CN107402154A - Automatic change magnetism solid phase extraction device - Google Patents
Automatic change magnetism solid phase extraction device Download PDFInfo
- Publication number
- CN107402154A CN107402154A CN201710840451.XA CN201710840451A CN107402154A CN 107402154 A CN107402154 A CN 107402154A CN 201710840451 A CN201710840451 A CN 201710840451A CN 107402154 A CN107402154 A CN 107402154A
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- China
- Prior art keywords
- phase extraction
- test tube
- extraction
- magnetic solid
- tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002414 normal-phase solid-phase extraction Methods 0.000 title claims abstract description 25
- 230000005389 magnetism Effects 0.000 title 1
- 238000000605 extraction Methods 0.000 claims abstract description 25
- 239000002699 waste material Substances 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 239000000523 sample Substances 0.000 abstract description 14
- 238000005516 engineering process Methods 0.000 abstract description 8
- 239000012488 sample solution Substances 0.000 abstract description 7
- 239000003480 eluent Substances 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 3
- 230000005672 electromagnetic field Effects 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 238000005191 phase separation Methods 0.000 abstract description 2
- 238000004401 flow injection analysis Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 7
- 238000002604 ultrasonography Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 239000000696 magnetic material Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N2030/009—Extraction
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention discloses an automatic magnetic solid phase extraction device, which comprises a parallel water tank (an extraction tank and a waste liquid tank), an electric sliding table, an ultrasonic generator, an electromagnet, a rotatable sample rack, a stepping motor and a control panel, wherein a sample solution, a cleaning solution, an eluent inlet and an eluent outlet are reserved above the test tube rack, and each pipeline is connected with an external flow injection pump. The ultrasonic field, the electromagnetic field, the electric sliding table and the rotatable sample rack are integrally controlled by the small programmable controller, extraction, phase separation, rotary waste discharge and washing operations are automatically carried out, errors caused by manual operation are reduced, the precision and the automation degree of a magnetic solid phase extraction technology are improved, and the whole set of system is reliable in operation and strong in adjustability and expansibility.
Description
Technical field
The present invention relates to a kind of automatized magnetic solid-phase extraction device, belongs to analytical chemistry Sample Pretreatment Technique field.
Background technology
Sample Pretreatment Technique is developed rapidly in recent years, and analysis workers are establishing new sample pre-treatments side
Method and while expand its application field, also focuses on the automation of implementation method.Compared with manual operations, automation mechanized operation tool
Have the advantages that to reappear that performance is good, errors of analytical results is small, sample throughput is high and saves labour, also can be operating personnel from evil
Freed in bad, dangerous working environment.
Magnetic solid phase extraction is a kind of new solid phase extraction techniques by propositions such as afa í kov á in 1999.This method be by
Magnetic adsorptive material is added into the sample solution containing target analytes, magnetic material is uniformly divided in the case where stirring aids in first
Dissipate in sample solution, fully contacted with target analytes and be adsorbed in material surface, then by externally-applied magnetic field, make magnetic
Property material and sample solution realize quick separating, finally the target analytes for being adsorbed in material surface are eluted and drawn
Enter instrument and carry out subsequent detection.Magnetic solid phase extraction technology combines the characteristics of SPE and Magneto separate, have analyze speed it is fast,
Enrichment times are high, are easy to the advantages that phase separation, and avoid the problems such as conventional solid extraction needs dress post and pillar easily to block, from
And it is widely used in separation/enrichment of trace object in the samples such as biology, environment and food.However, conventional magnetic solid phase extraction
Extract operation is carried out in beaker or test tube, carry out liquid relief manually, waste discharge, elution, magnetic material add, ultrasound (or stirring) and
The application in magnetic field etc. operates, and for large batch of sample analysis, the repeatability of operation and the reliability of result will be affected.
Zhengzhou Institute of Multipurpose Utilization of Mineral Resources, CAGS have developed a kind of automatized magnetic solid-phase extraction device, lead to
The one-touch Programmed control to ultrasonic field, electromagnetic field, electronic slide unit and rotatable sample frame is crossed, is extracted automatically, phase point
From, rotation waste discharge, washing operation, the error brought of manual operation is reduced, improves the precision of magnetic solid phase extraction technology and automatic
Change degree.The device has simple to operate, and sample throughput is high, the advantages that being easy to be combined with analytical instrument.
The content of the invention
The technical solution adopted by the present invention is：A kind of automatized magnetic solid-phase extraction device, including extraction tank, waste liquid tank, electricity
The part composition such as dynamic slide unit, supersonic generator, electromagnet, rotatable sample frame, stepper motor, solution gateway.Its feature
It is：The waste liquid tank and extraction tank are located on electronic slide unit, and electromagnet is located at rotatable rack for test tube bottom, and ultrasonic wave occurs
Device is located at extraction tank inside circumference, and solution gateway is located above rotatable rack for test tube.
The electromagnet is fixed on rotatable rack for test tube bottom, is fixed by screw, can be rotated with rotatable rack for test tube.
The waste liquid tank and extraction tank are co-located above electronic slide unit by bolt or mode connects for screw, can be with electric sliding
Platform moves.
The extraction tank inside circumference is provided with supersonic generator.
Solution gateway is set above the rotatable rack for test tube.
Compared with existing manual magnetic solid phase extraction technology, 1）The present invention by ultrasonic field, electromagnetic field, electronic slide unit and
The integrated control of rotatable sample frame, automation are extracted, are separated, rotating waste discharge, washing operation, reduce artificial behaviour
Make, improve magnetic solid phase extraction technology automaticity；Meet the trend that Sample Pretreatment Technique develops towards automation direction；
2）The present invention can handle multiple samples simultaneously, the hole count of rack for test tube can according to be actually needed be designed as 4 holes, 8 holes, 16 holes or
More, hole count is more, then the sample of pre-treatment simultaneously is more, and mass extraction can be achieved；
3）Traditional manual magnetic solid phase extraction mode of operation is relatively difficult to achieve with subsequent detection instrument on-line coupling.The present invention will can flow
Dynamic injecting systems are used for introducing, the extraction of eluent of sample solution and eluent, realize magnetic solid phase extraction and follow-up large-scale instrument
The on-line coupling of device, efficient separation and concentration technology and efficient separation, detection means are combined, improve the analysis speed of method
Degree, sensitivity and operating efficiency.
Compared with by the magnetic solid phase extraction technology of microtrabeculae or microchannel, 1）Magnetic is extracted material by the present invention by ultrasonic field
Material is fully dispersed in the sample solution of large volume, is fully contacted with sample solution, is reduced magnetic coagulation, gives full play to magnetic extraction
The high-specific surface area advantage drawn materials, thus there is higher extraction efficiency；
2）The device is easily assembled to, and cost is relatively low, and the magnetic solid phase extraction instrument that commercialization can be carried out on the basis of this device is ground
Hair.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Embodiment
As shown in figure 1, a kind of automatized magnetic solid-phase extraction device, including waste liquid tank 1, extraction tank 2, electronic slide unit 3, electromagnetism
The parts such as iron 4, supersonic generator 5, rotatable rack for test tube 6 and solution gateway 7 form.It is characterized in that：The waste liquid tank 1
It is located at extraction tank 2 on electronic slide unit 3, electromagnet 4 is located at the rotatable bottom of rack for test tube 6, and supersonic generator 5 is positioned at extraction
The inside circumference of groove 2, solution gateway 7 is positioned at the rotatable top of rack for test tube 6.Electromagnet 4 is fixed on the rotatable bottom of rack for test tube 6,
Fixed by screw, electromagnet 4 can rotate with rotatable rack for test tube 6.Waste liquid tank 1 and extraction tank 2 by bolt or mode connects for screw,
It is co-located above electronic slide unit 3, can be moved with electronic slide unit 3.The inside circumference of extraction tank 2 is provided with supersonic generator 5.Can
The top of Spin tubes frame 6 sets solution gateway 7.This automatized magnetic solid-phase extraction device is Programmed control, during work, sample
After solution and magnetic fiber material introduce test tube, ultrasonic wave vibration plate is powered first, carries out ultrasonic disperse and sorption extraction, and count
When；After reaching extraction time, ultrasound is automatically stopped, and electromagnet is actuated for being separated and timing；It is separated after time arrival, electricity
Magnet continues to power, and stepper motor drives rotatable rack for test tube rotation waste discharge, this process electromagnet continued power；Stepper motor is anti-
Turn to reset, electronic slide unit returns extraction position.After cleaning fluid introduces, rack for test tube is rotated and cleaning magnetic material is completed in slide unit movement
Work, this process electromagnet continued power；After eluent introduces, electromagnet power-off, ultrasound is actuated for eluting.Elution time reaches
After arriving, ultrasound stops, and magnetic field is actuated for being separated.
Claims (5)
1. a kind of automatized magnetic solid-phase extraction device, including waste liquid tank（1）, extraction tank（2）, electronic slide unit（3）, electromagnet（4）、
Supersonic generator（5）, rotatable rack for test tube（6）With solution gateway（7）Formed Deng part；It is characterized in that：The waste liquid
Groove（1）And extraction tank（2）Positioned at electronic slide unit（3）On, electromagnet（4）Positioned at rotatable rack for test tube（6）Bottom, ultrasonic wave hair
Raw device（5）Positioned at extraction tank（2）Inside circumference, solution gateway（7）Positioned at rotatable rack for test tube（6）Top.
A kind of 2. automatized magnetic solid-phase extraction device according to claim 1, it is characterised in that：The electromagnet（4）Gu
Due to rotatable rack for test tube（6）Bottom, fixed by screw, electromagnet（4）Can be with rotatable rack for test tube（6）Rotation.
A kind of 3. automatized magnetic solid-phase extraction device according to claim 1, it is characterised in that：The waste liquid tank（1）With
Extraction tank（2）By bolt or mode connects for screw, electronic slide unit is co-located at（3）Above, can be with electronic slide unit（3）It is mobile.
A kind of 4. automatized magnetic solid-phase extraction device according to claim 1, it is characterised in that：The extraction tank（2）It is interior
Portion's surrounding is provided with supersonic generator（5）.
A kind of 5. automatized magnetic solid-phase extraction device according to claim 1, it is characterised in that：The rotatable rack for test tube
（6）Top sets solution gateway（7）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710840451.XA CN107402154A (en) | 2017-09-18 | 2017-09-18 | Automatic change magnetism solid phase extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710840451.XA CN107402154A (en) | 2017-09-18 | 2017-09-18 | Automatic change magnetism solid phase extraction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107402154A true CN107402154A (en) | 2017-11-28 |
Family
ID=60388949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710840451.XA Pending CN107402154A (en) | 2017-09-18 | 2017-09-18 | Automatic change magnetism solid phase extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107402154A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944670A (en) * | 2020-03-19 | 2020-11-17 | 珠海艾博罗生物技术股份有限公司 | Ultrasonic processor |
| WO2023047362A1 (en) | 2021-09-27 | 2023-03-30 | Seylab | Washing device |
Citations (6)
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|---|---|---|---|---|
| JP2006007081A (en) * | 2004-06-25 | 2006-01-12 | Hitachi Koki Co Ltd | Automatic solid-phase extraction apparatus |
| CN103674675A (en) * | 2013-07-26 | 2014-03-26 | 山东省科学院海洋仪器仪表研究所 | Enrichment device and method for organic pollutants in seawater |
| CN204287171U (en) * | 2014-11-25 | 2015-04-22 | 上海华之光谱仪器有限公司 | A kind of magnetic solid-phase microextraction metal element analyse instrument |
| CN105214339A (en) * | 2015-10-21 | 2016-01-06 | 广州市食品检验所 | A kind of novel magnetic solid-phase extraction device |
| CN105301265A (en) * | 2015-10-10 | 2016-02-03 | 山西师范大学 | Automatic online magnetic solid-phase micro-extraction-desorption-detection apparatus and method thereof |
| CN207423632U (en) * | 2017-09-18 | 2018-05-29 | 中国地质科学院郑州矿产综合利用研究所 | Automatic change magnetism solid phase extraction device |
-
2017
- 2017-09-18 CN CN201710840451.XA patent/CN107402154A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006007081A (en) * | 2004-06-25 | 2006-01-12 | Hitachi Koki Co Ltd | Automatic solid-phase extraction apparatus |
| CN103674675A (en) * | 2013-07-26 | 2014-03-26 | 山东省科学院海洋仪器仪表研究所 | Enrichment device and method for organic pollutants in seawater |
| CN204287171U (en) * | 2014-11-25 | 2015-04-22 | 上海华之光谱仪器有限公司 | A kind of magnetic solid-phase microextraction metal element analyse instrument |
| CN105301265A (en) * | 2015-10-10 | 2016-02-03 | 山西师范大学 | Automatic online magnetic solid-phase micro-extraction-desorption-detection apparatus and method thereof |
| CN105214339A (en) * | 2015-10-21 | 2016-01-06 | 广州市食品检验所 | A kind of novel magnetic solid-phase extraction device |
| CN207423632U (en) * | 2017-09-18 | 2018-05-29 | 中国地质科学院郑州矿产综合利用研究所 | Automatic change magnetism solid phase extraction device |
Non-Patent Citations (1)
| Title |
|---|
| 王为中等: "磁固相萃取与高效液相色谱联用测定水体中防治白蚁农药残留" * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111944670A (en) * | 2020-03-19 | 2020-11-17 | 珠海艾博罗生物技术股份有限公司 | Ultrasonic processor |
| CN111944670B (en) * | 2020-03-19 | 2021-11-30 | 珠海艾博罗生物技术股份有限公司 | Ultrasonic processor |
| WO2023047362A1 (en) | 2021-09-27 | 2023-03-30 | Seylab | Washing device |
| FR3127418A1 (en) | 2021-09-27 | 2023-03-31 | Seylab | washing device |
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Application publication date: 20171128 |
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