CN107373274A - Vitamin c effervescent tablet and preparation method thereof - Google Patents
Vitamin c effervescent tablet and preparation method thereof Download PDFInfo
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- CN107373274A CN107373274A CN201710594377.8A CN201710594377A CN107373274A CN 107373274 A CN107373274 A CN 107373274A CN 201710594377 A CN201710594377 A CN 201710594377A CN 107373274 A CN107373274 A CN 107373274A
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- effervescent tablet
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 199
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229960005070 ascorbic acid Drugs 0.000 title description 3
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 99
- 239000011718 vitamin C Substances 0.000 claims abstract description 99
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 97
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 97
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 63
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 39
- 239000008103 glucose Substances 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 72
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000008187 granular material Substances 0.000 claims description 28
- 235000020717 hawthorn extract Nutrition 0.000 claims description 27
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 24
- 229920002472 Starch Polymers 0.000 claims description 22
- 235000019698 starch Nutrition 0.000 claims description 22
- 239000008107 starch Substances 0.000 claims description 22
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 12
- 238000005550 wet granulation Methods 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 3
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
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- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 241000227653 Lycopersicon Species 0.000 claims 4
- 239000006187 pill Substances 0.000 abstract description 10
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- 240000003768 Solanum lycopersicum Species 0.000 description 26
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- 150000003722 vitamin derivatives Chemical class 0.000 description 7
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 6
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of vitamin C effervescent tablet and preparation method thereof, is related to health product technology field, is mainly prepared by the following raw material according to the mass fraction：450 550 parts of vitamin C, 350 450 parts of glucose, sour 400 500 parts of agent, 350 450 parts of alkaline agent, the medicament for alleviating the existing C of replenishing vitamins on the market is mostly pill form, not only not easy to maintain and carrying, and some the elderly can not be met, children and swallow the technical problem that pill difficulty person directly takes needs, reach and be not only easy to preserve and carry, and can in water fater disintegration, it is convenient to take, work rapid, bioavilability is high, clinical efficacy can be improved, meet the elderly, children, the elderly and swallow the demand that pill difficulty person directly takes, effectively expand the technique effect of ascorbic application.
Description
Technical field
The present invention relates to health product technology field, more particularly, to a kind of vitamin C effervescent tablet and preparation method thereof.
Background technology
Vitamin C is also known as ascorbic acid, is one kind among antioxidant vitamins, and it can participate in internal hydroxylation reaction,
It is required to form bone, tooth, connective tissue and non-Epithelial cell, the normal work(of tooth, bone, blood vessel can be maintained
Can, increase the resistivity to disease.According to relevant information, vitamin C has different degrees of shortage in various crowds,
Especially person in middle and old age and teenager should more supplement some vitamin Cs in good time, to improve the immunity of itself.
The existing C of replenishing vitamins on the market medicament is mostly pill form, not only not easy to maintain and carrying, and can not
Meet some the elderly, children and swallow the needs that pill difficulty person directly takes, cause ascorbic application to be limited
System.
In view of this, it is special to propose the present invention.
The content of the invention
An object of the present invention is to provide a kind of vitamin C effervescent tablet, to alleviate existing replenishing vitamins C on the market
Medicament be mostly pill form, it is not only not easy to maintain and carry, and some the elderly can not be met, children and swallow medicine
Ball difficulty person directly takes the technical problem of needs.
Vitamin C effervescent tablet provided by the invention, mainly it is prepared by the following raw material according to the mass fraction：Vitamin
C 450-550 parts, glucose 350-450 parts, sour agent 400-500 parts, alkaline agent 350-450 parts.
Further, the vitamin C effervescent tablet is mainly prepared by the following raw material according to the mass fraction：Vitamin
C 450-500 parts, glucose 350-400 parts, tomato extract 50-75 parts, haw thorn extract 25-50 parts, water soluble starch 25-
50 parts, sour agent 400-450 parts, alkaline agent 350-400 parts.
Further, the vitamin C effervescent tablet is mainly prepared by the following raw material according to the mass fraction：Vitamin
C 470-480 parts, glucose 370-380 parts, tomato extract 65-75 parts, haw thorn extract 35-45 parts, water soluble starch 35-
45 parts, sour agent 420-430 parts, alkaline agent 370-380 parts.
Further, the sour agent in tartaric acid, malic acid, fumaric acid, citric acid or sodium citrate at least one
Kind；Preferably, the sour agent is citric acid.
Further, the alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate and calcium bicarbonate
At least one of；Preferably, the alkaline agent is sodium acid carbonate.
Further, the primary raw material also includes essence 2-5 parts according to the mass fraction.
The second object of the present invention is the provision of the preparation method of said vitamin C effervescent tablet, to alleviate existing market
Upper replenishing vitamins C medicament is mostly pill form, not only not easy to maintain and carrying, and can not meet some person in middle and old age
People, children and swallow the technical problem that pill difficulty person directly takes needs.
The preparation method of vitamin C effervescent tablet provided by the invention, comprises the following steps：
(a) vitamin C, optional tomato extract, optional haw thorn extract and sour agent are well mixed, by wet method
Pelletize and dry, the first granule is made；
(b) glucose, optional essence and alkaline agent are well mixed, by wet granulation and drying, the second particle is made
Agent；
(c) the first granule, the second granule and optional water soluble starch are well mixed, carry out tabletting, that is, be made
Vitamin C effervescent tablet.
Further, the preparation method of said vitamin C effervescent tablet also includes step (s), and the step (s) is arranged at institute
Before stating step (a), the step (s) is arranged at before the step (a), the step (s) be by vitamin C, glucose,
Optional tomato extract, optional haw thorn extract, optional essence, sour agent and alkaline agent is crushed, and crosses 80 mesh sieves.
Further, during the first granule and the second granule carry out wet granulation, used wetting agent
It is ethanol.
Further, in step (a) and step (b), dry temperature is 45-55 DEG C, preferably 50 DEG C.
Vitamin C effervescent tablet provided by the invention, by vitamin C, glucose, sour agent and alkaline agent coordinated, not only
Be easy to preserve and carry, and can in water fater disintegration, convenient to take, work rapid, bioavilability is high, it is possible to increase
Clinical efficacy, meet the elderly, children, the elderly and swallow pill difficulty person the needs of directly taking, can effectively expand
Big ascorbic application.
The preparation method of vitamin C effervescent tablet provided by the invention, technique is simple, easy to operate, is easy to carry out big industry
Production, reduce and prepare cost, improve preparation efficiency.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the invention provides a kind of vitamin C effervescent tablet, mainly by according to the mass fraction
The following raw material be prepared：Vitamin C 450-550 parts, glucose 350-450 parts, sour agent 400-500 parts, alkaline agent 350-
450 parts.
Vitamin C effervescent tablet provided by the invention, by vitamin C, glucose, sour agent and alkaline agent coordinated, not only
Be easy to preserve and carry, and can in water fater disintegration, convenient to take, work rapid, bioavilability is high, it is possible to increase
Clinical efficacy, meet the elderly, children, the elderly and swallow pill difficulty person the needs of directly taking, effectively expand dimension
Raw plain C application.
In the present invention, ascorbic typical but non-limiting mass fraction as 455,460,465,470,475,
480th, 485,490,495,500,505,510,515,520,525,530,535,540 or 545.
Vitamin C is called L-AA, is a kind of water soluble vitamin, and it has anti-oxidant, raising immunity, prevention
Cancer, heart disease, apoplexy, take care of one's teeth with gum etc..In addition, adhere to that taking vitamin C can also make dermal melanin calm
Reduce, so as to reduce blackspot and freckle, make whitening skin.
In the present invention, the typical but non-limiting mass fraction of glucose as 355,360,365,370,375,
380th, 385,390,395,400,405,410,415,420,425,430,435,440 or 445.
Glucose has critical role in field of biology, is the energy source of living cells and metabolic intermediate product,
That is biological main Energy supply material.
In the present invention, the typical but non-limiting mass fraction of sour agent as 405,410,415,420,425,430,
435th, 440,445,450,455,460,465,470,475,480,485,490 or 495.
In a preferred embodiment of the invention, sour agent is selected from tartaric acid, malic acid, fumaric acid, citric acid or citric acid
At least one of sodium, it is preferred that sour agent is citric acid.
When sour agent is citric acid, faster, the solution after dissolving is also more for the speed of obtained vitamin C effervescent tablet disintegration
Clarification.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of alkaline agent as 355,360,
365th, 370,375,380,385,390,395,400,405,410,415,420,425,430,435,440 or 445.
In a preferred embodiment of the invention, alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, bicarbonate
At least one of sodium and calcium bicarbonate, it is preferred that the alkaline agent is sodium acid carbonate.
When alkaline agent is sodium acid carbonate, the vitamin C effervescent tablet disintegration rate obtained by it faster, the solution after dissolving
More clarify.
In a preferred embodiment of the invention, vitamin C effervescent tablet is mainly by the following raw material system according to the mass fraction
It is standby to form：Vitamin C 450-500 parts, glucose 350-400 parts, tomato extract 50-75 parts, haw thorn extract 25-50 parts,
Water soluble starch 25-50 parts, sour agent 400-450 parts, alkaline agent 350-400 parts.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of tomato extract as 51,
52nd, 53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73 or 74.
Containing abundant vitamin, mineral matter, carbohydrate, organic acid and a small amount of protein in tomato, contained by it
Some has microorganism and the mineral matter element of protective effect to new blood vessel, can reduce cardiopathic breaking-out.Containing rich in tomato
Rich lycopene, it has unique oxidation resistance, can remove free radical, protects cell, prevents canceration, while also have
Pre- anti-aging, whitening fat-reducing, cancer prevention, treat anaemia and the effect of hypertension.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of haw thorn extract as 26,
27th, 28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48 or 49.
Hawthorn contains flavones, citric acid, malic acid, ascorbic acid and carbohydrate, has hypotensive, promotes stomach and intestine row's fat
Effect.The traditional Chinese medical science thinks, hawthorn can invigorating the spleen disperse accumulations, promote digestion, alleviate physical fatigue, anti-oxidant, the effect such as reducing blood lipid.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of water soluble starch as 26,
27th, 28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48 or 49.
By adding water soluble starch in vitamin C effervescent tablet provided by the invention so that vitamin C effervescent tablet collapses
Solve speed faster, effect is more stable, safer.
In a preferred embodiment of the invention, vitamin C, glucose, tomato extract, haw thorn extract, water are passed through
Soluble starch, sour agent and alkaline agent coordinated, not only vitamin C effervescent tablet is easy to carry and is drunk, and can prevent
Periodontitis, gingivitis, canker sore, strengthen the anti-stress ability and immunity of human body External Environment, preventing cold, while also have
There is the effect of pre- anti-aging, whitening is lost weight.
In a preferred embodiment of the invention, also include according to the mass fraction in the primary raw material of vitamin C effervescent tablet
Essence 2-5 parts, preferably 3 parts.
In order to cater to liking for consumer, in a preferred embodiment of the invention, essence can be added in the feed
The taste of vitamin C effervescent tablet is adjusted, such as adds lemon essence or the savory essence of fragrant citrus.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of essence as 2.2,2.4,
2.6th, 2.8,3,3.2,3.4,3.6,3.8,4,4.2,4.4,4.6 or 4.8.
According to another aspect of the present invention, present invention also offers the preparation method of said vitamin C effervescent tablet, including
Following steps：
(a) vitamin C, optional tomato extract, optional haw thorn extract and sour agent are well mixed, by wet method
Pelletize and dry, the first granule is made；
(b) glucose, optional essence and alkaline agent are well mixed, by wet granulation and drying, the second particle is made
Agent；
(c) the first granule, the second granule and optional water soluble starch are well mixed, carry out tabletting, that is, be made
Vitamin C effervescent tablet.
The preparation method of vitamin C effervescent tablet provided by the invention, technique is simple, easy to operate, is easy to carry out big industry
Production, reduce and prepare cost, improve preparation efficiency.
In a preferred embodiment of the invention, the preparation method of vitamin C effervescent tablet also comprises the following steps (s), institute
State step (s) to be arranged at before the step (a), the step (s) is to extract vitamin C, glucose, optional tomato
Thing, optional haw thorn extract, optional essence, sour agent and alkaline agent are crushed, and cross 80 mesh sieves.
By by by vitamin C, glucose, optional tomato extract, optional haw thorn extract, optional essence,
Sour agent and alkaline agent are crushed, and cross 80 mesh sieves, in order to which above-mentioned substance is easier to mix, so as to be vitamin C effervescent tablet
The stability of drug effect provides guarantee between each tablet.
In a preferred embodiment of the invention, the process of wet granulation is carried out in the first granule and the second granule
In, used wetting agent is ethanol, and preferably concentration is 70% ethanol.
It is auxiliary material by using ethanol, by vitamin C, optional tomato extract, optional haw thorn extract and sour agent
Mixed with ethanol, carry out wet granulation, during follow-up dry, ethanol evaporation, that is, the first granule is made；Similarly, then
In the preparation process for carrying out the second granule, ethanol is wetting agent, is mixed with glucose, optional essence and alkaline agent, is carried out wet
Method is pelletized, and during follow-up dry, ethanol evaporation, that is, the second granule is made.
In a preferred embodiment of the invention, in step (a) and step (b), dry temperature is 45-55 DEG C, excellent
Elect 50 DEG C as.
By the way that drying temperature is controlled at 45-55 DEG C, while by ethanol evaporation, while the drug effect of each raw material is ensured
Phenomena such as caking can also be avoided the formation of, especially when drying temperature is 50 DEG C, to the first granule and the second granule
Drying effect is more preferable, and drying efficiency is higher.
In a preferred embodiment of the invention, the preparation method of vitamin C effervescent tablet, carry out in accordance with the following steps：
(s) by vitamin C, glucose, optional tomato extract, optional haw thorn extract, optional essence, sour agent
Crushed with alkaline agent, and cross 80 mesh sieves；
(a) vitamin C after sieving, optional tomato extract, optional haw thorn extract and sour agent are well mixed,
And the ethanol that concentration is 70% is added, mix 20 minutes, carry out wet granulation, then in 50 DEG C of dry 3h, that is, be made first
Granula；
(b) glucose after sieving, optional essence and alkaline agent are well mixed, and add the ethanol that concentration is 70%,
Mixing 20 minutes, wet granulation is carried out, then in 50 DEG C of dry 3h, i.e., obtained second granule；
(c) the first granule, the second granule and water soluble starch are well mixed, carry out tabletting, that is, vitamin C is made
Effervescent tablet.
For the ease of understanding technical scheme provided by the invention, with reference to embodiment to technical scheme provided by the invention
It is further described.
Embodiment 1
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the following raw material according to the mass fraction：Dimension life
Plain 450 parts of C, 450 parts of glucose, 500 parts of citric acid, 400 parts of sodium acid carbonate.
Embodiment 2
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the following raw material according to the mass fraction：Dimension life
Plain 550 parts of C, 350 parts of glucose, 450 parts of citric acid, 450 parts of sodium acid carbonate.
Embodiment 3
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the following raw material according to the mass fraction：Dimension life
Plain 500 parts of C, 395 parts of glucose, 480 parts of citric acid, 425 parts of sodium acid carbonate.
Embodiment 4
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the following raw material according to the mass fraction：Dimension life
Plain 450 parts of C, 400 parts of glucose, 50 parts of tomato extract, 50 parts of haw thorn extract, 25 parts of water soluble starch, citric acid 425
Part, 400 parts of sodium acid carbonate.
Embodiment 5
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the raw material of following mass fraction meter：Vitamin
500 parts of C, 350 parts of glucose, 75 parts of tomato extract, 25 parts of haw thorn extract, 50 parts of water soluble starch, 450 parts of citric acid,
350 parts of sodium acid carbonate.
Embodiment 6
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the raw material of following mass fraction meter：Vitamin
470 parts of C, 380 parts of glucose, 75 parts of tomato extract, 35 parts of haw thorn extract, 45 parts of water soluble starch, 420 parts of citric acid,
375 parts of sodium acid carbonate.
Embodiment 7
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the raw material of following mass fraction meter：Vitamin
480 parts of C, 370 parts of glucose, 65 parts of tomato extract, 45 parts of haw thorn extract, 35 parts of water soluble starch, 430 parts of citric acid,
375 parts of sodium acid carbonate.
Embodiment 8
A kind of vitamin C effervescent tablet is present embodiments provided, is prepared by the raw material of following mass fraction meter：Vitamin
475 parts of C, 375 parts of glucose, 70 parts of tomato extract, 40 parts of haw thorn extract, 40 parts of water soluble starch, 425 parts of citric acid,
375 parts of sodium acid carbonate.
The preparation method for the vitamin C effervescent tablet that embodiment 1-8 is provided, is carried out in accordance with the following steps：
(s) by vitamin C, glucose, optional tomato extract, optional haw thorn extract, citric acid and bicarbonate
Sodium is crushed, and crosses 80 mesh sieves；
(a) vitamin C after sieving, optional tomato extract, optional haw thorn extract and citric acid are mixed equal
It is even, and the ethanol that concentration is 70% is added, mix 20 minutes, carry out wet granulation, then in 50 DEG C of dry 3h, that is, be made first
Granule；
(b) glucose after sieving and sodium acid carbonate are well mixed, and add the ethanol that concentration is 70%, mix 20 points
Clock, wet granulation is carried out, then in 50 DEG C of dry 3h, i.e., obtained second granule；
(c) the first granule, the second granule and water soluble starch are well mixed, carry out tabletting, that is, vitamin C is made
Effervescent tablet.
Comparative example 1
This comparative example provides a kind of vitamin C effervescent tablet, is prepared by the following raw material according to the mass fraction：Dimension life
Plain 300 parts of C, 600 parts of glucose, 300 parts of citric acid, 600 parts of sodium acid carbonate.
Comparative example 2
This comparative example provides a kind of vitamin C effervescent tablet, is prepared by the following raw material according to the mass fraction：Dimension life
Plain C700 parts, 250 parts of glucose, 600 parts of citric acid, 250 parts of sodium acid carbonate.
The preparation method for the vitamin C effervescent tablet that comparative example 1-2 is provided will not be repeated here with embodiment 8.
The vitamin C effervescent tablet that above-described embodiment 1-8 and comparative example 1-2 are provided carries out the detection of correlated performance, detection
As a result it is as shown in the table：
The vitamin C effervescent tablet performance detection table of table 1
It can be seen from Table 1 that the vitamin C effervescent tablet piece shape that 1-8 of the embodiment of the present invention is provided is good, without glutinous punching, dissolving
Solution clear afterwards, pH value is between 4.1-4.3, and disintegration is rapid, disintegration time 81-85s, the weight within the time of 3 months
Amount and taste keep being basically unchanged, and stability is good.
By embodiment 1-8 and comparative example 1-2 contrast, carried when by vitamin C, glucose, optional tomato
Thing, optional haw thorn extract, optional water soluble starch, citric acid and sodium acid carbonate are taken in the range of specific mass fraction
When, each raw material coordinated, obtained vitamin C effervescent tablet piece shape is good, and without glutinous punching, solution clear after dissolving allows drink
User more trusts.
In addition, the vitamin C effervescent tablet that embodiment 1-8 and comparative example 1-2 are provided enters respectively in January, 2 months and March
Go microbioassay, do not find the presence of microorganism.
In order to verify that the vitamin C effervescent tablet that embodiment 1-8 and comparative example 1-2 is provided carries out clinical test, oral cavity is chosen
The people of ulcers 550, is divided into 11 groups, every group of 50 people, respectively A-J groups, wherein, A-H groups take embodiment 1-8 offers respectively
Vitamin C effervescent tablet, I-J groups take the vitamin C effervescent tablet of comparative example 1-2 offers respectively, and K groups are blank control group, A-J groups
2 vitamin C effervescent tablets, every 1.8g are taken for each person every day, and K groups take placebo, curative effect is observed after one week, and its result is as follows
Shown in table：
The vitamin C effervescent tablet clinical detection table of table 2
In the effect of the present embodiment counts, cure as canker all healed；It is effective for ulcer healing up to 2/3, or burst
Ulcer shoals diminution；Effectively shoaled diminution up to 1/3 or ulcer for ulcer healing；Invalid is that ulcer is substantially unchanged.
The contrast of A-H groups and K groups can be seen that the dimension life that canker sore patient takes the present embodiment 1-8 offers from table 2
After plain C effervescent tablet, it is real obviously higher than blank control group, this explanation present invention that it cures number, effective number and efficiently individual quantity
Applying vitamin C effervescent tablet that 1-8 provides being capable of effective rapid healing canker sore.
From table 2 A-H groups and I-J groups contrast as can be seen that work as vitamin C, glucose, optional tomato extract,
When optional haw thorn extract, optional water soluble starch, citric acid and sodium acid carbonate is in the range of specific mass fraction, respectively
Raw material coordinated, obtained vitamin C effervescent tablet treatment canker sore action faster, cure rate and it is efficient also more
It is high.
The contrast of A-C groups and D-G groups can be seen that from table 2 adds tomato extract, mountain in vitamin C effervescent tablet
After short, bristly hair or beard extract and water soluble starch, vitamin C, glucose, tomato extract haw thorn extract water soluble starch, citric acid and
Sodium acid carbonate is in specific mass fraction scope coordinated, rapider, the biological utilisation of obtained vitamin C effervescent tablet action
Rate is higher, and cure rate and total effective rate are higher.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of vitamin C effervescent tablet, it is characterised in that be mainly prepared by the following raw material according to the mass fraction：Dimension life
Plain C 450-550 parts, glucose 350-450 parts, sour agent 400-500 parts, alkaline agent 350-450 parts.
2. vitamin C effervescent tablet according to claim 1, it is characterised in that mainly by following original according to the mass fraction
Material is prepared：Vitamin C 450-500 parts, glucose 350-400 parts, tomato extract 50-75 parts, haw thorn extract 25-
50 parts, water soluble starch 25-50 parts, sour agent 400-450 parts, alkaline agent 350-400 parts.
3. vitamin C effervescent tablet according to claim 1, it is characterised in that mainly by following original according to the mass fraction
Material is prepared：Vitamin C 470-480 parts, glucose 370-380 parts, tomato extract 65-75 parts, haw thorn extract 35-
45 parts, water soluble starch 35-45 parts, sour agent 420-430 parts, alkaline agent 370-380 parts.
4. according to the vitamin C effervescent tablet described in claim any one of 1-3, it is characterised in that the sour agent be selected from tartaric acid,
At least one of malic acid, fumaric acid, citric acid or sodium citrate；Preferably, the sour agent is citric acid.
5. according to the vitamin C effervescent tablet described in claim any one of 1-3, it is characterised in that the alkaline agent be selected from potassium carbonate,
At least one of sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate and calcium bicarbonate；Preferably, the alkaline agent is bicarbonate
Sodium.
6. according to the vitamin C effervescent tablet described in claim any one of 1-3, it is characterised in that primary raw material also includes pressing matter
Measure essence 2-5 parts of number meter.
7. the preparation method of the vitamin C effervescent tablet according to claim any one of 1-6, it is characterised in that including as follows
Step：
(a) vitamin C, optional tomato extract, optional haw thorn extract and sour agent are well mixed, by wet granulation
And dry, the first granule is made；
(b) glucose, optional essence and alkaline agent are well mixed, by wet granulation and drying, the second granule is made；
(c) the first granule, the second granule and optional water soluble starch are well mixed, carry out tabletting, that is, dimension life is made
Plain C effervescent tablet.
8. the preparation method of vitamin C effervescent tablet according to claim 7, it is characterised in that also including step (s), institute
State step (s) to be arranged at before the step (a), the step (s) is to extract vitamin C, glucose, optional tomato
Thing, optional haw thorn extract, optional essence, sour agent and alkaline agent are crushed, and cross 80 mesh sieves.
9. the preparation method of vitamin C effervescent tablet according to claim 7, carried out in the first granule and the second granule
During wet granulation, used wetting agent is ethanol.
10. the preparation method of vitamin C effervescent tablet according to claim 7, it is characterised in that in step (a) and step
(b) in, dry temperature is 45-55 DEG C, preferably 50 DEG C.
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| CN110881604A (en) * | 2019-12-07 | 2020-03-17 | 安徽克菱保健科技有限公司 | Vc effervescent tablet |
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Address after: No.1302, No.7, Dongqing street, high tech Industrial Development Zone, Zhengzhou City, Henan Province 450001 Applicant after: Bokai Pharmaceutical Co., Ltd Address before: 450000 No. 5 Acacia Street, hi tech Development Zone, Henan, Zhengzhou Applicant before: Zhengzhou Bokai Medicine &. Health-Care Products Co., Ltd. |
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