CN107478640A - A kind of enhanced Portable Raman spectrometer of optical fiber probe - Google Patents
A kind of enhanced Portable Raman spectrometer of optical fiber probe Download PDFInfo
- Publication number
- CN107478640A CN107478640A CN201710658688.6A CN201710658688A CN107478640A CN 107478640 A CN107478640 A CN 107478640A CN 201710658688 A CN201710658688 A CN 201710658688A CN 107478640 A CN107478640 A CN 107478640A
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- optical fiber
- raman
- optical
- raman spectrometer
- probe
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/088—Using a sensor fibre
Abstract
The invention discloses a kind of enhanced Portable Raman spectrometer of optical fiber probe, include Raman spectrometer main frame, fiber Raman probe and optical fiber SERS probes, laser, detector, Switching Power Supply are provided with Raman spectrometer main frame, the SMA905 optical fiber interfaces that the FC/PC optical fiber interfaces being joined directly together with laser are reserved with the front panel of Raman spectrometer main frame and are joined directly together with detector；Fiber Raman probe includes optical coupled module, input optical fibre, output optical fibre and Raman detection end；Input optical fibre, one end of output optical fibre are connected with two optical fiber interfaces of Raman spectrometer main frame respectively, and input optical fibre, the other end of output optical fibre access optical coupled module jointly, and optical coupled module is connected with Raman detection end simultaneously；Raman detection end is connected with the optical patchcord end direct-coupling of optical fiber SERS probes.The present invention has the advantages that miniaturization, high sensitivity, reproducible, detection process is simple.
Description
Technical field
The invention belongs to SERS detecting instrument field, and in particular to a kind of optical fiber probe is enhanced portable
Formula Raman spectrometer.
Background technology
The vibration of Raman spectrum and molecule, rotational energy level are closely related, have molecule " fingerprint " characteristic, are usually used in various points
The detection and identification of son, have important application prospect in fields such as analytical chemistry, biomedicine, environmental science, food securities.
Normally, Raman scattering of molecule section very little, Raman signal are weak, it is difficult to direct detection.Have benefited from laser technology, CCD detection skill
The development of art etc., people develop the micro- Confocal laser-scanning microscopy instrument of high sensitivity, realize the detection of faint Raman signal.But should
Equipment instrument is big, quality weight, is usually applicable only to laboratory use.In order to meet the Site Detection demand of Raman spectrum, people
Also develop Portable Raman spectrometer, but it is to realize volume-diminished as cost to sacrifice sensitivity, relatively low sensitivity compared with
Its use range is limited greatly.
In recent years, SERS is had benefited from（Surface Enhanced Raman Scattering,
SERS）The development of spectral technique, domestic and international scientific research personnel is by substrate type SERS substrates（Noble metal nano structure is prepared in Si or
SiO2Deng what is formed on substrate）It is combined with Portable Raman spectrometer, it is portable by the way that substrate type SERS substrates are placed in
The focal position of Raman spectrum instrument probe, utilize the local surface plasma resonance (Localized of noble metal nano structure
Surface Plasmon Resonance, LSPR) effect, to improve the detection sensitivity of Portable Raman spectrometer.Such as：
Britain Renishaw（Reinshaw）Company have developed commercial Klarite surface-enhanced Ramans chip, coordinate their portable drawing
Graceful spectrometer uses, and greatly improves the sensitivity of Raman detection；GE companies of the U.S. have developed the SERS of gold nano core shell structure
Label is to meet application demands of the Portable Raman spectrometer StreetLab Mobile in field of biological detection；Xiamen is big
, Xiamen Pu Shi nanosecond science and technology Co., Ltd etc. have developed based on shell isolated nano-particle reinforcement jointly（SHINERS）Just
Take formula Raman spectrometer etc..However, being limited by experiment preparation method, this kind of substrate type SERS substrates are generally difficult to realize
Uniformity of the SERS focuses (hotspots) in the range of macro-scale, so as to influence the repeatability of Raman detection and reliability,
It is unfavorable for actually detected application.
Optical fiber SERS probes are the new SERS substrates of one kind developed in recent years, by by noble metal nano particles/
Structure is prepared in optical fiber surface or end face, on the one hand, using the LSPR effects of noble metal nano particles, can realize Raman signal
Very big enhancing（Typical enhancer is up to 104-108Magnitude）；On the other hand, total Raman signal is whole optical fiber probe surface
The integration of the Raman signal of collection, thus it is not high in the uniformity requirement that optical fiber surface is distributed to nano particle, significantly improve drawing
The repeatability and stability of graceful detection.In addition, optical fiber has that light weight, pliability are good, transmission loss is small, antijamming capability
The advantages that strong, opportunity is provided for the remote probe of Raman spectrum, in situ detection, In vivo detection etc..Then, if optical fiber SERS is visited
Pin is combined with Portable Raman spectrometer, develops the enhanced Portable Raman spectrometer of optical fiber probe, is expected to ensuring preferably
Raman detection sensitivity is greatly improved while detecting repeated, greatly widens the practical application of current Portable Raman spectrometer
Scope.
The content of the invention
The present invention is directed to propose a kind of enhanced Portable Raman spectrometer of new optical fiber probe, to be greatly improved at present
The detection sensitivity and practicality of Portable Raman spectrometer.
To reach above-mentioned purpose, the technical solution adopted in the present invention is as follows：
A kind of enhanced Portable Raman spectrometer of optical fiber probe, it is characterised in that：Include Raman spectrometer main frame, optical fiber is drawn
It is graceful to pop one's head in and optical fiber SERS probe three parts, laser, detector, switch electricity are provided with the Raman spectrometer main frame
Source, the FC/PC optical fiber interfaces that are joined directly together with laser and straight with detector are reserved with the front panel of Raman spectrometer main frame
Connect connected SMA905 optical fiber interfaces；Fiber Raman probe include optical coupled module, input optical fibre, output optical fibre and
Raman detection end, Raman detection end is using FC/PC or SMA905 fiber coupling interfaces；The input optical fibre, output optical fibre
The FC/PC optical fiber interfaces with Raman spectrometer main frame, SMA905 optical fiber interfaces are connected respectively for one end, input optical fibre, output
The other end of optical fiber accesses optical coupled module jointly, and optical coupled module is connected with Raman detection end simultaneously；The Raman is visited
End is surveyed to be connected with the optical patchcord end direct-coupling of optical fiber SERS probes.
A kind of described enhanced Portable Raman spectrometer of optical fiber probe, it is characterised in that：What the laser used
It is 785nm narrow linewidth semiconductor lasers.
A kind of described enhanced Portable Raman spectrometer of optical fiber probe, it is characterised in that：What the detector used
It is the slim back lighting type CCD detector of TE refrigeration（Ocean Optics, QE-Pro）.
A kind of described enhanced Portable Raman spectrometer of optical fiber probe, it is characterised in that the optical fiber SERS probes
Be prepared using any of silica fibre, polymer optical fiber, Ti∶Sapphire laser optical fiber, photonic crystal fiber, its one end be with
Optical patchcord end that Raman detection end is of coupled connections, the other end be then by optical fiber surface, end face, the conical surface or it is internal prepare it is expensive
Metal nanoparticle and formed SERS enhancing end.During raman spectroscopy measurement, the SERS of optical fiber SERS probes is strengthened into end and directly inserted
Enter in testing liquid, testing molecule is adsorbed onto noble metal nano particles surface（Near or）, nano particle is attached under raman excitation light
The local fields of the big enhancing of proximal pole significantly improve Molecular Raman signal, so as to realize the in situ, real-time, quick, high of Raman spectrum
Sensitivity technique.
Raman detection end uses FC/PC or SMA905 fiber coupling interfaces, to realize optical fiber SERS probes and fiber Raman
Efficient, stable coupling between light path of popping one's head in；Meanwhile also the replacing for optical fiber SERS probes in actual field detection application provides just
It is prompt.
The present invention's is particularly advantageous in that：
First, using surface enhanced Raman scattering effect caused by optical fiber SERS detecting probe surface noble metal nano particles, greatly carry
The high detection sensitivity of Portable Raman spectrometer.
Second, total Raman signal is the integration of whole detecting probe surface Raman signal in optical fiber SERS probes, SERS is reduced
Requirement prepared by substrate uniformity, significantly improve the repeatability and stability of SERS detections.
Third, detection method is simple and convenient, the liquid phase that is particularly suitable for use in detection application.Only need to be by optical fiber SERS during Raman detection
The SERS enhancings end of probe is directly inserted into solution to be measured, due to space optical path coupling when avoiding the current Raman spectrum from detecting
The problems such as detection sensitivity caused by the defocus phenomenon of conjunction declines, repeatability is bad.
Fourth, the present invention comprehensively utilizes the local surface plasma resonance of noble metal nano particles in optical fiber SERS probes
Characteristic and Raman long range interaction, realize the very big enhancing of Raman signal and ensure excellent SERS repeatability, be advantageous to promote
Enter extensive use of the Portable Raman optical spectrum technology in fields such as environment, biology, medical science, food securities.
Brief description of the drawings
Fig. 1：The structural representation of the enhanced Portable Raman spectrometer of optical fiber probe.
Fig. 2：Commercially BWTEK Portable Raman spectrometers and the enhanced Portable Raman spectrometer of optical fiber probe are to 10-5M good fortune
U.S. double testing result compares.
Fig. 3：Detection sensitivity of the enhanced Portable Raman spectrometer of optical fiber probe to thiram.
Fig. 4：The SERS detection repeatability of the enhanced Portable Raman spectrometer of optical fiber probe.
Embodiment
To describe the technology contents of the present invention, structure arrangement, the purpose and effect reached in detail, below in conjunction with a tool
Body example simultaneously coordinates accompanying drawing to be described in detail.
The structural representation of the present invention is as shown in figure 1, a kind of enhanced Portable Raman spectrometer of optical fiber probe, includes
Raman spectrometer main frame 1, fiber Raman probe and the three parts of optical fiber SERS probes 8, the Raman spectrometer main frame 1 is interior to be set
There are 785nm narrow linewidth semiconductor lasers, the slim back lighting type CCD detector of TE refrigeration（Ocean Optics, QE-Pro）, open
Powered-down source, be reserved with the front panel of Raman spectrometer main frame 1 the FC/PC optical fiber interfaces 2 that are joined directly together with laser and with spy
Survey the SMA905 optical fiber interfaces 3 that device is joined directly together；Fiber Raman probe include optical coupled module 4, input optical fibre 5,
Output optical fibre 6 and Raman detection end 7, Raman detection end 7 is using FC/PC or SMA905 fiber coupling interfaces；The input
One end the FC/PC optical fiber interfaces 2 with Raman spectrometer main frame 1, the phase of SMA905 optical fiber interfaces 3 respectively of optical fiber 5, output optical fibre 6
Connection, input optical fibre 5, the other end of output optical fibre 6 access optical coupled module 4, optical coupled module 4 while and Raman jointly
End of probe 7 connects；The Raman detection end 7 is connected with the optical patchcord end direct-coupling of optical fiber SERS probes 8.
Optical fiber SERS probes 8 are using any in silica fibre, polymer optical fiber, Ti∶Sapphire laser optical fiber, photonic crystal fiber
Kind be prepared, its one end is the optical patchcord end that is of coupled connections with Raman detection end, the other end be then by optical fiber surface,
End face, the conical surface or inside prepare noble metal nano particles and form SERS enhancings end.During raman spectroscopy measurement, optical fiber SERS is visited
The SERS enhancings end of pin 8 is inserted directly into testing liquid, and testing molecule is adsorbed onto noble metal nano particles surface（Near or）, draw
The local fields that nano particle nearby greatly strengthens under graceful exciting light significantly improve Molecular Raman signal, so as to realize Raman spectrum
In situ, real-time, quick, high-sensitivity detection.
It is using common residues of pesticides thiram as molecular detection, laboratory is pre- for the advantage of the fully displaying present invention
The optical fiber SERS probes first prepared are inserted in solution to be measured, utilize the enhanced portable Raman light of the optical fiber probe voluntarily developed
Spectrometer carries out Raman spectrum detection to it（Excitation wavelength 785nm, power 70mW, time of integration 2s）.First, compare commercially
Portable Raman spectrometer（BWTEK, i-Raman）And the enhanced Raman spectrometer of optical fiber probe voluntarily developed is to 10-5M good fortune
The testing result of U.S. double solution, as shown in Figure 2.Using when commercially Portable Raman spectrometer is detected, fiber Raman is popped one's head in
Exciting light Space Coupling is focused in the cuvette for filling solution to be measured, other test conditions are constant.As seen from the figure, optical fiber is visited
The enhanced Portable Raman spectrometer of pin detects very high thiram Raman signal, and commercially Portable Raman spectrometer pair
10-5M thiram is substantially without response.Further, inspection of the enhanced Portable Raman spectrometer of optical fiber probe to thiram is utilized
Survey sensitivity to be tested, as a result as shown in figure 3, its detection sensitivity reaches 1 × 10-7M magnitudes, better than state food safety
Examination criteria（5×10-7M）.These results are enough to show optical fiber SERS probe significant increases Portable Raman spectrometer
Detection sensitivity.In addition, the SERS detections repeatability also to the enhanced Portable Raman spectrometer of optical fiber probe is assessed.
Fig. 4 provides is connected respectively to the enhanced portable Raman of optical fiber probe by laboratory with four optical fiber SERS probes of a collection of preparation
Spectrometer, to 10-5The testing result of M thiram Raman spectrums.It can be seen that five spectral lines are almost completely superposed, relative standard deviation
（RSD）Less than 6%.So good detection repeatability is main reason is that total Raman signal is whole probe in optical fiber SERS probes
The integration of surface Raman signal, so as to reduce the requirement of optical fiber SERS probes uniformity preparation, improve SERS spectra detection
Repeatability and stability.In summary, Raman detection is being greatly improved in the enhanced Portable Raman spectrometer of this kind of optical fiber probe
Good SERS detection repeatability is ensure that while sensitivity, may advantageously facilitate Portable Raman optical spectrum technology in environment, life
The extensive use in the fields such as thing, medical science, food security.
Obviously, those skilled in the art can enter to a kind of enhanced Portable Raman spectrometer of optical fiber probe of the present invention
The various changes of row and modification are without departing from the spirit and scope of the present invention.Therefore, if any modifications and variations belong to the present invention
Within the scope of claim and its equivalent technologies, then the present invention is also intended to comprising including these changes and modification.
Claims (4)
- A kind of 1. enhanced Portable Raman spectrometer of optical fiber probe, it is characterised in that：Include Raman spectrometer main frame, optical fiber Raman probe and optical fiber SERS probe three parts, laser, detector, switch electricity are provided with the Raman spectrometer main frame Source, the FC/PC optical fiber interfaces that are joined directly together with laser and straight with detector are reserved with the front panel of Raman spectrometer main frame Connect connected SMA905 optical fiber interfaces；Fiber Raman probe include optical coupled module, input optical fibre, output optical fibre and Raman detection end, Raman detection end is using FC/PC or SMA905 fiber coupling interfaces；The input optical fibre, output optical fibre The FC/PC optical fiber interfaces with Raman spectrometer main frame, SMA905 optical fiber interfaces are connected respectively for one end, input optical fibre, output The other end of optical fiber accesses optical coupled module jointly, and optical coupled module is connected with Raman detection end simultaneously；The Raman is visited End is surveyed to be connected with the optical patchcord end direct-coupling of optical fiber SERS probes.
- A kind of 2. enhanced Portable Raman spectrometer of optical fiber probe according to claim 1, it is characterised in that：It is described to swash Light device is using 785nm narrow linewidth semiconductor lasers.
- A kind of 3. enhanced Portable Raman spectrometer of optical fiber probe according to claim 1 or 2, it is characterised in that：Institute Detector is stated using the slim back lighting type CCD detector of TE refrigeration.
- A kind of 4. enhanced Portable Raman spectrometer of optical fiber probe according to claim 1, it is characterised in that the light Fine SERS probes are prepared using any of silica fibre, polymer optical fiber, Ti∶Sapphire laser optical fiber, photonic crystal fiber, Its one end be of coupled connections with Raman detection end optical patchcord end, the other end then be by optical fiber surface, end face, the conical surface or Inside prepares noble metal nano particles and forms SERS enhancings end.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108181296A (en) * | 2018-03-14 | 2018-06-19 | 南京信息工程大学 | Optical fiber surface enhancing Raman microprobe based on surface phasmon effect and preparation method thereof |
| CN109520994A (en) * | 2018-11-26 | 2019-03-26 | 东莞理工学院 | A kind of micro-fluidic biological detection system and method |
| CN109884025A (en) * | 2019-01-21 | 2019-06-14 | 东莞理工学院 | A kind of long-range SERS spectra detection system and method |
| CN112362306A (en) * | 2020-09-30 | 2021-02-12 | 深圳天祥质量技术服务有限公司 | Method and device for detecting biological safety of pulsed light source light |
| CN112710647A (en) * | 2020-12-03 | 2021-04-27 | 北京信息科技大学 | Optical fiber Raman probe for water pollution detection |
| CN112730374A (en) * | 2020-12-03 | 2021-04-30 | 北京信息科技大学 | Optical fiber Raman probe for detecting low-concentration components in-vivo blood |
| CN112858254A (en) * | 2021-01-11 | 2021-05-28 | 上海大学 | SERS excitation device and method based on column vector Bessel Gaussian beam |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1815197A (en) * | 2006-02-24 | 2006-08-09 | 清华大学 | Photon crystal optical-fiber probe sensor based on nano grain surface increasing Raman spectrum |
| CN104614360A (en) * | 2015-01-16 | 2015-05-13 | 中国科学院合肥物质科学研究院 | Method for assembling precious metal nanocrystalline on surface of conical fiber |
| CN105241864A (en) * | 2015-10-21 | 2016-01-13 | 中国科学院合肥物质科学研究院 | Laser-induce self-assembly method for preparing high-sensitivity optical fiber SERS probe |
-
2017
- 2017-08-04 CN CN201710658688.6A patent/CN107478640A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1815197A (en) * | 2006-02-24 | 2006-08-09 | 清华大学 | Photon crystal optical-fiber probe sensor based on nano grain surface increasing Raman spectrum |
| CN104614360A (en) * | 2015-01-16 | 2015-05-13 | 中国科学院合肥物质科学研究院 | Method for assembling precious metal nanocrystalline on surface of conical fiber |
| CN105241864A (en) * | 2015-10-21 | 2016-01-13 | 中国科学院合肥物质科学研究院 | Laser-induce self-assembly method for preparing high-sensitivity optical fiber SERS probe |
Non-Patent Citations (2)
| Title |
|---|
| 雷星 等: ""高灵敏度锥形光纤SERS探针及其在农残检测中的应用"", 《光学学报》 * |
| 黄竹林 等: ""贵金属纳米结构为敏感层的锥形光纤探针及其SERS活性"", 《光散射学报》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108181296A (en) * | 2018-03-14 | 2018-06-19 | 南京信息工程大学 | Optical fiber surface enhancing Raman microprobe based on surface phasmon effect and preparation method thereof |
| CN108181296B (en) * | 2018-03-14 | 2024-03-19 | 南京信息工程大学 | Optical fiber surface enhanced Raman probe based on surface plasmon effect |
| CN109520994A (en) * | 2018-11-26 | 2019-03-26 | 东莞理工学院 | A kind of micro-fluidic biological detection system and method |
| CN109884025A (en) * | 2019-01-21 | 2019-06-14 | 东莞理工学院 | A kind of long-range SERS spectra detection system and method |
| CN109884025B (en) * | 2019-01-21 | 2020-04-24 | 东莞理工学院 | Remote SERS spectrum detection system and method |
| US10876973B2 (en) | 2019-01-21 | 2020-12-29 | Dongguan University Of Technology | System and method for remote detection of SERS spectra |
| CN112362306A (en) * | 2020-09-30 | 2021-02-12 | 深圳天祥质量技术服务有限公司 | Method and device for detecting biological safety of pulsed light source light |
| CN112710647A (en) * | 2020-12-03 | 2021-04-27 | 北京信息科技大学 | Optical fiber Raman probe for water pollution detection |
| CN112730374A (en) * | 2020-12-03 | 2021-04-30 | 北京信息科技大学 | Optical fiber Raman probe for detecting low-concentration components in-vivo blood |
| CN112858254A (en) * | 2021-01-11 | 2021-05-28 | 上海大学 | SERS excitation device and method based on column vector Bessel Gaussian beam |
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