CN107375866A - A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care - Google Patents
A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care Download PDFInfo
- Publication number
- CN107375866A CN107375866A CN201710575247.XA CN201710575247A CN107375866A CN 107375866 A CN107375866 A CN 107375866A CN 201710575247 A CN201710575247 A CN 201710575247A CN 107375866 A CN107375866 A CN 107375866A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- chinese medicine
- medicine composition
- astragalus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 83
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000036541 health Effects 0.000 title claims abstract description 13
- 241001061264 Astragalus Species 0.000 claims abstract description 25
- 240000000451 Zingiber zerumbet Species 0.000 claims abstract description 25
- 235000014687 Zingiber zerumbet Nutrition 0.000 claims abstract description 25
- 235000006533 astragalus Nutrition 0.000 claims abstract description 25
- 210000004233 talus Anatomy 0.000 claims abstract description 25
- 244000269861 Nitraria schoberi Species 0.000 claims abstract description 24
- 235000009506 Nitraria schoberi Nutrition 0.000 claims abstract description 24
- 241000792914 Valeriana Species 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 208000003322 Coinfection Diseases 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 9
- 241000606807 Glaesserella parasuis Species 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000007858 starting material Substances 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 14
- 241000700605 Viruses Species 0.000 abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 10
- 208000015181 infectious disease Diseases 0.000 abstract description 7
- 238000001914 filtration Methods 0.000 abstract description 3
- 230000036737 immune function Effects 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 description 28
- 238000012360 testing method Methods 0.000 description 20
- 210000001161 mammalian embryo Anatomy 0.000 description 19
- 241000287828 Gallus gallus Species 0.000 description 15
- 206010012735 Diarrhoea Diseases 0.000 description 13
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000009835 boiling Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000003837 chick embryo Anatomy 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000002131 composite material Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 241000282887 Suidae Species 0.000 description 3
- 235000014590 basal diet Nutrition 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 102000006395 Globulins Human genes 0.000 description 2
- 108010044091 Globulins Proteins 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000012287 Prolapse Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000004013 groin Anatomy 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000009305 pseudorabies Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 229960000329 ribavirin Drugs 0.000 description 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 235000008671 Calycanthus floridus Nutrition 0.000 description 1
- 235000008670 Calycanthus occidentalis Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000009701 Embryo Loss Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241001365031 Isodon japonicus Species 0.000 description 1
- 244000148992 Lindera benzoin Species 0.000 description 1
- 235000004520 Lindera benzoin Nutrition 0.000 description 1
- 235000008262 Lindera benzoin var. benzoin Nutrition 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001104795 Nitraria sibirica Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 description 1
- 241000220151 Saxifragaceae Species 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 241000159213 Zygophyllaceae Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 208000027503 bloody stool Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 210000002726 cyst fluid Anatomy 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000022532 enlargement of lymph nodes Diseases 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003771 laboratory diagnosis Methods 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 201000005111 ocular hyperemia Diseases 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care, the Chinese medicine composition is by the parts by weight of Yunnan astragalus 7~21,11~33 parts by weight of the open country of falling root Soviet Union, the parts by weight of evil mind kiss-me 6~18, the parts by weight of Rhizoma Zingiberis zerumbet 9~27, the parts by weight of nitraria schoberi 10~30 are made.The preparation method of said composition is by Yunnan astragalus, and the open country of falling root is revived, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixes, and 7~8 times of amount water of dosing material gross weight soak 8~12h, boil and maintain 1 2h, filtering, 5~6 times of dosing material gross weight measures water to filter residue again, boils and maintains 0.5 1h, filters, merge filtrate twice, be condensed into medicinal extract.The Chinese medicine composition adds in pig feed, can prevent and treat the infection or mixed infection of the viruses such as the pseudoabies after weaned piglet, PCV-II, haemophilus parasuis, bacterium, promotes growth, is also improved the effect of immunologic function, noresidue is safe and convenient to use.
Description
Technical field
The invention belongs to herbal medicine pharmaceutical field, and it is somatotrophic for piglet health care in preparation to be related to a kind of Chinese medicine composition
Purposes in medicine, the invention further relates to the Chinese medicine composition to prepare preventing and treating piglet pseudoabies, smoothing filter operator, and secondary pig is thermophilic
Application in the herbal medicine of the viruses such as blood bacillus, the infection of bacterium or mixed infection.
Background technology
Chinese herb feed additive is with a long history, and great role is played in pig breeding production.Such as《Compendium of Materia Medica》Just once carry
Arrive:" root of three-nerved spicebush, pig, dog all kinds of diseases and ailments, and can take ";And《Complete ten thousand arts of Huainan》In numb salt dissipate (fructus cannabis 100g, salt 5g) tool
There is moisturize laxation, replenish qi to invigorate the spleen effect, so as to reach the purpose for weightening of fattening.Many Chinese herbal medicines are just used in aquaculture from ancient times,
Because of the unique advantage such as it has vdiverse in function, pollution-free, safe and harmless, economic, sustainable, wide material sources, has no toxic side effect and
Got off by succession.With going deep into for research, it is found that Chinese herb feed additive also has and optimize pig feed quality, improve the productivity of pig
Can, prevention disease, health care, improve swine product quality and other effects.Pig child care stage histoorgan ateliosis, resistance is poor,
Virus, bacteria mixed infection easily occurs.
For these problems, the present invention is by one kind with Yunnan astragalus, and the open country of falling root is revived, evil mind kiss-me, Rhizoma Zingiberis zerumbet, and fruitlet is white
The Chinese medicine composition pierced as raw material is added in the feed of piglet feeding, reaches preventing and treating pseudoabies, PCV-II, the bloodthirsty bar of secondary pig
The infection of bacterium or the effect of mixed infection, moreover it is possible to for piglet health care growth promotion, significant effect.
The content of the invention
It is an object of the present invention to provide a kind of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care
Purposes;Another object of the present invention is to provide the Chinese medicine composition and is preparing pseudoabies, PCV-II for preventing and treating piglet
Or the purposes in the medicine of infection or the two or more mixed infections of Haemophilus parasuis.
The purpose of the present invention is implemented by following technical measures:
A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care;Wherein, the Chinese traditional medicine composition
Thing is made up of the bulk drug of following parts by weight:The parts by weight of Yunnan astragalus 7~21,11~33 parts by weight of the open country of falling root Soviet Union, evil mind tiger ear
Careless 6~18 parts by weight, the parts by weight of Rhizoma Zingiberis zerumbet 9~27, the parts by weight of nitraria schoberi 10~30.
It is preferred that above-mentioned Chinese medicine composition is made up of the bulk drug of following parts by weight:The parts by weight of Yunnan astragalus 8~10, the open country of falling root
13~16 parts by weight of Soviet Union, the parts by weight of evil mind kiss-me 7~9, the parts by weight of Rhizoma Zingiberis zerumbet 10~12, the parts by weight of nitraria schoberi 11~13.
A kind of Chinese medicine composition is used to prevent and treat the pseudoabies of piglet, PCV-II or Haemophilus parasuis in preparation
Purposes in the medicine of infection or two or more mixed infections;Wherein, the Chinese medicine composition by following parts by weight bulk drug system
Into:The parts by weight of Yunnan astragalus 7~21,11~33 parts by weight of the open country of falling root Soviet Union, the parts by weight of evil mind kiss-me 6~18, Rhizoma Zingiberis zerumbet 9~27
Parts by weight, the parts by weight of nitraria schoberi 10~30.
It is preferred that above-mentioned Chinese medicine composition is made up of the bulk drug of following parts by weight:The parts by weight of Yunnan astragalus 8~10, the open country of falling root
13~16 parts by weight of Soviet Union, the parts by weight of evil mind kiss-me 7~9, the parts by weight of Rhizoma Zingiberis zerumbet 10~12, the parts by weight of nitraria schoberi 11~13.
Above-mentioned Chinese medicine composition can be prepared into powder.The Chinese medicine composition adds use in pig starter feed.
Above-mentioned Chinese medicine composition is prepared by the following method to obtain:
By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, 7~8 times of amounts of dosing material gross weight
Water soaks 8~12h, boils and maintains 1-2h, filters, and 5~6 times of dosing material gross weight measures water to filter residue again, boils and maintains 0.5-1h,
Filtering, merge filtrate twice, be condensed into medicinal extract.
Above-mentioned traditional Chinese powder medicine is prepared by the following method to obtain:
By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, 7~8 times of amounts of dosing material gross weight
Water soaks 8~12h, boils and maintains 1-2h, filters, and 5~6 times of dosing material gross weight measures water to filter residue again, boils and maintains 0.5h-
1h, filtering, merge filtrate twice, concentration, dry, pulverize.
Above-mentioned piglet health care growth promotion Chinese medicine composition adds in feed, reaches growth promotion and can and prevents and treats young pseudorabies
The infectious diseases such as disease, smoothing filter operator, Haemophilus parasuis or the purpose of two or more mixed infections.
Dosage and method:300-700g of the present invention, preferably 500g are added in feed per ton, is well mixed, freely adopts
Food.Said composition solves that Chinese medicine crushed material palatability is poor, addition is big, curative effect is single, it is impossible to adapts to piglet virus, bacterium mixes
Close the deficiency of infection.
Beneficial effects of the present invention:The present invention draws traditional Chinese veterinary medicine marrow;Yunnan astragalus, it is legume Yunnan astragalus
Astragatus yunnanensis Franch. root, function have invigorating qi for strengthening superficies, yang invigorating, torr sore myogenic.Cure mainly weak
Weak, deficiency of food receives difference, protracted dysentery chronic diarrhea, spontaneous sweating, anaemia, oedema, the prolapse of uterus, prolapse of the anus, chronic ulcer.The open country of falling root is revived, and is
Labiate rabdosia japonica Rabdosia japonica (Burm.f.) Hara var glaucocalyx (Maxim) Hara
Herb or leaf.Function has clearing heat and detoxicating, stomach strengthening and digestion promoting.Wrist abdominal distention and pain is cured mainly, food stagnation is indigestion and loss of appetite, hypochondriac pain jaundice, cold, fever, breast
Carbuncle, snake bite and insect sting.Evil mind kiss-me, it is saxifragaceae plant Herba Saxifragae melanocentrae Saxifra melanocentra Franch's
Herb, function have clearing heat and promoting diuresis, activating blood circulation and reducing swelling.Cure mainly jaundice with damp-heat pathogen, traumatic injury, cough, red eye, swell pain, carbuncle sore tumefacting virus.It is red
Ball ginger is zingiberaceous plant Rhizoma Zingiberis zerumbet Zergiber zerumbet (T.) smith. rhizome, and function has promoting blood circulation, and promoting the circulation of qi stops
Bitterly, warming middle energizer to stop diarrhea, consumer product dredge stasis.Cure mainly various hemostasis diseases caused by irritability stasis, energy-stagnation stomachache, diarrhoea, indigestion, food stagnation
Gastral cavilty.Nitraria schoberi is zygophyllaceae plant nitraria schoberi Nitraria sibirica Pall. fruit, and function has strengthening the spleen and stomach,
Replenishing qi and blood.Cure mainly spleen eating less, indigestion, qi-blood deficiency is in poor health.5 kinds of compatibility of drugs, the pseudo- mad dog of piglet can be prevented and treated
Virus, the infection of bacterium or the two or more mixed infections such as disease, PCV-II or Haemophilus parasuis, also growth promotion are made
With, while it is safe to use, have no toxic side effect.
Below further illustrated with regard to effect experiment the effect of of the invention.
First, the present invention is to pig growth promotion feeding experiment
1st, experimental animal:The similar 30 age in days DLYs hybridization wean pig 80 of selection parity, age in days, male and female half and half, with
Machine is divided into 4 groups, every group 20, pre- feeding 10 days, formally starts to test.
2nd, method:4 group basal diets are identical, and the 1st group is added 700 grams of Chinese medicine composition of the present invention in feed per ton
(being prepared by embodiment 1, be set to high dose group), the 2nd group is added 500 grams of Chinese medicine composition of the present invention (by real in feed per ton
Apply example 1 to prepare, be set to middle dose group), the 3rd group is added 300 grams of Chinese medicine composition of the present invention (by embodiment 1 in feed per ton
Prepare, be set to low dose group), the 4th group is only fed basal diet feed (being set to control group), is not added with any medicine.Free water with
Feeding, 40 days experimental periods.Experimental basis feed formula is shown in Table 1
The basal diet feed formula of table 1 and trophic level (%)
3rd, feeding management:
(1) sterilize:Before being enclosed in test pig, colony house is sterilized with 10% Betagen Solution, and test pig body surface is new clean with 0.1%
You go out sterilization.
(2) trial test:After test pig packet, start prerun, 10 days preliminary trial periods, feed and formal examination on March 9th, 2017
The feed tested is identical.
(3) formal test:On March 19th, 2017, morning 7:00 claims initial weight, morning 7 on April 18th, 2017 on an empty stomach:00 is empty
Abdomen claims end weight, totally 40 days, accurate recording feed intake, the situation such as the spirit of pig, fur, excrement, breathing.
(4) for test pig under identical feeding and management condition, special messenger is responsible for record data.
4th, content is tested:Weightening, feed consumption, feedstuff-meat ratio, health status, specific data are shown in Table 2.Taken a blood sample before off-test, point
From serum, total protein, albumin, globulin content in serum are determined, the XD811 of medical instrument companies' production is reached using upper Hisoon
Semi-automatic biochemical analyzer, using scattering speed turbidimetry for Determination, measure kit is purchased from health Bioisystech Co., Ltd of Erie,
Serum Indexes measurement result is shown in Table 3.
Diarrhoea criterion:Every morning 8:00 timing observation piglet excrement situation, excrement be divided into normal, loose stool, it is sticky,
5 grades of water sample and bloody stool, rear 4 grades are judged to suffer from diarrhoea.
Test data sheet:Every group of diarrhea of pigs head is recorded, calculates diarrhea rate (diarrhea rate=diarrhoea piglet head/total head of piglet
Number)
Influence of the compound traditional Chinese medicine composite of table 2 to Production Performance of Weaning Pigs
Note:Compared with control group, * ﹤ 0.05.
From table 2, middle dose group effect is best, improves 20.53% than control group daily gain, significant difference (P ﹤
0.05), diarrhea rate declines 68.29% (P ﹤ 0.05).High dose group, low dose group are respectively increased than control group daily gain
6.86%th, 9.77%, difference is not notable (P ﹥ 0.05).Diarrhea rate declines 63.41% significant difference (P ﹤ 0.05), 21.95%, poor
Different not notable (P ﹥ 0.05).
Influence of the compound traditional Chinese medicine composite of table 3 to piglet haemocyanin index
Note:Compared with control group, * ﹤ 0.05
From table 3 it can be seen that compared with control group, compound traditional Chinese medicine composite high dose group total protein, albumin, globulin
13.81%, 12.42%, 15.35% is respectively increased, difference is not notable (P ﹥ 0.05).Compound traditional Chinese medicine composite middle dose group is distinguished
29.88%, 33.81%, 15.27% is improved, difference is extremely significantly (P ﹤ 0.01).Compound traditional Chinese medicine composite low dose group is respectively increased
11.63%th, 7.45%, 15.27%, difference is not notable (P ﹥ 0.05).Haemocyanin improves, display body's resistance to disease enhancing.
2nd, the external resisting pstudorabies Viral Assay research of the present invention
1st, the age in days of chicken embryo 10 is non-exempts from chicken embryo for experiment, is purchased from emerging great Hua Nong birds, beasts and eggs Co., Ltd.
2nd, pseudorabies sickly look A strains AV25 strains are provided by China Veterinery Drug Inspection Office, strain normal saline dilution,
Be inoculated with it is non-exempt from chicken embryo, collect allantoic fluid, be for experiment.The HA potency of chick embryo allantoic liquid is 7log2。
3rd, this experiment of medicine is using the present composition as test drug;Ribavirin injection is that Western medicine compares medicine, by
The favorable to the people pharmaceutical Co. Ltd's production in Jinan, is made into 0.05g/mL concentration.Tannic acid is produced by Shanghai Ling Feng chemical reagent Co., Ltd.
4th, the preparation adult Balb/c mouse of experimental animal and red blood cell, are purchased from south China agricultural university animal experimental center.It is red thin
The preparation of born of the same parents:Eyeball of mouse is cut off with eye scissors, exposure optical fundus blood vessel, few drops is taken a blood sample in the centrifuge tube added with anti-coagulants, uses
PBS is washed 3 times, is then made into 10% red blood cell with PBS, is uniformly mixed in equal volume with 1/40000 concentration tan-liquor, in 37 DEG C
Effect centrifuges for 1 hour, then wash 3 times, is centrifuged with 1500r/min, each 5min with PBS, add during use PBS be made into 1% it is red carefully
Born of the same parents' suspension.
5th, experiment packet 40 pieces of instar chicken embryo on the 10th, is randomly divided into 4 groups, specific packet situation is shown in Table 4.
The chicken embryo of table 4 is grouped situation
6th, test method
(1) viral allantoic fluid is diluted different multiples by median lethal dose measure, and inoculation is non-to exempt from chicken embryo, show that embryo's half causes
Dead amount.By measure, the dilution factor of chicken embryo virus allantoic fluid median lethal dose is 1: 50, and formal test is inoculated with dilution factor with 1: 25
Allantoic fluid.
(2) toxicity trial Chinese medicine original liquid physiological saline makees doubling dilution, by Chinese medicine stoste and various concentrations
Decoction is inoculated in 3 piece of 10 age in days chick embryo allantoic cavity respectively, every 0.2mL, puts 37.8 DEG C of incubations 72 hours, observation daily
Survival condition, the highest liquor strength that chicken embryo is all survived is formal test initial concentration, while sets saline control group, medicine
Thing is shown in Table 5 to embryonic toxicity result of the test.
The Chinese medicine of table 5 is to embryonic toxicity experimental result (n=4)
★ denominators are inoculation embryo number, and molecule is survival embryo number.
(3) inhibitory action that medicine of the present invention is bred to porcine pseudorabies virus is determined with 1:The dilution factor of 25 allantoic fluids and
Foundation of the drug concentration of table 2 as inoculation.Specific method is as follows.
Test I group of each chick embryo allantoic cavity while be inoculated with medicine of the present invention and (be prepared 1 by the method for embodiment 1:5 dilutions
Stoste) 0.2mL, viral dilution liquid 0.1mL.
Test II group of each chick embryo allantoic cavity while meet Ribavirin 0.2mL, viral dilution liquid 0.1mL.
Test III group of each chick embryo allantoic cavity while be inoculated with physiological saline 0.2mL, viral dilution liquid 0.1mL.
IV group of blank control group is tested, virus inoculation, is not administered.
Above-mentioned chicken embryo is incubated in 37.8 DEG C of insulating boxs, shines egg daily 2~3 times, discards dead germ in 24 hours.It is small to collect 72
Shi Yihou work embryo and 24~72 hours dead germ allantoic fluids, Cord blood are standby.With every group of chicken embryo urine of blood clotting (HA) testing inspection
The virus titer of cyst fluid.
7th, the inhibitory action that Chinese medicine is bred to porcine pseudorabies virus
Dead 1 piece at 24~72 hours of Ith group of chicken embryo, survive 9 pieces within 72 hours, collect 1 piece of dead chicken embryo and 9 pieces of survivals
Chick embryo allantoic liquid, HA titres be 0.
Dead 10 pieces at 24~72 hours of IIth group of chicken embryo, 72 hours without survival, the allantoic fluid of 10 pieces of dead germs of collection, HA drops
Spend for 6log2。
Dead 10 pieces at 24~72 hours of IIIth group of chicken embryo, 10 pieces of dead germ allantoic fluids are collected, HA titres are 8log2。
IVth group in 72 hours without chicken embryo death, collect all embryo allantoic liquids living, HA titres are 0, and detailed results are shown in Table
6。
The inhibitory action measurement result that the Chinese medicine of table 6 is bred to porcine pseudorabies virus
Compared with the IIIth group, * * P < 0.01
3rd, the present invention is to virus and the prevention result of bacteria mixed infection
Jiangsu Taizhou Xinghua pig farm, feeding mother pig, on October 10th, 2016, weanling pig 320 is not bought back from market,
It is divided into 2 groups, the 1st group of 200 piglets, is added after buying back with Chinese medicine composition of the present invention (being prepared by embodiment 2) in feed per ton
Add 500 grams of progress health cares, buy back 30 days, observation swinery is more stable always daily, without any abnormal appearance.2nd group of 120 sons
Pig Amoxicillin health care, feed per ton add 750 grams, and since October 15, the 2nd group had indivedual temperature of pig body to rise to 40.6 DEG C
Left and right, there is spiritual depressed, anorexia.October 19, full mass-sending disease, performance breathe fast, rubefaction, diarrhoea, groin
Enlargement of lymph nodes.Cut open inspection 4;Cut open inspection changes:The visible hydropericardium of sick pig cut open inspection;Lymph nodes of body as a whole enlargement, particularly groin
Lymph node and submandibular lymph nodes, section are turned up, and have weak yellow liquid outflow;Lungs are in diffusivity interstitial pneumonia, have part be in
Pancreas sample meat becomes;Hydroabdomen, each internal organs adhesion, has albumen to ooze out;The slight enlargement of spleen, kidney is pale, and quality becomes fragile, Ge Bieyou
Tip-like blutpunkte;There is part pig liver enlargement, yellow is presented;There is part pig stomach mucous membrane ulcer occur;Arthroedema has light
Yellow liquid oozes out.
Laboratory diagnosis
1st, Viral diagnosis:Collection sick dead pig pathological material of disease is sent to Yangzhou University and carries out Pathogen test, have detected pig circular ring virus 2 respectively
Malicious 2 types (PCR method), porcine reproductive and respiratory syndrome virus (RT-PCR method), PRV (PCR method), swine fever
Viral (RT-PCR method), as a result only detection has PCV-II, and other viruses do not detect.
2nd, bacteriodiagnosis
(1) Bacteria Culture is sterile takes sick pig lungs, joint fluid, chambers of the heart hydrops and cardiac blood to be inoculated in TSA (to contain 5% calf
Cow's serum, 0.005%NAD) solid medium, it is inverted in culture 36h~48h in 37 DEG C of incubators.Bacterium colony on solid medium
Form for circle, grey, it is translucent, it is smooth moisten, tip-like size;Bacterium is through Gram's staining, visible list under microscope
Individual rod-short or the gramnegative bacterium of short chain shape.
(2) bacteria bio experiment intersects on sheep blood agar plate with staphylococcus first to the bacterium isolated and purified
Line, the hemolytic of its NAD dependence of culture identification, reselection is dependent on NAD but the progress of the bacterium without hemolytic is other
Biochemical identification.Every biochemical identification result meets the feature of haemophilus parasuis reference culture, as a result shows that the separation is thin
Bacterium is haemophilus parasuis.
3rd, treatment:It is dead to October 29 with Florfenicol and Effect of APS in Treating after 2nd group of 120 pigs morbidity
58, the death rate 48.3%, cause very big economic loss.
4th, safety testing
For the toxic side effect of Chinese medicine composition clearly of the present invention, and accurate, objective appraisal is made to its security, be
Clinical application provides scientific basis, it is ensured that drug safety, has carried out the toxicity test of the Chinese medicine composition.
Acute toxicity test:By (being prepared by embodiment 2) LD that Chinese medicine composition is carried out to ICR mouse50Most
Big tolerance test shows that after dosage is designed by oral administration, each group mouse behavior sign is normal in 8 days, does not occur nosotoxicosis
Shape and death.Therefore LD can not be determined50, and have to be using maximum dosage-feeding 60g/kg as maximum dose level.After 10th day slaughters, each group
The internal organs such as the liver,kidney,spleen of mouse, lung are without lesion.
Long term toxicity test:From SD rats 24, it is divided into 3 groups, every group 8, male and female half and half, gives various dose
The Chinese medicine preparation (being prepared by embodiment 1) of the invention of (30.0,15.0,7.5g crude drugs/kg), daily perfusion once, even
It is continuous 30 days.Three dosage group animal animations of the present invention are good, appearance sign, behavioral activity, food-intake and body weight increase
Change without exception.The internal organs such as the liver,kidney,spleen of each group rat, lung are without lesion.Show the Chinese medicine composition have no toxic side effect and
Adverse reaction, clinical practice are safe and reliable.
Embodiment
With reference to specific embodiment, the invention will be further described:
Embodiment 1
Prescription:Yunnan astragalus 9g, the open country of falling root Soviet Union 13g, evil mind kiss-me 8g, Rhizoma Zingiberis zerumbet 11g, nitraria schoberi 12g.
Specific preparation process is as follows:
By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, add up medicinal material and weigh 7 times of water loggings
10h is steeped, 1h is maintained after boiling, is filtered, filter residue adds up medicinal material and weighs 5 times of water again, and 30min is maintained after boiling, and filtrate merges twice,
The medicinal extract that density is 1.15 is obtained after 90 DEG C of condition concentrations, dry cream is dried to obtain, crushes and produce powder.
Embodiment 2
Prescription:Yunnan astragalus 8g, the open country of falling root Soviet Union 16g, evil mind kiss-me 7g, Rhizoma Zingiberis zerumbet 12g, nitraria schoberi 11g.
Specific preparation process is as follows:
By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, add up medicinal material and weigh 8 times of water loggings
12h is steeped, 1h is maintained after boiling, is filtered, filter residue adds up medicinal material and weighs 6 times of water again, and 30min is maintained after boiling, and filtrate merges twice,
The medicinal extract that density is 1.15 is obtained after 90 DEG C of condition concentrations, dry cream is dried to obtain, crushes and produce powder.
Embodiment 3
Prescription:Yunnan astragalus 14g, the open country of falling root Soviet Union 22g, evil mind kiss-me 12g, Rhizoma Zingiberis zerumbet 18g, nitraria schoberi 20g.
Specific preparation process is as follows:
By Yunnan astragalus, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, add up medicinal material and weigh 7 times of water immersion 10h, boil
After maintain 1h, filter, filter residue adds up medicinal material and weigh 5 times of water again, and 30min is maintained after boiling, and filtrate merges twice, dense in 90 DEG C of conditions
The medicinal extract that density is 1.15 is obtained after contracting, dry cream is dried to obtain, crushes and produce powder.
Embodiment 4
Prescription:Yunnan astragalus 21g, the open country of falling root Soviet Union 33g, evil mind kiss-me 16g, Rhizoma Zingiberis zerumbet 27g, nitraria schoberi 30g.
Specific preparation process is as follows:
By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, add up medicinal material and weigh 8 times of water loggings
8h is steeped, 1.5h is maintained after boiling, is filtered, filter residue adds up medicinal material and weighs 6 times of water again, and 1h is maintained after boiling, and filtrate merges twice, 90
The medicinal extract that density is 1.15 is obtained after the concentration of DEG C condition, (first begin to rehearse blower fan, then opens air inlet fan for spray drying.Then steam is opened
Valve, when waiting that temperature is to 110 DEG C in tower, open high pressure homogenizer and dusted), produce powder.
Claims (8)
- A kind of 1. purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care;Wherein, the Chinese medicine composition It is made up of the bulk drug of following parts by weight:The parts by weight of Yunnan astragalus 7~21,11~33 parts by weight of the open country of falling root Soviet Union, evil mind kiss-me 6 ~18 parts by weight, the parts by weight of Rhizoma Zingiberis zerumbet 9~27, the parts by weight of nitraria schoberi 10~30.
- 2. purposes according to claim 1, it is characterised in that the Chinese medicine composition is made up of the bulk drug of following parts by weight: The parts by weight of Yunnan astragalus 8~10,13~16 parts by weight of the open country of falling root Soviet Union, the parts by weight of evil mind kiss-me 7~9, the weight of Rhizoma Zingiberis zerumbet 10~12 Measure part, the parts by weight of nitraria schoberi 11~13.
- 3. a kind of Chinese medicine composition is preparing the sense of the pseudoabies, PCV-II or the Haemophilus parasuis that are used for preventing and treating piglet Purposes in dye or the medicine of two or more mixed infections;Wherein, the Chinese medicine composition is made up of the bulk drug of following parts by weight: The parts by weight of Yunnan astragalus 7~21,11~33 parts by weight of the open country of falling root Soviet Union, the parts by weight of evil mind kiss-me 6~18, the weight of Rhizoma Zingiberis zerumbet 9~27 Measure part, the parts by weight of nitraria schoberi 10~30.
- 4. purposes according to claim 3, it is characterised in that the Chinese medicine composition is made up of the bulk drug of following parts by weight: The parts by weight of Yunnan astragalus 8~10,13~16 parts by weight of the open country of falling root Soviet Union, the parts by weight of evil mind kiss-me 7~9, the weight of Rhizoma Zingiberis zerumbet 10~12 Measure part, the parts by weight of nitraria schoberi 11~13.
- 5. the purposes according to claim 1 or 3, it is characterised in that the Chinese medicine composition is prepared into powder.
- 6. the purposes according to claim 1 or 3, it is characterised in that the Chinese medicine composition is to be prepared by the following method to obtain 's:By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, 7~8 times of amount water loggings of dosing material gross weight 8~12h is steeped, boils and maintains 1-2h, is filtered, 5~6 times of dosing material gross weight measures water to filter residue again, boils and maintains 0.5-1h, mistake Filter, merge filtrate twice, be condensed into medicinal extract.
- 7. purposes according to claim 5, it is characterised in that the traditional Chinese powder medicine is prepared by the following method to obtain:By Yunnan astragalus, the open country of falling root Soviet Union, evil mind kiss-me, Rhizoma Zingiberis zerumbet, nitraria schoberi mixing, 7~8 times of amount water loggings of dosing material gross weight 8~12h is steeped, boils and maintains 1-2h, is filtered, 5~6 times of dosing material gross weight measures water to filter residue again, boils and maintains 0.5-1h, mistake Filter, merge filtrate twice, concentration, dry, pulverize.
- 8. the purposes according to claim 1 or 3, it is characterised in that the Chinese medicine composition adds use in pig starter feed.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710575247.XA CN107375866A (en) | 2017-07-14 | 2017-07-14 | A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710575247.XA CN107375866A (en) | 2017-07-14 | 2017-07-14 | A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107375866A true CN107375866A (en) | 2017-11-24 |
Family
ID=60340816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710575247.XA Pending CN107375866A (en) | 2017-07-14 | 2017-07-14 | A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107375866A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107929426A (en) * | 2017-12-11 | 2018-04-20 | 河南惠通天下生物工程有限公司 | A kind of herbal medicine of removing dampness to stop itchin and preparation method thereof |
CN109394859A (en) * | 2018-10-15 | 2019-03-01 | 江苏农牧科技职业学院 | The pharmaceutical composition and its preparation method and application for preventing and treating Haemophilus parasuis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106075241A (en) * | 2016-08-04 | 2016-11-09 | 江苏农牧科技职业学院 | A kind of piglet health care growth promotion Chinese medicine composition and preparation method thereof |
-
2017
- 2017-07-14 CN CN201710575247.XA patent/CN107375866A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106075241A (en) * | 2016-08-04 | 2016-11-09 | 江苏农牧科技职业学院 | A kind of piglet health care growth promotion Chinese medicine composition and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107929426A (en) * | 2017-12-11 | 2018-04-20 | 河南惠通天下生物工程有限公司 | A kind of herbal medicine of removing dampness to stop itchin and preparation method thereof |
CN109394859A (en) * | 2018-10-15 | 2019-03-01 | 江苏农牧科技职业学院 | The pharmaceutical composition and its preparation method and application for preventing and treating Haemophilus parasuis |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103719623A (en) | Traditional Chinese medicine feed additive capable of preventing or relieving stress syndrome of weaned pigs and preparation method of feed additive | |
CN106822890A (en) | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application | |
CN101780153B (en) | Traditional Chinese drug composition for pig and preparation method and application thereof | |
CN102895326B (en) | Traditional Chinese medicine composition for treating infantile common cold and preparation method for traditional Chinese medicine composition | |
CN107375866A (en) | A kind of purposes of Chinese medicine composition in preparing for the somatotrophic medicine of piglet health care | |
CN106173450A (en) | Improve compound feed additive and the feedstuff of pigeon immunity | |
CN100586454C (en) | Chinese medicine composition for birds, preparing method and application of the same | |
CN103720932B (en) | One boar Chinese medicine composition and its preparation method and application | |
CN102872307A (en) | Traditional Chinese medicine oral liquid for preventing and treating virus diseases of poultry and method for preparing traditional Chinese medicine oral liquid | |
CN102670694B (en) | Traditional Chinese medicine combination for treating porcine pseudorabies and preparation method and application thereof | |
CN104435023A (en) | Traditional Chinese medicine extract and application thereof | |
CN104189231B (en) | A kind of for the antiviral Chinese medicine preparation and its preparation method that strengthen immunity | |
CN103768157A (en) | Veterinary antiviral traditional Chinese medicine Ziqi effervescent granules and preparation method thereof | |
CN106075241A (en) | A kind of piglet health care growth promotion Chinese medicine composition and preparation method thereof | |
CN103652490B (en) | Pig feed for treating blue-eared pig disease and preparation method thereof | |
CN102716327A (en) | Immunopotentiator for poultry rearing | |
CN102579622B (en) | Chinese herbal preparation for treating haemophilusparasuis and preparation method thereof | |
CN104840591B (en) | A kind of Chinese medicine composition for having effects that to prevent ewcastle disease | |
CN108743693A (en) | A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications | |
CN101390965A (en) | Veterinary traditional Chinese herb medicine for treating livestock and poultry bacterial and viral infectious diseases and preparation method thereof | |
CN101032596B (en) | Medicine for treating respiratory tract diseases for chickens and its preparing process | |
CN111588801B (en) | Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof | |
CN101194995A (en) | Proprietary Chinese medicine for treating animal virus, bacterium and mix infection | |
CN103598445B (en) | For improving the Chinese medicine composition feed addictive of chick meat | |
CN107375458A (en) | Prevent and treat Chinese medicine composition, the preparation method and application of chicken colibacillosis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171124 |