CN107410495B - A kind of compound preparation of acidity lactase and zinc and preparation method thereof - Google Patents
A kind of compound preparation of acidity lactase and zinc and preparation method thereof Download PDFInfo
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- CN107410495B CN107410495B CN201710736813.0A CN201710736813A CN107410495B CN 107410495 B CN107410495 B CN 107410495B CN 201710736813 A CN201710736813 A CN 201710736813A CN 107410495 B CN107410495 B CN 107410495B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
Abstract
The present invention discloses the compound preparation of a kind of acid lactase and zinc, including acid lactase raw material powder, zinc gluconate, whole milk powder, PURE WHEY, maltodextrin, docosahexaenoic acid, arachidonic acid, nucleotide, transferrins, shuttle peptide and choline, the preparation method of the compound preparation of the acidity lactase and zinc is also disclosed, for infant's lactose intolerance caused by taking breast milk or formula milk, the compound preparation of oral acidity lactase and zinc can not only improve infant's lactose intolerance, and the diarrhea course of disease can also be shortened well, improve symptom of diarrhea.
Description
Technical field
The present invention relates to medical health fields, and in particular to compound preparation and its preparation side of a kind of acidity lactase and zinc
Method.
Background technology
The background of related of the present invention is illustrated below, but these explanations might not form the existing of the present invention
Technology.
Lactose intolerance is since lactase secretion is few, it is impossible to caused by the lactose completely in digestion decomposition breast milk or cow's milk
Noninfectious diarrhea, also known as lactase deficiency；Alactasia is the worldwide problem being widely present, and Far East crowd occurs
Rate is high, and symptom does not occur in majority of populations, but diarrhea etc. often occurs in using milk as the newborn and infant of major dietary
Symptom.
Carbohydrate in breast milk and cow's milk is mainly lactose, the top lactase of small intestine especially Jejunal mucosa surface villus
Secretory volume is reduced or activity is not high cannot digest and decompose lactose in milk completely, and portion of Lactose is by colonic microflora glycolysis into breast
Acid, hydrogen, methane and carbon dioxide；Lactic acid stimulates intestinal wall, increases enterocinesia and diarrhea occurs；Carbon dioxide generates in enteron aisle
Flatulence and increase enterocinesia, show children uneasy, are also possible to induction enterospasm once in a while and intestinal colic occur；The increase of lactic acid is also held
Easily leading to the pH value of excrement reduces.
And lactose-free formula milk mainly is fed to the solution of lactose intolerance at present, but due to lactose in vivo
The galactolipin being decomposed to form is the important nutrient of infant's brain development, therefore this method and is not suitable for long-term use, and
And long-term use of lactose-free formula milk can cause galactolipin insufficiency of intake, and brain development is caused to be affected；And children are in abdomen
Zinc preparation should be supplemented during rushing down can effectively shorten the course of disease and reduce sick hair rate, therefore is also required to during lactose intolerance diarrhea
Supplement zinc preparation.
And iron ion plays an important roll in the development, metabolism and functional activity of brain, and it is many important to participate in intracerebral
Physiology production process, is DNA replication dna, the necessary substance of cell cycle, as a co-factor to the function of normal cell and
Regulation and control play an important role, the synthesis including ATP, DNA in brain and a variety of monoamine neurotransmitters, it is therefore necessary to ensure brain
Iron ion in portion not easily runs off.
Therefore, need one kind that can improve infant's lactose intolerance during lactose intolerance diarrhea in the prior art,
The diarrhea course of disease can be shortened again, improve the solution of symptom of diarrhea.
The content of the invention
It is an object of the invention to propose compound preparation of a kind of acid lactase and zinc and preparation method thereof, for ensureing
Infant can improve lactose intolerance during lactose intolerance diarrhea, prevent from causing brain development because of galactolipin insufficiency of intake
It is affected, moreover it is possible to which the diarrhea course of disease is shortened in zinc supplementation, improves symptom of diarrhea.
The compound preparation of a kind of acid lactase and zinc according to the present invention, including following components and by weight percentage
Dosage：Acid lactase raw material powder 4~14%, zinc gluconate 0.2~1.2%, whole milk powder 38~74%, lactalbumin
Powder 5~15%, maltodextrin 14.3~27.3%, docosahexaenoic acid 0.5~1.1%, arachidonic acid 0.4~1%, core
Thuja acid 0.6~1.2%, transferrins 0.2~0.8%, shuttle peptide 0.3~0.9%, choline 0.4~1.1%.
A preferred embodiment according to the present invention, use of the compound preparation including following components and by weight percentage
Amount：Acid lactase raw material powder 6~12%, zinc gluconate 0.4~1%, whole milk powder 46~66%, PURE WHEY 7~
13%, maltodextrin 17.3~23.3%, docosahexaenoic acid 0.6~1%, arachidonic acid 0.5~0.9%, nucleotide
0.7~1.1%, transferrins 0.3~0.7%, shuttle peptide 0.4~0.8%, choline 0.5~1%.
Another preferred embodiment according to the present invention, use of the compound preparation including following components and by weight percentage
Amount：Acid lactase raw material powder 8~10%, 0.6~0.8.% of zinc gluconate, whole milk powder 53~59%, PURE WHEY 9
~11%, maltodextrin 19.3~21.3%, docosahexaenoic acid 0.7~0.9%, arachidonic acid 0.6~0.8%, core
Thuja acid 0.8~1%, transferrins 0.4~0.6%, shuttle peptide 0.5~0.7%, choline 0.6~0.9%.
Another preferred embodiment according to the present invention, use of the compound preparation including following components and by weight percentage
Amount：Acid lactase raw material powder 9%, zinc gluconate 0.7%, whole milk powder 55.8%, PURE WHEY 10%, maltodextrin
20.3%, docosahexaenoic acid 0.8%, arachidonic acid 0.7%, nucleotide 0.9%, transferrins 0.5%, shuttle peptide
0.6%, choline 0.7%.
An also preferred embodiment according to the present invention, the acidity lactase raw material powder is a kind of enzyme preparation, intolerant to
Acid is fermented by aspergillus oryzae and generates acid lactase.
The preparation method of a kind of acid lactase of the present invention and the compound preparation of zinc, step are as follows：
S1：Acid lactase raw material powder, zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out
Drying process, drying time are 5~60 seconds；
S2：Whole milk powder, PURE WHEY and maltodextrin are measured and matched somebody with somebody according to the ratio of compound preparation
Material mixing, incorporation time are 10~30 minutes；
S3：Pasteurize processing is carried out to the mixed dispensings of S2, sterilization temperature is 60~100 DEG C, sterilizing time for 2~
10 minutes；
S4：According to the ratio of compound preparation by transferrins and shuttle peptide by Peptide systhesis formed transferrins by
Body is added in the mix by pasteurize processing, for so that transferrins is more prone to by blood-brain barrier,
Prevent the loss of brain iron ion；
S5：According to the ratio of compound preparation by acid lactase raw material powder, zinc gluconate, two dodecahexaenes
Acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 10~30 minutes, ultimately forms production
Product.
Another preferred embodiment according to the present invention, in S1 zinc gluconate, whole milk powder, PURE WHEY and
Maltodextrin passes through heated-air drying；Acid lactase raw material powder then passes through cold air drying.
Another preferred embodiment according to the present invention, drying time is 15~20 seconds in S1.
An also preferred embodiment according to the present invention, the sterilization temperature of the pasteurize in S3 are controlled at 85 DEG C, killed
The bacterium time is 5 minutes.
Another preferred embodiment according to the present invention, incorporation time is 20 minutes in S2, the incorporation time in S5
For 20 minutes.
Dosage of the compound preparation of the present invention including following components and by weight percentage：Acid lactase raw material powder 4~
14%, zinc gluconate 0.2~1.2%, whole milk powder 38~74%, PURE WHEY 5~15%, maltodextrin 14.3~
27.3%, docosahexaenoic acid 0.5~1.1%, arachidonic acid 0.4~1%, nucleotide 0.6~1.2%, transferrins
0.2~0.8%, the compound preparation of the acidity lactase and zinc is also disclosed in shuttle peptide 0.3~0.9%, choline 0.4~1.1%
Preparation method, for infant's lactose intolerance caused by taking breast milk or formula milk, take orally acidity lactase and
The compound preparation of zinc can not only improve infant's lactose intolerance, but also can also shorten the diarrhea course of disease well, improve diarrhea
Symptom.
Compared with prior art, the invention has the beneficial effects that：1) for infant due to taking breast milk or formula
Lactose intolerance caused by milk powder can play apparent improvement result；2) prevent from taking sugar-free formulation milk during lactose intolerance
Cause galactolipin insufficiency of intake, so that infant's brain development is affected；3) this product can simultaneously be reconstituted with dairy produce
Afterwards without waiting, can directly take, it is easier；4) the energy zinc supplementation during lactose intolerance diarrhea, can be very good to shorten
The diarrhea course of disease improves symptom of diarrhea；5) it is used to improve regarding for baby containing docosahexaenoic acid and arachidonic acid in product
Power and intelligence promote neural cell development, improve human body memory function；6) enhance immune function containing nucleotide in product, promote
Into the development of small intestine；7) transferrins is synthesized by polyamines and shuttle peptide forms TfR, made by shuttle peptide
The blood-brain barrier for obtaining TfR through brain enters wherein, for the loss of brain iron ion；8) courage is contained in product
Alkali promotes brain growth and improves memory capability；Ensure that information is transferred；Promote fat metabolism.
Specific embodiment
Exemplary embodiments of the present invention are described in detail below；Description to illustrative embodiments is only
For illustration purposes, it is definitely not to the present invention and its application or the limitation of usage.
Shuttle peptide is a kind of shuttle body of blood-brain barrier, and it includes brain effector entity, connector and one to combine blood brain screen
Hinder the monovalent binding entity of receptor, wherein the connector is by the unit price of the effector entity and the combination blood-brain barrier receptor
Binding entity is coupled.
Embodiment 1：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 9%, zinc gluconate 0.7%, whole milk powder 55.8%, PURE WHEY 10%, maltodextrin 20.3%,
Docosahexaenoic acid 0.8%, arachidonic acid 0.7%, nucleotide 0.9%, transferrins 0.5%, shuttle peptide 0.6%, courage
Alkali 0.7%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 15 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 15 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 20 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 85 DEG C, and sterilizing time is then 5 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 20 minutes, finally
Form product.
Embodiment 2：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 4%, zinc gluconate 1.2%, whole milk powder 61.8%, PURE WHEY 5%, maltodextrin 23.3%, two
Dodecahexaene acid 0.9%, arachidonic acid 0.8%, nucleotide 0.8%, transferrins 0.6%, shuttle peptide 0.7%, choline
0.9%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 5 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 5 seconds；Further according to upper
It states ratio to measure whole milk powder, PURE WHEY and maltodextrin and carry out dispensing mixing, incorporation time is 10 minutes；
Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 100 DEG C, and sterilizing time is then 2 minutes, according to above-mentioned compound
Transferrins and shuttle peptide by Peptide systhesis formation TfR are added to and are killed by Pasteur by the ratio of preparation
In the mix of bacterium processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate, two
Dodecahexaene acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 10 minutes, most end form
Into product.
Embodiment 3：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 14%, zinc gluconate 1.2%, whole milk powder 38%, PURE WHEY 15%, maltodextrin 27.3%, two
Dodecahexaene acid 1.1%, arachidonic acid 0.4%, nucleotide 1%, transferrins 0.8%, shuttle peptide 0.2%, choline
1%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 20 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 20 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 25 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 90 DEG C, and sterilizing time is then 7 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 25 minutes, finally
Form product.
Embodiment 4：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 4.1%, zinc gluconate 0.2%, whole milk powder 74%, PURE WHEY 5%, maltodextrin 14.3%, two
Dodecahexaene acid 0.5%, arachidonic acid 0.4%, nucleotide 0.6%, transferrins 0.2%, shuttle peptide 0.3%, choline
0.4%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 60 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 60 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 30 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 60 DEG C, and sterilizing time is then 10 minutes, according to above-mentioned
The ratio of compound preparation by transferrins and shuttle peptide by Peptide systhesis formed TfR be added to by bar
In the mix of family name's sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, gluconic acid
Zinc, docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 30 minutes,
Ultimately form product.
Embodiment 5：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 6%, zinc gluconate 0.4%, whole milk powder 57.3%, PURE WHEY 13%, maltodextrin 17.3%,
Docosahexaenoic acid 1.1%, arachidonic acid 1%, nucleotide 1.2%, transferrins 0.8%, shuttle peptide 0.8%, choline
1.1%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 40 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 40 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 18 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 80 DEG C, and sterilizing time is then 6 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 18 minutes, finally
Form product.
Embodiment 6：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 12%, zinc gluconate 1%, whole milk powder 46%, PURE WHEY 11%, maltodextrin 25.4%, 20
Two carbon acids 1%, arachidonic acid 0.9%, nucleotide 1.1%, transferrins 0.7%, shuttle peptide 0.4%, choline
0.5%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 30 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 30 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 22 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 75 DEG C, and sterilizing time is then 4 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 22 minutes, finally
Form product.
Embodiment 7：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 10%, zinc gluconate 0.8%, whole milk powder 53%, PURE WHEY 10.6%, maltodextrin 21.3%,
Docosahexaenoic acid 0.7%, arachidonic acid 0.6%, nucleotide 1.1%, transferrins 0.8%, shuttle peptide 0.5%, courage
Alkali 0.6%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 24 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 24 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 16 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 70 DEG C, and sterilizing time is then 3 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 16 minutes, finally
Form product.
Embodiment 8：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 5.5%, zinc gluconate 0.8%, whole milk powder 66%, PURE WHEY 7%, maltodextrin 17.3%, two
Dodecahexaene acid 0.6%, arachidonic acid 0.5%, nucleotide 0.7%, transferrins 0.3%, shuttle peptide 0.6%, choline
0.7%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 40 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 40 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 19 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 65 DEG C, and sterilizing time is then 8 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 19 minutes, finally
Form product.
Embodiment 9：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：Acid breast
Carbohydrase raw material powder 8%, zinc gluconate 0.6%, whole milk powder 59%, PURE WHEY 9%, maltodextrin 19.3%, 20
Two carbon acids 0.8%, arachidonic acid 0.7%, nucleotide 0.7%, transferrins 0.4%, shuttle peptide 0.7%, choline
0.8%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 50 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 50 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 24 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 90 DEG C, and sterilizing time is then 4 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 24 minutes, finally
Form product.
Embodiment 10：The dosage of compound preparation by following component and by weight percentage in the present embodiment forms：It is acid
Lactase raw material powder 9%, zinc gluconate 0.9%, whole milk powder 52.2%, PURE WHEY 8%, maltodextrin 26.3%,
Docosahexaenoic acid 0.9%, arachidonic acid 0.5%, nucleotide 0.7%, transferrins 0.6%, shuttle peptide 0.4%, courage
Alkali 0.5%.
Preparation method：Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all carried out at heated-air drying
Reason, drying time are 18 seconds, acid lactase raw material powder are carried out cold air drying processing, drying time is also 18 seconds；Further according to
Whole milk powder, PURE WHEY and maltodextrin are measured and carry out dispensing mixing by said ratio ratio, and incorporation time is 20 points
Clock；Pasteurize processing is carried out to mixed dispensing, sterilization temperature is 85 DEG C, and sterilizing time is then 5 minutes, according to above-mentioned multiple
Transferrins and shuttle peptide are formed TfR by Peptide systhesis and are added to by Pasteur by the ratio of square preparation
In the mix of sterilization processing, according to the ratio of above-mentioned compound preparation by acid lactase raw material powder, zinc gluconate,
Docosahexaenoic acid, arachidonic acid, nucleotide and choline addition are mixed again, and incorporation time is 20 minutes, finally
Form product.
In conclusion this product is used for the infant of the lactose intolerance caused by service breast milk or formula milk, it can be straight
Interface enter or reconstituted simultaneously with dairy produce take into, you can improve infant's lactose intolerance, and the diarrhea course of disease can be shortened, improve abdomen
Rush down symptom；And by the way that transferrins and shuttle peptide are formed TfR by Peptide systhesis so that transferrins energy
Enough more easily by the blood-brain barrier of brain, the loss of brain iron ion is prevented.
Although with reference to illustrative embodiments, invention has been described, but it is to be understood that the present invention does not limit to
The specific embodiment that Yu Wenzhong is described in detail and shows, in the case of without departing from claims limited range, this
Field technology personnel can make various changes to the illustrative embodiments.
Claims (10)
1. the compound preparation of a kind of acidity lactase and zinc, which is characterized in that be made (by weight percentage) of following raw material：Acid
Property lactase raw material powder 4~14%, zinc gluconate 0.2~1.2%, whole milk powder 38~74%, PURE WHEY 5~
15%, maltodextrin 14.3~27.3%, docosahexaenoic acid 0.5~1.1%, arachidonic acid 0.4~1%, nucleotide
0.6~1.2%, transferrins 0.2~0.8%, shuttle peptide 0.3~0.9%, choline 0.4~1.1%.
2. the compound preparation of a kind of acid lactase according to claim 1 and zinc, which is characterized in that by following raw material system
Into (by weight percentage)：Acid lactase raw material powder 6~12%, zinc gluconate 0.4~1%, whole milk powder 46~66%,
PURE WHEY 7~13%, maltodextrin 17.3~23.3%, docosahexaenoic acid 0.6~1%, arachidonic acid 0.5~
0.9%, nucleotide 0.7~1.1%, transferrins 0.3~0.7%, shuttle peptide 0.4~0.8%, choline 0.5~1%.
3. the compound preparation of a kind of acid lactase according to claim 2 and zinc, which is characterized in that by following raw material system
Into (by weight percentage)：Acid lactase raw material powder 8~10%, 0.6~0.8.% of zinc gluconate, whole milk powder 53~
59%, PURE WHEY 9~11%, maltodextrin 19.3~21.3%, docosahexaenoic acid 0.7~0.9%, arachidonic
Acid 0.6~0.8%, nucleotide 0.8~1%, transferrins 0.4~0.6%, shuttle peptide 0.5~0.7%, choline 0.6~
0.9%.
4. the compound preparation of a kind of acid lactase according to claim 3 and zinc, which is characterized in that by following raw material system
Into (by weight percentage)：Acid lactase raw material powder 9%, zinc gluconate 0.7%, whole milk powder 55.8%, lactalbumin
Powder 10%, maltodextrin 20.3%, docosahexaenoic acid 0.8%, arachidonic acid 0.7%, nucleotide 0.9% turn iron egg
White 0.5%, shuttle peptide 0.6%, choline 0.7%.
5. the compound preparation of a kind of acid lactase according to claim 4 and zinc, it is characterised in that：The acidity lactose
Proenzyme feed powder is a kind of enzyme preparation, not acidproof, is fermented by aspergillus oryzae and generates acid lactase.
6. a kind of claim 1 is to the preparation method of the compound preparation of any one of claim 4, it is characterised in that step is such as
Under：
S1：Acid lactase raw material powder, zinc gluconate, whole milk powder, PURE WHEY and maltodextrin are all dried
Processing, drying time are 5~60 seconds；
S2：Whole milk powder, PURE WHEY and maltodextrin are measured according to ratio and carry out dispensing mixing, incorporation time
For 10~30 minutes；
S3：Pasteurize processing is carried out to the mixed dispensings of S2, sterilization temperature is 60~100 DEG C, and sterilizing time is 2~10 points
Clock；
S4：According to ratio by transferrins and shuttle peptide by Peptide systhesis formed TfR be added to by bar
In the mix of family name's sterilization processing, for so that transferrins is more prone to by blood-brain barrier, brain iron ion is prevented
Loss；
S5：According to ratio by acid lactase raw material powder, zinc gluconate, docosahexaenoic acid, arachidonic acid, core
Thuja acid and choline addition are mixed again, and incorporation time is 10~30 minutes, ultimately forms product.
7. the preparation method of the compound preparation of a kind of acid lactase according to claim 6 and zinc, it is characterised in that：
Zinc gluconate, whole milk powder, PURE WHEY and maltodextrin pass through heated-air drying in S1；Acid lactase raw material powder then leads to
Cross cold air drying.
8. the preparation method of the compound preparation of a kind of acid lactase according to claim 6 and zinc, it is characterised in that：
Drying time is 15~20 seconds in S1.
9. the preparation method of the compound preparation of a kind of acid lactase according to claim 6 and zinc, it is characterised in that：
At 85 DEG C, sterilizing time is 5 minutes for the sterilization temperature control of pasteurize in S3.
10. the preparation method of the compound preparation of a kind of acid lactase according to claim 6 and zinc, it is characterised in that：
Incorporation time is 20 minutes in S2, and incorporation time is 20 minutes in S5.
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