Nanometer Copper antibacterial granule, in step (1), the system of carboxymethyl chitosan
Preparation Method includes：Dissolve chitosan in absolute ethyl alcohol and stir, then add sodium hydroxide solution and carry out swell 4~5
Hour；Add monoxone to be well mixed, be then centrifuged for separation, supersound washing and drying, obtain carboxymethyl chitosan.
Preferably, in the preparation method of above-mentioned Nanometer Copper antibacterial granule, the concentration of the sodium hydroxide solution is
40%.
Preferably, in the preparation method of above-mentioned Nanometer Copper antibacterial granule, the chitosan and chloroacetic mass ratio
For (2.7~3):2.
Preferably, in the preparation method of above-mentioned Nanometer Copper antibacterial granule, the copper sulfate solution concentration is
0.078mol/L。
Preferably, in the preparation method of above-mentioned Nanometer Copper antibacterial granule, the carboxymethyl chitosan and copper sulphate
Mol ratio is (2~3):1.
Compared with prior art, the advantage of the invention is that：Nanometer Copper antibacterial granule of the present invention is to Escherichia coli, golden yellow
Staphylococcus has good antibacterial, bactericidal action, Durability of antimicrobial effect length.
Embodiment
The present invention is described further by the following example：According to following embodiments, the present invention may be better understood.
However, as it will be easily appreciated by one skilled in the art that specific material ratio, process conditions and its result described by embodiment are only used
In the explanation present invention, without should be also without limitation on the present invention described in detail in claims.
Embodiment 1
The preparation method of Nanometer Copper antibacterial granule
(1), dissolve chitosan in absolute ethyl alcohol and stir, then add sodium hydroxide solution and carry out swell 4~5
Hour, the concentration of sodium hydroxide solution is 40%；Add monoxone to be well mixed, be then centrifuged for separation, supersound washing and drying,
Obtain carboxymethyl chitosan.
Chitosan is 3 with chloroacetic mass ratio:2.
(2), carboxymethyl chitosan and copper sulfate solution are dissolved in distilled water, and are stirred, copper sulphate
Concentration of aqueous solution is 0.078mol/L.
The mol ratio of carboxymethyl chitosan and copper sulphate is 3:1.
(3) mixed solution, is warming up to 50 DEG C, N is added under stirring2H4·H2O, continue to be stirred；
(4), centrifugation, supersound washing and drying, Nanometer Copper antibacterial granule is obtained.
Product is characterized using the methods of SEM, TEM, XRD, obtaining product has the crystal structure of face-centered cubic copper,
Nano copper particle is flower-like structure, and particle size distribution is between 10~15nm.
Obtained product has good antibacterial, bactericidal action, Durability of antimicrobial effect to Escherichia coli, staphylococcus aureus
It is long.
Embodiment 2
The preparation method of Nanometer Copper antibacterial granule
(1), dissolve chitosan in absolute ethyl alcohol and stir, then add sodium hydroxide solution and carry out swell 4~5
Hour, the concentration of sodium hydroxide solution is 40%；Add monoxone to be well mixed, be then centrifuged for separation, supersound washing and drying,
Obtain carboxymethyl chitosan.
Chitosan is 2.8 with chloroacetic mass ratio:2.
(2), carboxymethyl chitosan and copper sulfate solution are dissolved in distilled water, and are stirred, copper sulphate
Concentration of aqueous solution is 0.078mol/L.
The mol ratio of carboxymethyl chitosan and copper sulphate is 2.2:1.
(3) mixed solution, is warming up to 50 DEG C, N is added under stirring2H4·H2O, continue to be stirred；
(4), centrifugation, supersound washing and drying, Nanometer Copper antibacterial granule is obtained.
Product is characterized using the methods of SEM, TEM, XRD, obtaining product has the crystal structure of face-centered cubic copper,
Nano copper particle is flower-like structure, and particle size distribution is in 13nm or so.
Finally, it is to be noted that, term " comprising ", "comprising" or its any other variant be intended to it is non-exclusive
Property includes, so that process, method, article or equipment including a series of elements not only include those key elements, and
Also include the other element that is not expressly set out, or also include for this process, method, article or equipment inherently
Key element.
Claims (6)
1. a kind of preparation method of Nanometer Copper antibacterial granule, it is characterised in that including step：
(1), carboxymethyl chitosan and copper sulfate solution are dissolved in distilled water, and are stirred；
(2) mixed solution, is warming up to 40~50 DEG C, N is added under stirring2H4·H2O, continue to be stirred；
(3), centrifugation, supersound washing and drying, Nanometer Copper antibacterial granule is obtained.
2. the preparation method of Nanometer Copper antibacterial granule according to claim 1, it is characterised in that：In step (1), carboxymethyl
The preparation method of chitosan includes：Dissolve chitosan in absolute ethyl alcohol and stir, then add sodium hydroxide solution and enter
Row swell 4~5 hours；Add monoxone to be well mixed, be then centrifuged for separation, supersound washing and drying, obtain carboxymethyl chitosan
Sugar.
3. the preparation method of Nanometer Copper antibacterial granule according to claim 1, it is characterised in that：The sodium hydroxide solution
Concentration be 40%.
4. the preparation method of Nanometer Copper antibacterial granule according to claim 1, it is characterised in that：The chitosan and chloroethene
The mass ratio of acid is (2.7~3):2.
5. the preparation method of Nanometer Copper antibacterial granule according to claim 1, it is characterised in that：The copper sulfate solution
Concentration is 0.078mol/L.
6. the preparation method of Nanometer Copper antibacterial granule according to claim 1, it is characterised in that：The carboxymethyl chitosan
Mol ratio with copper sulphate is (2~3):1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610452682.9A CN107518004A (en) | 2016-06-21 | 2016-06-21 | A kind of preparation method of Nanometer Copper antibacterial granule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610452682.9A CN107518004A (en) | 2016-06-21 | 2016-06-21 | A kind of preparation method of Nanometer Copper antibacterial granule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107518004A true CN107518004A (en) | 2017-12-29 |
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ID=60734059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201610452682.9A Withdrawn CN107518004A (en) | 2016-06-21 | 2016-06-21 | A kind of preparation method of Nanometer Copper antibacterial granule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113016823A (en) * | 2021-02-02 | 2021-06-25 | 南京师范大学 | Preparation method of photo-thermal antibacterial near-infrared bimetallic nanoparticles |
| CN113273580A (en) * | 2021-06-07 | 2021-08-20 | 广东顾纳凯材料科技有限公司 | Antibacterial agent and preparation method thereof, antibacterial polyolefin composite material and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101223887A (en) * | 2008-01-31 | 2008-07-23 | 吴继贤 | Nano silver antimicrobial solution and preparing method thereof |
| CN102388908A (en) * | 2011-09-20 | 2012-03-28 | 合肥学院 | Preparation process of silver/chitosan composite antimicrobial agents |
| CN104145993A (en) * | 2014-08-04 | 2014-11-19 | 太原理工大学 | Method for preparing complex antimicrobial agent by blending chitosan and silver copper |
| CN104642385A (en) * | 2015-01-07 | 2015-05-27 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano copper and polyhexamethylene guanidine and processing technic |
-
2016
- 2016-06-21 CN CN201610452682.9A patent/CN107518004A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101223887A (en) * | 2008-01-31 | 2008-07-23 | 吴继贤 | Nano silver antimicrobial solution and preparing method thereof |
| CN102388908A (en) * | 2011-09-20 | 2012-03-28 | 合肥学院 | Preparation process of silver/chitosan composite antimicrobial agents |
| CN104145993A (en) * | 2014-08-04 | 2014-11-19 | 太原理工大学 | Method for preparing complex antimicrobial agent by blending chitosan and silver copper |
| CN104642385A (en) * | 2015-01-07 | 2015-05-27 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano copper and polyhexamethylene guanidine and processing technic |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113016823A (en) * | 2021-02-02 | 2021-06-25 | 南京师范大学 | Preparation method of photo-thermal antibacterial near-infrared bimetallic nanoparticles |
| CN113273580A (en) * | 2021-06-07 | 2021-08-20 | 广东顾纳凯材料科技有限公司 | Antibacterial agent and preparation method thereof, antibacterial polyolefin composite material and preparation method thereof |
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Application publication date: 20171229 |
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