CN107456606A - A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method - Google Patents

A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method Download PDF

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Publication number
CN107456606A
CN107456606A CN201710764322.7A CN201710764322A CN107456606A CN 107456606 A CN107456606 A CN 107456606A CN 201710764322 A CN201710764322 A CN 201710764322A CN 107456606 A CN107456606 A CN 107456606A
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content
collagen
selfheal
ginseng
trehalose
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田娟
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Shanghai Xinji Biological Technology Co Ltd
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Shanghai Xinji Biological Technology Co Ltd
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Priority to CN201710764322.7A priority Critical patent/CN107456606A/en
Publication of CN107456606A publication Critical patent/CN107456606A/en
Priority to KR1020180101063A priority patent/KR20190024777A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
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    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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Abstract

The invention discloses a kind of plain formula of resurrection that adipocyte survival rate can be improved to 91% and preparation method, it is characterised in that including following raw material：Collagen, medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, and matched by following percentage by weight：The content of collagen is 50% 60%, the content of medium chain triglyceride is 10% 20%, the content of spirulina is 6% 14%, the content of kaempferia galamga is 1% 3%, the content of selfheal is 1% 3%, the content of Leaves of Hippophae L is 1% 5%, the content of trehalose is 6% 10%, the content of blueberry powder is 2% 6% and the content of ginseng is 1%, if skin elastic force itself is insufficient, collagen fabric net subalimentation, the missing of skin corium nutrient molecule causes the lipid nutrition of filling insufficient simultaneously, Large Scale Death, utilize nano-collagen, make the restorative state of dermal layer of the skin, cell is set to be lived again, the survival rate of adipocyte improves 91%.

Description

A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method
Technical field
The present invention relates to bring back to life plain preparing technical field, specially a kind of resurrection by adipocyte survival rate raising 91% Element formula and preparation method.
Background technology
Fat filling is the fat transfer of itself to required position, if skin elastic force itself is insufficient, for pinning fat The collagen fabric net subalimentation of fat particle, then can not a support increased fat, while skin corium nutrition point suddenly The missing of son can also directly affect the survival rate and absorptivity of the adipocyte being transplanted, cause the lipid nutrition supply of filling not Foot, Large Scale Death.
The content of the invention
It is an object of the invention to provide it is a kind of promote transplanting fatty absorptivity and survival rate resurrection element formula and Preparation method, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme：A kind of adipocyte survival rate improves 91% resurrection Element formula, it is characterised in that including following raw material：Collagen, medium chain triglyceride, spirulina, kaempferia galamga, selfheal, sea-buckthorn Leaf, trehalose, blueberry powder and ginseng, and matched by following percentage by weight：The content of collagen be 50%-60%, The content of medium chain triglyceride is 10%-20%, the content of spirulina is 6%-14%, the content of kaempferia galamga is 1%-3%, selfheal contains The content measured as 1%-3%, Leaves of Hippophae L is 1%-5%, the content of trehalose is 6%-10%, the content of blueberry powder is 2%-6% and people The content of ginseng is 1%.
Preferably, the content of the collagen is 53%-57%, the content of medium chain triglyceride is 13%-27%, spirulina Content be 8%-12%, the content of kaempferia galamga is 2%, the content of selfheal is 2%, the content of Leaves of Hippophae L is 2%-4%, trehalose contains The content measured as 7%-9%, blueberry powder is 3%-5% and the content of ginseng is 1%.
Preferably, the content of the collagen is 55%, the content of medium chain triglyceride is 15%, the content of spirulina is 10%th, the content of kaempferia galamga is 2%, the content of selfheal is 2%, the content of Leaves of Hippophae L is 3%, the content of trehalose is 8%, blueberries The content of powder is 4% and the content of ginseng is 1%.
Preferably, the selfheal is nutritious, in young stem and leaf containing protein, fat, carrotene, vitamin B2 and The compositions such as vitamin C.
The present invention provides another technical solution：A kind of adipocyte survival rate improves 91% resurrection element formula and system Preparation Method, comprise the following steps：
S1：By the three nanoscale collagen peptide elite extraction process in forward position and using three layers of critical high purification technique, reach To the critical form of protein, the elite level collagen of collagen is extracted, is stored after the small level to close to amino acid；
S2：Respectively according to medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng difference Chinese medicine The property of medicine, appearance and shape screen good medicinal material, wet concentration, and dedusting is stand-by；
S3：For the medicine of medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng characteristic with And the performance of associated carrier, different pharmaceutical and the requirement of different formulations, purposes, from suitable carrier and using different Technology path and nanometer preparation method；
S4：Fruit is selected to compact, dryness is full, and epidermis is fine and smooth, comparatively without leaf and stalk epidermis on adhere to uniform bloom Blueberry after, be to be stored after fruit powder is collected by " bloom "；
S5：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out by weight percentage after being well mixed, tablet is made, seals Storage；
Preferably, powder is made in medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng in the S3 End, powder are placed in jet collision type pulverizer, powder size is reached nanometer.
Compared with prior art, the beneficial effects of the invention are as follows：This adipocyte survival rate improves 91% resurrection element formula And preparation method, fat filling is the fat transfer of itself to required position, if skin elastic force itself is insufficient, for pinning The collagen fabric net subalimentation of lipochondrion, while the missing of skin corium nutrient molecule can also directly affect injection fat The survival rate and absorptivity of cell, cause the lipid nutrition of filling insufficient, Large Scale Death, using nano-collagen, The nutriment for directly supplementing skin corium missing reinforces collagen fabric net, makes the restorative state of dermal layer of the skin, makes Cell is lived again, and the survival rate of adipocyte improves 91%, promotes the fatty absorptivity and survival rate of transplanting.
Embodiment
The embodiment of the present invention is will be detailed below, however, the embodiment of the present invention is not limited thereto.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, Belong to the scope of protection of the invention.
Embodiment one：
A kind of adipocyte survival rate improves 91% resurrection element formula, it is characterised in that including following raw material：Collagen, in Chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, selfheal is nutritious, tender Containing compositions such as protein, fat, carrotene, vitamin B2 and vitamin Cs in cauline leaf, and carried out by following percentage by weight Proportioning：The content of collagen is 50%-60%, the content of medium chain triglyceride is 10%-20%, the content of spirulina is 6%- 14%th, the content of kaempferia galamga is 1%-3%, the content of selfheal is 1%-3%, the content of Leaves of Hippophae L is 1%-5%, the content of trehalose is 6%-10%, the content of blueberry powder are 2%-6% and the content of ginseng is 1%.
A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method, comprises the following steps：
The first step：Skills are purified by the three nanoscale collagen peptide elite extraction process in forward position and using three layers of critical height Art, reach the critical form of protein, extract the elite level collagen of collagen, stored after the small level to close to amino acid；
Second step：Respectively according in medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng difference The property of medicine of medicine, appearance and shape screen good medicinal material, wet concentration, and dedusting is stand-by；
3rd step：For the spy of the medicine of medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng The performance of property and associated carrier, medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and people Powder is made in ginseng, and powder is placed in jet collision type pulverizer, powder size is reached nanometer, different pharmaceutical and different agent Type requirement, purposes, from suitable carrier and use different technology paths and nanometer preparation method；
4th step：Select fruit to compact, dryness is full, and epidermis is fine and smooth, comparatively uniform without attachment on leaf and stalk epidermis It is to be stored after fruit powder is collected by " bloom " after the blueberry of bloom；
5th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out by weight percentage after being well mixed, tablet are made, Sealed storage；
6th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out after being well mixed by weight percentage, and tablet is made, close Seal storage up for safekeeping；
Embodiment two：
A kind of adipocyte survival rate improves 91% resurrection element formula, it is characterised in that including following raw material：Collagen, in Chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, selfheal is nutritious, tender Containing compositions such as protein, fat, carrotene, vitamin B2 and vitamin Cs in cauline leaf, and carried out by following percentage by weight Proportioning：The content of collagen is 53%-57%, the content of medium chain triglyceride is 13%-27%, the content of spirulina is 8%- 12%th, the content of kaempferia galamga is 2%, the content of selfheal is 2%, the content of Leaves of Hippophae L is 2%-4%, the content of trehalose be 7%-9%, The content of blueberry powder is 3%-5% and the content of ginseng is 1%.
A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method, comprises the following steps：
The first step：Skills are purified by the three nanoscale collagen peptide elite extraction process in forward position and using three layers of critical height Art, reach the critical form of protein, extract the elite level collagen of collagen, stored after the small level to close to amino acid；
Second step：Respectively according in medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng difference The property of medicine of medicine, appearance and shape screen good medicinal material, wet concentration, and dedusting is stand-by；
3rd step：For the spy of the medicine of medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng The performance of property and associated carrier, medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and people Powder is made in ginseng, and powder is placed in jet collision type pulverizer, powder size is reached nanometer, different pharmaceutical and different agent Type requirement, purposes, from suitable carrier and use different technology paths and nanometer preparation method；
4th step：Select fruit to compact, dryness is full, and epidermis is fine and smooth, comparatively uniform without attachment on leaf and stalk epidermis It is to be stored after fruit powder is collected by " bloom " after the blueberry of bloom；
5th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out by weight percentage after being well mixed, tablet are made, Sealed storage；
6th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out after being well mixed by weight percentage, and tablet is made, close Seal storage up for safekeeping.
Embodiment three：
A kind of adipocyte survival rate improves 91% resurrection element formula, it is characterised in that including following raw material：Collagen, in Chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, selfheal is nutritious, tender Containing compositions such as protein, fat, carrotene, vitamin B2 and vitamin Cs in cauline leaf, and carried out by following percentage by weight Proportioning：The content of collagen is 55%, the content of medium chain triglyceride is 15%, the content of spirulina is 10%, the content of kaempferia galamga Content for 2%, selfheal is 2%, the content of Leaves of Hippophae L is 3%, the content of trehalose is 8%, the content of blueberry powder is 4% and The content of ginseng is 1%.
A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method, comprises the following steps：
The first step：Skills are purified by the three nanoscale collagen peptide elite extraction process in forward position and using three layers of critical height Art, reach the critical form of protein, extract the elite level collagen of collagen, stored after the small level to close to amino acid；
Second step：Respectively according in medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng difference The property of medicine of medicine, appearance and shape screen good medicinal material, wet concentration, and dedusting is stand-by；
3rd step：For the spy of the medicine of medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng The performance of property and associated carrier, medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and people Powder is made in ginseng, and powder is placed in jet collision type pulverizer, powder size is reached nanometer, different pharmaceutical and different agent Type requirement, purposes, from suitable carrier and use different technology paths and nanometer preparation method；
4th step：Select fruit to compact, dryness is full, and epidermis is fine and smooth, comparatively uniform without attachment on leaf and stalk epidermis It is to be stored after fruit powder is collected by " bloom " after the blueberry of bloom；
5th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out by weight percentage after being well mixed, tablet are made, Sealed storage；
6th step：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out after being well mixed by weight percentage, and tablet is made, close Seal storage up for safekeeping.
Example IV：
A kind of adipocyte survival rate improves 91% resurrection element formula, including following raw material：Collagen, medium chain triglyceride, Spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, custom, the skin for the baby being just born is best , it is tender to pinch water outlet, but with advancing age, nutriment is constantly lost in, skin engender bleed, relaxation, The problems such as coarse, the ginseng as " kings of hundred grass " can solve these problems, and the leachate of ginseng can be by skin slow-absorbing And without pessimal stimulation, capillary of skin can be expanded, promotes skin blood circulation, increases skin-nourishing, adjusts the water oil of skin Balance, prevents skin dehydration, hardening, corrugation, and the active material of ginseng suppresses the reducing property of melanin, makes the pure white light of skin It is sliding, skin elasticity can be strengthened, obtain cell newborn, be the superfine product improved looks；Fat filling can repair face or figure, But in the case where not adding other compositions, simple fat transfer survival rate probably 30%~60%, lose by skin nutrition itself Weighing apparatus, it is impossible to the nutriment of abundance is provided, has crossed of short duration freshness date after fat filling, postoperative effect will be undesirable, very To there is a series of side effect, selfheal is nutritious, and protein, fat, carrotene, vitamin B2 are contained in young stem and leaf With the composition such as vitamin C, skin cell tissue can be directly acted on, fully provide during postoperative recovery needed for nutrition into Point, reach the purpose for repairing damaged cell；If pre-surgical skin state is not adjusted, the collagenous fibres of individual's skin in itself Absorption that net can not fill enough simultaneously bears unexpected increased fat, and significant quantities of fat accumulation can cause fat bad because of blood supply insufficiency Extremely, dissolve, absorb, easily trigger infection, the sequelae such as fibrosis or calcification, adiponecrosis occur, medium chain triglyceride is to suffering from There is the bad people of fat absorption to improve fat absorption rate, prevent uneven caused by adiponecrosis, eat in addition With the ester of Medium chain fatty three to the body weight of human body, the reduction of stomach fat area, the reduction of waistline, there is obvious effect；Marine alga Sugar can substitute the water in tissue when plant hydropenia, and protection cell exempts from the injury of dehydration, maintains the natural machine of cell Structure, when having water, plant absorption and storage moisture are helped, under desert plant is survived in harsh climate environment Come, possess moisturizing, the function of water lock, with the growth at our age, the moisture in cell gradually decreases, skin gradually because For the loss of moisture, occur wrinkle, drying, it is obscure the problems such as, trehalose can keep the skin wet, and recover the life of collagen Power, while the effect of water lock is may also reach up, prevent the loss of moisture；Nano-collagen is nano level, and molecular weight approaches Scintilla rank, nano-collagen have the function that again repair damaged cell, be directly entered flesh bottom and repaired, collagen Human body itself just has, and supplement nano-collagen, which completely dispenses with worry, side effect, may also reach up the effect of moisturizing water lock.
A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method, comprises the following steps：
Fat filling is the fat transfer of itself to required position, if skin elastic force itself is insufficient, for pinning fat The collagen fabric net subalimentation of grain, then can not a support increased fat suddenly, while skin corium nutrient molecule Missing can also directly affect the survival rate and absorptivity of injection adipocyte, cause the lipid nutrition of filling insufficient, big face Product is dead, it is therefore desirable to brings back to life the prime time that element is repaired after surgery, using nano-collagen, directly supplements skin corium missing Nutriment reinforce collagen fabric net, make the restorative state of dermal layer of the skin, cell is lived again, fat carefully The survival rate of born of the same parents improves 91%, promotes the fatty absorptivity and survival rate of transplanting.
In summary：The resurrection element formula and preparation method of this adipocyte survival rate raising 91%, fat filling are certainly The fat transfer of body is to required position, if skin elastic force itself is insufficient, for pinning the collagen fabric net of lipochondrion Subalimentation, while the missing of skin corium nutrient molecule can also directly affect the survival rate and absorptivity of injection adipocyte, lead Cause the lipid nutrition of filling insufficient, Large Scale Death, using nano-collagen, directly supplement the nutrition that skin corium lacks Material reinforces collagen fabric net, makes the restorative state of dermal layer of the skin, cell is lived again, adipocyte is deposited Motility rate improves 91%, promotes the fatty absorptivity and survival rate of transplanting.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (6)

1. a kind of adipocyte survival rate improves 91% resurrection element formula, it is characterised in that including following raw material：Collagen, Medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose, blueberry powder and ginseng, and press following weight percent Than being matched：The content of collagen is 50%-60%, the content of medium chain triglyceride is 10%-20%, the content of spirulina is 6%-14%, the content of kaempferia galamga are 1%-3%, the content of selfheal is 1%-3%, the content of Leaves of Hippophae L is 1%-5%, the content of trehalose Content for 6%-10%, blueberry powder is 2%-6% and the content of ginseng is 1%.
2. a kind of adipocyte survival rate according to claim 1 improves 91% resurrection element formula, it is characterised in that bag The content for including collagen is 53%-57%, the content of medium chain triglyceride is 13%-27%, the content of spirulina is 8%-12%, mountain Content how is 2%, the content of selfheal is 2%, the content of Leaves of Hippophae L is 2%-4%, the content of trehalose is 7%-9%, blueberries The content of powder is 3%-5% and the content of ginseng is 1%.
3. a kind of adipocyte survival rate according to claim 1 improves 91% resurrection element formula, it is characterised in that bag The content for including collagen is 55%, the content of medium chain triglyceride is 15%, the content of spirulina is 10%, the content of kaempferia galamga is 2%th, the content of selfheal is 2%, the content of Leaves of Hippophae L is 3%, the content of trehalose is 8%, the content of blueberry powder is 4% and people The content of ginseng is 1%.
4. a kind of adipocyte survival rate according to claim 1 improves 91% resurrection element formula, it is characterised in that the summer Withered grass is nutritious, and the compositions such as protein, fat, carrotene, vitamin B2 and vitamin C are contained in young stem and leaf.
5. a kind of adipocyte survival rate according to claim 1 improves 91% resurrection element formula and preparation method, its It is characterised by, comprises the following steps：
S1：By the three nanoscale collagen peptide elite extraction process in forward position and using three layers of critical high purification technique, reach To the critical form of protein, the elite level collagen of collagen is extracted, is stored after the small level to close to amino acid；
S2：Respectively according to medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng difference Chinese medicine The property of medicine, appearance and shape screen good medicinal material, wet concentration, and dedusting is stand-by；
S3：For the medicine of medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng characteristic with And the performance of associated carrier, different pharmaceutical and the requirement of different formulations, purposes, from suitable carrier and using different Technology path and nanometer preparation method；
S4：Fruit is selected to compact, dryness is full, and epidermis is fine and smooth, comparatively without leaf and stalk epidermis on adhere to uniform bloom Blueberry after, be to be stored after fruit powder is collected by " bloom "；
S5：Nano-collagen, nano traditional Chinese medicine and fruit powder are carried out by weight percentage after being well mixed, tablet is made, seals Storage.
6. a kind of adipocyte survival rate according to claim 5 improves 91% resurrection element formula and preparation method, it is special Sign is, powder, powder is made for medium chain triglyceride, spirulina, kaempferia galamga, selfheal, Leaves of Hippophae L, trehalose and ginseng in S3 End is placed in jet collision type pulverizer, powder size is reached nanometer.
CN201710764322.7A 2017-08-30 2017-08-30 A kind of adipocyte survival rate improves 91% resurrection element formula and preparation method Pending CN107456606A (en)

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CN102284084A (en) * 2011-05-30 2011-12-21 王影 Injectable breast restoration material, and preparation method and application thereof
CN102906250A (en) * 2010-02-23 2013-01-30 赛巴纳医药有限公司 Methods and compositions for enhancing fat graft survival
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CN102906250A (en) * 2010-02-23 2013-01-30 赛巴纳医药有限公司 Methods and compositions for enhancing fat graft survival
CN102284084A (en) * 2011-05-30 2011-12-21 王影 Injectable breast restoration material, and preparation method and application thereof
US20140276384A1 (en) * 2013-03-12 2014-09-18 Allergan, Inc. Adipose tissue combinations, devices, and uses thereof

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Application publication date: 20171212