CN107469129A - A kind of antiseptic dressing and preparation method thereof - Google Patents
A kind of antiseptic dressing and preparation method thereof Download PDFInfo
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- CN107469129A CN107469129A CN201710709116.6A CN201710709116A CN107469129A CN 107469129 A CN107469129 A CN 107469129A CN 201710709116 A CN201710709116 A CN 201710709116A CN 107469129 A CN107469129 A CN 107469129A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The present invention relates to medical dressing field, and in particular to a kind of antiseptic dressing and preparation method thereof.A kind of preparation method of antiseptic dressing, including polysaccharide biological fiber and silver ion solution are provided；The polysaccharide biological fiber is placed in the silver ion solution polysaccharide biological fiber for impregnating, being infiltrated；The polysaccharide biological fiber of infiltration is placed in a confined space, and ultraviolet light is provided and irradiated, obtains the antiseptic dressing for being loaded with Nano Silver.Prepared using ultraviolet light irradiation, preparation process is green and simple and convenient；Obtained antiseptic dressing has good permeable breathable, and the Nano Silver loaded has good antibiotic property, can effectively prevent microorganism, particulates emission or other harmful substance contaminated wounds using polysaccharide biological fiber as carrier.A kind of antiseptic dressing, it is prepared using the preparation method of above-mentioned antiseptic dressing.
Description
【Technical field】
The present invention relates to medical dressing field, and in particular to a kind of antiseptic dressing and preparation method thereof.
【Background technology】
The increase for the movement of population that urbanization and globalization are brought, makes various forms of bacterium infections become more and more tighter
Weight, the increase and breeding for suppressing bacterium also become to be even more important.
Bacterium infection is to influence one of principal element of wound healing, the substantial amounts of inflammation contained in wound fluid because
Son, protease and free radical can all slow down the healing rate of wound, and traditional gauze can not meet the needs of repairing wound.
【The content of the invention】
To overcome existing technical problem, the present invention provides a kind of antiseptic dressing and preparation method thereof.
A kind of preparation method for antiseptic dressing that the present invention provides for solution above-mentioned technical problem, including polysaccharide biology is provided
Fiber and silver ion solution；The polysaccharide biological fiber is placed in the silver ion solution and impregnated, the polysaccharide life infiltrated
Fibres；The polysaccharide biological fiber of infiltration is placed in a confined space, and ultraviolet light is provided and irradiated, acquisition is loaded with receiving
Meter Yin antiseptic dressing.
Preferably, the power of the ultraviolet light is 200-400W, wavelength 300-450nm.
Preferably, 5-40min is irradiated under the ultraviolet light.
Preferably, the amount ratio of the polysaccharide biological fiber and the silver ion solution is (10-35) mg:1mL.
Preferably, the concentration of the silver ion solution is 0.01-0.1mg/mL.
Preferably, the polysaccharide biological fiber of infiltration is placed under ultraviolet light irradiate when, also provide in the confined space
Microwave and/or ultrasonic wave.
Preferably, when providing microwave, the power of the microwave is 100-500W.
Preferably, when providing ultrasonic wave, the power of the ultrasonic wave is 100-400W, frequency 20-40KHz.
Preferably, the polysaccharide biological fiber is alginic acid fibre or chitin fiber.
The present invention also provides a kind of antiseptic dressing, and it uses the preparation method of above-mentioned antiseptic dressing to be prepared.
Relative to prior art, the preparation method of antiseptic dressing provided by the present invention, with polysaccharide biological fiber and silver from
Sub- solution is as raw material, non-toxic, no antigen；Prepared using ultraviolet light irradiation, preparation process is green and simple
It is convenient；Obtained antiseptic dressing has good permeable breathable, and the Nano Silver loaded using polysaccharide biological fiber as carrier
With good antibiotic property, microorganism, particulates emission or other harmful substance contaminated wounds can be effectively prevented.
The present invention also provides a kind of antiseptic dressing, is prepared using the preparation method of above-mentioned antiseptic dressing, the antibacterial
Dressing has good permeable breathable, and the Nano Silver loaded has good antibiotic property, can effectively prevent microorganism, be harmful to
Particulate or other harmful substance contaminated wounds.
【Brief description of the drawings】
Fig. 1 is the schematic flow sheet of the preparation method of antiseptic dressing in embodiment one.
Fig. 2 is X-ray diffraction (XRD) figure of experimental group 1-1,1-2,1-3 and 1-4 in embodiment one, and wherein a represents real
Test a group 1-1, b represents experimental group 1-2, and c represents experimental group 1-3, d and represents experimental group 1-4.
Fig. 3 is experimental group 1-5,1-6 and 1-7 XRD in embodiment one, and wherein a represents experimental group 1-5, b and represents experiment
Group 1-6, c represent experimental group 1-7.
Fig. 4 is that the SEM of original alginic acid fibre (SAFs), experimental group 1-6 and experimental group 1-7 in embodiment one schemes, wherein a
Original SAFs is represented, b represents experimental group 1-6, c and represents experimental group 1-7.
Fig. 5 is the silver ion elution profiles that antiseptic dressing obtained by alginic acid fibre is utilized in embodiment one.
Fig. 6 is the firm curve of silver ion that antiseptic dressing obtained by alginic acid fibre is utilized in embodiment one.
Fig. 7 is the XRD of experimental group 2-1,2-2,2-3 and 2-4 in embodiment one, and wherein a represents experimental group 2-1, b representative
Experimental group 2-2, c represent experimental group 2-3, d and represent experimental group 2-4.
Experimental group 2-5,2-6 and 2-7 XRD in Fig. 8 embodiments one, wherein a represent experimental group 2-5, b and represent experimental group
2-6, c represent experimental group 2-7.
Fig. 9 is that the SEM of original chitin fiber (CFs), experimental group 2-6 and experimental group 2-7 in embodiment one schemes, wherein a
Original SAFs is represented, b represents experimental group 2-6, and it is a magnified partial view that c, which represents experimental group 2-7, d, and e is b magnified partial view,
F is c magnified partial view.
Figure 10 is the silver ion elution profiles that antiseptic dressing obtained by chitin fiber is utilized in embodiment one.
Figure 11 is the firm curve of silver ion that antiseptic dressing obtained by chitin fiber is utilized in embodiment one.
【Embodiment】
In order that the purpose of the present invention, technical scheme and advantage are more clearly understood, below in conjunction with accompanying drawing and embodiment,
The present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only to explain the present invention, and
It is not used in the restriction present invention.
Embodiment one
As shown in figure 1, a kind of preparation method of antiseptic dressing includes：
Step S1:Polysaccharide biological fiber and silver ion solution are provided；
Step S2：The polysaccharide biological fiber is placed in the silver ion solution and impregnated, the polysaccharide biology infiltrated
Fiber；
Step S3：The polysaccharide biological fiber of infiltration is placed in a confined space, and ultraviolet light is provided and irradiated, is obtained
It is loaded with the antiseptic dressing of Nano Silver.
Wherein, confined space can be box, case, bucket an even room to provide.
It is relative to prior art, the advantages of the preparation method of antiseptic dressing provided by the present invention：
(1) raw material, non-toxic, no antigen are used as using polysaccharide biological fiber and silver ion solution；
(2) prepared using ultraviolet light irradiation, preparation process is green and simple and convenient；And load effect is good,
So that it is uniformly distributed Nano Silver on polysaccharide biological fiber；
(3) antiseptic dressing obtained by has good permeable breathable, and can inhale using polysaccharide biological fiber as carrier
Unnecessary exudate is received, certain humidity is kept with wound facing face, there is well easy into gelation, adhesiveness and bio-compatible
Property, wound secondary damage will not be caused when removing the antiseptic dressing；, can be effective and the Nano Silver of load has good antibiotic property
Prevent microorganism, particulates emission or other harmful substance contaminated wounds；
(4) antiseptic dressing has good biological degradability.
Furthermore, it is necessary to, it is emphasized that can be Nano Silver by silver ion reduction using ultraviolet light irradiation, and for polysaccharide biology
This body structure of fiber is more uniformly distributed on the polysaccharide biological fiber without considerable influence, more so as to both can guarantee that
The permeable breathable having and biocompatibility of sugared biological fiber, the very strong antibacterial ability of and can combination Nano Silver, for controlling
Treating the surgical infection wounds such as ulcer, burn has great significance.
Preferably, the polysaccharide biological fiber is alginic acid fibre or chitin fiber.As polysaccharide biological fiber, marine alga
Sour fiber and chitin fiber are respectively provided with nontoxic and good biocompatibility；And alginic acid fibre be then have it is highly hygroscopic,
The advantages of easy removal, high oxygen flow；Chitin fiber is then with antibiotic property, to Escherichia coli, hay bacillus, Staphylococcus aureus
The common strain such as bacterium, Bacillus acidi lactici has good bacteriostasis, can preferably promote wound healing.In general, directly purchase
Available polysaccharide biological fiber in length it is thread, can clip as needed, obtain needed for length polysaccharide biological fiber.One
A bit preferably in embodiment, polysaccharide biological fiber can be cleaned, be dried i.e. after such as cleaning its surface impurity dust with water
Can.
The silver ion solution can be silver nitrate solution, silver sulfate solution etc., it is possible to understand that only need that silver ion can be provided
.The dipping duration is generally 5-30min, ensures that the infiltration of polysaccharide biological fiber fully absorbs silver nitrate solution.It is excellent
Selection of land, the amount ratio of the polysaccharide biological fiber and the silver ion solution is (10-35) mg:1mL.By determining polysaccharide biology
The amount ratio of fiber and silver ion solution, to ensure that polysaccharide biological fiber is fully wet out, and avoid the wave of silver ion solution
Take.Wherein it is preferred that the amount ratio of the polysaccharide biological fiber and the silver ion solution is (15-25) mg:1mL, specifically
The amount ratio of the polysaccharide biological fiber and the silver ion solution be 16mg:1mL、18mg:1mL、19mg:1mL、22mg:
1mL or 24mg:1mL.
In some preferred embodiments, the concentration of the silver ion solution is 0.01-0.1mg/mL.It is it is appreciated that silver-colored
The concentration of solion is related to the load capacity of Nano Silver on obtained antiseptic dressing；When the concentration of silver ion solution is relatively low,
The load capacity of Nano Silver is few on antiseptic dressing, it is impossible to plays antibacterial action well；When the concentration of silver ion solution is higher, silver
Rate of release too soon can to human body produce injury.And the concentration of silver ion solution is also to the mechanical property of the antiseptic dressing of gained
It can influence, mechanical property here refers to the ultimate strength, extension at break and elongation of antiseptic dressing.Therefore, pass through
The concentration for determining the silver ion solution is 0.01-0.1mg/mL, both avoids discharging silver too much and human body is damaged, and can is true
Bactericidal effect is protected, and the antiseptic dressing of good mechanical properties can be obtained.Specifically the concentration of the silver ion solution can be
0.01mg/mL、0.02mg/mL、0.03mg/mL、0.04mg/mL、0.05mg/mL、0.06mg/mL、0.07mg/mL、0.08mg/
ML, 0.09mg/mL or 0.1mg/mL.
When the polysaccharide biological fiber is alginic acid fibre, the concentration of the silver ion solution is preferably 0.02mg/mL；
When the polysaccharide biological fiber is chitin fiber, the concentration of the silver ion solution is preferably 0.05mg/mL.
Preferably, the power of the ultraviolet light is 200-400W, wavelength 300-450nm, can ensure load effect well
Fruit, that is, ensure to load for nano-Ag particles, and the nano-Ag particles crystallization degree, so as to ensure antibiotic property；And
And also ensure to obtain the good antiseptic dressing of mechanical property.It is preferred that the power of the ultraviolet light is 250-350W, wavelength is
300-400nm.It is still further preferred that the power of the ultraviolet light is 300W, wavelength 365nm.
The polysaccharide biological fiber of infiltration is placed in a confined space, 5-40min is irradiated under the ultraviolet light, is born
It is loaded with the antiseptic dressing of Nano Silver.By confirming exposure time, to ensure the power of the load effect of Nano Silver and antiseptic dressing
Learn performance.Exposure time can be specifically 5min, 10min, 20min, 30min, 40min.
In some preferred embodiments, the polysaccharide biological fiber of infiltration is placed under ultraviolet light irradiate when, it is described close
Close and microwave and/or ultrasonic wave are also provided in space.Microwave and ultrasound can provide energy, therefore can accelerate loading speed, contracting
The short irradiation time.
Wherein microwave is electromagnetic wave, and microwave heating is that body heats caused by material medium is lost in electromagnetic field, is
Whole molecular level heating, warming temperature gradient are small and without hysteresis effect.Because homogeneous heating can accelerate the load effect of Nano Silver
Rate and crystallization rate, and prevent from reuniting between particle, so as to obtain loading nano silvery be evenly distributed and better crystallinity degree it is anti-
Bacterium dressing.Preferably, when providing microwave, the power of the microwave is 100-500W.Specifically, the power of the microwave can be with
For 100W, 200W, 250W, 300W, 350W, 400W or 500W.
Wherein ultrasonic wave has cavitation so that loading speed is accelerated, and can play scattered nano-Ag particles, prevents
The generation of agglomeration.Preferably, when providing ultrasonic wave, the power of the ultrasonic wave is 100-400W, frequency 20-
40KHz.It is further preferred that the power of the ultrasonic wave is 150-300W, frequency 25-35KHz.The power of the ultrasonic wave
Can be 150W, 200W, 250W, 300W, frequency can be 25KHz, 26KHz, 28KHz, 30KHz, 32KHz or 35KHz.
In general, after the preparation method of the antiseptic dressing is additionally included in ultraviolet light irradiation, collection is dried.Specifically
, as it is placed in after ultraviolet light irradiation at 50-200 DEG C and dries 2-4h.
Specific experimental group is further provided below
First, alginic acid fibre
Experimental group 1-1
(1) alginic acid fibre (SAFs) pre-processes
It is most short required for follow-up monofilament strength test to meet from the fiber of clip 7cm or so on alginic acid long filament
Length 25mm, surface impurity dust is cleaned with distilled water, is then dried with hair-dryer, stood.
(2) silver nitrate solution is prepared
A certain amount of silver nitrate and soluble in water is weighed, obtains 0.1mg/mL AgNO3Solution, and measured with graduated cylinder
1mL0.1mg/mL AgNO3Solution is placed in beaker.
(3) impregnate
The pretreated SAFs in 19mg steps (1) is weighed, puts it into step (2) and has AgNO3The burning of solution
In cup, and stirred with glass bar, be allowed to complete wetting, the SAFs that dipping 10min is infiltrated.
(4) loading nano silvery
The SAFs of infiltration in step (3) is taken out with tweezers and is put into new beaker, and the beaker is placed in reaction instrument；
Parameter in reaction instrument is set：The power of ultraviolet light is 300W, wavelength 365nm；Ultrasonic power is 200W, frequency
Rate is 28KHz；Microwave power is 250W；
Start to take out beaker after reacting 5min, be put into 60 DEG C of oven drying 4h.
Experimental group 1-2
The experimental group and experimental group 1-1 difference be, a length of 10min during the reaction of loading nano silvery, namely step (4)
Loading nano silvery is specially：
The SAFs of infiltration in step (3) is taken out with tweezers and is put into new beaker, and the beaker is placed in reaction instrument；
Parameter in reaction instrument is set：The power of ultraviolet light is 300W, wavelength 365nm；Ultrasonic power is 200W, frequency
Rate is 28KHz；Microwave power is 250W；
Start to take out beaker after reacting 10min, be put into 60 DEG C of oven drying 4h.
Experimental group 1-3
The experimental group and experimental group 1-1 difference be, a length of 20min during the reaction of loading nano silvery, specific steps ginseng
On, it will not be repeated here.
Experimental group 1-4
The experimental group and experimental group 1-1 difference be, a length of 30min during the reaction of loading nano silvery, specific steps ginseng
On, it will not be repeated here.
Experimental group 1-5
The experimental group and experimental group 1-1 difference be, silver nitrate solution concentration is 0.01mg/L, loading nano silvery it is anti-
Seasonable a length of 10min；Namely the experimental group and experimental group 1-2 difference are, silver nitrate solution concentration is 0.01mg/L.Cause
This, step (2) prepares silver nitrate solution and is specially：
A certain amount of silver nitrate and soluble in water is weighed, obtains 0.01mg/mL AgNO3Solution, and measured with graduated cylinder
1mL0.01mg/mL AgNO3Solution is placed in beaker.
Experimental group 1-6
The experimental group and experimental group 1-1 difference be, silver nitrate solution concentration is 0.02mg/L, loading nano silvery it is anti-
Seasonable a length of 10min；Namely the experimental group and experimental group 1-2 difference are, silver nitrate solution concentration is 0.02mg/L.Specifically
In step ginseng, it will not be repeated here.
Experimental group 1-7
The experimental group and experimental group 1-1 difference be, silver nitrate solution concentration is 0.05mg/L, loading nano silvery it is anti-
Seasonable a length of 10min；Namely the experimental group and experimental group 1-2 difference are, silver nitrate solution concentration is 0.05mg/L.Specifically
In step ginseng, it will not be repeated here.
Mechanics Performance Testing, X-ray diffraction (XRD) analysis, Flied emission scanning electron microscopy are carried out for above-mentioned experimental group
Mirror (SEM) analysis, the sustained release test of silver ion and the firm test of silver ion.Concrete outcome and it is analyzed as follows：
1st, Mechanics Performance Testing
Experiment condition is as shown in the table to when test result：
Contrast experiment organize 1-1,1-2,1-3 and 1-4 understand, when concentration of silver ions is identical, with reaction duration increase,
Mechanical property is first gradually reduced and then lifted；Contrast experiment organizes 1-2,1-5,1-6,1-7 and understood, grows when reacted identical
When, concentration of silver ions 0.02mg/mL, mechanical property is optimal.
2nd, X-ray diffraction (XRD) is analyzed
(1) Fig. 2 is experimental group 1-1,1-2,1-3 and 1-4 XRD, and a represents experimental group 1-1, b and represents reality in the figure
A group 1-2 is tested, c represents experimental group 1-3, d and represents experimental group 1-4.
As shown in Figure 2, experimental group 1-1,1-2,1-3 and 1-4 has stronger peak four positions, this four positions point
It it is not 38.3 °, 44.3 °, 64.5 °, 77.2 °, the standard card contrast with silver can be drawn：Nano Silver has been gone up in load on SAFs,
Ag/SAFs can be designated as.The crystal of silver is (111), (200), (220) of more typical face-centered cubic type, four peaks and Ag
And (311) this four crystal faces correspond to respectively, and the peak of Ag crystal faces is more sharp, and peak value is higher, illustrates obtained Ag/SAFs knots
Brilliant degree is better.
As seen from the figure, the peak of experimental group 1-2 Ag crystal faces is most sharp, peak value highest, illustrates that its crystallization degree is better.
That is, a length of 10min when preferably reacting.
(2) Fig. 3 is experimental group 1-5,1-6 and 1-7 XRD, and a represents experimental group 1-5, b and represents experimental group in the figure
1-6, c represent experimental group 1-7.
In Fig. 3, each experimental group is also stronger peak occur 38.3 °, 44.3 °, 64.5 °, 77.2 ° of four positions,
Namely Nano Silver has been drawn on SAFs on appendix, and the crystal of silver is more typical face-centered cubic type.As seen from the figure, experimental group
1-6 peak type is most sharp, peak value highest, it was demonstrated that when concentration of silver ions is 0.2mg/mL, crystallization degree is best.
3rd, field emission scanning electron microscope (SEM) is analyzed
In order to further be verified to carrying silver-colored effect, SEM points are carried out for original SAFs, experimental group 1-6 and experiment 1-7
Analysis.The SEM that Fig. 4 is original SAFs, experimental group 1-6 and experimental group 1-7 schemes, and wherein a represents original SAFs, and b represents experimental group 1-
6, c represent experimental group 1-7.
Contrast original SAFs and experimental group 1-6, experimental group 1-7, it can be seen that original SAFs surfaces are penetrating, smooth, and real
Test group 1-6 and experimental group 1-7 surfaces have white bright spot.EDS power spectrums point are further carried out to experimental group 1-6 and experimental group 1-7
Analysis, in addition to the intrinsic C and O elements of SAFs, have also appeared the characteristic peak of Ag elements, therefore can prove white bright spot i.e.
For Nano Silver.And white bright spot is more on experimental group 1-6, illustrate that the silver-colored effect of load is more preferable, it is consistent with XRD analysis result.
4th, the sustained release test of silver ion
Fig. 5 is the silver ion elution profiles of obtained antiseptic dressing, the specially antiseptic dressing obtained by experimental group 1-6.
Ag in the quality and fiber of the antibiotic property of antiseptic dressing+Release it is relevant, Ag+Minimum bactericidal concentration is 0.1ug/mL,
Toxic concentration to human body cell is 1.6ug/mL, so diluting the Ag+Concentration should between 0.1-1.6ug/mL,
It is played bactericidal action, and do not damage cell.
As shown in Figure 5, in 1.5h, Ag+Quick release, 1.5-3h are in slow releasing trend, after 3h, Ag+Concentration is substantially at
Saturation state.The Ag that this experiment is detected+Concentration is between 0.1-1.6ug/mL, it was demonstrated that the Ag discharged+Sterilization can be played to make
With health will not be damaged again.
5th, the firm test of silver ion
It is sustained and is tested from silver ion, the Ag of antiseptic dressing provided by the present invention+Concentration 0.1-1.6ug/mL it
Between, meet antibacterial and do not damage the requirement of health, in order to further investigate the Ag discharged+Fastness, change water every 3h,
Sampling, it is as shown in Figure 6 to obtain result.
As can be known from Fig. 6, within 9h, Ag in water+Concentration has bactericidal action in 0.1-1.6ug/mL.Proof is carried
The fastness of the silver ion of the antiseptic dressing of confession is good.
2nd, chitin fiber
Experimental group 2-1
The experimental group and experimental group 1-1 difference are that the polysaccharide biological fiber used is chitin fiber, dry and collect
Shi Wendu is 150 DEG C, a length of 3h when drying, is concretely comprised the following steps：
(1) chitin fiber (CFs) pre-processes
It is most short required for follow-up monofilament strength test to meet from the fiber of clip 7cm or so on chitin long filament
Length 25mm, surface impurity dust is cleaned with distilled water, is then dried with hair-dryer, stood.
(2) silver nitrate solution is prepared
A certain amount of silver nitrate and soluble in water is weighed, obtains 0.1mg/mL AgNO3Solution, and measured with graduated cylinder
1mL0.1mg/mL AgNO3Solution is placed in beaker.
(3) impregnate
The pretreated Cs in 19mg steps (1) is weighed, puts it into step (2) and has AgNO3The beaker of solution
In, and stirred with glass bar, it is allowed to complete wetting, the CFs that dipping 10min is infiltrated.
(4) loading nano silvery
The CFs of infiltration in step (3) is taken out with tweezers and is put into new beaker, and the beaker is placed in reaction instrument；
Parameter in reaction instrument is set：The power of ultraviolet light is 300W, wavelength 365nm；Ultrasonic power is 200W, frequency
Rate is 28KHz；Microwave power is 250W；
Start to take out beaker after reacting 5min, be put into 150 DEG C of oven drying 3h.
Experimental group 2-2
The experimental group and experimental group 2-1 difference be, a length of 10min during the reaction of loading nano silvery, namely step (4)
Loading nano silvery is specially：
The CFs of infiltration in step (3) is taken out with tweezers and is put into new beaker, and the beaker is placed in reaction instrument；
Parameter in reaction instrument is set：The power of ultraviolet light is 300W, wavelength 365nm；Ultrasonic power is 200W, frequency
Rate is 28KHz；Microwave power is 250W；
Start to take out beaker after reacting 10min, be put into 150 DEG C of oven drying 3h.
Experimental group 2-3
The experimental group and experimental group 2-1 difference be, a length of 20min during the reaction of loading nano silvery, specific steps ginseng
On, it will not be repeated here.
Experimental group 2-4
The experimental group and experimental group 2-1 difference be, a length of 30min during the reaction of loading nano silvery, specific steps ginseng
On, it will not be repeated here.
Experimental group 2-5
The experimental group and experimental group 2-3 difference be, silver nitrate solution concentration is 0.01mg/L, loading nano silvery it is anti-
Seasonable a length of 20min；Namely the experimental group and experimental group 2-3 difference are, silver nitrate solution concentration is 0.01mg/L.Cause
This, step (2) prepares silver nitrate solution and is specially：
A certain amount of silver nitrate and soluble in water is weighed, obtains 0.01mg/mL AgNO3Solution, and measured with graduated cylinder
1mL0.1mg/mL AgNO3Solution is placed in beaker.
Experimental group 2-6
The experimental group and experimental group 2-1 difference be, silver nitrate solution concentration is 0.02mg/L, loading nano silvery it is anti-
Seasonable a length of 20min；Namely the experimental group and experimental group 2-3 difference are, silver nitrate solution concentration is 0.02mg/L.Specifically
In step ginseng, it will not be repeated here.
Experimental group 2-7
The experimental group and experimental group 2-1 difference be, silver nitrate solution concentration is 0.05mg/L, loading nano silvery it is anti-
Seasonable a length of 20min；Namely the experimental group and experimental group 2-3 difference are, silver nitrate solution concentration is 0.05mg/L.Specifically
In step ginseng, it will not be repeated here.
Mechanics Performance Testing, X-ray diffraction (XRD) analysis, Flied emission scanning electron microscopy are carried out for above-mentioned experimental group
Mirror (SEM) analysis, the sustained release test of silver ion and the firm test of silver ion.Concrete outcome and it is analyzed as follows：
1st, Mechanics Performance Testing
Experiment condition is as shown in the table to when test result：
Contrast experiment organize 2-1,2-2,2-3 and 2-4 understand, when concentration of silver ions is identical, with reaction duration increase,
Mechanical property gradually increases；Contrast experiment organizes 2-3,2-5,2-6,2-7 and understands that simultaneously, concentration of silver ions is appearance when reacted
0.05mg/mL, mechanical property are optimal.
2nd, X-ray diffraction (XRD) is analyzed
(1) Fig. 7 is experimental group 2-1,2-2,2-3 and 2-4 XRD, and a represents experimental group 2-1, b and represents reality in the figure
A group 2-2 is tested, c represents experimental group 2-3, d and represents experimental group 2-4.
As shown in Figure 7, experimental group 2-1,2-2,2-3 and 2-4 has stronger peak four positions, this four positions point
It it is not 38.3 °, 44.3 °, 64.5 °, 77.2 °, the standard card contrast with silver can be drawn：Nano Silver has been gone up in load on SAFs,
Ag/SAFs can be designated as.The crystal of silver is (111), (200), (220) of more typical face-centered cubic type, four peaks and Ag
And (311) this four crystal faces correspond to respectively, and the peak of Ag crystal faces is more sharp, and peak value is higher, illustrates obtained Ag/SAFs knots
Brilliant degree is better.
As seen from the figure, the peak of the Ag crystal faces of experimental group 2-3,2-4 is most sharp, peak value highest, illustrates that its crystallization degree is better.
That is, a length of 20min-30min when preferably reacting.
(2) Fig. 8 is experimental group 2-5,2-6 and 2-7 XRD, and a represents experimental group 2-5, b and represents experimental group in the figure
2-6, c represent experimental group 2-7.
In Fig. 8, each experimental group is also stronger peak occur 38.3 °, 44.3 °, 64.5 °, 77.2 ° of four positions,
Namely Nano Silver has been drawn on SAFs on appendix, and the crystal of silver is more typical face-centered cubic type.As seen from the figure, experimental group
2-7 peak type is most sharp, peak value highest, it was demonstrated that when concentration of silver ions is 0.5mg/mL, crystallization degree is best.
3rd, field emission scanning electron microscope (SEM) is analyzed
In order to further be verified to carrying silver-colored effect, SEM points are carried out for original SAFs, experimental group 2-6 and experiment 2-7
Analysis.The SEM that Fig. 9 is original SAFs, experimental group 2-6 and experimental group 2-7 schemes, and wherein a represents original SAFs, and b represents experimental group 2-
6, c represent the magnified partial view of experimental group 2-7, d for a, and e is b magnified partial view, and f is c magnified partial view.
Contrast original SAFs and experimental group 2-6, experimental group 2-7, it can be seen that original SAFs surfaces are penetrating, smooth, and real
Test group 2-6 and experimental group 2-7 surfaces have white bright spot.EDS power spectrums point are further carried out to experimental group 2-6 and experimental group 2-7
Analysis, in addition to the intrinsic C and O elements of SAFs, have also appeared the characteristic peak of Ag elements, therefore can prove white bright spot i.e.
For Nano Silver.And white bright spot is more on experimental group 2-7, illustrate that the silver-colored effect of load is more preferable, it is consistent with XRD analysis result.
4th, the sustained release test of silver ion
Figure 10 is the silver ion elution profiles of obtained antiseptic dressing, the specially antiseptic dressing obtained by experimental group 2-7.
As shown in Figure 10, in 3h, Ag+Quick release, after 3h, Ag+Concentration is substantially at saturation state.This experiment is detected
Ag+Concentration is between 0.1-1.6ug/mL, it was demonstrated that is the Ag of release+Bactericidal action can be played, human body will not be damaged again and be good for
Health.
5th, the firm test of silver ion
It is sustained and is tested from silver ion, the Ag of antiseptic dressing provided by the present invention+Concentration 0.1-1.6ug/mL it
Between, meet antibacterial and do not damage the requirement of health, in order to further investigate the Ag discharged+Fastness, change water every 3h,
Sampling, it is as shown in figure 11 to obtain result.
As can be known from Fig. 11, within 9h, Ag in water+Concentration has bactericidal action in 0.1-1.6ug/mL.Proof is carried
The fastness of the silver ion of the antiseptic dressing of confession is good.
Embodiment two
A kind of antiseptic dressing, it is prepared using the preparation method of the antiseptic dressing provided in embodiment one, the antibacterial
Dressing has good permeable breathable, and the Nano Silver loaded has good antibiotic property, can effectively prevent microorganism, be harmful to
Particulate or other harmful substance contaminated wounds.
Compared with prior art, the preparation method of antiseptic dressing provided by the present invention, with polysaccharide biological fiber and silver from
Sub- solution is as raw material, non-toxic, no antigen；Prepared using ultraviolet light irradiation, preparation process is green and simple
It is convenient；Obtained antiseptic dressing has good permeable breathable, and the Nano Silver loaded using polysaccharide biological fiber as carrier
With good antibiotic property, microorganism, particulates emission or other harmful substance contaminated wounds can be effectively prevented.
It is further that the power of the ultraviolet light is 200-400W, wavelength 300-450nm, can ensure to bear well
Carry effect, that is, ensure to load for nano-Ag particles, and the nano-Ag particles crystallization degree, so as to ensure antibacterial
Property；And also ensure to obtain the good antiseptic dressing of mechanical property.
It is further to irradiate 5-40min under the ultraviolet light.By confirming exposure time, to ensure Nano Silver
The mechanical property of load effect and antiseptic dressing.
It is further that the amount ratio of the polysaccharide biological fiber and the silver ion solution is (10-35) mg:1mL.It is logical
The amount ratio for determining polysaccharide biological fiber and silver ion solution is crossed, to ensure that polysaccharide biological fiber is fully wet out, and is avoided
The waste of silver ion solution.
It is further that the concentration of the silver ion solution is 0.01-0.1mg/mL.By determining the silver ion solution
Concentration be 0.01-0.1mg/mL, both avoid discharging too many silver and human body damaged, and can ensures bactericidal effect, Er Qieneng
Obtain the antiseptic dressing of good mechanical properties.
Be further, the polysaccharide biological fiber of infiltration is placed under ultraviolet light irradiate when, in the confined space also
Microwave and/or ultrasonic wave are provided.Microwave and ultrasound can provide energy, therefore can accelerate loading speed, shorten exposure time.
Wherein microwave is electromagnetic wave, and microwave heating is that body heats caused by material medium is lost in electromagnetic field, is
Whole molecular level heating, warming temperature gradient are small and without hysteresis effect.Because homogeneous heating can accelerate the load effect of Nano Silver
Rate and crystallization rate, and prevent from reuniting between particle, so as to obtain loading nano silvery be evenly distributed and better crystallinity degree it is anti-
Bacterium dressing.It is further that, when providing microwave, the power of the microwave is 100-500W.
Wherein ultrasonic wave has cavitation so that loading speed is accelerated, and can play scattered nano-Ag particles, prevents
The generation of agglomeration.It is further that, when providing ultrasonic wave, the power of the ultrasonic wave is 100-400W, frequency 20-
40KHz。
It is further that the polysaccharide biological fiber is alginic acid fibre or chitin fiber.As polysaccharide biological fiber,
Alginic acid fibre and chitin fiber are respectively provided with nontoxic and good biocompatibility；And alginic acid fibre is then to have high inhale
The advantages of wet, easy removal, high oxygen flow；Chitin fiber is then with antibiotic property, to Escherichia coli, hay bacillus, golden yellow Portugal
The common strain such as grape coccus, Bacillus acidi lactici has good bacteriostasis, can preferably promote wound healing.
The present invention also provides a kind of antiseptic dressing, is prepared using the preparation method of above-mentioned antiseptic dressing.The antibacterial
Dressing has good permeable breathable, and the Nano Silver loaded has good antibiotic property, can effectively prevent microorganism, be harmful to
Particulate or other harmful substance contaminated wounds.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all originals in the present invention
Any modification made within then, equivalent substitution and improvement etc. all should be included within protection scope of the present invention.
Claims (10)
- A kind of 1. preparation method of antiseptic dressing, it is characterised in that：Including providing polysaccharide biological fiber and silver ion solution；By institute State polysaccharide biological fiber and be placed in the silver ion solution polysaccharide biological fiber for impregnating, being infiltrated；The polysaccharide of infiltration is given birth to Fibres are placed in a confined space, and are provided ultraviolet light and irradiated, and obtain the antiseptic dressing for being loaded with Nano Silver.
- 2. the preparation method of antiseptic dressing as described in the appended claim 1, it is characterised in that：The power of the ultraviolet light is 200- 400W, wavelength 300-450nm.
- 3. the preparation method of antiseptic dressing as described in the appended claim 1, it is characterised in that：5- is irradiated under the ultraviolet light 40min。
- 4. such as the preparation method of the antiseptic dressing in claim 1, it is characterised in that：The polysaccharide biological fiber with it is described The amount ratio of silver ion solution is (10-35) mg:1mL.
- 5. such as the preparation method of the antiseptic dressing in claim 4, it is characterised in that：The concentration of the silver ion solution is 0.01-0.1mg/mL。
- 6. such as the preparation method of the antiseptic dressing in claim 1, it is characterised in that：By the polysaccharide biological fiber of infiltration It is placed under ultraviolet light when irradiating, microwave and/or ultrasonic wave is also provided in the confined space.
- 7. such as the preparation method of the antiseptic dressing in claim 6, it is characterised in that：When providing microwave, the microwave Power be 100-500W.
- 8. such as the preparation method of the antiseptic dressing in claim 6, it is characterised in that：It is described super when providing ultrasonic wave The power of sound wave is 100-400W, frequency 20-40KHz.
- 9. the preparation method of antiseptic dressing as described in claim any one of 1-8, it is characterised in that：The polysaccharide biological fiber For alginic acid fibre or chitin fiber.
- A kind of 10. antiseptic dressing, it is characterised in that：It is prepared into using the preparation method of antiseptic dressing as described in the appended claim 1 Arrive.
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| CN111499220A (en) * | 2020-04-24 | 2020-08-07 | 东莞市冠和光学玻璃有限公司 | Preparation method of antibacterial glass and antibacterial glass |
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