CN107402441A - The bright glimmering scanning means of one kind automatic switchover - Google Patents
The bright glimmering scanning means of one kind automatic switchover Download PDFInfo
- Publication number
- CN107402441A CN107402441A CN201710557952.7A CN201710557952A CN107402441A CN 107402441 A CN107402441 A CN 107402441A CN 201710557952 A CN201710557952 A CN 201710557952A CN 107402441 A CN107402441 A CN 107402441A
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- China
- Prior art keywords
- light
- scanning
- focusing unit
- scanning means
- driver element
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Facsimile Scanning Arrangements (AREA)
Abstract
The invention provides the bright glimmering scanning means of one kind automatic switchover, the switching with fluorescent scanning is scanned applied to light field, wherein, including：Luminescence unit, to changeable the fluorescent scanning pattern of formation one or a light field scan pattern；Light focusing unit, it is arranged at luminescence unit bottom；Driver element, it is arranged at the side of light focusing unit；Transmission mechanism；Light-blocking member, light-blocking member include：Light-shielding structure；Attachment structure, attachment structure one end are connected the other end with light-shielding structure and are connected with drive mechanism；When luminescence unit switches to fluorescent scanning pattern, driver element drive transmission device moves along horizontal direction, and transmission mechanism traction attachment structure drives light-shielding structure to form masking between luminescence unit and light focusing unit；Section pallet, to place the section for scanning.The beneficial effect of its technical scheme is, the switching of two kinds of scan patterns is realized on same device, can be avoided during fluorescent scanning reflective the problem of causing image serious overexposure of light focusing unit.
Description
Technical field
The present invention relates to microscopic detection device field, more particularly to a kind of bright glimmering scanning means that automatically switches.
Background technology
Section scanning is that section is checked, managed and analyzed, and a kind of auxiliary of in-vitro diagnosis is provided for pathologist
Means.The mode of section scanning generally includes, and light field scan pattern and fluorescent scanning pattern, wherein light field scan pattern refer to
Scan mode based on the color and its transmissivity of section preparation, fluorescent scanning pattern refer to by sending fluorescence to section
The mode that section in pallet is scanned, in the prior art can not be enterprising in same table apparatus for both scanning means
Row scan operation, made troubles to user's operation, it is existing to usually require to purchase two kinds of scanning means and be scanned operation, and then
The problem of bringing cost increase and more space apparatus for placing need to be taken, it is on the other hand existing to carry out fluorescent scanning
When, there is reflective phenomenon in light focusing unit, have a strong impact on the imaging of picture.
The content of the invention
For above mentioned problem existing for scanning means in the prior art, one kind is now provided and is intended to realize light field on same device
Scanning and the switching of fluorescent scanning both of which, and can effectively be solved existing for light focusing unit when carrying out fluorescent scanning
The reflective bright glimmering scanning means of automatic switchover for having a strong impact on picture imaging.
Concrete technical scheme is as follows：
The bright glimmering scanning means of one kind automatic switchover, applied to light field scanning and the switching of fluorescent scanning, wherein, including：
Luminescence unit, to changeable the fluorescent scanning pattern of formation one or a light field scan pattern；
Light focusing unit, it is arranged at the luminescence unit bottom；
Driver element, it is arranged at the side of the light focusing unit；
Transmission mechanism, connected with the driver element and the same of the light focusing unit is arranged at together with the driver element
Side；
Light-blocking member, the light-blocking member include：
Light-shielding structure；
Attachment structure, described attachment structure one end are connected with the light-shielding structure, and the other end is connected with the drive mechanism；
When the luminescence unit switches to the fluorescent scanning pattern, the driver element drives the transmission mechanism edge
Horizontal direction movement, the transmission mechanism further draws the attachment structure and drives the light-shielding structure described luminous
Masking is formed between unit and the light focusing unit；
Section pallet, the top of the light focusing unit is fixed on, to place the section for scanning.
Preferably, the transmission mechanism includes a rack, the rack under the driving of the driver element along
Horizontal direction reciprocates, so that the attachment structure moves toward and away from the light focusing unit.
Preferably, the transmission mechanism includes：
One rack, the rack under the driving of the driver element along dampening square to reciprocating so that institute
Attachment structure is stated to move toward and away from the light focusing unit；
Line slideway, it is fixedly installed on the top of the rack；
Sliding block, it is arranged on the line slideway and can be slided toward and away from the light focusing unit, the sliding block is set
There is a through hole run through；
The bottom of the line slideway, which along the slidable direction of the sliding block is provided with one and extends vertically through the straight line, leads
The fluting in flange of rail portion, the attachment structure are connected through the through hole and the fluting with the rack.
Preferably, the topside area of the light-shielding structure is more than the topside area of the light focusing unit.
Preferably, the rectangular shape in junction between the light-shielding structure and the attachment structure.
Preferably, the light-shielding structure is integrally formed an anti-dazzling screen with the attachment structure.
Preferably, the light-shielding structure is the lighttight shading pallet in a bottom.
Preferably, section the distance between the pallet and the light focusing unit are 2mm.
Preferably, the driver element is stepper motor.
Preferably, the luminescence unit includes：
Fluorescent moieties, the fluorescent moieties include a variety of luminous groups, and described luminous group includes：
Blue excitation light group, and/or green exciting light group, and/or purple exciting light group, and/or uv excitation light group；
Selecting module, to select default a kind of luminous group in the fluorescent moieties to be used as under the fluorescent scanning pattern
Light emitting source.
Above-mentioned technical proposal has the following advantages that or beneficial effect：Can be realized on same device light field scan pattern and
The switching of fluorescent scanning pattern, and can effectively avoid the reflective of light focusing unit from causing image serious when carrying out fluorescent scanning
Overexposure, the problem of influenceing image quality, need to be purchased when overcoming the scanning for carrying out above two pattern in the prior art corresponding to two kinds
The cost increase that scanning means is brought, and the defects of space-consuming is larger.
Brief description of the drawings
With reference to appended accompanying drawing, more fully to describe embodiments of the invention.However, appended accompanying drawing be merely to illustrate and
Illustrate, and be not meant to limit the scope of the invention.
Fig. 1 is a kind of structural representation of the embodiment for the bright glimmering scanning means that automatically switches of the present invention；
Fig. 2 is the structural representation on luminescence unit in a kind of embodiment for the bright glimmering scanning means that automatically switches of the present invention
Figure.
Reference represents：
1st, luminescence unit；2nd, light focusing unit；3rd, driver element；4th, drive mechanism；5th, light-blocking member；51st, light-shielding structure；
52nd, attachment structure；6th, section pallet；7th, sliding block；8th, line slideway；A1, object lens.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art obtained on the premise of creative work is not made it is all its
His embodiment, belongs to the scope of protection of the invention.
It should be noted that in the case where not conflicting, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, but not as limiting to the invention.
Technical scheme includes a kind of bright glimmering scanning means that automatically switches.
As shown in Figure 1 to Figure 2, it is shown, a kind of embodiment for the bright glimmering scanning means of automatically switching, applied to light field scanning and
The switching of fluorescent scanning, wherein, including：
Luminescence unit 1, to changeable formation fluorescent scanning pattern or light field scan pattern；
Light focusing unit 2, it is arranged at the bottom of luminescence unit 1；
Driver element 3, it is arranged at the side of light focusing unit 2；
Transmission mechanism 4, it is connected with driver element 3, and the homonymy of light focusing unit 2 is arranged at together with driver element 3；
Light-blocking member 5, light-blocking member 5 include：
Light-shielding structure 51；
Attachment structure 52, the one end of attachment structure 52 are connected the other end with light-shielding structure 51 and are connected with drive mechanism 4；
When luminescence unit 1 switches to fluorescent scanning pattern, the drive transmission device of driver element 3 moves along horizontal direction
Dynamic, transmission mechanism further draws attachment structure 52 and drives light-shielding structure 51 to be formed between luminescence unit 1 and light focusing unit 2
Masking；
Section pallet 6, the top of light focusing unit 2 is fixed on, to place the section for scanning.
For in the prior art, when carrying out light field scanning and fluorescent scanning both of which, it is desirable to provide corresponding to sweep
The operation inconvenience that imaging apparatus is brought to user, and because the reflective of light focusing unit 2 causes to be imaged under fluorescent scanning pattern
Overexposure shadow, ring image quality the problem of.
In the present invention when carrying out fluorescent scanning, fluorescent scanning pattern is switched to by luminescence unit 1, while control driving
Unit 3 drives drive mechanism 4, drive mechanism 4 further draw attachment structure 52 drive light-shielding structure 51 in luminescence unit 1 and
Masking is formed between light focusing unit 2, and then the reflective influence of light focusing unit 2 can be avoided to be imaged image quality；
As shown in Fig. 2, it is necessary to which explanation is that light focusing unit 2 is condenser in above-mentioned technical proposal, luminescence unit 1 is sent
Light source be radiated at by being arranged on the object lens A1 of the top of light focusing unit 2 in the section of section pallet 6.
In a kind of preferably embodiment, transmission mechanism 4 includes a rack, and rack is in the driving of driver element 3
Reciprocated along horizontal direction, so that attachment structure 52 moves toward and away from light focusing unit 2.
In above-mentioned technical proposal, driver element 3 also includes a gear, is coordinated by rack and pinion, driver element 3 controls
Gear rotates and then rack is reciprocated along horizontal direction.
In a kind of preferably embodiment, transmission mechanism 4 includes：
Rack, rack under the driving of driver element 3 along dampening square to reciprocating so that the court of attachment structure 52
Move to or away from light focusing unit 2；
Line slideway 8, it is fixedly installed on the top of rack；
Sliding block 7, it is arranged on line slideway 8 and can be slided toward and away from light focusing unit 2, sliding block 7, which is provided with one, is run through
Through hole (not shown in figure)；
The bottom of line slideway 8 is provided with one along 7 slidable direction of sliding block and extends vertically through opening for the bottom of line slideway 8
Groove (does not show) that attachment structure 52 is connected through through hole and fluting with rack in figure.
In above-mentioned technical proposal, the combination of line slideway 8 and sliding block 7 can use it is a variety of, such as in line slideway 8
Both sides are respectively arranged with a chute, and the both sides of sliding block 7 are provided with the holding section matched with chute, sliding block 7 is limited in into cunning
Slide in groove, do not limit herein in the horizontal direction, it should be noted that it is existing using between sliding block and line slideway
Set-up mode, within the scope of the present invention.
The driver element 3 of driver element 3 also includes a gear, is coordinated by rack and pinion, and driver element 3 controls gear rotation
Rotate into and rack is reciprocated along horizontal direction.
In a kind of preferably embodiment, the topside area of light-shielding structure 51 is more than the topside area of light focusing unit 2.
In above-mentioned technical proposal, when entering fluorescent scanning pattern, the final light-shielding structure 51 under the driving of driver element 3
It is completely covered by the top of light focusing unit 2.
In a kind of preferably embodiment, light-shielding structure 51 is integrally formed an anti-dazzling screen with attachment structure 52.
In a kind of preferably embodiment, the rectangular shape in junction between light-shielding structure 51 and attachment structure 52.
In a kind of preferably embodiment, light-shielding structure 51 is the lighttight shading pallet in a bottom.
In above-mentioned technical proposal, the bottom of shading pallet is made of light tight material, and then can cover light focusing unit 2
What is formed is reflective.
In a kind of preferably embodiment, section the distance between pallet 6 and light focusing unit 2 are 2mm.
In a kind of preferably embodiment, driver element 3 is stepper motor.
In above-mentioned technical proposal, driver element 3 drives the movement travel of drive mechanism 4, can be by pre-setting.
In a kind of preferably embodiment, luminescence unit 1 includes：
Fluorescent moieties (do not show) that fluorescent moieties include a variety of luminous groups, and luminous group includes a blue excitation light in figure
Group.
In a kind of preferably embodiment, luminous group includes a green exciting light group.
In a kind of preferably embodiment, luminous group includes a purple exciting light group.
In a kind of preferably embodiment, luminous group includes a uv excitation light group.
Selecting module (is not shown) in figure, to select default a kind of luminous group in fluorescent moieties to be swept as fluorescence
Retouch the light emitting source under pattern.
In above-mentioned technical proposal, luminescence unit 1 can select fluorescent scanning or light field scanning means, be swept when carrying out fluorescence
When retouching pattern, default one kind in fluorescent moieties can be may be selected by the rotational structure or rotary switch set in luminescence unit
Luminous group is scanned operation as light emitting source.
Preferred embodiments of the present invention are the foregoing is only, not thereby limit embodiments of the present invention and protection model
Enclose, to those skilled in the art, should can appreciate that all with made by description of the invention and diagramatic content
Scheme obtained by equivalent substitution and obvious change, should be included in protection scope of the present invention.
Claims (10)
- The bright glimmering scanning means 1. one kind automatically switches, applied to light field scanning and the switching of fluorescent scanning, it is characterised in that bag Include：Luminescence unit, to changeable the fluorescent scanning pattern of formation one or a light field scan pattern；Light focusing unit, it is arranged at the luminescence unit bottom；Driver element, it is arranged at the side of the light focusing unit；Transmission mechanism, connected with the driver element and the homonymy of the light focusing unit is arranged at together with the driver element；Light-blocking member, the light-blocking member include：Light-shielding structure；Attachment structure, described attachment structure one end are connected with the light-shielding structure, and the other end is connected with the drive mechanism；When the luminescence unit switches to the fluorescent scanning pattern, the driver element drives the transmission mechanism along dampening Square to movement, the transmission mechanism further draws the attachment structure and drives the light-shielding structure in the luminescence unit Masking is formed between the light focusing unit；Section pallet, the top of the light focusing unit is fixed on, to place the section for scanning.
- 2. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the transmission mechanism includes a tooth Bar, the rack under the driving of the driver element along dampening square to reciprocating so that the attachment structure court To or away from the light focusing unit movement.
- 3. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the transmission mechanism includes：One rack, the rack under the driving of the driver element along dampening square to reciprocating so that the company Binding structure moves toward and away from the light focusing unit；Line slideway, it is fixedly installed on the top of the rack；Sliding block, it is arranged on the line slideway and can be slided toward and away from the light focusing unit, the sliding block is provided with one The through hole run through；The bottom of the line slideway is provided with one along the slidable direction of the sliding block and extends vertically through the line slideway bottom The fluting in portion, the attachment structure are connected through the through hole and the fluting with the rack.
- 4. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the top surface of the light-shielding structure Topside area of the product more than the light focusing unit.
- 5. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the light-shielding structure and the company The rectangular shape in junction between binding structure.
- 6. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the light-shielding structure and the company Binding structure is integrally formed an anti-dazzling screen.
- 7. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the light-shielding structure is a bottom Lighttight shading pallet.
- 8. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the section pallet gathers with described The distance between light unit is 2mm.
- 9. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the driver element is stepping electricity Machine.
- 10. the bright glimmering scanning means according to claim 1 that automatically switches, it is characterised in that the luminescence unit includes：Fluorescent moieties, the fluorescent moieties include a variety of luminous groups, and described luminous group includes：Blue excitation light group, and/or green exciting light group, and/or purple exciting light group, and/or uv excitation light group；Selecting module, to select in the fluorescent moieties default a kind of luminous group as the hair under the fluorescent scanning pattern Light source.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710557952.7A CN107402441A (en) | 2017-07-10 | 2017-07-10 | The bright glimmering scanning means of one kind automatic switchover |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710557952.7A CN107402441A (en) | 2017-07-10 | 2017-07-10 | The bright glimmering scanning means of one kind automatic switchover |
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| Publication Number | Publication Date |
|---|---|
| CN107402441A true CN107402441A (en) | 2017-11-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710557952.7A Pending CN107402441A (en) | 2017-07-10 | 2017-07-10 | The bright glimmering scanning means of one kind automatic switchover |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111169303A (en) * | 2020-01-06 | 2020-05-19 | 深圳巴斯巴科技发展有限公司 | Switching connection structure |
| CN112858293A (en) * | 2021-01-11 | 2021-05-28 | 宁波江丰生物信息技术有限公司 | Shading switching device and digital pathological section scanner |
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| US4515445A (en) * | 1982-02-11 | 1985-05-07 | Carl-Zeiss-Stiftung, Heidenheim/Brenz | Optical system for transmitted-light microscopy with incident illumination |
| CN101438147A (en) * | 2006-05-31 | 2009-05-20 | 奥林巴斯株式会社 | Biological specimen imaging method and biological specimen imaging apparatus |
| CN102305776A (en) * | 2011-05-26 | 2012-01-04 | 浙江大学 | Transparent-medium-microsphere-based super-resolution microscopic imaging system |
| JP2012022206A (en) * | 2010-07-15 | 2012-02-02 | Olympus Corp | Microscopic observation system |
| CN105324698A (en) * | 2013-05-01 | 2016-02-10 | 生物辐射实验室股份有限公司 | Adjustable digital microscope display |
| CN106175808A (en) * | 2015-05-29 | 2016-12-07 | 伯托科技有限公司 | Apparatus and method for multi-modal imaging |
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2017
- 2017-07-10 CN CN201710557952.7A patent/CN107402441A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515445A (en) * | 1982-02-11 | 1985-05-07 | Carl-Zeiss-Stiftung, Heidenheim/Brenz | Optical system for transmitted-light microscopy with incident illumination |
| CN101438147A (en) * | 2006-05-31 | 2009-05-20 | 奥林巴斯株式会社 | Biological specimen imaging method and biological specimen imaging apparatus |
| JP2012022206A (en) * | 2010-07-15 | 2012-02-02 | Olympus Corp | Microscopic observation system |
| CN102305776A (en) * | 2011-05-26 | 2012-01-04 | 浙江大学 | Transparent-medium-microsphere-based super-resolution microscopic imaging system |
| CN105324698A (en) * | 2013-05-01 | 2016-02-10 | 生物辐射实验室股份有限公司 | Adjustable digital microscope display |
| CN106175808A (en) * | 2015-05-29 | 2016-12-07 | 伯托科技有限公司 | Apparatus and method for multi-modal imaging |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111169303A (en) * | 2020-01-06 | 2020-05-19 | 深圳巴斯巴科技发展有限公司 | Switching connection structure |
| CN112858293A (en) * | 2021-01-11 | 2021-05-28 | 宁波江丰生物信息技术有限公司 | Shading switching device and digital pathological section scanner |
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Application publication date: 20171128 |