CN107456567A - Moist heel cream and preparation method thereof is repaired in a kind of anticracking detumescence - Google Patents
Moist heel cream and preparation method thereof is repaired in a kind of anticracking detumescence Download PDFInfo
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- CN107456567A CN107456567A CN201710707401.4A CN201710707401A CN107456567A CN 107456567 A CN107456567 A CN 107456567A CN 201710707401 A CN201710707401 A CN 201710707401A CN 107456567 A CN107456567 A CN 107456567A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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Abstract
The invention provides a kind of detumescence of anticracking to repair moist heel cream and preparation method thereof, contains following material：Snake oil, shea butter, fat soluble vitamin E, olive emulsifying agent, general-purpose self-emulsifying mixed emulsifier AC 402, distilled water, sodium carboxymethylcellulose, sodium alginate, Carbopol 941, angelica extract, Folium Artemisiae Argyi extractive liquid, ginger extract, Flos Carthami extract, honey, glycerine, silicone oil, urea, allantoin, ethylparaben, 75% ethanol solution, essence.Compared with prior art, heel cream character of the present invention is stable, the effect of possessing good anticracking, myogenic, promote foot open wound heals, can effectively maintenance, regeneration, skin care, reparation chapped skin bursting by freezing.Layer protecting film can be formed in skin, isolation low temperature, the environmental stimuli of cold wind, prevent heel water loss, make heel still keep moist in the winter time.
Description
Technical field
The present invention relates to a kind of heel cream, and in particular to moist heel cream and its preparation side are repaired in a kind of anticracking detumescence
Method.
Background technology
Foot chap is a kind of winter relatively conventional skin disease, and Chang Yin is stimulated by mechanicalness or chemical substance,
Such as under the stimulation of cold environment, the reduction of subcutaneous sweat gland secretion, dry skin, skin keratin thicken and follow the string, multilist
It is now heel, foot edge and vola side dry skin, thickens, and depth breach different in size, if be not protected by, pole occurs
Easily there is breach, severe patient can also cause pain, bleeding, influence patient daily activity and work.
After entering the winter, foot fissura patient gradually increases.Old application on human skin is more dried, and cuticula is more easy to thicken, therefore is passed through
Foot chap often occurs.It is exactly to pay attention to daily protection to prevent winter chapped skin best bet.And heel cream can not only be quick
Repair damaged skin, moreover it is possible to persistently nourish moisturizing, prevent skin from chapping again, therefore liked by consumers in general.
Heel cream nutritional ingredient now on the market is few, can only play the effect of moist moisturizing, can not play well
Protect the effect of heel.Therefore, developing a kind of new efficient heel cream can make people be chapped from the cold away from heel the pain brought,
Enjoy the comfortable life of health.
The content of the invention
It is an object of the invention to provide a kind of detumescence of anticracking to repair moist heel cream, is extracted containing a variety of natural components
Thing, heel is played and repairs the effect moistened and prevent chap.
Present invention also offers the preparation method that moist heel cream is repaired in a kind of detumescence of anticracking.
Moist heel cream, the raw material containing following proportioning are repaired in a kind of anticracking detumescence provided by the invention:
Described angelica extract is prepared by the following method：
It is appropriate to weigh Radix Angelicae Sinensis coarse powder, soaks 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 14-18 times measure water, extract
1.5-2.0h；2nd time plus 10-14 times measure water, extract 1.0-1.5h；3rd time plus 8-10 times measure water, extract 0.5-1.0h；Every time
Filter to obtain filtrate, merging filtrate, 3-6 times of g/mL of the volume concentration of filtrate to Radix Angelicae Sinensis weight be standby.
Described Folium Artemisiae Argyi extractive liquid is prepared by the following method：
It is appropriate to weigh folium artemisiae argyi, shreds, soaks 0.3-0.6h, heating and refluxing extraction 3 times with the ethanol of volumetric concentration 75%：1st
It is secondary to add 18-22 times to measure 75% ethanol, extract 2.0-2.5h；2nd time plus 16-18 times measure 75% ethanol, extract 1.5-2.0h；3rd
It is secondary to add 10-14 times to measure 75% ethanol, extract 1.0-1.5h；Filtrate, merging filtrate are filtered to obtain every time, and the volume concentration of filtrate extremely ends
4-8 times of g/mL of leaf weight, it is standby.
Described ginger extract is prepared by the following method：
It is appropriate to weigh shredded ginger, heating and refluxing extraction 3 times：Water is measured with 22-25 times for the first time, extracts 1.5-2.5h；Second
It is secondary to measure water with 18-20 times, extract 1.0-1.5h；Third time measures water with 16-18 times, extracts 1.0-1.5h；Filtrate is filtered to obtain every time,
Merging filtrate, 2-4 times of g/mL of the volume concentration of filtrate to ginger weight are standby.
Described Flos Carthami extract is prepared by the following method：
It is appropriate to weigh safflower, shreds, soaks 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 14-18 times measure water, carry
Take 1.5-2.0h；2nd time plus 12-14 times measure water, extract 1.0-1.5h；3rd time plus 10-12 times measure water, extract 0.5-1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, 3-7 times of g/mL of the volume concentration of filtrate to safflower weight be standby.
Described essence is milk flavour, peach flavor, lily essence, cream jasmin france, osmanthus flower fragrance or flavoring rose essence
In one or more.
The preparation method of moist heel cream is repaired in a kind of anticracking detumescence provided by the invention, is comprised the following steps：
A) sodium carboxymethylcellulose 0.08-1.5g is weighed, is added in 50.0-100.0mL distilled water, 40-50 DEG C of water-bath
Heating, heats while stirring, and standing allows it to be fully swelled, and forms sodium carboxymethylcellulose coagulant liquid, standby；
B) sodium alginate 0.06-2.0g is weighed, is added in 50.0-100.0mL distilled water, 60-80 DEG C of heating water bath,
Heat while stirring, standing allows it to be fully swelled, and forms sodium alginate gel liquid, standby；
C) Carbopol 941 0.05-1.5g is weighed, is added in 50.0-100.0mL distilled water, 60-80 DEG C of heating water bath,
Heat while stirring, standing allows it to be fully swelled, and forms Carbopol 941 coagulant liquid, standby；
D) snake oil 2.0-9.0g, shea butter 1.0-8.0g, olive emulsifying agent 1.0-8.0g, general-purpose self-emulsifying is taken to answer respectively
Mould assembly emulsifying agent AC-402 2.0-8.0g are mixed, and are placed in 60-90 DEG C of water-bath and are heated, treat to melt completely, stand-by as oil phase.
E) 7.0-25.0mL distilled water is measured, is placed in 60-90 DEG C of water-bath, it is stand-by as aqueous phase；
F) angelica extract 0.4-2.0mL, Folium Artemisiae Argyi extractive liquid 0.3-2.2mL, ginger extract 0.3-1.8mL are measured respectively
With Flos Carthami extract 0.4-2.0mL, stir, form solution A, it is stand-by；
G) 1.0-5.0mL distilled water is measured, 0.5-1.2g urea and 1.0-2.5g allantoins are dissolved, forms solution B；
H) ethylparaben 0.5-1.0g is weighed in 75% ethanol solution 1.0-2.0mL, is stirred, and forms solution C,
It is stand-by；
Etc. i) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase in thread shape, it is stirring while adding, until
Form the fine and smooth uniform emulsion bases of milky；
J) solution A, solution B, solution C, sodium carboxymethylcellulose coagulant liquid, sodium alginate are sequentially added into emulsion bases
Coagulant liquid, Carbopol 941 coagulant liquid, glycerine 2.0-7.0mL, silicone oil 0.5-1.0g, fat soluble vitamin E 1.0-4.0g, honey
1.0-3.0g and essence 0.08-0.35mL, stir and produce the moist heel cream of anticracking detumescence reparation.
Various composition in the present invention is as follows：
Snake oil contains unrighted acid, leukotrienes, linoleic acid, there is good permeability, and its quality is fine and smooth, feels during use
Feel refrigerant, comfortable, and have splendid compatibility and complementarity with the physiological growth feature of human skin, have to skin very well
Permeate, moisten, repair, moreover, in the present invention, snake oil also has detumescence, bacteria growing inhibiting, stimulated circulation
The effect of, energy anti-inflammation is evident in efficacy to pernio, chapped skin.
Shea butter is fully natural green plant source solid grease, can promote reepithelialization.Shea butter and human body
The indices of sebum secretion grease are closest, contain abundant non-saponified composition, are extremely easy to absorption of human body, can not only prevent
Season cracking, moreover it is possible to further recover and keep the natural elasticity of skin, there is splendid deep layer to moisten effect, while can also rise
To antiinflammation.
Radix Angelicae Sinensis nature and flavor sweet, acrid, warm.It can not only make skin ruddy glossy, moreover it is possible to nourishes rough skin, pachylosis is prevented,
Myogenic holds back mouth, bacteria growing inhibiting.Although the traditional Chinese medical science think pernio disease on skin, in fact mostly exogeneous cold attack, blood stasis due to accumulation of cold and
Cause.Therefore the present invention is added when warming channel and expelling cold, promoting blood circulation and removing blood stasis, swelling and pain relieving of coming back.
Folium artemisiae argyi contains tannin, flavones, alcohol, polysaccharide, trace element and other organic principles etc., and these compositions can be nourished effectively
Skin.For the wound of chap, folium artemisiae argyi has the effect such as antibacterial, hemostasis and anticoagulation.In addition, in the present invention, folium artemisiae argyi also have antibacterial,
Dispel cold, anti-inflammatory analgetic, pain of releiving, reduce pain and strengthen the function such as resistance.
Ginger acrid flavour, slightly warm in nature.Return lung, spleen, stomach.With relieving exterior syndrome and dispelling cold, removing toxic substances and other effects.It contains zingerone, ginger
Phenol and various trace elements, can effective nourishes rough skin, also with dispelling cold, clearing damp, promoting blood circulation and removing obstruction in channels, a variety of guarantors for the treatment of carbuncle swells boil etc.
Health-care function.Ginger mud and ginger leachate have obvious facilitation to wound healing.In addition, ginger extract has in the present invention
The effect of significantly inhibiting dermatophyte, various carbuncle sore tumefacting virus can be treated.
Safflower can invigorate blood circulation, blood stasis removing analgesic.Safflower can alleviate chap wound pain, healing acceleration, prevent wound infection,
Also there is certain anti-inflammatory and antalgic activity.Mesopodium ulcers of the present invention are carried out on the basis of conventional therapy is carried out plus with safflower
During treatment, therapeutic effect can be significantly improved, the further development of effective reduction of patient foot ulcers, promotes ulcer surface healing.
Honey is rich in various trace elements, energy nourishes rough skin, promotes damaged cell regeneration；The skin damage of moderate can be cured
Wound, is particularly scalded.In addition, honey is added in the present invention the effect to sterilize, can using honey as during skin wound dressing
Bacteria growing inhibiting.Honey has convergence, nutrition to the surface of a wound and promotes Healing, while the good treatment of rhagadia manus et pedis is imitated
Fruit.
Glycerine is water white transparency viscous liquid, has good water imbibition and moisturizing effect, removes to have in the present invention and protect
Outside wet, humectation function, also with the special efficacy such as high activity, anti-oxidant.Winter people are often put on the skin sudden and violent in hand and face etc. with glycerine
Reveal aerial skin surface, skin can be made to keep soft, high resilience, do not damaged and dried by dust, weather etc., risen
To the effect for preventing skin frostbite.
Urea is a kind of useful moisturizing ingredient, belongs to skin NMF NMF main component.The present invention
In, urea has the effect of moisturizing and soft cutin, so can also prevent cuticula from blocking pore.Urea can be maximum
Limit reduces water loss.Simultaneously as it has superpower water lock ability, urea can be done with withdrawing moisture to skin moisturizing
Dry region.In addition, urea can help skin cell renewal and regeneration, therefore skin protection function and health can be strengthened.Instead
Come over, the skin with powerful safeguard function can prevent various potential stimulations.
Allantoin, which has, to be promoted cell growth, accelerates the physiological functions such as wound healing, cutin-softening albumen, main in the present invention
To be used as consolidant and antiulcer agents.Allantoin is added in the present invention, due also to allantoin is a kind of amphoteric compound, can be tied
Close many kinds of substance and form double salt, there is sterilization and anticorrosion, analgesic, antioxidation, skin can be made to keep moisture content, moisten and soft.
Fat soluble vitamin E can promote human metabolism, be a kind of high-efficiency antioxidant agent, can protect body cell from
The murder by poisoning of free radical, playing improves skin blood circulation, strengthens the effect of skin cell vitality and anti-aging, reduces peroxidating
The generation of lipid and scar, the deposition of pigment.Vitamin E has " moist " effect to the collagenous fibres in skin and elastic fibers,
So as to improve and safeguard the elasticity of skin；The blood circulation in skin can be promoted, skin is obtained sufficient nutrition and moisture.
In a word, each mutual compatibility of raw material of the present invention, there is maintenance, regeneration, skin care effect, chapped skin jelly can be repaired
Split, form layer protecting film in skin surface, isolate environmental stimuli, prevent skin water loss, make heel chap skin rapid
Healing, remain in that children is tender moist in the winter time.
Compared with prior art, the heel cream made by the present invention, smell is pure and fresh simple and elegant, and viscosity is suitable, and lotion is fine and smooth
Even, stretchability is good, and stability is good, feels to moisten comfortably after, can effectively reduce the pain at chap, nourishes protection affected part skin
Skin, meanwhile, dry cracked skin can be repaired, isolates environmental stimuli, anti-inflammatory sterilization, and skin healing, regeneration can be promoted.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
Moist heel cream, the raw material components containing following proportionings are repaired in a kind of anticracking detumescence：
The preparation of 1.1 angelica extracts
Radix Angelicae Sinensis coarse powder 50g is weighed, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 14 times amount water, extracts 1.5h；2nd
Secondary plus 10 times of amount water, extract 1.0h；3rd time plus 8 times amount water, extracts 0.5h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration to Radix Angelicae Sinensis weight 3 times of g/mL, it is standby.
The preparation of 1.2 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 50g is weighed, is shredded, 75% ethanol immersion 0.3h, heating and refluxing extraction 3 times：1st time plus 18 times 75% second of amount
Alcohol, extract 2.0h；2nd time plus 16 times 75% ethanol of amount, extracts 1.5h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, 4 times of g/mL of the volume concentration of filtrate to folium artemisiae argyi weight are standby.
The preparation of 1.3 ginger extracts
Weigh shredded ginger 40g, heating and refluxing extraction 3 times：For the first time with 22 times of amount water, 1.5h is extracted；Second with 18 times
Water is measured, extracts 1.0h；16 times of amount water of third time, extract 1.0h；Filter to obtain filtrate every time, merging filtrate, the volume of filtrate is dense
2 times of g/mL of ginger weight are reduced to, it is standby.
The preparation of 1.4 Flos Carthami extracts
Safflower 60g is weighed, is shredded, soaks 0.3h, heating and refluxing extraction 3 times：1st time plus 14 times amount water, extracts 1.5h；The
2 times plus 12 times amount water, extract 1.0h；3rd time plus 10 times amount water, extracts 0.5h；Filter to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to safflower weight 3 times of g/mL, it is standby.
The preparation method of moist heel cream is repaired in the detumescence of 1.5 anticrackings, is comprised the following steps：
A) sodium carboxymethylcellulose 0.08g is weighed, is added in the beaker equipped with 50.0mL distilled water, 40 DEG C of water-baths add
Heat, heat while stirring, standing allows it to be fully swelled, and forms sodium carboxymethylcellulose coagulant liquid, standby；
B) sodium alginate 0.06g is weighed, is added in the beaker equipped with 50.0mL distilled water, 60 DEG C of heating water baths, Bian Jia
Hot side stirring, standing allow it to be fully swelled, and form sodium alginate gel liquid, standby；
C) Carbopol 941 0.05g is weighed, is added in the beaker equipped with 50.0mL distilled water, 60 DEG C of heating water baths, side
Side stirring is heated, standing allows it to be fully swelled, and forms Carbopol 941 coagulant liquid, standby；
D) snake oil 2.0g, shea butter 1.0g, olive emulsifying agent 1.0g, general-purpose self-emulsifying mixed emulsifier are taken respectively
AC-402 2.0g are placed in beaker, and beaker is placed in 60 DEG C of water-baths and heated, and treat to melt completely, stand-by as oil phase.
E) 7.0mL distilled water is measured, is placed in 60 DEG C of water-baths, it is stand-by as aqueous phase；
F) angelica extract 0.4mL, Folium Artemisiae Argyi extractive liquid 0.3mL, ginger extract 0.3mL and Flos Carthami extract are measured respectively
0.4mL, stir, form solution A, it is stand-by；
G) 1.0mL distilled water is measured, for 0.5g urea and 1.0g allantoins to be dissolved, forms solution B；
H) ethylparaben 0.5g is weighed in beaker, is measured 75% ethanol solution 1.0mL additions, is stirred, is formed molten
Liquid C, it is stand-by；
Etc. i) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase in thread shape, it is stirring while adding, until
Form the fine and smooth uniform emulsion bases of milky；
J) solution A, solution B, solution C, sodium carboxymethylcellulose coagulant liquid, sodium alginate are sequentially added into emulsion bases
Coagulant liquid, Carbopol 941 coagulant liquid, glycerine 2.0mL, silicone oil 0.5g, fat soluble vitamin E 1.0g, honey 1.0g and milk are fragrant
Smart 0.08mL, stir and produce the moist heel cream of anticracking detumescence reparation.
Embodiment 2
Moist heel cream, the raw material components containing following proportionings are repaired in a kind of anticracking detumescence：
The preparation of 2.1 angelica extracts
Radix Angelicae Sinensis coarse powder 50g is weighed, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 16 times amount water, extracts 1.5h；2nd
Secondary plus 12 times of amount water, extract 1.0h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration to Radix Angelicae Sinensis weight 5 times of g/mL, it is standby.
The preparation of 2.2 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 30g is weighed, is shredded, 75% ethanol immersion 0.5h, heating and refluxing extraction 3 times：1st time plus 20 times 75% second of amount
Alcohol, extract 2.0h；2nd time plus 18 times 75% ethanol of amount, extracts 2.0h；3rd time plus 12 times 75% ethanol of amount, extracts 1.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, 5 times of g/mL of the volume concentration of filtrate to folium artemisiae argyi weight are standby.
The preparation of 2.3 ginger extracts
Weigh shredded ginger 30g, heating and refluxing extraction 3 times：For the first time with 24 times of amount water, 2.0h is extracted；Second with 18 times
Water is measured, extracts 1.5h；18 times of amount water of third time, extract 1.0h；Filter to obtain filtrate every time, merging filtrate, the volume of filtrate is dense
3 times of g/mL of ginger weight are reduced to, it is standby.
The preparation of 2.4 Flos Carthami extracts
Safflower 40g is weighed, is shredded, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 16 times amount water, extracts 1.5h；The
2 times plus 12 times amount water, extract 1.0h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to safflower weight 6 times of g/mL, it is standby.
The preparation method of moist heel cream is repaired in the detumescence of 2.5 anticrackings：
A) sodium carboxymethylcellulose 1.0g is weighed, is added in the beaker equipped with 80.0mL distilled water, 50 DEG C of heating water baths,
Heat while stirring, standing allows it to be fully swelled, and forms sodium carboxymethylcellulose coagulant liquid, standby；
B) sodium alginate 1.0g is weighed, is added in the beaker equipped with 90.0mL distilled water, 70 DEG C of heating water baths, side heating
Side is stirred, and standing allows it to be fully swelled, and forms sodium alginate gel liquid, standby；
C) Carbopol 941 1.2g is weighed, is added in the beaker equipped with 100.0mL distilled water, 70 DEG C of heating water baths, side
Side stirring is heated, standing allows it to be fully swelled, and forms Carbopol 941 coagulant liquid, standby；
D) snake oil 5.0g, shea butter 4.0g, olive emulsifying agent 4.0g, general-purpose self-emulsifying mixed emulsifier are taken respectively
AC-402 5.0g are placed in beaker, and beaker is placed in 80 DEG C of water-baths and heated, and treat to melt completely, stand-by as oil phase.
E) 18.0mL distilled water is measured, is placed in 80 DEG C of water-baths, it is stand-by as aqueous phase；
F) angelica extract 1.0mL, Folium Artemisiae Argyi extractive liquid 1.2mL, ginger extract 1.5mL and Flos Carthami extract are measured respectively
0.8mL, stir, form solution A, it is stand-by；
G) 2.0mL distilled water is measured, 1.0g urea and 1.5g allantoins are dissolved, forms solution B；
H) ethylparaben 0.8g is weighed in beaker, is measured 75% ethanol solution 1.5mL additions, is stirred, is formed molten
Liquid C, it is stand-by；
Etc. i) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase in thread shape, it is stirring while adding, until
Form the fine and smooth uniform emulsion bases of milky；
J) solution A, solution B, solution C, sodium carboxymethylcellulose coagulant liquid, sodium alginate are sequentially added into emulsion bases
Coagulant liquid, Carbopol 941 coagulant liquid, glycerine 5.0mL, silicone oil 0.8g, fat soluble vitamin E 2.5g, honey 2.0g and rose fragrant
Smart 0.1mL, stir and produce the moist heel cream of anticracking detumescence reparation.
Embodiment 3
Moist heel cream, the raw material components containing following proportionings are repaired in a kind of anticracking detumescence：
The preparation of 3.1 angelica extracts
Radix Angelicae Sinensis coarse powder 50g is weighed, soaks 0.8h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 2.0h；2nd
Secondary plus 14 times of amount water, extract 1.5h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration to Radix Angelicae Sinensis weight 6 times of g/mL, it is standby.
The preparation of 3.2 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 50g is weighed, is shredded, 75% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 22 times 75% second of amount
Alcohol, extract 2.5h；2nd time plus 18 times 75% ethanol of amount, extracts 2.0h；3rd time plus 14 times 75% ethanol of amount, extracts 1.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, 8 times of g/mL of the volume concentration of filtrate to folium artemisiae argyi weight are standby.
The preparation of 3.3 ginger extracts
Weigh shredded ginger 60g, heating and refluxing extraction 3 times：For the first time with 25 times of amount water, 2.5h is extracted；Second with 20 times
Water is measured, extracts 1.5h；18 times of amount water of third time, extract 1.5h；Filter to obtain filtrate every time, merging filtrate, the volume of filtrate is dense
4 times of g/mL of ginger weight are reduced to, it is standby.
The preparation of 3.4 Flos Carthami extracts
Safflower 50g is weighed, is shredded, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 2.0h；The
2 times plus 14 times amount water, extract 1.5h；3rd time plus 12 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to safflower weight 7 times of g/mL, it is standby.
The detumescence of 3.5 anticrackings, the preparation for repairing moist heel cream
A) sodium carboxymethylcellulose 1.5g is weighed, is added in the beaker equipped with 100.0mL distilled water, 50 DEG C of water-baths add
Heat, heat while stirring, standing allows it to be fully swelled, and forms sodium carboxymethylcellulose coagulant liquid, standby；
B) sodium alginate 2.0g is weighed, is added in the beaker equipped with 100.0mL distilled water, 80 DEG C of heating water baths, Bian Jia
Hot side stirring, standing allow it to be fully swelled, and form sodium alginate gel liquid, standby；
C) Carbopol 941 1.5g is weighed, is added in the beaker equipped with 100.0mL distilled water, 80 DEG C of heating water baths, side
Side stirring is heated, standing allows it to be fully swelled, and forms Carbopol 941 coagulant liquid, standby；
D) snake oil 8.0g, shea butter 6.0g, olive emulsifying agent 6.0g, general-purpose self-emulsifying mixed emulsifier are taken respectively
AC-402 8.0g are placed in beaker, and beaker is placed in 90 DEG C of water-baths and heated, and treat to melt completely, stand-by as oil phase.
E) 25.0mL distilled water is measured, is placed in 90 DEG C of water-baths, it is stand-by as aqueous phase；
F) angelica extract 2.0mL, Folium Artemisiae Argyi extractive liquid 2.2mL, ginger extract 1.8mL and Flos Carthami extract are measured respectively
2.0mL, stir, form solution A, it is stand-by；
G) 5.0mL distilled water is measured, 1.2g urea and 2.5g allantoins are dissolved, forms solution B；
H) ethylparaben 1.0g is weighed in beaker, is measured 75% ethanol solution 2.0mL additions, is stirred, is formed molten
Liquid C, it is stand-by；
Etc. i) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase in thread shape, it is stirring while adding, until
Form the fine and smooth uniform emulsion bases of milky；
J) solution A, solution B, solution C, sodium carboxymethylcellulose coagulant liquid, sodium alginate are sequentially added into emulsion bases
Coagulant liquid, Carbopol 941 coagulant liquid, glycerine 7.0mL, silicone oil 1.0g, fat soluble vitamin E 4.0g, honey 3.0g and jasmine are fragrant
Smart 0.15mL, stir and produce anticracking detumescence, repair moist heel cream.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows：
4.1 character
Heel cream made by the present invention is in faint yellow, and viscosity is suitable, and lotion is fine and smooth uniformly, and stretchability is good, feels after
Feel and moisten comfortably, stability is good, and smell is pure and fresh simple and elegant.
4.2pH values check
A small amount of heel cream, pH 6-7 are dipped with the pH test paper of wetting.
4.3 caloric test
Heel cream is packaged in transparent emulsifiable paste bottle bottle, in 4 DEG C of refrigerator cold-storage observations in one week or so without lamination.In
24h in 55 DEG C of insulating box, no layering emulsify phenomena such as spoiled.
4.4 centrifugal test
Heel cream is packaged in 3000r/min in tool plug test tube, centrifuges 20min, no lamination.
4.5 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears the heel cream prepared by embodiment 1,2,3 respectively in cutting plucked position, and do not have
Apply position to be compared, as a result without excitant and allergic reaction.
Heel cream made from Example is applied in volunteer (20-70 year, 50 people) gesture and facial expression in right amount, is seen after spending 30 minutes
Examine, do not occur rubescent, dermexanthesis, foaming phenomena.
4.6 room temperatures place experiment
The made heel cream of embodiment 1,2,3 is placed in emulsifiable paste bottle, investigation 6 months is stored at room temperature, no lamination, uses
After feel unchanged, smell is unchanged.
Embodiment 5
Resultant effect is investigated
The effect of following with trier's effect to evaluate heel cream that embodiment 1,2,3 produces.Using opinion poll
Point system, the people of 300 20-65 year age brackets is chosen as object on probation, 3 groups are divided at random, respectively with embodiment 1,2,3
The heel cream of preparation is applied at a foot chap, and usage time is one week, is applied 3 times within one day, is not applied each and on another foot
Compared at ointment.Every using effect total score is 5 points：5 points are best result, represent fine, very satisfied；4 points are preferable；3
Being divided into receive；Less than 3 points are bad, it is impossible to are received.It is every average below.It the results are shown in Table 1：
The heel cream resultant effect of table 1 is investigated
In summary, the made heel cream of the present invention, goodlooking, viscosity is suitable, and hardness is suitable, and lotion is fine and smooth uniformly,
Stretchability is good, and comfortable after, stability is good, and smell is pure and fresh simple and elegant, has good anticracking, moistens moisturizing, promotes wound healing
The effect of.
Claims (7)
1. moist heel cream is repaired in a kind of anticracking detumescence, it is characterised in that the anticracking detumescence is repaired moist heel cream and contained
There is the raw material of following proportioning:
2. moist heel cream is repaired in anticracking detumescence according to claim 1, it is characterised in that described angelica extract
It is prepared by the following method：
It is appropriate to weigh Radix Angelicae Sinensis coarse powder, soaks 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 14-18 times measure water, extract 1.5-
2.0h；2nd time plus 10-14 times measure water, extract 1.0-1.5h；3rd time plus 8-10 times measure water, extract 0.5-1.0h；Filtration every time
Filtrate, merging filtrate, 3-6 times of g/mL of the volume concentration of filtrate to Radix Angelicae Sinensis weight are standby.
3. moist heel cream is repaired in anticracking detumescence according to claim 1 or 2, it is characterised in that described folium artemisiae argyi carries
Liquid is taken to be prepared by the following method：
It is appropriate to weigh folium artemisiae argyi, shreds, soaks 0.3-0.6h, heating and refluxing extraction 3 times with the ethanol of volumetric concentration 75%：1st time plus
18-22 times is measured 75% ethanol, extracts 2.0-2.5h；2nd time plus 16-18 times measure 75% ethanol, extract 1.5-2.0h；3rd time plus
10-14 times is measured 75% ethanol, extracts 1.0-1.5h；Filtrate, merging filtrate are filtered to obtain every time, and volume concentration to the folium artemisiae argyi of filtrate weighs
4-8 times of g/mL of amount, it is standby.
4. moist heel cream is repaired in the anticracking detumescence according to claim any one of 1-3, it is characterised in that described life
Ginger extract solution is prepared by the following method：
It is appropriate to weigh shredded ginger, heating and refluxing extraction 3 times：Water is measured with 22-25 times for the first time, extracts 1.5-2.5h；Second of use
18-20 times is measured water, extracts 1.0-1.5h；Third time measures water with 16-18 times, extracts 1.0-1.5h；Filtrate is filtered to obtain every time, is merged
Filtrate, 2-4 times of g/mL of the volume concentration of filtrate to ginger weight are standby.
5. moist heel cream is repaired in the anticracking detumescence according to claim any one of 1-4, it is characterised in that described is red
Flower extract solution is prepared by the following method：
It is appropriate to weigh safflower, shreds, soaks 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 14-18 times measure water, extract
1.5-2.0h；2nd time plus 12-14 times measure water, extract 1.0-1.5h；3rd time plus 10-12 times measure water, extract 0.5-1.0h；Every time
Filter to obtain filtrate, merging filtrate, 3-7 times of g/mL of the volume concentration of filtrate to safflower weight be standby.
6. moist heel cream is repaired in the anticracking detumescence according to claim any one of 1-5, it is characterised in that described perfume (or spice)
Essence is the one or more in milk flavour, peach flavor, lily essence, cream jasmin france, osmanthus flower fragrance or flavoring rose essence.
7. the preparation method of moist heel cream is repaired in the anticracking detumescence described in a kind of any one of claim 1-6, its feature exists
In the preparation method comprises the following steps：
A) sodium carboxymethylcellulose 0.08-1.5g is weighed, is added in 50.0-100.0mL distilled water, 40-50 DEG C of heating water bath,
Heat while stirring, standing allows it to be fully swelled, and forms sodium carboxymethylcellulose coagulant liquid, standby；
B) sodium alginate 0.06-2.0g is weighed, is added in 50.0-100.0mL distilled water, 60-80 DEG C of heating water bath, Bian Jia
Hot side stirring, standing allow it to be fully swelled, and form sodium alginate gel liquid, standby；
C) Carbopol 941 0.05-1.5g is weighed, is added in 50.0-100.0mL distilled water, 60-80 DEG C of heating water bath, Bian Jia
Hot side stirring, standing allow it to be fully swelled, and form Carbopol 941 coagulant liquid, standby；
D) take snake oil 2.0-9.0g, shea butter 1.0-8.0g, olive emulsifying agent 1.0-8.0g, general-purpose self-emulsifying compound respectively
Emulsifying agent AC-402 2.0-8.0g are mixed, and are placed in 60-90 DEG C of water-bath and are heated, treat to melt completely, stand-by as oil phase.
E) 7.0-25.0mL distilled water is measured, is placed in 60-90 DEG C of water-bath, it is stand-by as aqueous phase；
F) angelica extract 0.4-2.0mL, Folium Artemisiae Argyi extractive liquid 0.3-2.2mL, ginger extract 0.3-1.8mL and red are measured respectively
Flower extract solution 0.4-2.0mL, stirs, and forms solution A, stand-by；
G) 1.0-5.0mL distilled water is measured, 0.5-1.2g urea and 1.0-2.5g allantoins are dissolved, forms solution B；
H) ethylparaben 0.5-1.0g is weighed in 75% ethanol solution 1.0-2.0mL, is stirred, and is formed solution C, is treated
With；
Etc. i) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase in thread shape, it is stirring while adding, until being formed
The fine and smooth uniform emulsion bases of milky；
J) solution A, solution B, solution C, sodium carboxymethylcellulose coagulant liquid, sodium alginate gel are sequentially added into emulsion bases
Liquid, Carbopol 941 coagulant liquid, glycerine 2.0-7.0mL, silicone oil 0.5-1.0g, fat soluble vitamin E 1.0-4.0g, honey 1.0-
3.0g and essence 0.08-0.35mL, stir and produce the moist heel cream of anticracking detumescence reparation.
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| CN (1) | CN107456567A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374916A (en) * | 2020-03-16 | 2020-07-07 | 中山市天图精细化工有限公司 | Binary capsular bag packaged frost cracking ointment composition aerosol and preparation method thereof |
| CN115671239A (en) * | 2022-11-14 | 2023-02-03 | 皖南医学院 | Anti-inflammatory, detumescence, antibacterial, itching-relieving, anti-cracking and repairing jelly and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374916A (en) * | 2020-03-16 | 2020-07-07 | 中山市天图精细化工有限公司 | Binary capsular bag packaged frost cracking ointment composition aerosol and preparation method thereof |
| CN115671239A (en) * | 2022-11-14 | 2023-02-03 | 皖南医学院 | Anti-inflammatory, detumescence, antibacterial, itching-relieving, anti-cracking and repairing jelly and preparation method thereof |
| CN115671239B (en) * | 2022-11-14 | 2024-04-16 | 皖南医学院 | Anti-inflammatory, detumescence, antibacterial, antipruritic, anticracking and repairing jelly-curing cream and preparation method thereof |
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