CN107375327A - A kind of purposes of composition - Google Patents
A kind of purposes of composition Download PDFInfo
- Publication number
- CN107375327A CN107375327A CN201710706215.9A CN201710706215A CN107375327A CN 107375327 A CN107375327 A CN 107375327A CN 201710706215 A CN201710706215 A CN 201710706215A CN 107375327 A CN107375327 A CN 107375327A
- Authority
- CN
- China
- Prior art keywords
- composition
- purposes
- carbonaceous material
- stomach
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
Abstract
The present invention proposes a kind of purposes of composition, composition is the medicine for treating or preventing stomach cancer, wherein composition includes a carbonaceous material and an active particle, and active particle is carried on carbonaceous material, and the material of active particle is silver, gold, zinc, copper, aluminium, palladium, platinum, nickel, cobalt, calcium, titanium, chromium or silicon.
Description
Technical field
The present invention relates to a kind of purposes of composition, composition is the medicine for treating or preventing stomach cancer.
Background technology
Counted according to the World Health Organization (World Health Organization, WHO), stomach cancer in 2015 is the whole world
4th common cancer, and the death rate is residence time in all cancers, thus it is considered as international great Health risk.Clinically, it is main
The modes such as surgical operation, radiation cure, chemotherapy or target therapy are used to treat stomach cancer.However, the whole world of stomach cancer is put down
Equal five-year survival rate represents overall therapeutic effect not as expected in less than 10%.
Therefore it is necessary to develop new medicine really to treat stomach cancer.
The content of the invention
It is an object of the invention to propose a kind of purposes of composition, composition can suppress Growth of Gastric, so as to carry
For the more various selection of curing gastric cancer.
To reach above-mentioned and/or other purposes, the present invention proposes a kind of purposes of composition, and composition is to be controlled for preparing
The medicine of stomach cancer is treated or prevents, wherein composition includes a carbonaceous material and an active particle, and active particle is to be carried on carbon
On material, and its material is silver, gold, zinc, copper, aluminium, palladium, platinum, nickel, cobalt, calcium, titanium, chromium or silicon.
According to the present invention, this medicine administering to have treatment or prevention demand in vivo after, it is thin that carbonaceous material can adsorb stomach cancer
Born of the same parents are attached on stomach organization.Further, since stomach cancer cell surface carries a large amount of negative electricity, the cation that active particle is discharged
Cell surface can be then attached to.Through this mode, the cell membrane of stomach cancer cell can be destroyed, so as to suppress Growth of Gastric.Cause
This, the composition that the present invention is carried is really potential as the medicine for treating or preventing stomach cancer.
Brief description of the drawings
Fig. 1 is one scan formula electron microscope (scanning electron microscope, SEM) photo figure, display
The outward appearance (X100,000) of the composition of preparation example 1.
Fig. 2 is an optical microscope photograph figure, shows preparation examples 1 of Human Gastric carcinoma's cell MKN45 through concentration 0.1mg/mL
Outward appearance of the compositions-treated after 24 hours.
Fig. 3 is an optical microscope photograph figure, shows preparation examples 1 of Human Gastric carcinoma's cell SC-M1 through concentration 0.1mg/mL
Outward appearance of the compositions-treated after 24 hours.
Fig. 4 is an optical microscope photograph figure, shows preparation examples 1 of Human Gastric carcinoma's cell MKN45 through concentration 0.5mg/mL
Outward appearance of the compositions-treated after 24 hours.
Fig. 5 is an optical microscope photograph figure, shows preparation examples 1 of Human Gastric carcinoma's cell SC-M1 through concentration 0.5mg/mL
Outward appearance of the compositions-treated after 24 hours.
Embodiment：
To allow the above-mentioned and/or other purposes of the present invention, effect, feature to become apparent, better embodiment cited below particularly,
Elaborate under：
One embodiment of the present invention proposes that a kind of composition is used to prepare the medical purposes for treating or preventing stomach cancer, this
Composition contains a carbonaceous material and an active particle, and active particle is is carried on carbonaceous material, and its material be silver,
Gold, zinc, copper, aluminium, palladium, platinum, nickel, cobalt, calcium, titanium, chromium or silicon.This medicine administering to have treatment or prevention demand in vivo after,
Carbonaceous material can adsorb stomach cancer cell or be attached on stomach organization.Moreover, stomach cancer cell surface carries a large amount of negative electricity, thus it is active
The cation that particle is discharged can be attached to cell surface and destroy cell membrane.Through this mechanism, it is thin that this medicine can suppress stomach cancer
Intracellular growth treats or prevents the purpose of stomach cancer to reach.
Term used herein treats a word and means to reach reduction, slow down or terminate growth of tumour cell, spread or turn
The purpose of shifting；Term used herein treats a word and means to reach the purpose for taking precautions against growth of tumour cell, diffusion or transfer；This
The word of term stomach cancer one used in text means sdenocarcinoma of stomach (gastric adenocarcinoma), gastrointestinal stromal knurl
(gastrointestinal stromal tumor, GIST) or stomach lymph cancer (gastric lymphoma).
In addition, the example of carbonaceous material can be but be not limited to activated carbon fiber, activated carbon powder, charcoal, bamboo charcoal grain, carbon black,
Graphite powder, expanded graphite powder, graphene, carbon dust made of nm carbon dust or phenolic resin or artificial resin.In this embodiment party
Formula, with the gross weight meter of composition, the percentage by weight of carbonaceous material and active particle can be respectively 80% to 99.9999% with
0.0001% to 20%, preferably respectively 85% to 99.9999% and 0.0001% to 15%.
In present embodiment, the BET specific surface area of carbonaceous material can be 10 to 2500m2/ g, preferably 600 to
1800m2/g。
In present embodiment, the particle diameter of active particle can be 1nm to 500 μm, preferably 5nm to 200 μm.
According to Examples below, this medicine administering to the effective dose of individual is daily per kilogram individual 0.1 to 30g, compared with
Goodly for daily per kilogram individual 0.1 to 24g, be more preferably daily per kilogram individual 0.1 to 1g.
In addition, this medicine can orally or tumour administers to individual and and different dosage forms can be presented in vivo, such as：Capsule, lozenge,
Powder, suspension or emulsion.To allow medicine that different dosage forms are presented,
This composition can more contain an additive, such as：Nutritional agents (vitamin), flavor enhancement (citric acid, malic acid, second
Acid or lactic acid), sweetener (glucose, oligosaccharides, fructose, maltose, Aspartame, saccharin, sucrose essence, vinegar sultone potassium, radix glycyrrhizae
Alcohol, acesulfame potassium, stevioside, glycyrrhizin, D-sorbite, maltitol or xylitol), sticky dose (Clear powder, albumen, card Derain glue,
Carboxymethyl cellulose, sodium alginate, antler glue, sodium carboxymethylcellulose, acidified starch, gelatinized starch, bleaching starch, oxidation
Starch, acetic starch or starch phosphate), solvent (propane diols or glycerine), emulsifying agent (fatty glyceride) or moisture controlling agent
(sorbierite, lactic acid, glycerine, hexitol or propane diols).
In addition, to lift the absorption of stomach cancer cell, carbonaceous material can more have an at least hole.In general, carbonaceous material
Material is in addition to adsorbing stomach cancer cell, and also adsorbable other normal cells or benefit materials are (such as：Vitamin, ferment or probiotics).
In avoiding adsorbing other normal cells or benefit materials, the radius of hole is less than 2.5nm, and preferably 0.5 to 2.3nm.It is again
Convenient administering medicine to it is individual in vivo, in carbonaceous material under the conditions of granular, its particle diameter may be greater than 1nm but less than 3mm；
Carbonaceous material under conditions of bar-shaped, its length may be greater than 1nm but less than 3mm, and its cross-sectional diameter may be greater than 1nm but
Less than 3mm；Under conditions of carbonaceous material is irregular, its maximum length may be greater than 1nm but less than 3mm.It is again offer
The different degrees of hydrophily of medicine, carbonaceous material can more have different acidic groups or alkali base；On this condition, acidic groups or
Alkali base content can be more than 0.3mEq/g.
Being manufactured in for composition on present embodiment is detailed below：
First, there is provided a living solution, it contains an active salt.Active salt comes mainly as consequent activities particle
Source, its concentration can be but be not limited to 0.00001M to 20M, and example can be but be not limited to silver salt, gold salt, zinc salt, mantoquita, aluminium
Salt, palladium salt, platinum salt, nickel salt, cobalt salt, calcium salt, titanium salt, chromic salts or silicon salt.Specifically, active salt can be for halide salt (such as：
Silver fluoride, silver chlorate, silver bromide or silver iodide), acetate (such as：Silver acetate), nitrate (such as：Silver nitrate, copper nitrate or nitric acid
Zinc), phosphate (such as：Silver orthophosphate) or sulfonate is (such as：Sulfonic acid silver).To allow the active particle subsequently obtained to be uniformly distributed in carbon
On material, living solution can more contain a reducing agent, and the example can be but be not limited to glacial acetic acid, ammoniacal liquor, ascorbic acid or Portugal
Grape sugar.
Secondly, leaching puts carbonaceous material into living solution or sprays living solution to carbonaceous material.Carry out leaching and put step
When, carbonaceous material can be soaked with stirring about 0.5 to 24 hour in living solution, be preferably about 1 to 12 hour.In addition, with
The gross weight meter of living solution and carbonaceous material, the percentage by weight of active salt and carbonaceous material can be respectively 0.01% to
1% and 0.01% to 30%.Under conditions of living solution contains reducing agent, with the gross weight of living solution and carbonaceous material
Meter, active salt, reducing agent, can be respectively 0.01% to 1% with the percentage by weight of carbonaceous material, 0.01% to 30%, with
0.01% to 30%.
Then, heated drying living solution makes active salt be attached on carbonaceous material., can be by work when carrying out heated drying step
Property solution is maintained at 80 to 500 DEG C about 0.5 to 6 hour, is preferably about 1 to 4 hour.
Then, thermal cracking activity salt makes it be reduced into active particle and obtains composition., can when carrying out cracking step
Active salt is maintained at 200 to 1000 DEG C about 0.5 to 10 hour.In addition, thermal cracking can exist in nitrogen or inert gas
Carried out under lower or vacuum.
Then, with water cleaning combination to remove free active particle.When carrying out cleaning step, it can be rinsed and combined with water
Composition is soaked in water about 0.5 to 6 hour by thing.
Finally, heated drying composition is to remove moisture removal.When carrying out heated drying step herein, composition can be maintained at 80
About 0.5 to 6 hour to 120 DEG C.
Hereby with following embodiments, embodiment of above is illustrated：
Preparation example 1
First, there is provided a polyacrylonitrile (polyacrylonitrile, PAN) is activated carbon fiber cloth, and feature is as follows：BET
Specific surface area 1,100m2/ g, the weight % of carbon content 80.7.Then, fiber cloth is soaked in 2 in 0.0025M silver nitrate aqueous solutions
After hour, heated drying fiber cloth 2 hours, make silver nitrate be attached in fiber cloth at 100 DEG C.In the presence of 600 DEG C and nitrogen
Thermal cracking silver nitrate, it is reduced into Argent grain and be attached in fiber cloth.Afterwards, fiber cloth is cleaned 2 hours with water to remove
Free Argent grain.Then, heated drying fiber cloth and Argent grain attached to it are to remove moisture removal.Finally, milled fibre cloth
To obtain a composition (as shown in Figure 1), this composition contains Argent grain and carries the activated carbon fiber powder of Argent grain, and
The feature of this composition is as follows：The weight % of carbon content 78.1, silver content 0.3 weight %, below length 0.1mm, BET specific surface area
980m2/ g, the hole diameter 2.41nm of activated carbon fiber powder, below the particle diameter 100nm of Argent grain.
Preparation example 2
First, there is provided a polyacrylonitrile activated carbon fiber cloth, feature are as follows：BET specific surface area 1,100m2/ g, carbon contain
Measure 80.7 weight %.Then, fiber cloth is soaked in 0.0025M silver nitrates and 0.0025M copper nitrate aqueous solutions after 2 hours,
Heated drying fiber cloth 2 hours at 100 DEG C, silver nitrate is set to be attached to copper nitrate in fiber cloth.In the presence of 600 DEG C and nitrogen
Thermal cracking silver nitrate and copper nitrate, it is reduced into Argent grain and copper particle and be attached in fiber cloth.Afterwards, cleaned with water fine
Cloth is tieed up 2 hours to remove free Argent grain and copper particle.Then, heated drying fiber cloth and Argent grain and copper attached to it
Particle is to remove moisture removal.Finally, for milled fibre cloth to obtain a composition, this composition contains Argent grain, copper particle, with carrying
There is the activated carbon fiber powder of Argent grain and copper particle, and the feature of this composition is as follows：The weight % of carbon content 78.0, silver content
0.32 weight %, copper content 0.30 weight %, below length 0.1mm, BET specific surface area 980m2/ g, activated carbon fiber powder
Hole diameter 2.41nm, below the particle diameter 100nm of Argent grain, below the particle diameter 200nm of copper particle.
Analyze example 1
According to International Organization for standardization (International Organization for Standardization, ISO)
10993-5:2009 (E) specifications, the composition of each example and mouse fibroblast L-929 is taken to cultivate 24 hours to carry out toxicity point
Analysis, and the dosage of composition is the cumulative volume of 24mg/1mL cells and nutrient solution.As shown in table 1, the composition of each example is in high agent
To normal cell without significant toxicity under amount.
The toxicity of composition obtained by table 1, each example to mouse fibroblast
Analyze example 2
After the composition of preparation example 1 and Human Gastric carcinoma's cell MKN45 or SC-M1 are cultivated 24 hours, progress MTT (3- (4,
5-Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide) analysis, its middle dosage such as institute of table 2
Show, its be 1mL cells and nutrient solution cumulative volume under composition weight.As shown in Fig. 2 to 5 and table 2, the combination of preparation example 1
Thing has significant toxicity under low dosage to Human Gastric carcinoma's cell.It is anticipated that the composition of preparation example 1 is such as analyzing example 1
There must be significant toxicity under shown high dose to Human Gastric carcinoma's cell.
Table 2, the composition of the gained of preparation example 1 are under various dose to the toxicity of Human Gastric carcinoma's cell
In summary, illustrate that the composition of present embodiment is really potential as the doctor for treating or preventing stomach cancer
Medicine.
Only as described above, only presently preferred embodiments of the present invention, but the scope that the present invention is implemented can not be limited with this；
Therefore all simple equivalent changes and modification made according to scope of the present invention patent and description of the invention content, all still belong to this
In the range of patent of invention covers.
Claims (10)
1. a kind of purposes of composition, composition is the medicine for treating or preventing stomach cancer, it is characterised in that said composition includes：
One carbonaceous material；And
One active particle, be carried on the carbonaceous material, and the material of active particle be silver, gold, zinc, copper, aluminium, palladium, platinum, nickel,
Cobalt, calcium, titanium, chromium or silicon.
2. a kind of purposes of composition as claimed in claim 1, it is characterised in that the stomach cancer is selected from by sdenocarcinoma of stomach, stomach and intestine
The group that road stromal tumor and stomach lymph cancer are formed.
3. a kind of purposes of composition as claimed in claim 1, it is characterised in that the carbonaceous material is selected from fine by activated carbon
Dimension, activated carbon powder, charcoal, bamboo charcoal grain, carbon black, graphite powder, expanded graphite powder, graphene, nm carbon dust, phenolic resin and artificial
The group that carbon dust made of resin is formed.
4. a kind of purposes of composition as claimed in claim 1, it is characterised in that the particle diameter of the active particle is 1nm to 500
μm。
5. a kind of purposes of composition as claimed in claim 1, it is characterised in that medicine administering to one has treatment or prevention
The individual effective dose of demand is daily per kilogram individual 0.1 to 30g.
6. a kind of purposes of composition as claimed in claim 1, it is characterised in that with the gross weight meter of said composition, the carbon
The percentage by weight of material is 80% to 99.9999%, and the percentage by weight of the active particle is 0.0001% to 20%.
A kind of 7. purposes of composition as claimed in claim 1, it is characterised in that the carbonaceous material has an at least hole,
The radius of the hole is less than 2.5nm.
8. a kind of purposes of composition as claimed in claim 1, it is characterised in that the BET specific surface area of the carbonaceous material is
10 to 2500m2/g。
9. a kind of purposes of composition as claimed in claim 1, it is characterised in that in the carbonaceous material be granular condition
Under, its particle diameter is more than 1nm but less than 3mm；In the carbonaceous material under conditions of bar-shaped, its length be more than 1nm but less than
3mm, and its cross-sectional diameter is more than 1nm but less than 3mm；Under conditions of the carbonaceous material is irregular, it is most greatly enhanced
Spend for more than 1nm but less than 3mm.
10. a kind of purposes of composition as claimed in claim 1, it is characterised in that said composition more contains an additive, should
Additive is selected from the group being made up of nutritional agents, flavor enhancement, sweetener, sticky dose, solvent, emulsifying agent and moisture controlling agent
Group.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710706215.9A CN107375327A (en) | 2017-08-17 | 2017-08-17 | A kind of purposes of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710706215.9A CN107375327A (en) | 2017-08-17 | 2017-08-17 | A kind of purposes of composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375327A true CN107375327A (en) | 2017-11-24 |
Family
ID=60352407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710706215.9A Pending CN107375327A (en) | 2017-08-17 | 2017-08-17 | A kind of purposes of composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375327A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316043A (en) * | 2013-06-07 | 2013-09-25 | 逢甲大学 | Medical application of composition comprising carbon material and active particles |
| WO2015015301A2 (en) * | 2013-07-31 | 2015-02-05 | Palama Ilaria El | Cancer therapy with silver nanoparticles |
-
2017
- 2017-08-17 CN CN201710706215.9A patent/CN107375327A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316043A (en) * | 2013-06-07 | 2013-09-25 | 逢甲大学 | Medical application of composition comprising carbon material and active particles |
| WO2015015301A2 (en) * | 2013-07-31 | 2015-02-05 | Palama Ilaria El | Cancer therapy with silver nanoparticles |
Non-Patent Citations (4)
| Title |
|---|
| LIN ET AL.: "Inhibition of autophagy enhances the anticancer activity of silver nanoparticles", 《AUTOPHAGY》 * |
| LIU ET AL.: "Impact of silver nanoparticles on human cells: Effect of particle size", 《NANOTOXICOLOGY》 * |
| SALEHI ET AL.: "Phytosynthesis of silver nanoparticles using Artemisia marschalliana Sprengel aerial part extract and assessment of their antioxidant, anticancer, and antibacterial properties", 《INTERNATIONAL JOURNAL OF NANOMEDICINE》 * |
| 冯权莉等著: "《微波-活性炭纤维处理有机废气》", 30 June 2017, 冶金工业出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107982534B (en) | Preparation method of chitosan/copper sulfide nano composite hollow sphere, product thereof and application thereof | |
| CN109876008B (en) | Medicine for treating tumor and preparation method and application thereof | |
| CN109394730A (en) | A kind of erythrocyte membrane package carries gambogicacid and indocyanine green albumin nano granular and its preparation method and application altogether | |
| JP2016532446A (en) | Enbu fermented food or beverage composition | |
| CN110101860A (en) | Nano metal sulfide flower of bismuth doping and preparation method thereof | |
| CN107049951B (en) | Preparation and triple integrated application of thermosensitive liposome carrying hollow gold nanoparticles and tumor therapeutic agent together | |
| CN104905237A (en) | Inonotus obliquus composite electuary and production method thereof | |
| CN1709475A (en) | Chinese medicine formulation for treating extensive anxiety, and its preparing method | |
| Dadashi et al. | Optimization, in-vitro release and in-vivo evaluation of bismuth-hyaluronic acid-melittin-chitosan modified with oleic acid nanoparticles computed imaging-guided radiotherapy of cancer tumor in eye cells | |
| CN107375327A (en) | A kind of purposes of composition | |
| CN107281492A (en) | A kind of purposes of composition | |
| JP6719715B2 (en) | Medicine to treat or prevent colorectal cancer | |
| CN101912487B (en) | Medicament for treating neuroendocrine disturbance, sexual function decline and skin aging | |
| CN110314149B (en) | Poly-pregnen-zinc tablet and preparation process thereof | |
| CN113117077B (en) | Platinum-based monatomic nanoenzyme for tumor combined treatment and preparation method thereof | |
| US9999598B1 (en) | Pharmaceutical composition for gastric cancer treatment and/or prevention | |
| CN109157531B (en) | Porous bismuth nano-microsphere and preparation method and application thereof | |
| CN202154882U (en) | Capsule containing nanometer coenzyme Q10 particles | |
| CN102688248A (en) | Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors | |
| Chen et al. | Dual-responsive targeted hollow mesoporous silica nanoparticles for cancer photodynamic therapy and chemotherapy | |
| CN112386695A (en) | Chitosan-based nano prodrug carrying indocyanine green and platinum drugs and preparation method thereof | |
| CN100391549C (en) | Medical use polyurethane film in use for bracket of human body's cavity, and preparation method | |
| CN110680921B (en) | Degradable anti-tumor nano-medicament based on hunger therapy and preparation method and application thereof | |
| Jenita Rani et al. | Eco-friendly extraction and characterization of chitosan encapsulated nanoparticles for anti-diabetic application | |
| CN1517118A (en) | Bamboo extract and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171124 |
|
| RJ01 | Rejection of invention patent application after publication |