CN107440818A - A kind of new back room artificial lens based on innovation biocompatibility hydrophobic material - Google Patents
A kind of new back room artificial lens based on innovation biocompatibility hydrophobic material Download PDFInfo
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- CN107440818A CN107440818A CN201610380915.9A CN201610380915A CN107440818A CN 107440818 A CN107440818 A CN 107440818A CN 201610380915 A CN201610380915 A CN 201610380915A CN 107440818 A CN107440818 A CN 107440818A
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- 239000000463 material Substances 0.000 title claims description 60
- 230000002209 hydrophobic effect Effects 0.000 title description 8
- 230000004075 alteration Effects 0.000 claims abstract description 101
- 230000003287 optical effect Effects 0.000 claims abstract description 94
- 210000004087 cornea Anatomy 0.000 claims abstract description 22
- 229920000098 polyolefin Polymers 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 3
- 238000005457 optimization Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 description 85
- 230000007423 decrease Effects 0.000 description 10
- 238000003384 imaging method Methods 0.000 description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 230000004313 glare Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 210000001747 pupil Anatomy 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010036346 Posterior capsule opacification Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004446 light reflex Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
- A61F2/164—Aspheric lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to a kind of aspheric intraocular lens.Specifically, artificial lens includes the opticator with optical surface and the several buttons loop being connected with the opticator.The optical surface of the opticator is aspherical, wherein in the convergence light reflected through cornea under 5 millimeters of effective optical apertures after the incident artificial lens, the spherical aberration that the artificial lens is presented is 0.1-0 μm.
Description
Technical field
The present invention relates to a kind of aspheric intraocular lens, particularly to a kind of weak aspheric intraocular lens.
Background technology
Background description provided herein is used for the background content for generally introducing the present invention.Stated in this section
Content may form or may not form prior art.
Artificial lens（IOL）It is a kind of artificial lens that can be implanted into intraocular, it is used to substitute human eye itself because cataract
Disease and the natural crystal become cloudy, or correct the eyesight of human eye deviation for refractive surgery.
Existing artificial lens majority is fabricated from a flexible material, because it is generally folded or crimped to reduce in operation
After its area intraocular, therefore also known as collapsible crystal are implanted into for example, by the otch of 2-3 millimeters.Artificial lens is in human eye is implanted
Afterwards by supporting the interaction force between button loop and human eye pouch to maintain the relative position in pouch.Collapsible crystal enters pleasing to the eye
Energy Automatic-expanding after interior, thus the material of collapsible crystal is mostly elastomer.Material master currently used for folded iol
It is divided into silica gel, hydrogel, hydrophilic acrylate and hydrophobic acrylic acid's ester, wherein hydrophobic acrylic acid's ester is because of its refractive power
Index is of a relatively high and the preferably but current most popular artificial crystal material of the characteristic opened in performing the operation.
The opticator of artificial lens and the cornea of human eye collectively constitute dioptric system, and in the dioptric system, spherical aberration is
Influence the most important factor of image quality.In general, the cornea of people has positive spherical aberration, and the natural crystal of people has negative ball
Difference, the cornea and natural crystal of usual people have the mutual balanced action of spherical aberration in human eye dioptric system.In most cases
The sphere artificial lens with positive spherical aberration being implanted into after cataract operation in human eye can increase the positive spherical aberration of whole vision systems,
Increased positive spherical aberration can make the image quality decrease on retina, particularly even more so in the case of pupil insufficient light.
Accordingly, it is desired to provide a kind of artificial lens, can weaken after the natural crystal of human eye is replaced because of positive spherical aberration liter
Image quality caused by height declines, and so as to establish new vision systems, improves image quality.
The content of the invention
An object of the present invention is to provide a kind of aspheric intraocular lens, and it can make up the positive ball of cornea initiation
Difference, so as to the contrast of image quality when improving that for example pupil is larger under dark surrounding enviroment.
Another object of the present invention is to provide a kind of weak aspherical artificial lens, it can aid in eyes and obtains more
Good depth of focus, aspheric faceted crystal is placed eccentric and/or inclination to eyeglass higher tolerance tolerance, weakens aspheric faceted crystal
The increase of higher order aberratons is so as to the phenomenon of the too fast decline of whole image quality caused by when placing eccentric and/or inclination.
According to an aspect of the present invention, there is provided a kind of artificial lens, the artificial lens include：
Opticator with optical surface；
The several buttons loop being connected with the opticator；
Wherein, the optical surface of the opticator is aspherical, and wherein in the convergence light reflected through cornea at 5 millimeters
Under effective optical aperture after the incident artificial lens, the spherical aberration that the artificial lens is presented is -0.1-0 μm.
According to another aspect of the present invention, the artificial lens has the clear aperature more than 6.0 millimeters, has in particular
6.5 millimeters of clear aperature.
According to another aspect of the present invention, the artificial lens provides the diopter from 6.0D to 34.0D.
According to another aspect of the present invention, the artificial lens is made using crosslinked polyolefin materials, in particular using light
Learn refractive index to be made with crosslinked polyolefin materials of the Abbe number more than 49.5 more than 1.51, be using light refractive index more specifically
1.515 and Abbe number be made up of 50 crosslinked polyolefin materials.
According to another aspect of the present invention, the optical surface includes preceding optical surface and rear optical surface, wherein preceding light
It is aspherical to learn surface and/or rear optical surface.
According to another aspect of the invention, the optical surface includes preceding optical surface and rear optical surface, wherein preceding light
Surface and rear optical surface are combined as aspherical with certain proportion.
According to another aspect of the invention, the spherical aberration to the optical modeling of the optical surface by optimizing reality
It is existing, wherein the optical modeling includes the selected shape factor, the curvature of centre of optical surface, the center thickness of optical surface, side
Along thickness, focus incident light degree, effective optical aperture, paraxial smooth focus point, distal shaft light focus point, material light refractive index
And dispersive power.
According to another aspect of the invention, the optics edge thickness described in optimization process, focus incident light degree, effectively
Optical aperture, paraxial smooth focus point, distal shaft light focus point, the light refractive index of material and dispersive power are held essentially constant.
According to another aspect of the invention, the form factor is between 0.1-0.75, preferably 0.16-0.38 it
Between.
In accordance with a further aspect of the present invention, the expression formula of the optical modeling of the optical surface is：S(r) =
Wherein：C is the curvature of the optical surface；K is the constant of the cone；A1, A2, A3... are order aspherical coefficients.
In accordance with a further aspect of the present invention, the spherical aberration be -0.05 μm, wherein k between -91.774 to -9.583, A1=
A2=0, A3 are between 5.867E-05 to 8.059E-05.
In accordance with a further aspect of the present invention, the spherical aberration is -0.05 μm, and wherein k=0, A1=0, A2 arrive in 1.225E-04
Between 4.547E-04, A3 is arrived in -5.062E-06 between -1.083E-06.
In accordance with a further aspect of the present invention, the spherical aberration is -0.1 μm, and wherein k is between -115.376 to -10.666, A1
Between 1.865E-04 to 2.220E-04, A3 is arrived in -8.928E-07 between -1.793E-06 by=0, A2.
In accordance with a further aspect of the present invention, the spherical aberration is 0 μm, and wherein k is between -86.841 to -7.413, A1=A2
=A3=0。
In accordance with a further aspect of the present invention, the excursion of the position of the optics secondary principal plane of the artificial lens exists
In 0.054 millimeter.
The further scope of application will become apparent from the description provided herein.It should be understood that this description and particular case
Son is only intended to illustrate purpose, and is not intended to limitation the scope of the present invention.
Brief description of the drawings
The features and advantages of the invention will be from below in conjunction with the accompanying drawings to the preferred embodiment of the present invention and other implementations
Become apparent in the detailed description of mode.In the accompanying drawings, wherein：
Fig. 1 is the schematic diagram of the artificial lens with opticator and several support buttons loop.
Fig. 2 is the composition schematic diagram of the opticator of artificial lens.
Fig. 3 shows that two kinds of different spherical aberration compensations design the influence to depth of focus.
Fig. 4 A show that lens tilt and bias are right in the case of the design of numerous values negative spherical aberration and the design of weak negative spherical aberration respectively
The influence of image quality.
Fig. 4 B are shown respectively in the design of numerous values negative spherical aberration and the design of weak negative spherical aberration under the influence of eyeglass set error
The comparison of MTF slippages.
Fig. 5 A show influence of the light refractive index for MTF.
Fig. 5 B are shown with the eyeglass schematic diagram manufactured by the material of different light refractive indexes.
Fig. 6 A and 6B respectively schematically show axially and also laterally aberration.
Fig. 7 shows influence of the different dispersive power materials for eyeglass aberration.
Fig. 8 shows influence of the different dispersive power materials for white light imaging quality.
Fig. 9 A show influence of the veiling glare for image quality.
Fig. 9 B show the situation of the artificial lens edge reflection veiling glare under different clear aperatures.
Figure 10 shows influence of the set deviation of artificial lens to image quality.
Figure 11 shows influence of the clear aperature for optical transfer function.
Figure 12 schematically shows the relation of spherical aberration and form factor.
Figure 13 shows an example being distributed according to the form factor of the present invention.
Figure 14 shows another example being distributed according to the form factor of the present invention.
Figure 15 shows the another example being distributed according to the form factor of the present invention.
Figure 16 shows the another example being distributed according to the form factor of the present invention.
Figure 17 shows the change of the optics secondary principal plane position according to the present invention.
Embodiment
Following description is substantially only exemplary rather than limitation of the present invention.
Referring to Fig. 1, artificial lens generally includes a circular opticator or optical body 1 and coupled several
Support button loop 2.Although two support buttons loop are illustrate only in figure, it will be recognized to those skilled in the art that the number of button loop 2 can be more than
2, such as 3,4 or more etc..Referring to Fig. 2, opticator 1 has preceding optical surface 3 and rear optical surface 4, and light
The center thickness reference 5 of the department of the Chinese Academy of Sciences point represents, edge thickness reference 6 represents and the table of diameter reference 7
Show.
According to Fig. 2, total diopter of opticator calculates as follows：
=1+2- (t/N_iol)12 （1）
1=(N_iol-N_medium)/R1（2）
2=(N_iol-N_medium)/R2（3）
Wherein：IOL total diopter is represented,The diopter of optical surface before 1 representative,The dioptric of optical surface after 2 representatives
Degree, t represent center thickness, and N_iol is the refractive index of optical material, and N_medium is the liquid environment in human eye（Aqueous humor environment）
Light refractive index, be used as standard figures usually using 1.336, the radius of curvature of optical surface before R1 is represented, light after R2 representatives
Learn the radius of curvature on surface.
As it was previously stated, spherical aberration is to influence the most important factor of image quality.Therefore, in order to obtain preferable visual performance,
Artificial lens makes every effort to recover as much as possible the refractive power and aberration characteristic of natural human eye crystal.Because the cornea of people has positive ball
Difference, the natural crystal of people have negative spherical aberration, so, substitute people it is natural crystal, collectively constitute human eye with the cornea of human eye and bend
The artificial lens of photosystem needs to provide negative spherical aberration, to make up the positive spherical aberration of cornea initiation.
The inventors discovered that in the convergence light reflected through cornea under 5 millimeters of effective optical apertures incident artificial lens
The spherical aberration that artificial lens is presented afterwards can not only be added to the depth of focus of picture when being -0.1-0 μm, and can weaken aspherical
Artificial lens causes whole image quality because of the increase of the higher order aberratons caused by eccentric and/or inclination occurs in placement location
Decline too fast phenomenon.
Generally, cornea has about 42D refraction to light, and it is big that directional light converges in natural crystal rear after cornea reflects
At about 27-29 millimeters, and the spherical aberration of eye cornea substantially distribution, between 0-0.32 μm, average spherical aberration is in 0.21 μ
m.Here, artificial lens of the spherical aberration design between -0.3--0.2 μ ms is referred to as numerous values negative spherical aberration crystal, spherical aberration design
Artificial lens between -0.2--0.1 μm is referred to as average magnitude negative spherical aberration crystal, and spherical aberration design at -0.1-0 μm
Between artificial lens be referred to as small value（It is weak）Negative spherical aberration crystal.Compared to current numerous values and the design of average magnitude negative spherical aberration
Speech（As spherical aberration is less than -0.2 μm）Situation, weak negative spherical aberration artificial lens of the invention can offset cornea after human eye is implanted into
A part of positive spherical aberration, make total spherical aberration of whole eye close to zero but be slightly in positive spherical aberration.This has on whole opthalmic optics are imaged prolongs
Open up the effect of depth of focus.Referring to Fig. 3, the depth of focus effect that people's eye is obtained under different spherical aberration values is shown.Artificial lens A is designed
Negative spherical aberration with numerous values, after eyes are implanted into, the positive spherical aberration of cornea is completely counterbalanced by by it, i.e., the positive ball of 100% compensation cornea
Poor (referring to upper row's image).Artificial lens B designs have small value（It is weak）Negative spherical aberration, after eyes are implanted into, it only offsets cornea
A part of positive spherical aberration, total spherical aberration of whole eye is maintained at 0.1 μm（Referring to lower row's image）.The simulative display of the figure has small
The crystal of value negative spherical aberration（Crystal B）At least better than numerous values negative spherical aberration crystal 0.5D in depth of focus extension（Equivalent to 50 degree
Degree of focus）.
As it was previously stated, the inventors discovered that the crystal phase ratio designed with numerous values negative spherical aberration, is set using small value negative spherical aberration
The crystal of meter, which can make aspheric faceted crystal place inclination and bias to crystal, higher tolerance tolerance.As known in the art
, the objective description of lens optical image quality typically uses optical-modulation transfer function MTF（Modulation Transfer
Function）Quantized value.MTF characterizes transmission of the picture contrast in different space frequency from thing to picture.MTF values are got over
Height, crystal（Eyeglass）Image quality it is better.Referring to Fig. 4 A and 4B, respectively illustrate two kinds of different spherical aberration compensation modes for
The influence of image quality.In figures 4 a and 4b, negative spherical aberration of the crystal A designs with numerous values, after being implanted into eyes, by cornea just
Spherical aberration is completely low to disappear；Crystal B designs have small value negative spherical aberration, after being implanted into eyes, only offset part cornea positive spherical aberration, and make whole
Total spherical aberration of eye is also maintained at 0.1 μm.Fig. 4 A show that two kinds of crystal without set error and are having MTF under set error condition respectively
Decline.In Figure 4 A, crystal A is bold curve system, and crystal B is thin curvilinear system, and solid line represents crystal without inclination and nothing
It is eccentric（Normotopia）Set situation, dotted line represents that crystal in average set error is to tilt 2.6 degree and 0.4 millimeter of set of bias
Situation.Generally, for artificial lens after pouch is implanted into, average tilt angle is 2.6 degree, and average set is eccentric for 0.4 milli
Rice.It can be seen that small value（It is weak）Negative spherical aberration crystal（Crystal B）Tilting 2.6 degree and eccentric 0.4 millimeter set feelings
Under condition, MTF, which has no, to be decreased obviously.On the contrary, numerous values negative spherical aberration crystal（Crystal A）Shown in the case of identical set obvious
MTF decline.As it is further relatively, Fig. 4 B directly illustrate crystal A that the design of numerous values negative spherical aberration is respectively adopted and weak negative
The crystal B of spherical aberration design is in usual set error（Tilt 2.6 degree and 0.4 millimeter of bias）Under the influence of optical transfer function each
The decline of individual spatial frequency., it is apparent that crystal A MTF tools significantly decrease from 4B, and crystal B MTF has no
It is decreased obviously.From here it can be clearly seen that the present invention artificial lens weak negative spherical aberration design to crystal place tilt and
Bias has higher tolerance, so as to which the crystal phase ratio with numerous values negative spherical aberration has significant advantage.
In order to further improve artificial lens（IOL）The superiority and stability of optical property, this hair after human eye is implanted into
It is bright to utilize high index of refraction and low dispersion（The dispersion of material is to describe the ginseng for the different refractivity that material is shown at different wavelengths
Number, it is defined by Abbe number, and wherein high Abbe number corresponds to low dispersion, and low Abbe number corresponds to high dispersion）Bio-compatible
Material, such as the bio-compatible material with the light refractive index more than 1.51 and the Abbe number more than 49.5, such as in patent
Crosslinked polyolefin materials disclosed in document CN200880124361.X.The patent document is incorporated into this by reference of text
In.With the crystal phase ratio using design of material of the low-refraction less than 1.5, the present invention uses the crosslinked polyolefin materials（Folding
Rate is penetrated more than 1.51 and Abbe number is more than 49.5）The crystal of design can have less surface curvature, less so as to present
Primary sphere positive spherical aberration.Referring to Fig. 5 A and 5B, wherein, crystal A represents the conventional silica gel material system that light refractive index is 1.427
The artificial lens made, crystal B represent the artificial lens that the crosslinked polyolefin materials that light refractive index is 1.515 manufacture, shown
In same optical power and form factor（It will be explained below）In the case of material light refractive index for artificial lens spy
The influence of property.Find out from Fig. 5 A, using crosslinked polyolefin materials manufacture artificial lens MTF values it is higher, so as to compared with
Good image quality.From Fig. 5 B and table one as can be seen that with artificial lens B made of high-index material than low-refraction system
Into artificial lens A there is smaller volume（Also smaller area of section）, because opticator center thickness and surface curvature
It is directly proportional.Simultaneously from table one it can also be seen that identical diopter（Focal power）When, if optics edge thickness is identical, height folding
Penetrate crystal made of rate material（The Refractive Index of Material that the present invention uses is 1.515）Center than crystal made of low-refraction is thick
Degree wants thin by 44%, and small volume 39%.Can the volume of crystal determines make crystal volume enough to small to enter people by syringe
Eye, which determine the size of operative incision.One of small incision surgery is advantageous for using the artificial lens of high-index material
Key parameter.
Table one
。
For the optical design of low-index material, there is higher primary positive ball because surface curvature is larger
Difference, thus image quality is less than the design based on high-index material.In addition, for small radius surfaces（High-index material）
Crystal for, by crystal bias and tilt caused higher order aberratons increase phenomenon can be than deep camber surface（Low-refraction
Material）Crystal it is weaker, therefore image quality stability can get well.I.e. the artificial lens of high-index material is designed in optics set
It is better than the artificial lens of low-index material as matter stability and designed under error.In addition with using low Abbe（Such as
Less than 40）Design of material crystal phase ratio, the present invention use the crosslinked polyolefin materials（Abbe number is more than 49.5）Design
Crystal there is less axially and longitudinally aberration.Axial chromatic aberration refers to that the focus point of different wave length is different, referring to Fig. 6 A, spectrum
C lines, d lines, F lines have different focus points；Longitudinal chromatic aberration refers to that the lateral magnification of different wave length is different, referring to Fig. 6 B, light
Spectrum C lines, d lines, F lines have different lateral magnifications, and in Fig. 6 A, 6B, Z-axis represents optical axis, also represents light propagation side
To；Stop represents limitation clear aperature, or limitation pupil.Referring to Fig. 7, the different dispersive power materials under same design are shown
Expect the influence for crystal aberration, wherein crystal A is using artificial lens, crystal made of the high chromatic dispersion material that Abbe number is 37
B is using artificial lens made of the low chromatic dispersion material that Abbe number is 50.It is apparent that the present invention use there is high Abbe number value
（Equal to 50）Crosslinked polyolefin materials be substantially better than in the focus proliferation as caused by aberration and common there is low Abbe number
Value（Here it is 37）Hydrophobic acrylic acid's ester material.It is 21.0D and visible spectrum that table two, which is given in focal power,
The present invention, which uses, in the case of for 486nm-656nm has high Abbe number value（Equal to 50）Crosslinked polyolefin materials design people
Work crystal has low Abbe with commonly used in the art（Here it is 37）Hydrophobic acrylic acid's ester material design people
The comparison of work crystal.As can be seen from Table II, the people that the present invention is designed using the crosslinked polyolefin materials with high Abbe number value
The focus movement ultimate range of work crystal and maximum fuzzy spot diameter, which are far smaller than, commonly used in the art has low Abbe number
The artificial lens of hydrophobic acrylic acid's ester material design of value, spreads so as to greatly reduce the focus caused by aberration, improves
Image quality.
Table two
。
Moreover, for same aspheric design, the artificial crystalline substance designed using the crosslinked polyolefin materials of high Abbe number value
Body can reduce high-order ball aberration, thus overall image quality can be better than the artificial crystalline substance using low Abbe design of material under white light
Body.Referring to Fig. 8, influence of the different dispersive power materials for white light imaging quality under same design is shown.Wherein, crystal A
Being used for the present invention has high Abbe number value（Equal to 50）Crosslinked polyolefin materials design artificial lens, crystal B is ability
Domain it is usually used there is low Abbe（Equal to 37）Hydrophobic acrylic acid's ester material design artificial lens.It is aobvious and easy
See, the present invention, which uses, has high Abbe number value（Equal to 50）Crosslinked polyolefin materials design artificial lens have it is higher
MTF values, namely more preferable image quality so that the weak negative spherical aberration Heterosis of artificial lens of the present invention obtain it is more abundant.
Due to the high elasticity that extends of above-mentioned crosslinked polyolefin materials, the present inventor can design optical body diameter by it
（That is clear aperature）Artificial lens more than 6.0 millimeters such as 6.5 millimeters.It is less than 6.0 millimeters with current optical body diameter
Artificial lens（IOL）Compare, there is the artificial lens of 6.5 millimeters of optical body diameters closer to the natural crystal of people, to crystal light
It is more helpful to learn image quality.On the one hand, it can substantially reduce the probability of the unnecessary edge reflection veiling glare of eyeglass.Such as ability
Field technique personnel understand that veiling glare can directly slacken the contrast of imaging, so as to reduce picture quality（Referring to Fig. 9 A）.This is
Because after artificial lens implantation human eye, gap between pupil and crystal be present, the incident light of wide-angle is likely to reach crystal side
Along so as to causing the reflection of edge veiling glare.This reflected light is referred to as non-imaged light, and such non-imaged light beam is not only not involved in into
Picture, interference effect is played to image quality on the contrary.The non-imaged light can directly reduce picture contrast in hour, and can be when big
One of emergency light reflex arc is formed on retina.Referring to Fig. 9 B, show that the artificial lens edge reflection under different clear aperatures is miscellaneous
The situation of astigmatism.The incident light to same angle is can be seen that from Fig. 9 B, optical body diameter is less than 6 millimeters of artificial lens
There is edge and reflected spuious optical phenomenon, and the artificial lens of a diameter of 6.5 millimeters of optical body does not have any edge reflex.
This illustrates that the crystal of big optical body diameter can reduce the probability that skew ray reaches crystal edge, so as to effectively eliminate or weaken side
Reflected along veiling glare.On the other hand, the artificial lens of big optical body diameter can also improve the eccentric and inclined energy of the resistance to set of eyeglass
Power.As it was previously stated, set deviation of the eyeglass in pouch can cause the decline of lens imaging quality, referring further to Figure 10, wherein
Show without set error（Without inclination and without acceptance of persons）Artificial lens A ratios under state are in average set error（Tilt 2.6 degree with
It is eccentric 0.4 millimeter）Artificial lens B under state has bigger MTF values, and this explanation set deviation causes lens imaging quality
Decline.Figure 11 shows influence of the optic diameter for optical transfer function.In fig. 11, crystal A represents to be in averagely
Optic diameter under set error state is less than 6.0 millimeters of artificial lens, and crystal B represents to be in average set error state
Under optic diameter be 6.5 millimeters of artificial lens.As can be seen from Figure 11 there is the artificial lens of big optic diameter
The eccentric and inclined ability of the resistance to set of eyeglass can be improved.
As it is known in the art, in order to beneficial to artificial lens（IOL）Design, it is necessary to using relying on substantially simplified human eye
The theoretical eye models of construction, such as Liou-Brennan phantom eyes.As it was previously stated, the design object of artificial lens is that it can
Image quality similar to crystal of human eye is provided.Therefore, the design of artificial lens of the present invention is that its negative spherical aberration provided can
Positive spherical aberration that cornea or model eye provide is made up to improve image quality.
Referring back to Fig. 2, the opticator 1 of artificial lens has preceding optical surface 3 and rear optical surface 4.Therefore, this hair
It is bright can be by designing preceding optical surface 3, rear optical surface 4 or the preceding optical surface 3 and rear optical surface 4 of artificial lens
Both have desired aspheric region feature so as to realize the desired imaging effect of artificial lens.
Usually, the aspheric region feature of the optical surface of artificial lens can be represented by a variety of expression formulas.For example, dipole
Aspherical formula (even order aspherical formula), strange level aspherical formula (odd order aspherical
Formula) and Q types richness compares expression formula（Q-type Forbes）Deng.Certainly, it will be readily apparent to those skilled in the art that also existing
For many kinds of expression formulas of the aspheric region feature for representing optical surface.In addition, the selection of aspherical expression formula is for artificial brilliant
The design of body is not crucial, and key is the design object of spherical aberration value, as it was previously stated, the present invention based on extended depth of field and
Improve the consideration of eyeglass omnibearing imaging quality and set -0.1-0 μm of weak spherical aberration.In addition as those skilled in the art institute is bright
In vain, spherical aberration value is with selecting effective optical aperture size and the light convergence for inciding artificial lens to have direct relation.Such as preceding institute
State, -0.1-0 μm of the weak negative spherical aberration that the present invention limits is that artificial lens is effective at 5 millimeters in the convergence light reflected through cornea
The spherical aberration presented under optical aperture after incident artificial lens.What the present invention was so designed that by providing has weak aspherical people
Work crystal, more preferable depth of focus can be obtained, aspheric intraocular lens is placed eccentric and is tilted in the presence of higher tolerance to eyeglass
Tolerance, so as to weaken aspheric intraocular lens because place it is eccentric and/or when tilting caused by higher order aberratons increase.
As it was previously stated, the aspherical shape of the optical surface of artificial lens can be described by various expression formulas.Here, originally
Application characterizes the optical surface of artificial lens with following formula：
Wherein：S (r) represent on curved surface a little when radius is r and interplanar vertical range, C is the curvature on circular arc summit, k
It is the constant of the cone, A1, A2, A3... is even aspheric surface coefficient.
In order to optimize artificial lens（IOL）Surface configuration to obtain foregoing weak negative spherical aberration design object, this hair
It is bright that form factor, the curvature of centre of optical surface, the center thickness of optical surface, edge thickness, incident ray is preferably used
The parameters such as degree of focus, effective optical aperture, paraxial smooth focus point, distal shaft light focus point, the light refractive index of material and dispersive power
Optimize.Certainly, it will be readily apparent to those skilled in the art that can also have other specification.Preferably, optimizing to obtain
During obtaining design object of the present invention, selected parameter such as edge thickness, focus incident light degree, effective optical aperture
Footpath, paraxial smooth focus point, distal shaft light focus point, the light refractive index of material and dispersive power are held essentially constant.
As it was previously stated, total diopter of artificial lensIt is the diopter of preceding optical surface 3 and rear optical surface 41 He2
Summation.It is obvious, for same total diopter, can have different number of1 He2 combination.In order to be carried out to various combinations
Difference, is represented using the parameter X for being referred to as form factor1 HeRelative distribution between 2, it is defined as：X=（R1+
R2）/（R2-R1）, wherein, R1 and R2 are the radius of curvature of preceding optical surface and rear optical surface respectively.According to Weir Buddhist moral
Weford equations（Referring to G.Smith, C-W.Lu, " The Spherical Aberration of Intraocular
Lens ", Opthal. Physiol. Opt 8:287-294,1988）Understand, the spherical aberration of lens and the form factor phase of lens
Close.Referring to Figure 12, it is schematically shown that the primary positive spherical aberrations of IOL of certain material and the relation of form factor.Can be with from Figure 12
Find out, intrinsic positive spherical aberration（I.e. primary positive spherical aberration）It can be controlled relatively small, such as when form factor is selected in 0.21-
When between 2.1, intrinsic positive spherical aberration is less than 0.01 micron.But the form factor more than 1 is generally not used for artificial lens, because
That is substantially concave-convex lens.Preferably, between form factor is limited to 0.1-0.75 by the present invention, it is highly preferred that in 0.16-
Between 0.38.On the one hand the selection of the numerical value of form factor can improve the precision that target negative spherical aberration designs in actual production
（Such as primary positive spherical aberration is reduced to less than 0.01 micron）, on the other hand can also reduce putting after being implanted into due to artificial lens
The too fast phenomenon of aspherical crystal image quality decrease caused by the error of position.
Referring to Figure 13, the first example that the form factor designed according to the present invention is distributed is shown.Can from Figure 13
Go out, form factor of the crystal that the present invention designs when diopter is 10D-30D is between 0.16-0.38.
Referring to Figure 14, the second example that the form factor designed according to the present invention is distributed is shown.Can from Figure 14
Go out, form factor of the crystal that the present invention designs when diopter is 6.0D-34.0D is between 0.1-0.29.
Referring to Figure 15, the 3rd example that the form factor designed according to the present invention is distributed is shown.Can from Figure 15
Go out, form factor of the crystal that the present invention designs when diopter is 6.0D-34.0D is between 0.20-0.36.
Referring to Figure 16, the 4th example that the form factor designed according to the present invention is distributed is shown.Can from Figure 16
Go out, form factor of the crystal that the present invention designs when diopter is 6.0D-34.0D is between 0.30-0.45.
Referring to table three, show that according to the negative spherical aberration of the present invention a kind of Exemplary artificial's crystal when being -0.05 micron is set
Meter（Corresponding to the first example of form factor distribution）, between -91.774 to -9.583, A1=A2=0, A3's wherein parameter k exists
5.867E-05 between 8.059E-05.
Table three
Referring to table four, another Exemplary artificial's crystal when being -0.05 micron is shown according to the negative spherical aberration of the present invention
Design（Corresponding to the 3rd example of form factor distribution）, wherein parameter k=0, A1=0, A2 is in 1.225E-04 to 4.547E-04
Between, A3 is arrived in -5.062E-06 between -1.083E-06.
Table four
Referring to table five, show that according to the negative spherical aberration of the present invention another Exemplary artificial's crystal when being -0.1 micron is set
Meter（Corresponding to the 4th example of form factor distribution）, between -115.376 to -10.666, A1=0, A2's wherein parameter k exists
Between 1.865E-04 to 2.220E-04, A3 is arrived in -8.928E-07 between -1.793E-06.
Referring to table six, another Exemplary artificial's crystal design when being 0 is shown according to the negative spherical aberration of the present invention（It is corresponding
In the second example of form factor distribution）, wherein parameter k is between -86.841 to -7.413, A1=A2=A3=0.
Table six
One skilled in the art will readily appreciate that the aspherical of designed artificial lens can be arranged on preceding optical surface,
Rear optical surface can be arranged on, can be aspherical etc. with preceding optical surface and rear optical surface.
As it was previously stated, between form factor is limited to 0.1-0.75 by the present invention, it is highly preferred that being limited to 0.16-
Between 0.38.Form factor is limited in such narrow range region and objectively also acted to artificial lens by the present invention
Optics secondary principal plane（Optics principal plane after i.e.）Excursion control.Optics secondary principal plane is considered as eyeglass light
" center of gravity " of focal power, represent the active position of crystal.For the aspheric faceted crystal of weak negative spherical aberration, the meter of control crystal focal power
It is precisely to realize the guarantee of negative spherical aberration design to calculate error.For the artificial lens with different optical powers, if effective optics
Position relative constancy, then the error that crystal focal power calculates will be relatively reduced.Generally, effective optical position of crystal is not true
The qualitative linear relationship for having about 1.72 times with the calculation error of focal power.That is, 0.1 millimeter of effective optics position
The error put causes the calculation error of crystal 0.172D focal power.As shown in figure 17, crystal form factor in 0.16-
The change of corresponding optics secondary principal plane position when between 0.38.As can be seen from Figure 17, optics secondary principal plane position from-
0.028mm is changed between 0.026mm, i.e. excursion is in 0.054mm, therefore correspondingly, by effective optical position
The calculation error of focal power caused by uncertainty is controlled in 0.09D.It can thus be seen that the present invention is for optics the
The stability contorting of two principal planes can realize that artificial lens is injected into the calculating accuracy of rear focal power.
Although describing at least one one exemplary embodiment in detailed description above, it should be appreciated that existing a large amount of
Deformation.It is to be further appreciated that an one exemplary embodiment described here or multiple one exemplary embodiments are only example, not
It is intended to the scope, applicability or construction limiting the invention in any way.On the contrary, detailed description above will be art technology
Personnel provide convenient guide to implement an one exemplary embodiment or multiple one exemplary embodiments.It should be understood that without departing from by
The function of element and arrangement can be done in the case of the scope of the invention that appended claims and its legal equivalent illustrate
Go out various change.
Claims (15)
1. a kind of artificial lens, the artificial lens includes：
Opticator with optical surface；
The several buttons loop being connected with the opticator；
Characterized in that, the optical surface of the opticator is aspherical, wherein in the convergence light reflected through cornea in 5 millis
Under meter You Xiao optical apertures after the incident artificial lens, the spherical aberration that the artificial lens is presented is -0.1-0 μm.
2. artificial lens as claimed in claim 1, it is characterised in that the artificial lens has the thang-kng more than 6.0 millimeters
Aperture, in particular with 6.5 millimeters of clear aperature.
3. the artificial lens as any one of preceding claims, it is characterised in that the artificial lens is provided from 6.0D
To 34.0D diopter.
4. the artificial lens as any one of preceding claims, it is characterised in that the artificial lens is poly- using crosslinking
Olefin material is made, and is more than 1.51 and crosslinked polyolefin materials system of the Abbe number more than 49.5 using light refractive index in particular
Into more specifically being made up using light refractive index of 1.515 and Abbe number of 50 crosslinked polyolefin materials.
5. the artificial lens as any one of preceding claims, it is characterised in that the optical surface includes preceding optics
Surface and rear optical surface, wherein preceding optical surface and/or rear optical surface are aspherical.
6. the artificial lens as any one of preceding claims, it is characterised in that the optical surface includes preceding optics
Surface and rear optical surface, wherein preceding optical surface and rear optical surface be combined as with certain proportion it is aspherical.
7. the artificial lens as any one of preceding claims, it is characterised in that the spherical aberration passes through to the optics
The optical modeling on surface optimizes realization, wherein the optical modeling includes the selected shape factor, the middle innermost being of optical surface
Rate, the center thickness of optical surface, edge thickness, focus incident light degree, effective optical aperture, paraxial smooth focus point, distal shaft
Light focus point, the light refractive index of material and dispersive power.
8. the artificial lens as any one of preceding claims, it is characterised in that the optics side described in optimization process
Along thickness, focus incident light degree, effective optical aperture, paraxial smooth focus point, distal shaft light focus point, material light refractive index
It is held essentially constant with dispersive power.
9. the artificial lens as any one of preceding claims, it is characterised in that the form factor is in 0.1-
Between 0.75, preferably between 0.16-0.38.
10. the artificial lens as any one of preceding claims, it is characterised in that the optics of the optical surface is built
The expression formula of mould is：S(r)=
Wherein：C is the curvature of the optical surface；K is the constant of the cone；A1, A2, A3... are order aspherical coefficients.
11. artificial lens as claimed in claim 10, it is characterised in that the spherical aberration is -0.05 μm, and wherein k is -91.774
Between to -9.583, A1=A2=0, A3 is between 5.867E-05 to 8.059E-05.
12. artificial lens as claimed in claim 10, it is characterised in that the spherical aberration is -0.05 μm, wherein k=0, A1=0,
Between 1.225E-04 to 4.547E-04, A3 is arrived between -1.083E-06 A2 in -5.062E-06.
13. artificial lens as claimed in claim 10, it is characterised in that the spherical aberration is -0.1 μm, and wherein k is -115.376
Between to-10.666, A1=0, A2 between 1.865E-04 to 2.220E-04, A3-8.928E-07 to-1.793E-06 it
Between.
14. artificial lens as claimed in claim 10, it is characterised in that the spherical aberration is 0 μm, and wherein k is -86.841
Between to -7.413, A1=A2=A3=0.
15. the artificial lens as any one of preceding claims, it is characterised in that the optics second of the artificial lens
The excursion of the position of principal plane is in 0.054 millimeter.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610380915.9A CN107440818A (en) | 2016-06-01 | 2016-06-01 | A kind of new back room artificial lens based on innovation biocompatibility hydrophobic material |
| PCT/CN2017/085890 WO2017206789A1 (en) | 2016-06-01 | 2017-05-25 | Innovative biocompatible hydrophobic material-based new posterior chamber artificial lens |
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| CN201610380915.9A CN107440818A (en) | 2016-06-01 | 2016-06-01 | A kind of new back room artificial lens based on innovation biocompatibility hydrophobic material |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111658232A (en) * | 2020-06-24 | 2020-09-15 | 西安眼得乐医疗科技有限公司 | Clinical decentration and tilt resistant intraocular lens |
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| CN104849782B (en) * | 2015-06-01 | 2016-05-18 | 南开大学 | Based on the large depth of focus artificial lens of human eye residual accommodation power |
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| US20040156014A1 (en) * | 2002-11-29 | 2004-08-12 | Piers Patricia Ann | Multifocal ophthalmic lens |
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| US20090125105A1 (en) * | 2006-05-05 | 2009-05-14 | Cedric Lesage | Aspheric intraocular lens and method for making the same |
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Address after: 710304 building 3, science and technology enterprise accelerator Park, west 2, Qinling Avenue, Caotang science and technology industrial base, high tech Zone, Xi'an City, Shaanxi Province Applicant after: Xi'an yandele Medical Technology Co.,Ltd. Address before: 710304 building 3, science and technology enterprise accelerator Park, west 2, Qinling Avenue, Caotang science and technology industrial base, high tech Zone, Xi'an City, Shaanxi Province Applicant before: XI'AN PILLAR BIOSCIENCE Co.,Ltd. |
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