CN107412842A - A kind of preparation method of the alginate Wound dressing with fibrin ferment - Google Patents

A kind of preparation method of the alginate Wound dressing with fibrin ferment Download PDF

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Publication number
CN107412842A
CN107412842A CN201710294066.XA CN201710294066A CN107412842A CN 107412842 A CN107412842 A CN 107412842A CN 201710294066 A CN201710294066 A CN 201710294066A CN 107412842 A CN107412842 A CN 107412842A
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Prior art keywords
fibrin ferment
alginate
wound dressing
preparation
wound
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CN201710294066.XA
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Chinese (zh)
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CN107412842B (en
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卢亢
陈***
徐海涛
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Guangdong Taibao Medical Science Technology Co Ltd
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Guangdong Taibao Medical Science Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/50—Lubricants; Anti-adhesive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to medical care, and in particular to a kind of preparation method of the alginate Wound dressing with fibrin ferment, concretely comprises the following steps：Configure the ethanol water of fibrin ferment, then alginate fibre bundle is put into constant temperature in the reactive tank of the ethanol water containing fibrin ferment soak, after immersion through drying, cut alginate chopped fiber be made, and chopped fiber is crimped, non-woven fabrics is made without spinning process through shredding, combing, lapping, acupuncture etc. again, and cut into the deposited core for needing size, deposited core and silicone gel film with holes, thin polyurethane membrane adhesive tape, adherent layer is compound through applicator, last packaged, sterilizing, you can the alginate Wound dressing finished product with fibrin ferment is made.Composite plaster obtained by the present invention, the activity of fibrin ferment can be kept to greatest extent, there is outstanding hemostasis and absorbent, while can prevent application and the adhesion of wound, the healing environment of moistening is provided for the surface of a wound, promote wound healing.

Description

A kind of preparation method of the alginate Wound dressing with fibrin ferment
Technical field
The present invention relates to medical care, and in particular to a kind of preparation side of the alginate Wound dressing with fibrin ferment Method.
Background technology
Skin is the maximum organ of human body, and the first line of defence that human body is set with external environment, and it is to protecting body The stabilization of interior environment, the stimulation and pathogen invasion for resisting external environment play an important role.
In medical care, researcher increasingly pay attention to how more preferable nursing skin, the practicality of product, Yi Jibian Profit is with regard to particularly important.Wound dressing has good protective effect to wound, is protected from the secondary pollution in the external world, alleviates The risk of patient's infection, many convenience are also brought to people.
But deposited cores of most of application products or relatively simple, this composite only plays absorption wound for wound The effect of sepage, the effect of wound moisturizing can not be played, stop blooding and deposit.
With the development of functional dressing, Wound dressing is constantly improving, and the simple function of product can not meet to face How the demand of bed hospitalized patients, for hemorrhagic wound, more effectively stop blooding, and is effectively promoted the healing of wound, promotees Enter the growth of wound granulation, still occur without a more effectively product.
Therefore, how to overcome disadvantage mentioned above, there is provided it is a kind of can effectively stop blooding, healing effect significantly, mitigate patient suffering Wound dressing, it is a necessary and meaningful thing.
The content of the invention
It is an object of the invention to overcome above-mentioned deficiency of the prior art, there is provided a kind of alginate wound with fibrin ferment The preparation method of mouth application.To achieve the above object, technical scheme provided by the invention is：
A kind of preparation method of the alginate Wound dressing with fibrin ferment, specifically includes following steps：
S1. the ethanol water of fibrin ferment is configured, ethanol is with water volume ratio（2~3）﹕ 1, thrombin amount are 50~100 single Position/ml；
S2., alginate fibre bundle is put into constant temperature in the reactive tank of the ethanol water containing fibrin ferment and soaks 0.5~1h, temperature Spend for 30~35 DEG C, reactive tank sets " S " type passage；
S3. after soaking, fibre bundle is pulled out into reactive tank, through oven drying, drying temperature is 35~37 DEG C, drying time For 1~2h；
S4. after drying, cut technique, the alginate chopped fiber with fibrin ferment that length is 38~65mm is made, and will Chopped fiber crimps, and crispation number is no less than 3/cm；
S5. chopped fiber is made into non-woven fabrics through shredding, combing, lapping, acupuncture etc. without spinning process；
S6., the cut machine of non-woven fabrics cut into the deposited core of needs；
S7. it is deposited core and silicone gel film with holes, thin polyurethane membrane adhesive tape, adherent layer is compound through applicator；
S8. packaged, sterilizing, that is, obtain the alginate Wound dressing finished product with fibrin ferment.
Further, described fibrin ferment is human body blood coagulation enzyme, thrombin of beef or restructuring fibrin ferment.
Further, the alginate non-woven fabrics punch frequency with fibrin ferment is 250~500 pins/min.
Further, the alginate non-woven fabrics grammes per square metre with fibrin ferment is 120~150g/m2。
Further, described silicone gel film with holes, aperture are 0.5~1mm, and peel strength is 1~3N/cm.
Further, described medical polyurethane film adhesive tape upper surface is coated with pressure sensitive adhesive.
Further, described pressure sensitive adhesive is acrylate pressure sensitive adhesive, polyurethane contact adhesive and medical Medical PSA In any one.
Further, described silicone gel film with holes and medical polyurethane film adhesive tape homalographic, and silicon with holes Sandwich layer and medical polyurethane film tape-stripping are applied in the covering of ketone gel film, make it is packed by deposited core parcel wherein.
Further, described adherent layer is Ge Laxin silicone oil papers, has the advantages of easily peelable；The adherent layer is two Page, mutual covering is extended up to from application both ends toward centre respectively, and be adhesively fixed with application outer rim.
Further, described sterilization method is the irradiation sterilization of cobalt -60, and irradiation dose is 25kGy~50kGy, irradiation Time is 2h~3h.
Compared with prior art, the invention has the advantages that:
(1）The present invention loads fibrin ferment by " S " type passage infusion method on alginate fiber, and " S " type passage increases fibre Dimension and the contact area of fibrin ferment, while ensure constant reaction temperature, it can ensure that fibrin ferment is attached to fiber to greatest extent On uniformity, solve the problems, such as that protein is difficult to fix on dressing base material.
(2）After alginate contact wound fluid, calcium ion is discharged, with fibrin ferment double action, is strengthened to wound Haemostatic effect.
(3）Silicone gel film with holes and deposited core are compound, and alginate fiber chip can be avoided to be lost on wound, rise To the effect of preventing adhesion, secondary injury will not be caused when opening application to wound, and it is inert hydrophobic material, can be reduced to skin Sensitization rate.
(4）Polyurethane film waterproof and breathable, transparent shape is convenient to observe wound situation, while provides moistening for the surface of a wound Closed environment, promote wound healing.
Specific embodiment
The present invention is described in further details below in conjunction with specific embodiment.
Embodiment 1：
A kind of preparation method of the alginate Wound dressing with fibrin ferment, its preparation process are as follows：
（1）The ethanol water of fibrin ferment is configured, ethanol is 2 with water volume ratio:1, thrombin amount is 50 units/ml；
（2）Alginate fibre bundle is put into constant temperature in the reactive tank of the ethanol water containing fibrin ferment to soak, reactive tank is set " S " type passage, soak time 0.5h, temperature are 30 DEG C；
（3）After immersion, fibre bundle is pulled out into reactive tank, through oven drying, drying temperature is 35 DEG C, drying time 1h；
（4）After drying, cut technique is made the alginate chopped fiber with fibrin ferment of certain length, and by chopped fiber Curling, it is 38mm to cut staple length, and crispation number is 3/cm；
（5）Chopped fiber is made into non-woven fabrics through shredding, combing, lapping, acupuncture etc. without spinning process, punch frequency is 250 pins/min, Non-woven fabrics grammes per square metre is 120g/m2；
（6）The cut machine of non-woven fabrics cut into the deposited core of needs；
（7）Deposited core and silicone gel film with holes, thin polyurethane membrane adhesive tape, adherent layer is compound through applicator, and silicone with holes coagulates Glue membrane pore size is 0.5mm, peel strength 1N/cm；
（8）Packaged, sterilizing, that is, obtain the alginate Wound dressing finished product with fibrin ferment, irradiation dose 28kGy, irradiation Time is 2h.
Embodiment 2：
A kind of preparation method of the alginate Wound dressing with fibrin ferment, its preparation process are as follows：
（1）The ethanol water of fibrin ferment is configured, ethanol is 3 with water volume ratio:1, thrombin amount is 100 units/ml；
（2）Alginate fibre bundle is put into constant temperature in the reactive tank of the ethanol water containing fibrin ferment to soak, reactive tank is set " S " type passage, soak time 1h, temperature are 35 DEG C；
（3）After immersion, fibre bundle is pulled out into reactive tank, through oven drying, drying temperature is 37 DEG C, drying time 2h；
（4）After drying, cut technique is made the alginate chopped fiber with fibrin ferment of certain length, and by chopped fiber Curling, it is 60mm to cut staple length, and crispation number is 4/cm；
（5）Chopped fiber is made into non-woven fabrics through shredding, combing, lapping, acupuncture etc. without spinning process, punch frequency is 300 pins/min, Non-woven fabrics grammes per square metre is 140g/m2；
（6）The cut machine of non-woven fabrics cut into the deposited core of needs；
（7）Deposited core and silicone gel film with holes, thin polyurethane membrane adhesive tape, adherent layer is compound through applicator, and silicone with holes coagulates Glue membrane pore size is 0.8mm, peel strength 2N/cm；
（8）Packaged, sterilizing, that is, obtain the alginate Wound dressing finished product with fibrin ferment, irradiation dose 38kGy, irradiation Time is 3h.
Embodiment 3：Anthemorrhagic performance is tested
Test group：Product made from embodiment 2 is chosen as test group；
Control group：Gauze hemostasia products are control group on the market.
Testing procedure is as follows：
（1）According to 1ml/kg, 3% yellow Jackets are slowly injected into rabbit auricular vein, are anaesthetized, then in the left abdomen of rabbit Sidepiece spreads wound towel, with the tincture of iodine, 75% alcohol disinfecting operative site.
（2）Along left side inner edge, about 1cm does 5.0cm longitudinal cuts on the left of ventrimeson, cuts abdominal muscle to peritoneal layer, cuts off abdomen Film.
（3）With 2 fingers or tweezers, the spleen of rabbit is found out, and keeps spleen to moisten with physiological saline.
（4）Blank control group：In the visceral surface of spleen, long 1cm is scratched along spleen major axis with knife blade, two of deep 1mm Symmetry wound, surface of a wound bleeding enliven.Surface of a wound bleeding is observed, and records the time that rabbit is stopped blooding automatically.
（5）Control group：In the visceral surface of spleen, long 1cm, deep 1mm wound, the surface of a wound are scratched along spleen major axis with knife blade Bleeding enlivens.Common gauze hemostasis is coated with after 10 seconds, finger is gently pressed 1 minute, using non-activity bleeding as degree.After 1 minute, observation wound Face bleeding, if not bleeding again in 2 minutes, that is, think to stop blooding successfully, surface of a wound blood clot and gauze are otherwise removed, is applied again Medicine, and finger is gently pressed 1 minute, so repeatedly, until successfully stopping blooding.Bleeding stopping period is recorded, and observes agent for stanching and the surface of a wound Bonding situation.
（6）Test group：In the visceral surface of spleen, long 1cm, deep 1mm wound, the surface of a wound are scratched along spleen major axis with knife blade Bleeding enlivens.The alginates Wound dressing hemostasis with fibrin ferment is coated with after 10 seconds, finger gently presses 1 minute, using non-activity bleeding as Degree observes surface of a wound bleeding after 1 minute, if not bleeding again in 2 minutes, that is, think to stop blooding successfully, otherwise removes surface of a wound blood clotting Block and the alginates Wound dressing with fibrin ferment, the again topical application of drug, and finger are gently pressed 1 minute, so repeatedly, until successfully stopping blooding. Bleeding stopping period is recorded, and observes the bonding situation of agent for stanching and the surface of a wound.
Result of the test is as shown in table 1：
Table 1：Anthemorrhagic performance result of the test
Packet Sex Without material or gauze bleeding stopping periods（min） Material bleeding stopping period（min） Gauze bleeding stopping period（min）
Blank group It is female 30 — —
It is male 33 — —
Control group It is female — — 17
It is male — — 16
Test group It is female — 9 —
It is male — 10 —
As can be seen from the test results, product of the present invention has outstanding fast short stopping compared with the hemostatic gauze on existing market Courageous and upright energy.
It should be noted that the description of above embodiment is only intended to clearly illustrate example of the present invention, It is not the restriction to embodiments of the present invention.It is any modification for being made within the spirit and principles of the invention, equivalent Replace and improve etc., it should be included within the protection domain of the claims in the present invention.

Claims (10)

  1. A kind of 1. preparation method of the alginate Wound dressing with fibrin ferment, it is characterised in that the preparation method include with Lower specific steps：
    S1. the ethanol water of fibrin ferment is configured, ethanol is with water volume ratio（2~3）﹕ 1, thrombin amount are 50~100 single Position/ml；
    S2., alginate fibre bundle is put into constant temperature in the reactive tank of the ethanol water containing fibrin ferment and soaks 0.5~1h, temperature Spend for 30~35 DEG C, reactive tank sets " S " type passage；
    S3. after soaking, fibre bundle is pulled out into reactive tank, through oven drying, drying temperature is 35~37 DEG C, drying time For 1~2h；
    S4. after drying, cut technique, the alginate chopped fiber with fibrin ferment that length is 38~65mm is made, and will Chopped fiber crimps, and crispation number is no less than 3/cm；
    S5. chopped fiber is made into non-woven fabrics through shredding, combing, lapping, acupuncture etc. without spinning process；
    S6., the cut machine of non-woven fabrics cut into the deposited core of needs；
    S7. it is deposited core and silicone gel film with holes, thin polyurethane membrane adhesive tape, adherent layer is compound through applicator；S8. through bag Dress, sterilizing, that is, obtain the alginate Wound dressing finished product with fibrin ferment.
  2. A kind of 2. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that Described fibrin ferment is human body blood coagulation enzyme, thrombin of beef or restructuring fibrin ferment.
  3. A kind of 3. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that The described alginate non-woven fabrics punch frequency with fibrin ferment is 250~500 pins/min.
  4. A kind of 4. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that The described alginate non-woven fabrics grammes per square metre with fibrin ferment is 120~150g/m2。
  5. A kind of 5. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that Described silicone gel film with holes, aperture are 0.5~1mm, and peel strength is 1~3N/cm.
  6. A kind of 6. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that Described medical polyurethane film adhesive tape upper surface is coated with pressure sensitive adhesive.
  7. A kind of 7. preparation method of alginate Wound dressing with fibrin ferment according to claim 6, it is characterised in that Described pressure sensitive adhesive is any one in acrylate pressure sensitive adhesive, polyurethane contact adhesive and medical Medical PSA.
  8. A kind of 8. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that Described silicone gel film with holes and medical polyurethane film adhesive tape homalographic, and sandwich layer is applied in silicone gel film with holes covering With medical polyurethane film tape-stripping, make it is packed by deposited core parcel wherein.
  9. A kind of 9. preparation method of alginate Wound dressing with fibrin ferment according to claim 1, it is characterised in that Described adherent layer is Ge Laxin silicone oil papers, and the adherent layer is page two, is extended up to mutually toward centre from application both ends respectively Covering, and be adhesively fixed with application outer rim.
  10. 10. a kind of preparation method of alginate Wound dressing with fibrin ferment according to claim 1, its feature exist In described sterilization method is the irradiation sterilization of cobalt -60, and irradiation dose is 25kGy~50kGy, and exposure time is 2h~3h.
CN201710294066.XA 2017-04-28 2017-04-28 Preparation method of alginate wound dressing with thrombin Expired - Fee Related CN107412842B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210976A (en) * 2018-02-05 2018-06-29 广东泰宝医疗器械技术研究院有限公司 A kind of preparation method of antibacterial silicone composite foam application
CN108379644A (en) * 2018-03-03 2018-08-10 青岛大学 A kind of preparation method for the efficient hemostatic material being suitable for open drowned wound
CN115161873A (en) * 2022-07-26 2022-10-11 深圳市鑫鸿佳科技有限公司 Degradable seaweed non-woven fabric

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051340A1 (en) * 2003-01-20 2006-03-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Hemostatic materials
CN103131037A (en) * 2013-01-28 2013-06-05 北京化工大学常州先进材料研究院 Preparation of natural polymer base hemostasis dressing
CN203885716U (en) * 2014-05-27 2014-10-22 江西3L医用制品集团股份有限公司 Self-adhesive alginate applying patch
CN104338173A (en) * 2013-08-06 2015-02-11 许春晖 Preparation method and application of quick absorption saturation gelation seaweed hemostatic dressing
CN104721878A (en) * 2015-04-07 2015-06-24 广州市电纺生物科技有限公司 Preparation method of hemostatic material

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051340A1 (en) * 2003-01-20 2006-03-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Hemostatic materials
CN103131037A (en) * 2013-01-28 2013-06-05 北京化工大学常州先进材料研究院 Preparation of natural polymer base hemostasis dressing
CN104338173A (en) * 2013-08-06 2015-02-11 许春晖 Preparation method and application of quick absorption saturation gelation seaweed hemostatic dressing
CN203885716U (en) * 2014-05-27 2014-10-22 江西3L医用制品集团股份有限公司 Self-adhesive alginate applying patch
CN104721878A (en) * 2015-04-07 2015-06-24 广州市电纺生物科技有限公司 Preparation method of hemostatic material

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210976A (en) * 2018-02-05 2018-06-29 广东泰宝医疗器械技术研究院有限公司 A kind of preparation method of antibacterial silicone composite foam application
CN108379644A (en) * 2018-03-03 2018-08-10 青岛大学 A kind of preparation method for the efficient hemostatic material being suitable for open drowned wound
CN115161873A (en) * 2022-07-26 2022-10-11 深圳市鑫鸿佳科技有限公司 Degradable seaweed non-woven fabric

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