CN107441546A - A kind of preparation method of silver-containing antibacterial dressing - Google Patents
A kind of preparation method of silver-containing antibacterial dressing Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The invention belongs to medical and health technology field, more particularly to a kind of preparation method of silver-containing antibacterial dressing, comprise the following steps：A, egg white is well mixed with deionized water to obtain egg white solution, and it is 9 12 to adjust pH value, obtains the first mixed liquor；B, in the first mixed liquor obtained into step A, add silver nitrate solution and stir, obtain the second mixed liquor；C, under 90 100 DEG C of water bath conditions, the second mixed liquor is placed in water-bath and reacted, room temperature is cooled to after reaction, and it is 6.8 7.3 to adjust pH value, obtains the 3rd mixed liquor；D, in the 3rd mixed liquor obtained into step C, stirred when adding konjaku glucomannan, after standing 1 2h, be further continued for stirring, finally pour into mould, and 12 18h are freezed, it is placed in freeze drier and dries after freezing, produces high antibacterial, securely and reliably, water imbibition is high, and beneficial to the silver-containing antibacterial dressing of wound healing, it prepares simple and easy.
Description
Technical field
The invention belongs to medical and health technology field, more particularly to a kind of preparation method of silver-containing antibacterial dressing.
Background technology
Skin is the maximum organ of human body, and it is the natural cover for defense between human body and the external world.Skin damage may cause disease
Substance is invaded, and causes the symptom such as wound infection, suppuration, the life of human body is threatened.Therefore, when skin damage, with wound
It is very important that mouth dressing carries out protection to wound.Preferable wound dressing should be nontoxic, nonirritant, biocompatibility
It is good, it furthermore should also have good water imbibition, to absorb the diffusate of wound；Good moisture-retaining capacity, one is provided for wound
The healing environment of moistening；Antibiotic property is also essential, and it can protect wound not by extraneous bacterial infestation.
Konjaku glucomannan is a kind of non-ionic water-soluble plant polysaccharides.It has the ability of combination water closed very much and
Moisture retention.In addition it also has a good film forming, biocompatibility, the property such as nontoxic.There are some researches show konjaku glucomannan
The breeding of fibroblast can be promoted, wound healing can be promoted, be expected to wound dressing of the exploitation for a new generation.
Nano silver particles are a kind of silver-colored simple substance of particle diameter within 100nm, and 20-50nm is relatively common, due to uniqueness
Physics and chemical property, be widely used in the fields such as chemical industry, medical treatment, photoelectric material.Nano silver particles have very outstanding
Antibiotic property, compared with general antibacterial material, it has small bio-toxicity, broad-spectrum antiseptic, come into force the advantages of fast, and will not be right
Bacterium produces drug resistance.However, the aggregation of nano-Ag particles can decline the antibiotic property of Nano Silver.Therefore prepare it is well dispersed,
Bio-toxicity is low, and efficient antibiotic property turns into current emphasis.
The content of the invention
In order to solve the above-mentioned technical problem the present invention provides a kind of high antibacterial, securely and reliably, water imbibition is high, is cured beneficial to wound
The silver-containing antibacterial dressing of conjunction, it prepares simple and easy.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of preparation method of silver-containing antibacterial dressing, including
Following steps：
A, egg white is well mixed with deionized water to obtain egg white solution, and it is 9- to add sodium hydroxide solution regulation pH value
12, obtain the first mixed liquor；
B, in the first mixed liquor obtained into step A, add silver nitrate solution and stir, stand, obtain at room temperature
Second mixed liquor；
C, under 90-100 DEG C of water bath condition, the second mixed liquor is placed in water-bath and reacts 8-25min, is cooled to after reaction
Room temperature, and it is 6.8-7.3 to adjust pH value with hydrochloric acid solution, obtains the 3rd mixed liquor；
D, in the 3rd mixed liquor obtained into step C, stirred when adding konjaku glucomannan, after standing 1-2h, then
Continue to stir 3-5min, finally pour into mould, and 12-18h is freezed under -18 DEG C to -24 DEG C temperature conditionss, be placed in after freezing
Dried in freeze drier, produce silver-containing antibacterial dressing.
The beneficial effects of the invention are as follows：The present invention is raw material using konjaku glucomannan and egg white, and nitre is reduced with egg white
Sour silvery is for nano-Ag particles, and technological process is simple, advantages of nontoxic raw materials, pollution-free, green, and the Nano Silver of preparation has biology
The characteristics of compatibility is high, and antibiotic property is excellent, then be carried on konjaku glucomannan, the silver-containing antibacterial dressing of acquisition has height
Antibacterial, securely and reliably, water imbibition and water-retaining property are excellent, can effectively facilitate wound healing；
In addition, konjaku glucomannan is vegetalitas source, allergy will not be caused to human body, safe, egg white is a kind of
Natural biological macromolecular, rich in multiple proteins, rich in abundant functional group, it can be used for reducing Ag+, Mn2+/Mn3Fe2+/Fe3 +, Cu2+, Zn2+, Ni2+Etc. nano-particle is prepared, with traditional chemical synthesis, egg white prepares Nano Silver and had many advantages, egg
Large biological molecule is used as clearly, the slow motion power of itself can effectively reduce the aggregation of nano silver particles, make nano-Ag particles stabilization
Distribution, and the Nano Silver prepared has lower cytotoxicity, and excellent antibiotic property, egg white source is wide, cheap, and
It is green and preparation process is pollution-free, in addition, egg white also has the effects such as foaming, emulsification, crosslinking, can be used for being crosslinked evil spirit
Taro Glucomannan, lift its mechanical performance.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
As the present invention further preferably, in step, the volume fraction of the egg white solution is 0.4-0.6%, described
The mass fraction of sodium hydroxide solution is 0.5-2.5%.
As the present invention further preferably, in step, the egg white is one kind in egg, pale blue, goose albumen
Or several mixture.
As the present invention further preferably, in stepb, the volume ratio of first mixed liquor and silver nitrate solution is
800：(3-20).
As the present invention further preferably, in stepb, the mass fraction of the silver nitrate solution is 0.5-2%.
As the present invention further preferably, in step C, the mass fraction of the hydrochloric acid solution is 5-15%.
As the present invention further preferably, in step D, the quality of the konjaku glucomannan and the 3rd mixed liquor
Than for 1：(65-70).
As the present invention further preferably, in step D, the konjaku glucomannan particle diameter is 0.125-0.4mm.
As the present invention further preferably, in step D, the drying time control is in 36-48h.
As the present invention further preferably, in step D, the condenser temperature of the freeze drier is -55 DEG C to -45
DEG C, vacuum 0-0.2mbar.
Brief description of the drawings
Fig. 1 is the electron microscope of the silver-containing antibacterial dressing of embodiment 1；
Fig. 2 is the transmission electron microscope picture of Nano Silver prepared by embodiment 1；
Fig. 3 is that the silver-containing antibacterial dressing of embodiment 1 carries out the antibacterial loop graph of anti-microbial property test result；
Fig. 4 is comparing result figure before and after embodiment 1 absorbs water to the silver-containing antibacterial dressing of embodiment 3；
Fig. 5 is animal wound healing situation shape appearance figure.
Embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
A, 0.25mL eggs are well mixed with deionized water to obtain the egg white solution that volume fraction is 0.4%, and added
It is 9 to enter the sodium hydroxide solution regulation pH value that mass fraction is 0.5%, obtains the first mixed liquor；
B, in the first mixed liquor obtained into step A, it is that the stirring of 0.5% silver nitrate solution is equal to add 1mL mass fractions
It is even, stand at room temperature, obtain the second mixed liquor；
C, under 90 DEG C of water bath conditions, the second mixed liquor is placed in water-bath and reacts 8min, room temperature is cooled to after reaction, and
The hydrochloric acid solution for being 5% with mass fraction regulation pH value is 6.8, obtains the 3rd mixed liquor；
D, in the 3rd mixed liquor obtained into step C, side adds the konjaku glucomannan that 0.75g particle diameters are 0.125mm
Side is stirred, and after standing 1h, is further continued for stirring 3min, is finally poured into mould, and freezes 12h under -18 DEG C of temperature conditionss, is freezed
After be placed in freeze drier and dry 36h, the condenser temperature of freeze drier is -55 DEG C, vacuum 0.05mbar, produces and contains
Silver-colored antiseptic dressing.
Embodiment 2
0.2mL pale blues are well mixed to obtain volume fraction with deionized water for 0.5% egg white solution A, and added
The sodium hydroxide solution regulation pH value that mass fraction is 1% is 11, obtains the first mixed liquor；
B, in the first mixed liquor obtained into step A, it is that the stirring of 1% silver nitrate solution is equal to add 0.3mL mass fractions
It is even, stand at room temperature, obtain the second mixed liquor；
C, under 95 DEG C of water bath conditions, the second mixed liquor is placed in water-bath and reacts 15min, room temperature is cooled to after reaction,
And the hydrochloric acid solution regulation pH value for mass fraction being 10% is 7.0, obtains the 3rd mixed liquor；
D, in the 3rd mixed liquor obtained into step C, stirred when adding the konjaku glucomannan that 0.7g particle diameters are 0.2mm
Mix, after standing 1.5h, be further continued for stirring 4min, finally pour into mould, and 16h is freezed under -20 DEG C of temperature conditionss, after freezing
It is placed in freeze drier and dries 40h, the condenser temperature of freeze drier is -50 DEG C, vacuum 0.1mbar, produces argentiferous
Antiseptic dressing.
Embodiment 3
0.3mL goose albumens are well mixed to obtain volume fraction with deionized water for 0.6% egg white solution A, and added
The sodium hydroxide solution regulation pH value that mass fraction is 2.5% is 12, obtains the first mixed liquor；
B, in the first mixed liquor obtained into step A, it is that the stirring of 2% silver nitrate solution is equal to add 0.75mL mass fractions
It is even, stand at room temperature, obtain the second mixed liquor；
C, under 100 DEG C of water bath conditions, the second mixed liquor is placed in water-bath and reacts 25min, room temperature is cooled to after reaction,
And the hydrochloric acid solution regulation pH value for mass fraction being 15% is 7.3, obtains the 3rd mixed liquor；
D, in the 3rd mixed liquor obtained into step C, when adding the konjaku glucomannan that 0.75g particle diameters are 0.4mm
Stirring, after standing 2h, it is further continued for stirring 5min, finally pours into mould, and 18h is freezed under -24 DEG C of temperature conditionss, after freezing
It is placed in freeze drier and dries 48h, the condenser temperature of freeze drier is -45 DEG C, vacuum 0.2mbar, produces argentiferous
Antiseptic dressing.
Experimental example
1st, silver-containing antibacterial dressing micro-analysis
Silver-containing antibacterial dressing is prepared to embodiment 1 under 15KV and carries out metal spraying processing, uses scanning electron microscopic observation embodiment 1
Prepare the configuration of surface of silver-containing antibacterial dressing.As shown in figure 1, silver-containing antibacterial dressing shows loose structure, aperture is on 100 μm of left sides
It is right.This three-dimensional cavernous structure is advantageous to extend after absorbing water the moisture preserving time, the Absorption Growth of cell etc. of dressing, beneficial to wound
The healing of mouth.
2nd, Nano Silver granularmetric analysis
The 3rd mixed liquor for taking example 1 to prepare, partially liq is drawn with liquid-transfering gun, uniformly drops on carbon copper mesh, dries,
Use the size of transmission electron microscope observation nano-Ag particles.As shown in Fig. 2 the diameter of the nano silver particles prepared is in 30nm
Left and right, be advantageous to the antibacterial of dressing.
3rd, antibacterial experiment
Embodiment 1 prepares the circular shaped patches that silver-containing antibacterial dressing is cut into a diameter of 0.6mm, respectively to Escherichia coli and gold
Staphylococcus aureus carry out Bactericidal test.Method of testing：Configuration 108CFU/mL bacterium solution, it is added dropwise 200 microlitres and arrives beef extract egg
On white peptone agar medium, uniformly it is coated with glass bar, the wound dressing of preparation is placed on culture medium, in 37 DEG C of constant temperature
Incubator culture, inhibition zone size is observed after 24 hours.Experimental result as shown in figure 3, prepare sample to Escherichia coli and gold
The caused inhibition zone of staphylococcus aureus, has inhibition zone, shows there is antibiotic property, and inhibition zone is bigger, and antibiotic property is better.This shows
The silver-containing antibacterial dressing being prepared in embodiment 1 has obvious inhibitory action to Escherichia coli and staphylococcus aureus,
Wound infection can effectively be prevented.
4th, water imbibition is tested
Water imbibition test experiments are carried out to silver-containing antibacterial dressing prepared by embodiment 1,2,3 respectively.Experimental method is as follows：Will
Sample is cut into a diameter of 25mm, high 8mm specification, dries 24h in 37 DEG C of baking oven, weighs.In deionized water after drying
In fully water suction 6h after, take out, unnecessary moisture is sucked with filter paper, is weighed, calculate.Test result such as table 1 below：
Table 1：
| Sample | Water imbibition/% |
| Embodiment 1 | 1832 |
| Embodiment 2 | 1865 |
| Embodiment 3 | 1902 |
Test result shows that product of the invention has good water imbibition.Fig. 4 shows the front and rear change of product water suction
Change, gel is formed after product water suction, this form is advantageous to provide the healing environment of moistening for wound, promotes wound healing.
5th, wound healing assay
Embodiment 1 carries out animal wound healing assay.It is blank group to choose without any processing, is made with embodiment 1
Standby silver-containing antibacterial dressing is handled as experimental group, commercially available " U.S. skin patch " (Mepitel silicone for originating in Sweden
Wound contact layer) processing for control group.The identical new zealand white rabbit (20 week old) of 15 upgrowth situations is chosen,
It is randomly divided into 3 groups, respectively blank group, experimental group and control group.After the liquor-saturated rabbit of Animal Anesthesia drug anesthesia, performed the operation at its back
Knife produces a diameter of 20mm circular wound, hypodermis is fully exposed, then according to place group, carries out respectively
Processing.Wherein blank group is without any processing, and the silver-containing antibacterial dressing that experimental group is prepared with embodiment 1 applies wound, control group
Wound is handled with " U.S. skin patch ".After treatment of wounds, it is respectively placed in rabbit-hutch and individually raises, and 5 days after surgery, 10 days, 15 days
White Rabbit wound healing situation is observed afterwards.Healing state as shown in figure 5, compared with untreated wound, hinder by control group and experimental group
Mouth healing rate is substantially accelerated, and experimental group healing rate is better than control group, absorbs wound after silver-containing antibacterial dressing contact wound
Mouth diffusate, forms gel, there is provided the healing environment of a moistening；The nano-Ag particles of carrying can effective antibacterial, prevent
Wound infection.As can be seen here, wound healing can be obviously promoted for exterior trauma, silver-containing antibacterial dressing provided by the invention.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
1. a kind of preparation method of silver-containing antibacterial dressing, it is characterised in that comprise the following steps：
A, egg white is well mixed with deionized water to obtain egg white solution, and it is 9-12 to add sodium hydroxide solution regulation pH value,
Obtain the first mixed liquor；
B, in the first mixed liquor obtained into step A, add silver nitrate solution and stir, stand at room temperature, obtain second
Mixed liquor；
C, under 90-100 DEG C of water bath condition, the second mixed liquor is placed in water-bath and reacts 8-25min, room is cooled to after reaction
Temperature, and it is 6.8-7.3 to adjust pH value with hydrochloric acid solution, obtains the 3rd mixed liquor；
D, in the 3rd mixed liquor obtained into step C, stir when adding konjaku glucomannan, after standing 1-2h, be further continued for
3-5min is stirred, is finally poured into mould, and 12-18h is freezed under -18 DEG C to -24 DEG C temperature conditionss, freezing is placed in after freezing
Dried in drying machine, produce silver-containing antibacterial dressing.
A kind of 2. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step, the egg
The volume fraction of clear solution is 0.4-0.6%, and the mass fraction of the sodium hydroxide solution is 0.5-2.5%.
A kind of 3. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step, the egg
Clear one or more of mixtures in egg, pale blue, goose albumen.
A kind of 4. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in stepb, described
The volume ratio of one mixed liquor and silver nitrate solution is 800：(3-20).
A kind of 5. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in stepb, the nitre
The mass fraction of the silver-colored solution of acid is 0.5-2%.
A kind of 6. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step C, the salt
The mass fraction of acid solution is 5-15%.
A kind of 7. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step D, the evil spirit
The mass ratio of taro Glucomannan and the 3rd mixed liquor is 1：(65-70).
A kind of 8. preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step D, the evil spirit
Taro Glucomannan particle diameter is 0.125-0.4mm.
9. a kind of preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step D, described dry
Dry time control is in 36-48h.
10. a kind of preparation method of silver-containing antibacterial dressing according to claim 1, it is characterised in that in step D, described
The condenser temperature of freeze drier is -55 DEG C to -45 DEG C, vacuum 0-0.2mbar.
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| US20240133045A1 (en) * | 2022-10-21 | 2024-04-25 | King Faisal University | Acid-induced steel corrosion inhibitor based on rotten eggs |
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| CN113068883A (en) * | 2021-04-02 | 2021-07-06 | 陕西科技大学 | Antibacterial mask chip and preparation method thereof |
| CN113068883B (en) * | 2021-04-02 | 2024-02-13 | 陕西科技大学 | Antibacterial mask chip and preparation method |
| CN114870068A (en) * | 2022-06-29 | 2022-08-09 | 西北工业大学 | Antibacterial egg white hydrogel and preparation method and application thereof |
| CN114870068B (en) * | 2022-06-29 | 2023-02-14 | 西北工业大学 | Antibacterial egg white hydrogel and preparation method and application thereof |
| US20240133045A1 (en) * | 2022-10-21 | 2024-04-25 | King Faisal University | Acid-induced steel corrosion inhibitor based on rotten eggs |
| US20240133044A1 (en) * | 2022-10-21 | 2024-04-25 | King Faisal University | Acid-induced steel corrosion inhibitor based on rotten eggs |
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