CN107445938A - 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 - Google Patents
依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 Download PDFInfo
- Publication number
- CN107445938A CN107445938A CN201610375158.6A CN201610375158A CN107445938A CN 107445938 A CN107445938 A CN 107445938A CN 201610375158 A CN201610375158 A CN 201610375158A CN 107445938 A CN107445938 A CN 107445938A
- Authority
- CN
- China
- Prior art keywords
- ligelusita
- crystal form
- mixed solution
- preparation
- tartrates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
角(2θ°) | d值(埃) | 相对强度I(%) |
5.309 | 16.63236 | 10.2% |
6.165 | 14.32367 | 16.9% |
7.407 | 11.92542 | 30.7% |
10.174 | 8.68779 | 37.7% |
10.644 | 8.30512 | 5.9% |
11.852 | 7.46073 | 5.1% |
12.400 | 7.12360 | 48.6% |
13.566 | 6.52205 | 37.3% |
14.878 | 5.94978 | 48.0% |
15.491 | 5.71556 | 16.7% |
15.898 | 5.57001 | 22.6% |
16.295 | 5.43535 | 21.6% |
16.741 | 5.29138 | 9.2% |
17.112 | 5.17744 | 12.7% |
17.608 | 5.03284 | 18.4% |
17.989 | 4.92721 | 17.3% |
18.379 | 4.82333 | 27.2% |
18.649 | 4.75409 | 17.9% |
18.985 | 4.67074 | 27.5% |
19.456 | 4.55878 | 17.5% |
19.844 | 4.47052 | 18.7% |
20.106 | 4.41278 | 34.4% |
20.442 | 4.34096 | 8.3% |
20.838 | 4.25941 | 28.9% |
22.118 | 4.01568 | 99.5% |
23.634 | 3.76146 | 11.1% |
23.898 | 3.72050 | 20.3% |
24.168 | 3.67961 | 14.2% |
24.405 | 3.64437 | 8.8% |
25.312 | 3.51586 | 10.0% |
25.838 | 3.44535 | 9.0% |
30.363 | 2.94149 | 6.5% |
峰 | 保留时间 | 面积% | 分离度 |
1 | 3.949 | 0.013 | 0.000 |
2 | 8.302 | 0.029 | 19.179 |
3 | 21.789 | 0.068 | 34.983 |
4 | 22.620 | 99.890 | 1.222 |
总计 | 100.000 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610375158.6A CN107445938B (zh) | 2016-05-31 | 2016-05-31 | 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610375158.6A CN107445938B (zh) | 2016-05-31 | 2016-05-31 | 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107445938A true CN107445938A (zh) | 2017-12-08 |
CN107445938B CN107445938B (zh) | 2020-04-03 |
Family
ID=60485864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610375158.6A Active CN107445938B (zh) | 2016-05-31 | 2016-05-31 | 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107445938B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110878079A (zh) * | 2018-12-31 | 2020-03-13 | 北京启慧生物医药有限公司 | 一种高纯度依利格鲁司他的制备方法 |
US10888547B2 (en) | 2009-11-27 | 2021-01-12 | Genzyme Corporation | Amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
WO2023083293A1 (zh) | 2021-11-12 | 2023-05-19 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102712629A (zh) * | 2009-11-27 | 2012-10-03 | 基酶有限公司 | 作为葡糖神经酰胺合酶的抑制剂的无定型和结晶形式的Genz112638半酒石酸盐 |
-
2016
- 2016-05-31 CN CN201610375158.6A patent/CN107445938B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102712629A (zh) * | 2009-11-27 | 2012-10-03 | 基酶有限公司 | 作为葡糖神经酰胺合酶的抑制剂的无定型和结晶形式的Genz112638半酒石酸盐 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10888547B2 (en) | 2009-11-27 | 2021-01-12 | Genzyme Corporation | Amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
US11458119B2 (en) | 2009-11-27 | 2022-10-04 | Genzyme Corporation | Amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
CN110878079A (zh) * | 2018-12-31 | 2020-03-13 | 北京启慧生物医药有限公司 | 一种高纯度依利格鲁司他的制备方法 |
WO2023083293A1 (zh) | 2021-11-12 | 2023-05-19 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
Also Published As
Publication number | Publication date |
---|---|
CN107445938B (zh) | 2020-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104650091B (zh) | 替格瑞洛的微粉化及其晶型,以及制备方法和药物应用 | |
CN105769792A (zh) | 含1-(β-D-吡喃葡糖基)-3-(苯基噻吩基甲基)苯化合物的片剂 | |
KR20120113285A (ko) | 다사티닙 다결정체 및 그의 제조방법과 약물 조성물 | |
CN103936725B (zh) | 卡格列净的c晶型及其结晶制备方法 | |
CN101605767A (zh) | 制备哌嗪基苯甲酰胺衍生物和二氮杂环庚烷基苯甲酰胺衍生物的方法 | |
CN107445938A (zh) | 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物 | |
CN103570621B (zh) | 一种(-)-石杉碱甲的制备 | |
CN104955801B (zh) | 取代的二芳基磺酰胺及其用途 | |
CN105801568B (zh) | 阿法替尼一马来酸盐晶型及其制备方法和药物组合物 | |
CN105985394A (zh) | 一种索非布韦新晶型及其制备方法 | |
CN1443178A (zh) | (r)-n-[5-甲基-8-(4-甲基哌嗪-1-基)-1,2,3,4-四氢-2-萘基]-4-吗啉代苯甲酰胺的新形态 | |
CN102351812B (zh) | 甲磺酸桂哌齐特晶型iii及其制备方法 | |
CN103191051B (zh) | 一种奈拉滨注射液组合物及其制备方法 | |
CN105884680A (zh) | 吡非尼酮衍生物及其制备方法与用途 | |
CN104045598B (zh) | 一种含芳胺结构的硫脲类化合物及其制备方法和应用 | |
CN110167535A (zh) | 包含噁嗪衍生物的药物组合物及其在治疗或预防阿尔茨海默病中的用途 | |
CN105683162A (zh) | N-(4-氯-2-羟基-3((3s)-3-哌啶基磺酰基)苯基)-n’-(3-氟-2-甲基苯基)脲的氢溴酸盐 | |
CN107235973A (zh) | 具有药物活性的哌啶酮链接邻氟苯‑钙配合物的制备方法 | |
CN104086531B (zh) | 一种埃索美拉唑钠化合物及其药物组合物 | |
CN107556294A (zh) | 一种新型抗真菌感染药物及其制备方法和用途 | |
CN110049765B (zh) | 一种组合、其应用及治疗方法 | |
CN102267952B (zh) | 喹唑啉类化合物、其制备方法和用途 | |
CN104710355B (zh) | 一类含尼克酰胺砌块的二苯基硫脲化合物及其盐的制备方法和用途 | |
CN105030776A (zh) | Src蛋白抑制剂在制备预防和/治疗阿尔兹海默病药物中的应用 | |
KR20200099016A (ko) | 모사프리드시트르산염수화물의 제조방법 및 이를 포함하는 약학제제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 102609 Beijing Daxing District biomedical industry base No. 26, Zhongguancun medical instrument garden 16, wing Wan West Road. Applicant after: Beijing Qihui Biomedical Co., Ltd. Address before: 102609 Beijing Daxing District biomedical industry base No. 26, Zhongguancun medical instrument garden 16, wing Wan West Road. Applicant before: Beijing Rev Medical Instrument Co., Ltd. |
|
CB02 | Change of applicant information | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210422 Address after: 102609 No.401, building 16, Zhongguancun medical equipment Park, No.26 Yongwang West Road, Daxing District biological medicine industrial base, Beijing Patentee after: BEIJING KAILAI TIANCHENG MEDICINE TECHNOLOGY Co.,Ltd. Address before: 102609 Beijing City, Daxing District biological medicine industry base AEON Road No. 26 Hospital of Zhongguancun Medical Park Building No. 16 Patentee before: Beijing Qihui Biomedical Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220525 Address after: 102609 Beijing Daxing District biomedical industry base No. 26, Zhongguancun medical instrument garden 16, wing Wan West Road. Patentee after: Beijing Qihui Biomedical Co.,Ltd. Address before: 102609 Room 401, building 16, Zhongguancun medical instrument Park, No. 26, Yongwang West Road, biological medicine industrial base, Daxing District, Beijing Patentee before: BEIJING KAILAI TIANCHENG MEDICINE TECHNOLOGY CO.,LTD. |
|
TR01 | Transfer of patent right |