CN107353196A - A kind of method for extracting succinic acid/succinate - Google Patents
A kind of method for extracting succinic acid/succinate Download PDFInfo
- Publication number
- CN107353196A CN107353196A CN201710433382.0A CN201710433382A CN107353196A CN 107353196 A CN107353196 A CN 107353196A CN 201710433382 A CN201710433382 A CN 201710433382A CN 107353196 A CN107353196 A CN 107353196A
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- succinic acid
- aqueous solution
- organic solvent
- organic
- succinate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to chemical field, specifically discloses a kind of method for extracting succinic acid/succinate.By the aqueous solution containing succinic acid by being mixed with organic solvent, it is concentrated by evaporation the moisture removed in the succinic acid aqueous solution, so that succinic acid molecule preferably enters organic phase, the organic phase product containing succinic acid is obtained and inorganic salts and the less entrance organic phase of other organic impurities, so as to realize succinic acid and the separation of the other impurities in the aqueous solution.It can be obtained into the succinic acid in organic phase by a variety of traditional methods known to industry technical staff and arrive more pure succinic acid, succinate and/or other succinic acid products.The method of the invention extracts succinic acid, and process route is short, easy to operation, and gained succinic acid purity is high.Succinic acid product yield is high, environmental pollution is small, avoids operating process complicated in traditional succinic acid production technology.
Description
Technical field
The present invention relates to chemical field, specifically, is related to the method for extraction succinic acid/succinate.
Background technology
Succinic acid, also known as butanedioic acid, it is colourless crystallization；Relative density 1.572 (25/4 DEG C), 188 DEG C of fusing point, at 235 DEG C
When decompose；Distillation can distil under reduced pressure；Water can be dissolved in, is slightly soluble in ethanol, ether and acetone.
Industrially, butanedioic acid is often made by butene dioic acid catalysis reduction, and butanedioic acid can also be hydrolyzed by succinonitrile and prepared.Amber
The important use of acid is to prepare five member ring heterocyclic compound.Succinic anhydride is the important source material for manufacturing medicine, dyestuff and alkyd resin.
Diethyl succinate is the important intermediate of organic synthesis.Dibutyl succinate, dioctyl ester are the plasticizer of plastics.Butanedioic acid two
Allyl ester is copolymerized with 1,3-butadiene, can manufacture artificial rubber.
Industrial making method is more, and chemical method mainly has following several:Oxidizing process, hydrogenation method, acrylic acid oxo synthesis, electrolysis
Oxidizing process.Compared with chemical method, Production by Microorganism Fermentation butanedioic acid has many advantages, such as fermentation method：Production cost has competing
Strive power；Include carbon dioxide as raw material by the use of reproducible agricultural resource, avoid the dependence to petrochemical material；Reducing
Learn pollution of the synthesis technique to environment.
Fermentation method production succinic acid is that it is opened by the use of renewable sugar source (such as glucose) and carbon dioxide as primary raw material
The new way that GHG carbon dioxide utilizes has been warded off, and cost is cheap, it is environment-friendly.
The method for extracting succinic acid from zymotic fluid has the methods of membrane separation process, ion-exchange, extraction.Extraction leads to
Toluene, isopropyl-ketone, n-octyl alcohol, coal are often respectively adopted for extractant with tributyl phosphate (TBP), trialkylamine (7301)
Oil extracts as diluent to succinic acid.
However, for current succinic acid complex production process, product yield is low and the situation of high energy consumption, needs badly and propose one
The more economical and effective method for preparing succinic acid of kind.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide one kind to extract succinic acid/succinic acid
The method of salt.
In order to realize the object of the invention, technical scheme is as follows：
The present invention provides a kind of method for extracting succinic acid/succinate, comprises the following steps：
1) the crude product aqueous solution containing succinic acid is mixed with organic solvent, concentration is evaporated to mixed liquor and goes to remove water
Point, obtain the organic solvent containing succinic acid；
2) extraction step 1) gained in succinic acid.
The extracting method can use conventional method well-known to those skilled in the art or conventional use of extracting method,
Succinic acid/the succinate for entering organic phase is extracted from organic solvent, obtains more pure succinic acid/succinic acid
Salt/other succinic acid products.
Further, the crude product aqueous solution containing succinic acid may be selected from (1) or (2) or (3)：
(1) succinic acid fermentation liquor obtained by fermentation or enzymatic conversion；
(2) by acidolysis succinic acid fermentation liquor, the succinic acid acid hydrolysis solution that is further obtained after filtering or by other method
Treated succinic acid fermentation liquor；
(3) aqueous solution containing succinic acid obtained by other approach.
The crude product aqueous solution containing succinic acid can also be the aqueous solution by pre-concentration.
Further, the organic solvent is selected from the mixture of a kind of following organic compound or a variety of organic compounds：
Esters (such as amyl acetate), ketone (such as 2-HEPTANONE), ethers (such as butyl ether), alcohols (such as octanol), phosphoric acid ester
(such as tributyl phosphate), phosphorus oxygen class (trioctylphosphine oxide (TOPO)), phosphine sulphur class (triisobutyl phosphine sulfide), amine (such as trioctylamine), acyl
Amine (N.N- dibutyl formamides), other boiling points are more than 100 DEG C of organic compound at ambient pressure.
Further, the mixed proportion of the crude product aqueous solution containing succinic acid and organic solvent is 1：100~100：
1。
Preferably, the mixed proportion of the crude product aqueous solution containing succinic acid and organic solvent is 1：50~50：1.
Further, for the condition of the evaporation and concentration to be concentrated in vacuo, temperature of charge is 30~95 DEG C.
Preferably, temperature of charge is 40~90 DEG C.
Further, the step 2) is specially：Organic solvent containing succinic acid is mixed with water, the fourth purified
Diacid solution；Or mix the organic solvent containing succinic acid with alkaline solution, obtain succinate solution.
The alkaline solution is sodium hydroxide solution and/or carbonate solution.
Organic solvent after separation succinic acid, which can return in step 1), to be recycled.
Preferably, the temperature when organic solvent containing succinic acid mixes with water/alkaline solution is 1~150 DEG C.
The present invention relates to raw material or reagent be ordinary commercial products, the operation being related to is unless otherwise specified
This area routine operation.
On the basis of common sense in the field is met, above-mentioned each optimum condition, it can be mutually combined, obtain specific embodiment party
Formula.
The beneficial effects of the present invention are：
The method of the invention extracts succinic acid, and process route is short, easy to operation, and gained succinic acid purity is high.Succinic acid
Product yield is high, environmental pollution is small, avoids operating process complicated in traditional succinic acid production technology.
Embodiment
The preferred embodiment of the present invention is described in detail below in conjunction with embodiment.It is it will be appreciated that following real
Providing merely to play the purpose of explanation for example is applied, is not used to limit the scope of the present invention.The skill of this area
Art personnel can carry out various modifications and replacement in the case of without departing substantially from spirit of the invention and spirit to the present invention.
Experimental method used in following embodiments is conventional method unless otherwise specified.
Material used, reagent etc., unless otherwise specified, are commercially obtained in following embodiments.
Embodiment 1
Take 5% (mass percent) succinic acid solution 500g, organic solvent 200g (wherein three pungent ammonium 80g, eight charcoal alcohol 20g,
Kerosene 100g) it is put in three-necked flask, it is concentrated in vacuo in 80 DEG C, is concentrated into after being come out there is no condensed water, is contained
There is the organic solvent of succinic acid.
Organic solvent containing succinic acid is transferred in another three-necked flask, add water with it is organic molten containing succinic acid
Agent is in 80 DEG C of mixing then by the isolated solution containing succinic acid of organic solvent.
It is computed, the yield of succinic acid is 99%.
After testing, isolated succinic acid purity is 99.5%.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
- A kind of 1. method for extracting succinic acid/succinate, it is characterised in that comprise the following steps：1) the crude product aqueous solution containing succinic acid is mixed with organic solvent, being evaporated concentration to mixed liquor removes moisture removal, obtains To the organic solvent containing succinic acid；2) extraction step 1) gained in succinic acid.
- 2. according to the method for claim 1, it is characterised in that the crude product aqueous solution containing succinic acid may be selected from：(1) The succinic acid fermentation liquor obtained by fermentation or enzymatic conversion；(2) by acidolysis succinic acid fermentation liquor, further obtained after filtering Succinic acid acid hydrolysis solution or the succinic acid fermentation liquor treated by other method；(3) succinic acid is contained by what other approach obtained The aqueous solution.
- 3. according to the method for claim 2, it is characterised in that the crude product aqueous solution containing succinic acid is by pre- dense The aqueous solution of contracting.
- 4. according to the method described in any one of claims 1 to 3, it is characterised in that the organic solvent, which is selected from following one kind, to be had The mixture of machine compound or a variety of organic compounds：Esters, ketone, ethers, alcohols, phosphoric acid ester, phosphorus oxygen class, phosphine sulphur class, amine, amide-type, other boiling points are big at ambient pressure In 100 DEG C of organic compound.
- 5. according to the method described in any one of claims 1 to 3, it is characterised in that the crude product aqueous solution containing succinic acid Mixed proportion with organic solvent is 100：1~1：100.
- 6. according to the method for claim 5, it is characterised in that the condition of the evaporation and concentration is is concentrated in vacuo, material temperature Spend for 10~100 DEG C.
- 7. according to the method for claim 6, it is characterised in that the step 2) is specially：The organic of succinic acid will be contained Solvent mixes with water, the succinic acid solution purified；Or mix the organic solvent containing succinic acid with alkaline solution, obtain Succinate solution.
- 8. according to the method for claim 7, it is characterised in that the organic solvent containing succinic acid mixes with water/alkaline solution Temperature during conjunction is 1~150 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710433382.0A CN107353196A (en) | 2017-06-09 | 2017-06-09 | A kind of method for extracting succinic acid/succinate |
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| CN201710433382.0A CN107353196A (en) | 2017-06-09 | 2017-06-09 | A kind of method for extracting succinic acid/succinate |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108675927A (en) * | 2018-07-09 | 2018-10-19 | 安徽丰原发酵技术工程研究有限公司 | A method of extracting succinic acid or succinate using the solvent way of distillation |
| CN108727182A (en) * | 2018-07-09 | 2018-11-02 | 安徽丰原发酵技术工程研究有限公司 | A method of extracting pyruvic acid using the solvent way of distillation |
| CN108929295A (en) * | 2018-07-09 | 2018-12-04 | 安徽丰原发酵技术工程研究有限公司 | A method of Vc is extracted using the solvent way of distillation |
| CN108929218A (en) * | 2018-07-09 | 2018-12-04 | 安徽丰原发酵技术工程研究有限公司 | A method of organic acid is extracted using the solvent way of distillation |
| CN115417763A (en) * | 2022-09-22 | 2022-12-02 | 盛虹控股集团有限公司 | Preparation method of bio-based succinic acid |
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| CN103193622A (en) * | 2013-04-26 | 2013-07-10 | 山东潍坊润丰化工有限公司 | Recovery method of glycolic acid in phenoxy carboxylic acid industrial wastewater |
| CN104053641A (en) * | 2011-12-23 | 2014-09-17 | 普拉克生化公司 | Lactic acid extraction |
| CN105503579A (en) * | 2015-12-18 | 2016-04-20 | 南京工业大学 | Method for complexation extraction and recovery of succinic acid from succinic acid crystallization mother liquor containing high-concentration inorganic salt |
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2017
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| CN103193622A (en) * | 2013-04-26 | 2013-07-10 | 山东潍坊润丰化工有限公司 | Recovery method of glycolic acid in phenoxy carboxylic acid industrial wastewater |
| CN105503579A (en) * | 2015-12-18 | 2016-04-20 | 南京工业大学 | Method for complexation extraction and recovery of succinic acid from succinic acid crystallization mother liquor containing high-concentration inorganic salt |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108675927A (en) * | 2018-07-09 | 2018-10-19 | 安徽丰原发酵技术工程研究有限公司 | A method of extracting succinic acid or succinate using the solvent way of distillation |
| CN108727182A (en) * | 2018-07-09 | 2018-11-02 | 安徽丰原发酵技术工程研究有限公司 | A method of extracting pyruvic acid using the solvent way of distillation |
| CN108929295A (en) * | 2018-07-09 | 2018-12-04 | 安徽丰原发酵技术工程研究有限公司 | A method of Vc is extracted using the solvent way of distillation |
| CN108929218A (en) * | 2018-07-09 | 2018-12-04 | 安徽丰原发酵技术工程研究有限公司 | A method of organic acid is extracted using the solvent way of distillation |
| CN115417763A (en) * | 2022-09-22 | 2022-12-02 | 盛虹控股集团有限公司 | Preparation method of bio-based succinic acid |
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Application publication date: 20171117 |