CN107356659A - The system and method taken drugs by saliva detection - Google Patents
The system and method taken drugs by saliva detection Download PDFInfo
- Publication number
- CN107356659A CN107356659A CN201710534537.XA CN201710534537A CN107356659A CN 107356659 A CN107356659 A CN 107356659A CN 201710534537 A CN201710534537 A CN 201710534537A CN 107356659 A CN107356659 A CN 107356659A
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- saliva
- detection zone
- drugs
- detection
- filter layer
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- 210000003296 saliva Anatomy 0.000 title claims abstract description 71
- 238000001514 detection method Methods 0.000 title claims abstract description 65
- 239000003814 drug Substances 0.000 title claims abstract description 49
- 229940079593 drug Drugs 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000012546 transfer Methods 0.000 claims abstract description 17
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- 230000005540 biological transmission Effects 0.000 claims abstract description 14
- 238000005070 sampling Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 3
- 150000002500 ions Chemical class 0.000 claims description 19
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 206010013654 Drug abuse Diseases 0.000 claims description 7
- 208000011117 substance-related disease Diseases 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 125000004494 ethyl ester group Chemical group 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 239000008055 phosphate buffer solution Substances 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 5
- 238000007689 inspection Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000002203 pretreatment Methods 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 238000001819 mass spectrum Methods 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000002117 illicit drug Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The system and method taken drugs is detected by saliva the invention provides a kind of, the detecting system includes sampling device and detection means；The sampling device includes：Bearing part, the bearing part are used to carry transfer unit；Transfer unit, the transfer unit include using detection zone and transmission range made of water wetted material, and one end of the transmission range connects the detection zone, and the other end gos deep into container；Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the transverse direction of the detection zone, and the saliva of transmission range is only capable of by just entering detection zone through filter layer；Container, the inner containment saliva to be measured of the container；Detection means knows the content of drugs in the saliva of the detection zone by analysis.The present invention has the advantages that good accuracy, high sensitivity, high efficiency, low cost.
Description
Technical field
The present invention relates to illicit drugs inspection analysis, more particularly to detects the system and method taken drugs by saliva.
Background technology
In recent years, abuse of the drugs in worldwide gradually penetrates into the various aspects of daily life, such as takes drugs
After drive, in public place of entertainment workplace drug abuse etc. in one's power.The quick and accurate detection of drugs has become the emphasis of research
And focus.
Drugs are analyzed in urine and blood sample relative to traditional, drugs are analyzed in saliva has many advantages.
The common practices of illicit drugs inspection is in saliva：Protein deposition agent such as acetonitrile is added in saliva, for protein precipitation, is divided after filtering
Supernatant is taken to carry out LC-MS analyses after analysis or centrifugation.This analysis method has many deficiencies, such as：
1. pre-treatment is more complicated, and is required for repeating pre-treatment for different samples；
2.LC-MS analyses can only analyze single sample every time, it is impossible to continuous sample introduction, can not realize fast and automatically change and height
Flux distribution.
The content of the invention
To solve the deficiency in above-mentioned prior art, the invention provides a kind of automatic sampling, high sensitivity, inspection
That surveys efficiency high detects the system taken drugs by saliva.
The purpose of the present invention is achieved through the following technical solutions：
A kind of to detect the system taken drugs by saliva, the system that drug abuse is detected by saliva includes sampling device and inspection
Survey device；The sampling device includes：
Bearing part, the bearing part are used to carry transfer unit；
Transfer unit, the transfer unit include using detection zone and transmission range made of water wetted material, the transmission range
One end connect the detection zone, the other end gos deep into container；
Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the horizontal stroke of the detection zone
To the saliva of transmission range is only capable of by just entering detection zone through filter layer；
Container, the inner containment saliva to be measured of the container；
Detection means knows the content of drugs in the saliva of the detection zone by analysis.
It is high according to above-mentioned the present invention also aims to provide a kind of automatic sampling, high sensitivity, detection efficiency
The system taken drugs by saliva detection detects the method taken drugs by saliva, and the goal of the invention is able to by the following technical programs
Realize：
According to the above-mentioned method that drug abuse is detected by saliva that the system taken drugs is detected by saliva, methods described includes
Following steps：
(A1) capillarity is utilized, the saliva in container is delivered up by transmission range；
(A2) stickum in saliva is stopped by filter layer；
(A3) saliva by filtering enters detection zone；
(A4) detection means knows the content of drugs in the saliva of the detection zone by analysis.
Compared with prior art, the device have the advantages that being：
1. using filter paper is obtained added with the porous filter layer after chemical treatment, so as to realize paper substrate auto injection, without
Sample pre-treatments, ambient noise can be reduced, improve sensitivity for analysis；
Further, equipped with mobile platform, sample introduction is accurately controlled to eliminate interference caused by human factor by motor,
Precision of analysis is improved, fast and automatically change and high throughput analysis can be realized to the saliva sample that Different Individual obtains；
2. can ensure that hydrophilic area moistens for a long time during analysis, be advantageous to the ionization of testing sample, ensure and divide
The sensitivity of analysis and repeatability；
3. device is simple, without liquid chromatogram and artificial pre-treatment；It is simultaneously easy to operate, detection efficiency can be lifted.
Brief description of the drawings
Referring to the drawings, the disclosure will be easier to understand.Skilled addressee readily understands that be：This
A little accompanying drawings are used only for illustrating technical scheme, and are not intended to and protection scope of the present invention is construed as limiting.
In figure：
Fig. 1 is according to embodiments of the present invention 1 structure diagram that the system taken drugs is detected by saliva；
Fig. 2 is the structure diagram of according to embodiments of the present invention 1 sampling device；
Fig. 3 is mass spectrogram corresponding to the saliva of No. 1 drug abstainer according to embodiments of the present invention 3；
Fig. 4 is mass spectrogram corresponding to the saliva of No. 1 non-drug addict according to embodiments of the present invention 3；
Fig. 5 is mass spectrogram corresponding to the saliva of No. 2 drug abstainers according to embodiments of the present invention 4；
Fig. 6 is mass spectrogram corresponding to the saliva of No. 2 non-drug addicts according to embodiments of the present invention 4.
Embodiment
Fig. 1-6 and the optional embodiment of the present invention is following description described to instruct how those skilled in the art implement
It is of the invention with reproducing.In order to instruct technical solution of the present invention, simplify or eliminate some conventional aspects.Those skilled in the art
It should be appreciated that modification or replacement from these embodiments will within the scope of the invention.Those skilled in the art should understand that
Following characteristics can combine to form multiple modifications of the present invention in a variety of ways.Thus, the invention is not limited in it is following can
Embodiment is selected, and is only limited by claim and their equivalent.
Embodiment 1：
Fig. 1 schematically illustrates the structure diagram that the system taken drugs is detected by saliva of the embodiment of the present invention, such as Fig. 1
Shown, the system that drug abuse is detected by saliva includes：
Ion gun, mass spectrograph, the ion gun, mass spectrograph are separately positioned on the both sides of sampling device；
Fig. 2 schematically illustrates the structure diagram of the sampling device of the embodiment of the present invention, as shown in Fig. 2 the sample introduction
Device includes：
Guide rail 11, the guide rail are horizontally disposed with；
Bearing part 21, the bearing part are arranged on the guide rail, including horizontal component and vertical portion；
Transfer unit, the upper end of transfer unit are fixed on the horizontal component of the bearing part, and lower end is goed deep into container；It is described
Transfer unit uses filter paper, and is divided into hydrophobic region 31 and hydrophilic detection zone 32 by printing paraffin in the above and passes
Area 33 is sent, on the operative orientation of detection means such as horizontal direction, bearing part is unable to occlusion detection area, namely detection zone is in water
The bottom of flat part；Wherein, hydrophobic region is in detection zone and transmits the one or both sides in area, namely periphery；Transmit the one end in area
Connecting detection area, the other end are deep into container；
Filter layer 34, the filter layer are used to filter out the stickum in saliva, such as mucin；Filter layer gathers for cellular
Ethyl ester filter layer uses after the solution that 0.1% Tween-20 and PH7.2 phosphate buffer solutions are made into is dried；Filter layer is set
In transmission area so that the saliva in container has to pass through the filter layer and gets to detection zone；
Container 41, the container are arranged on the guide rail, inner containment saliva to be measured；
Drive module (not shown), such as stepper motor, the drive module drive the bearing part to be moved on guide rail, made
The line obtained between the nozzle and mass spectrograph injection port of the ion gun passes through the detection zone, such as detects district center.
The embodiment of the present invention detects the side taken drugs according to the above-mentioned system that drug abuse is detected by saliva by saliva
Method, it the described method comprises the following steps：
(A1) capillarity is utilized, the saliva sample in container reaches filter layer by transmitting area；
(A2) stickum in saliva is stopped by filter layer；
(A3) saliva by filtering enters detection zone；
(A4) driving bearing part moves on guide rail so that the plasma that the ion gun projects is mapped to one of inspection
Area is surveyed, sample is ionized；
Spectrometer analysis ion, so as to obtain the content of drugs or metabolite in saliva corresponding to the detection zone, so as to
Know whether to take drugs；
(A5) repeat step (A4), so as to adjust the relative position of ion gun and detection zone, so as to obtain another detection zone
The content of drugs or metabolite in corresponding saliva.
Embodiment 2：
The embodiment of the present invention detects the system taken drugs by saliva, as different from Example 1：
Ion gun and mass spectrograph are arranged on guide rail, so as to adjust the relative position of ion gun and detection zone.
Embodiment 3：
The systematic difference example taken drugs is detected by saliva described in the embodiment of the present invention 1.
In the application examples, detection zone is circular, a diameter of 3-5mm, such as 4mm；A width of 1-1.5mm in area is transmitted, such as
1.5mm, such as a length of 10-20mm, 20mm；Container is 2mL polyethylene centrifuge tubes；Ion gun nozzle is with mass spectrograph injection port distance
2cm；Transfer unit is 0.2mm apart from mass spectrograph injection port distance between ion gun nozzle and mass spectrum injection port, ion gun
Nozzle, the circle detection area center of circle and mass spectrograph injection port are located in same horizontal line.Mass Spectrometer Method m/z scopes are set to 50-500,
Ion source heating temperature is set to 100 DEG C, and inert gas flow velocity is set to 4L/min, detection sample for a drug abstainer saliva and one not
The saliva of drug addict, respectively as shown in Figure 3 and Figure 4.The signal peak that m/z is 100, signal intensity can be substantially observed from Fig. 3
1.90e5, and signal peak corresponding to not observed in Fig. 4, it may be drugs or the matter of its metabolite thus to speculate this feature peak
Compose peak-to-peak signal.Four measured value relative standard deviations are 7.93% obtained by mobile motor.
Embodiment 4：
The systematic difference example taken drugs is detected by saliva described in the embodiment of the present invention 1.
In the application examples, detection zone is circular, a diameter of 3-5mm, such as 3mm；A width of 1-1.5mm in area is transmitted, such as
1mm, such as a length of 10-20mm, 10mm；Container is 2mL polyethylene centrifuge tubes；Ion gun nozzle is with mass spectrograph injection port distance
2cm；Transfer unit is 0.2mm apart from mass spectrograph injection port distance between ion gun nozzle and mass spectrum injection port, ion gun
Nozzle, the circle detection area center of circle and mass spectrograph injection port are located in same horizontal line.Mass Spectrometer Method m/z scopes are set to 50-500,
Ion source heating temperature is set to 100 DEG C, and inert gas flow velocity is set to 4L/min, and detection sample is a drug abstainer and a non-drug addict
Saliva, show respectively such as Fig. 5 and Fig. 6.M/z can be substantially observed from Fig. 5 as 121 signal peak, signal intensity 4.26e5, and
The signal peak that m/z is 121 is observed in Fig. 6, signal intensity e3, it may be drugs or its metabolism production thus to speculate this feature peak
The mass spectrum of thing goes out peak-to-peak signal.Measured value relative standard deviation is 8.65% three times obtained by mobile motor.
Claims (10)
1. a kind of detect the system taken drugs by saliva, the system that drug abuse is detected by saliva includes sampling device and detection
Device；It is characterized in that：The sampling device includes：
Bearing part, the bearing part are used to carry transfer unit；
Transfer unit, the transfer unit include using detection zone and transmission range made of water wetted material, and the one of the transmission range
End connects the detection zone, and the other end gos deep into container；
Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the transverse direction of the detection zone, passes
The saliva in defeated area is only capable of by just entering detection zone through filter layer；
Container, the inner containment saliva to be measured of the container；
Detection means knows the content of drugs in the saliva of the detection zone by analysis.
2. according to claim 1 detect the system taken drugs by saliva, it is characterised in that：The making side of the filter layer
Method is：Porous poly- ethyl ester filter layer uses after the solution that Tween-20 and phosphate buffer solution are made into is dried.
3. according to claim 1 detect the system taken drugs by saliva, it is characterised in that：The transfer unit also wraps
Include：
Hydrophobic region, the hydrophobic region are distributed in the one or both sides of the detection zone and transmission range.
4. according to claim 3 detect the system taken drugs by saliva, it is characterised in that：By printing stone on filter paper
Wax and form hydrophobic region, non-paraffin region forms detection zone and transmission range.
5. according to claim 1 detect the system taken drugs by saliva, it is characterised in that：The detection means includes：
Ion gun, the ion gun are used to launch plasma；
Mass spectrograph, the line between the nozzle of the ion gun and mass spectrometric injection port pass through the detection zone.
6. according to claim 1 detect the system taken drugs by saliva, it is characterised in that：The detection zone is diameter 3-
5mm circle, transmission range are wide 1-1.5mm, long 10-20mm strip.
7. according to claim 1 detect the system taken drugs by saliva, it is characterised in that：The transfer unit is at least
Two, the container corresponds with transfer unit.
8. according to claim 5 detect the system taken drugs by saliva, it is characterised in that：The sampling device is further
Including：
Guide rail, the bearing part and container are arranged on the guide rail, or the detection means is arranged on the guide rail；
Drive module, the drive module drive guide rail so that the bearing part relatively moves with detection means, the company
Line passes through the detection zone.
9. according to any described sides that drug abuse is detected by saliva that the system taken drugs is detected by saliva of claim 1-8
Method, the detection method comprise the following steps：
(A1) capillarity is utilized, the saliva in container is delivered up by transmission range；
(A2) stickum in saliva is stopped by filter layer；
(A3) saliva by filtering enters detection zone；
(A4) detection means knows the content of drugs in the saliva of the detection zone by analysis.
10. according to claim 9 detect the method taken drugs by saliva, it is characterised in that：The detection method enters one
Step comprises the following steps：
(A5) detection means and the relative position of detection zone are adjusted so that detection means analyzes drugs in another detection zone saliva
Content.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710534537.XA CN107356659A (en) | 2017-07-03 | 2017-07-03 | The system and method taken drugs by saliva detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710534537.XA CN107356659A (en) | 2017-07-03 | 2017-07-03 | The system and method taken drugs by saliva detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107356659A true CN107356659A (en) | 2017-11-17 |
Family
ID=60291830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710534537.XA Pending CN107356659A (en) | 2017-07-03 | 2017-07-03 | The system and method taken drugs by saliva detection |
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| Country | Link |
|---|---|
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226317A (en) * | 1996-06-28 | 1999-08-18 | 霍华德·M·钱德勒 | Chromatographic assay or test device |
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| CN101644686A (en) * | 2008-08-08 | 2010-02-10 | 李海洋 | United on-line detector for explosive and poison and application thereof |
| CN103163275A (en) * | 2011-12-16 | 2013-06-19 | 同方威视技术股份有限公司 | Detection apparatus and detection method of dangerous substances on article surfaces |
| CN103823059A (en) * | 2012-11-19 | 2014-05-28 | 南京路始生物科技有限公司 | Saliva direct detection device |
| CN204951607U (en) * | 2012-10-28 | 2016-01-13 | 珀金埃尔默健康科技有限公司 | Sample keeps ware and application method thereof |
| CN106198702A (en) * | 2015-05-06 | 2016-12-07 | 中国科学院大连化学物理研究所 | A kind of method of drugs in quick detection saliva |
| CN207894869U (en) * | 2017-07-03 | 2018-09-21 | 宁波华仪宁创智能科技有限公司 | The system taken drugs using saliva detection |
-
2017
- 2017-07-03 CN CN201710534537.XA patent/CN107356659A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226317A (en) * | 1996-06-28 | 1999-08-18 | 霍华德·M·钱德勒 | Chromatographic assay or test device |
| CN2468040Y (en) * | 2001-03-29 | 2001-12-26 | 农业部农药检定所 | Pesticide residue poison fast detecting instrument |
| CN101297193A (en) * | 2005-06-09 | 2008-10-29 | 阿斯派克磁体有限公司 | A portable quality and process control system for simultaneous magnetic resonance imaging of multiple samples |
| CN101241136A (en) * | 2007-11-30 | 2008-08-13 | 广州万孚生物技术有限公司 | Multi-linked immunity chromatography test paper for detecting saliva abusing drug, system and its preparation method |
| CN101644686A (en) * | 2008-08-08 | 2010-02-10 | 李海洋 | United on-line detector for explosive and poison and application thereof |
| CN103163275A (en) * | 2011-12-16 | 2013-06-19 | 同方威视技术股份有限公司 | Detection apparatus and detection method of dangerous substances on article surfaces |
| CN204951607U (en) * | 2012-10-28 | 2016-01-13 | 珀金埃尔默健康科技有限公司 | Sample keeps ware and application method thereof |
| CN103823059A (en) * | 2012-11-19 | 2014-05-28 | 南京路始生物科技有限公司 | Saliva direct detection device |
| CN106198702A (en) * | 2015-05-06 | 2016-12-07 | 中国科学院大连化学物理研究所 | A kind of method of drugs in quick detection saliva |
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