CN107334940A - Treat Chinese medicine composition of diabetes and preparation method thereof - Google Patents
Treat Chinese medicine composition of diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to division of endocrinology's treating diabetes technical field, more particularly to a kind of Chinese medicine composition for treating diabetes and preparation method thereof.Endo-medicine is made up of the component of following mass fraction：58 parts of soybean, 35 parts of golden cypress, 35 parts of seven leaf courage, 46 parts of asparagus fern, 35 parts of turnip, 46 parts of stevia rebaudian leaf, 35 parts of fermented Chinese gall herb and tea leaves, 35 parts of Dendrobium densiflorum lindl, 35 parts of square olive, 46 parts of Triglochin martimum, 35 parts of the dried rhizome of rehmannia, 46 parts of red ginseng, 35 parts of dogwood fruit, 58 parts of Poria cocos.External used medicine is made up of the component of following mass fraction：58 parts of the fruit of Chinese wolfberry, 58 parts of sweet potato leaves, 46 parts of HERBA DENDROBII, 35 parts of Radix Angelicae Sinensis, 35 parts of the root of kudzu vine, 58 parts of pollen pini, 46 parts of radix ampelopsis, 35 parts of garden burnet, 58 parts of calcined and quenched CALAMINA, 35 parts of pinkflower ecdysanthera root and leaf.The Chinese medical extract sheerly Chinese medicine preparation of the present invention, by the conditioning of Chinese medicine after fermentation, avoids the blood glucose stimulating factor in medicine, has no side effect, and regulation blood glucose is rapid-action, and effect is good；Foot blood glucose is reduced with reference to external used medicine, sterilizes sore, promotes to recover.
Description
Technical field
The invention belongs to division of endocrinology's treating diabetes technical field, more particularly to a kind of Chinese medicine group for treating diabetes
Compound and preparation method thereof.
Background technology
Division of endocrinology is a place for specifically treating division of endocrinology disease in hospital, be mainly responsible for diabetes, obesity,
The clinic of the disease such as osteoporosis, gout, disorders of lipid metabolism and thyroid gland, hypophysis, adrenal gland, sexual gland, parathyroid gland is examined
Control.
Diabetes are one group of metabolic diseases characterized by hyperglycaemia.Hyperglycaemia be due to then defect of insulin secretion or
Its biological agent is damaged, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, cause various tissues, particularly eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.Foot is a complicated target of this multisystem disease of diabetes
Organ.Diabetic can cause soft group of foot because peripheral neuropathy merges too high mechanical pressure with peripheral artery disease
Knit and the destruction of osteoarticular system and teratogenesis, and then trigger a series of foot problems, from slight nervous symptoms to serious
Ulcer, infection, vascular diseases, Charcot arthropathies and Neuropathic fracture.If active treatment can not be solved down fully
The symptom and complication that limb occurs, then can cause catastrophic consequence.Therefore, carry out in diabetic to foot problems
Early prevention and treatment will have important meaning.
The method that there is no radical cure diabetes group at present, diabetes treatment by western medicine foot, can be dirty to liver, kidney, the heart, spleen, stomach etc.
Device brings side effect.
The content of the invention
Present invention solves the technical problem that being the method that there is no radical cure diabetes group at present, diabetes treatment by western medicine is sufficient,
Side effect can be brought to internal organs such as liver, kidney, the heart, spleen, stomaches.
To solve the above problems, the present invention provides a kind of Chinese medicine composition for treating diabetes, endo-medicine is by following
The component composition of mass fraction：Soybean 5-8 parts, golden cypress 3-5 parts, seven leaf courage 3-5 parts, asparagus fern 4-6 parts, turnip 3-5 parts, stevia rebaudian leaf
4-6 parts, fermented Chinese gall herb and tea leaves 3-5 parts, Dendrobium densiflorum lindl 3-5 parts, square olive 3-5 parts, Triglochin martimum 4-6 parts, dried rhizome of rehmannia 3-5 parts, red ginseng 4-6 parts, mountain cornel
Meat 3-5 parts, Poria cocos 5-8 parts.
Further optimization, is made up of the component of following mass fraction：6 parts of soybean, 4 parts of golden cypress, 4 parts of seven leaf courage, asparagus fern 5
Part, 4 parts of turnip, 5 parts of stevia rebaudian leaf, 4 parts of fermented Chinese gall herb and tea leaves, 4 parts of Dendrobium densiflorum lindl, 4 parts of square olive, 5 parts of Triglochin martimum, 4 parts of the dried rhizome of rehmannia, 5 parts of red ginseng, mountain
4 parts of cornus, 7 parts of Poria cocos.
External used medicine is made up of the component of following mass fraction：Fruit of Chinese wolfberry 5-8 parts, sweet potato leaves 5-8 parts, HERBA DENDROBII 4-6
Part, Radix Angelicae Sinensis 3-5 parts, root of kudzu vine 3-5 parts, pollen pini 5-8 parts, radix ampelopsis 4-6 parts, garden burnet 3-5 parts, calcined and quenched CALAMINA 5-8 parts, pinkflower ecdysanthera root and leaf
3-5 parts.
Further optimization, is made up of the component of following mass fraction：7 parts of the fruit of Chinese wolfberry, 6 parts of sweet potato leaves, 5 parts of HERBA DENDROBII,
4 parts of Radix Angelicae Sinensis, 4 parts of the root of kudzu vine, 6 parts of pollen pini, 5 parts of radix ampelopsis, 4 parts of garden burnet, 7 parts of calcined and quenched CALAMINA, 4 parts of pinkflower ecdysanthera root and leaf.
The preparation method of wherein medicine for oral administration comprises the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, then at -10~-18 DEG C
Lower freezing 10-20h is standby；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, is carried
High cellular damage rate, laid the first stone for the microwave bulking of next step.
(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1)
Chinese medicine material after freezing processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking；Then by temperature
Degree is adjusted to 40-80 DEG C, microwave power 90-120w, dries 6-9min；It is swollen that Chinese medicine after freezing is directly carried out to microwave
To change, the strength for being directly changed into the distillation of gas moment from ice using hydrone completes puffing process, does not then have to take out Chinese medicine,
Directly be dried using microwave, in dry process open stirring, Chinese medicine during stirring uniform drying and because
Microwave bulking, which is dried, to become fragile, and disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder
End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) Chinese medicine material after crushing is weighed in proportion and adds yeast, is 1 according to solid-liquid ratio:20-1：10 ratio adds water
Afterwards in 24-26 DEG C of temperature, fermentation 30-90min is carried out under the conditions of relative humidity 95%；Fermented and decomposed in medicine using yeast
The carbohydrate of the easily lifting blood glucose such as monose；
(5) zymotic fluid is according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Monose is less soluble
In ethanol, the polar component sugar content after ethanol extracts is low, is readily dissolved in body fluid, is oriented to target location, quick；Ultrafiltration
Macromolecular is further filtered, what is left is biological micromolecule, is worked faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into
The destruction divided, drug effect are more preferable.
Further, stage drying is used after step (2) microwave bulking, i.e., it is 70-80 DEG C to adjust temperature first, work(
Rate 110-120w, dry 2-3min；Then it is 50-70 DEG C, power 100-110w to adjust temperature, dries 2-3min；Finally adjust
Temperature is 40-50 DEG C, power 90-100w, dries 2-3min.
Further, the pulverization conditions of the step (3) are to shut down 3min, then anti-mill after 15min is just being ground using ball mill
3min is shut down after 15min, so repeatedly 2 times.
Further, the molecular weight that milipore filter retains in the step (5) is 15000-20000.It is demonstrated experimentally that molecular weight
It is to retain the most molecular weight of active ingredient for 15000-20000, and it is rapid-action, effect is good.
Further, step (6) the microwave disinfection condition is 70 DEG C -105 DEG C, second time 90-180.It can kill
Farthest retain active ingredient on the basis of microorganism not to be destroyed.
The preparation method of externally applied drug comprises the steps of：Chinese medicine material is weighed according to formula and is added in container, is added
Water covers powder immersion 25-30 minutes, adds water and does not cross 5-7 centimetres of powder, decocts to seething with excitement to use instead again and is cooked by slow fire with high heat
30-40 minutes, take filtrate；Then add water and do not cross 5-7 centimetres of powder, decoct with high heat to seething with excitement to use instead again and be cooked by slow fire 30-
40 minutes, then remove slag and take filtrate, filtrate merges twice.
Application method：Each taking 100ml, three times per day, one after each meal, take in endo-medicine half an hour and use externally applied drug
Thing rinses affected part, and ten days are a course for the treatment of.
Toxicity Analysis：
Soybean：It is sweet, mild-natured, enter spleen, large intestine channel, in having invigorating the spleen wide, the effect of moisturizing the water that disappears, clearing heat and detoxicating, QI invigorating；
Cure mainly the thin thin, gestosis of infantile malnutrition due to digestive disturbances or intestinalparasites rush down dysentery, abdominal distension, sore and toxic, traumatism and bleeding etc..Soya bean can also anti-inflammation, to pharyngitis, knot
Film inflammation, stomatitis, bacillary dysentery, enteritis are effective.Immunity of organism can be strengthened, vascular sclerosis is prevented, promote skeleton development, resistance iron deficiency
Property anaemia, being capable of anti-oxidant and anti-aging effect.
Golden cypress：Bitter, it is cold in nature；Return kidney, bladder, large intestine channel.Function heat-clearing, eliminating dampness, purging intense heat, removing toxic substances；Hot dysentery is cured mainly, is let out
Rush down, quench one's thirst, jaundice , crippling wilts, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, leukorrhea with reddish discharge, hectic fever due to yin labor heat, red eye, swell pain, aphthae, sore
Ulcer pyogenic infections.
Seven leaf courages：Bitter, micro-sweet are cool in nature.Effect replenishes qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, clearing heat and detoxicating；With reducing blood lipid, drop blood
The effects such as sugared, antitumor, anti-aging, protection liver and enhancing body immune function.It is mainly used in treating liver cancer, lung cancer, uterus
The propagation of the cancer cells such as cancer, cutaneum carcinoma, there is obvious inhibitory action.
Asparagus fern：It is cold in nature, sweet, slight bitter.With replenishing the vital essence and removing heat, the effect of moistening lung nourshing kidney.For control fever due to yin deficiency, lung carbuncle,
The illness such as quench one's thirst.There are hemocytes increasing, enhancing reticuloendothelial system phagocytic function and extend antibody existence time.
Turnip：Toil is sweet, puts down.Function appetizer under the gas, eliminating damp, detoxifying；Accumulation of food in the stomach and intes tine due to indigestion is controlled, jaundice, is quenched one's thirst, heat toxin wind swells, malignant boil
Sore, acute mastitis.
Stevia rebaudian leaf：It is sweet, it is cool.Nourishing Yin and promoting production of body fluid, for deficiency of stomach-Yin, help digest, promote pancreas and spleen and stomach function.
Fermented Chinese gall herb and tea leaves：Acid；It is puckery；Micro-sweet；It is flat.Moistening lung for removing phlegm；Hemostasis antidiarrheal；It is antipyretic to promote the production of body fluid.Main chronic cough due to asthenia of viscera；Pharyngalgia；Aphtha；
Noma；Have blood in stool；Bloody flux；Diarrhea；Prolapse of the anus；Hot summer weather is thirsty.
Dendrobium densiflorum lindl：Orchid family Dendrobium densiflorum lindl, is used as medicine with stem；There is nourishing YIN for benefiting the kidney, promote the production of body fluid to quench thirst.Spider pyreticosis, hinders Tianjin, and dry is tired of
Yearningly, the effect of eak after being ill.
Square olive：It is sour, sweet, puckery, it is mild-natured.Removing heat from the lung and relieving sorethroat, promote the production of body fluid to quench thirst.Pharyngalgia is cured mainly, is coughed, polydipsia.
Triglochin martimum：Clearing heat and nourishing yin, promote the production of body fluid to quench thirst.For deficiency of Yin hectic fever, stomach energy polydipsia, mouth parched and tongue scorched.
The dried rhizome of rehmannia：Clearing heat and promoting fluid, after cool, hemostasis；For hot blast impairment of yin, the deep red polydipsia of tongue, spot dermexanthesis, haematemesis, bleeding from five sense organs or subcutaneous tissue, throat
Swelling and pain.Radix rehmanniae recen clearing heat and cooling blood, yin-nourishing, promotes the production of body fluid；For pyreticosis polydipsia, spot dermexanthesis, yin asthenia generating intrinsic heat, haematemesis, bleeding from five sense organs or subcutaneous tissue, glycosuria
Disease, catarrhal jaundice.
Red ginseng：Reinforce vital energy, prevent prolapse and engender liquid, calm the nerves.It is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, regurgitation and emesis, lingering diarrhea of defecating, void
Cough and asthma promotees, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, infantile chronic fright, and long void is not
It is multiple, the card of all qi-blood-body fluid deficiencies.
Dogwood fruit：Function tonifies the liver and kidney, astringing and avoiding visceroptosis.Cure mainly waist to have a dizzy spell, deafness and tinnitus, soreness and weakness of waist and knees, Xian essences are sliding
Essence, frequent urination, incessant sweating due to debility, woman uterine bleeding；For Heat Diabetes, warm liver kidney tonifying, except a wind cutting, only menorrhalgia, punish-old
People's frequent micturition.
Poria cocos：With anti-oxidant, anti-aging, increase immunity, the effect of raising brain cell activity.Poria cocos has stronger
Diuresis, ephritis, heart failure oedema can be treated.There is sedation in addition, it is effective to neurasthenia.It is lightly seasoned mild-natured, it is apt to QI invigorating
Blood-nourishing, antitoxic heart-soothing and sedative, internal heat anticance；Mild in medicine property and, for dampness removing without hindering healthy tendency, contained pachymic acid has strengthen immunity, anti-swollen
Knurl and the effect of calmness, hypoglycemic etc.；Can be relaxed gastrointestinal smooth muscle, gastric acid secretion inhibiting, prevent necrosis of liver cells, antibacterial
And other effects.
The fruit of Chinese wolfberry：Pharmacological research shows that the fruit of Chinese wolfberry has hypoglycemic, reducing blood lipid, norcholesterol, improves immune function of human body
Effect.It is usually used in treating senile dementia caused by liver and kidney deficiency disease, it is simultaneous to control cough due to consumptive disease, the vexed disease such as quench one's thirst.
Sweet potato leaves：Have the function that to strengthen immunologic function, improve body resistance against diseases, enhance metabolism, anti-aging,
Also hypoglycemic, defaecation diuresis simultaneously, blood platelet-increasing, hemostasis, prevention of arterial hardening, prevention cell carcinogenesis, lactagogue removing toxic substances, protection
Eyesight, prevent the good healthcare function of yctalopia.
HERBA DENDROBII：It is cold in nature, it is sweet, light, bitter；Enter stomach, kidney channel.Function is mainly reinforcing stomach reg fluid, replenishing the vital essence and removing heat.Clinic is used
In consumption of body fluid caused by febrile disease, thirsty tongue is dry, abnormal heat, stomach trouble, retch, tongue light lack tongue after being ill.With enhancing is immune, strong cloudy strengthening the essence, promote the production of body fluid it is foster
Stomach, moisten the lung and relieve the cough, nourishing Yin and clearing heat, promote the production of body fluid to quench thirst, for consumption of body fluid caused by febrile disease, thirsty tongue is dry, abnormal heat, anticancer, reinforcing stomach reg fluid after being ill, grow
Cloudy heat-clearing, clearing liver, improving eyesight, regulation blood fat, hypoglycemic etc..There have to cardiovascular and cerebrovascular, digestive system and respiratory system, ophthalmology etc. to be special
Effect.
Radix Angelicae Sinensis：It is sweet, pungent, warm；With oxygen lack resistant function；Regulation body's immunity, there is antitumaous effect；Improve looks
Effect；Replenishing and activating blood effect；Antibacterial, anti arteriosclerosis effect.
The root of kudzu vine：Can promoting blood circulation and removing blood stasis, antitoxic heart-soothing and sedative, calming the liver, having improves heart and brain circulation, increases cerebral blood flow (CBF) and reduction
The effect of blood pressure.
Pollen pini：It is warm-natured, it is sweet.The effect of with nourishing qi and blood, soothing the liver wind-dispelling, hygroscopic, hemostasis；Head rotation dizziness is cured mainly,
Middle void has a stomach-ache, protracted dysentery, and all sores are wet rotten, traumatic bleeding.
Radix ampelopsis：Function is clearing heat and detoxicating；Eliminating stagnation to stop pain；Myogenic sore；Treatment of ulcer pyogenic infections, scrofula, scald, wet sore, a kind of malaria,
Frightened epilepsy, bloody flux, intestines wind, anal fistula, leukorrhea, traumatic injury, traumatism and bleeding.Modern pharmacology proves that there is radix ampelopsis auxiliary analgesia to make
With can significantly increase and RADIX ACONITI LATERALIS PREPARATA and process the analgesic activity of monkshood.
Garden burnet：Cold in nature, bitter acid is nontoxic；Return liver, lung, kidney and large intestine channel.There is cooling blood and hemostasis, it is clearing heat and detoxicating, train clear support
The moon, healing up sore and subduing swelling and other effects.
Calcined and quenched CALAMINA：It is odorless, taste micro-puckery.Function removing toxic substances removing nebula, the antipruritic sore of hygroscopic；Cure mainly red eye, swell pain, eyes-affinity
Red rotten, the screen film triangular mass of mucous membrane growing from the inner corner of the eye, unhealing ulcer, pus is dripping, wet sore, pruitus.
Pinkflower ecdysanthera root and leaf：Relieving dyspepsia, promote the production of body fluid to quench thirst, sterilize, sore.Control food stagnation turgor, stomatitis, laryngitis, gingivitis, sore
Furuncle ulcer；Solution big tea medicine poison, wood eat poison, crotons poison；Washout purulence ulcer.
The Chinese medical extract sheerly Chinese medicine preparation of the present invention, by the conditioning of Chinese medicine after fermentation, avoids the blood in medicine
Sugared stimulating factor, has no side effect, and regulation blood glucose is rapid-action, and effect is good；Foot blood glucose is reduced with reference to external used medicine, sterilizes sore,
Promote to recover.Wherein, soybean, golden cypress, seven leaf courages, asparagus fern, turnip have the function that clearing heat-fire；Stevia rebaudian leaf, fermented Chinese gall herb and tea leaves, thick Huang
Careless, square olive, Triglochin martimum have the function that to promote the production of body fluid to quench thirst；The dried rhizome of rehmannia, red ginseng, dogwood fruit, Poria cocos have the function that supplementing qi and nourishing yin；Matrimony vine
Son, sweet potato leaves, HERBA DENDROBII, Radix Angelicae Sinensis, the root of kudzu vine have the function that hypoglycemic；Pollen pini, radix ampelopsis, garden burnet, calcined and quenched CALAMINA, pinkflower ecdysanthera
Rattan has the function that sterilization sore, and a variety of medicinal material comprehensive functions, regulation blood glucose is rapid-action inside, and effect is good；It is quick outside to reduce
Foot blood glucose, sore is sterilized, promote to recover.By taking 200 patients as an example, treated using medicine of the present invention, 195 patients have
Effect, total effective rate are up to 97.5%, effective compared to 93 people only using endo-medicine, and effective percentage improves 51%, compared to
Only effective using 58 people of external used medicine, effective percentage improves 68.5%.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making
The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1：
A kind of Chinese medicine composition for treating diabetes, endo-medicine are made up of the component of following mass fraction：Soybean 6
Part, 4 parts of golden cypress, 4 parts of seven leaf courage, 5 parts of asparagus fern, 4 parts of turnip, 5 parts of stevia rebaudian leaf, 4 parts of fermented Chinese gall herb and tea leaves, 4 parts of Dendrobium densiflorum lindl, 4 parts of square olive, sea
5 parts of leek, 4 parts of the dried rhizome of rehmannia, 5 parts of red ginseng, 4 parts of dogwood fruit, 7 parts of Poria cocos.External used medicine is made up of the component of following mass fraction：Chinese holly
7 parts of matrimony vine, 6 parts of sweet potato leaves, 5 parts of HERBA DENDROBII, 4 parts of Radix Angelicae Sinensis, 4 parts of the root of kudzu vine, 6 parts of pollen pini, 5 parts of radix ampelopsis, 4 parts of garden burnet, forge furnace
Sweet 7 parts of stone, 4 parts of pinkflower ecdysanthera root and leaf.
Endo-medicine preparation method comprises the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 6 DEG C under the conditions of refrigerate 17h, at -15 DEG C freeze 15h it is standby
With；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is
The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 120 DEG C, microwave storehouse is preheated, and then puts into 1.5kg steps (1) freezing
Chinese medicine material after processing, regulation microwave power are 500w, and operation 160s carries out microwave bulking；Then it is 40- by temperature adjustment
80 DEG C, microwave power 90-120w, dry 6-9min；Chinese medicine after freezing is directly subjected to microwave bulking, utilizes hydrone
The strength for being directly changed into the distillation of gas moment from ice completes puffing process, does not then have to take out Chinese medicine, directly utilizes microwave
It is dried, stirring, Chinese medicine uniform drying and because microwave bulking drying during stirring is opened in dry process
Become fragile, be broken into disintegrating slag naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder
End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) Chinese medicine material after crushing is weighed in proportion and adds yeast, is 1 according to solid-liquid ratio:15 ratio add after water
25 DEG C of temperature, fermentation 60min is carried out under the conditions of relative humidity 95%；The monose decomposed in medicine etc. that fermented using yeast is easily lifted
The carbohydrate of blood glucose；
(5) zymotic fluid is according to 1:300 solid-liquid ratio soaks ultrafiltration after 18h in ethanol.Monose is not readily dissolved in ethanol, through second
Polar component sugar content after alcohol extracting is low, is readily dissolved in body fluid, is oriented to target location, quick；Ultrafiltration is further filtered
Macromolecular, what is left is biological micromolecule, is worked faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into
The destruction divided, drug effect are more preferable.
Stage drying is used after step (2) microwave bulking, i.e., it is 75 DEG C, power 105w to adjust temperature first, is dried
2min；Then it is 60 DEG C, power 105w to adjust temperature, dries 3min；It is 45 DEG C, power 95w finally to adjust temperature, is dried
2min。
The pulverization conditions of the step (3) are to shut down 3min after 15min is just being ground using ball mill, then are stopped after instead grinding 15min
Machine 3min, so repeatedly 2 times.
The molecular weight that milipore filter retains in the step (5) is 18000.It is demonstrated experimentally that molecular weight is for 15000-20000
Retain the most molecular weight of active ingredient, and it is rapid-action, effect is good.
Step (6) the microwave disinfection condition is 85 DEG C, 150 seconds time.Can be maximum on the basis of microorganism is killed
The reservation active ingredient of degree is not destroyed.
External used medicine comprises the steps of：Chinese medicine material is weighed according to formula and is added in container, adds water to cover medicine
Face is soaked 28 minutes, is added water and is not crossed 6 centimetres of powder, is decocted to seething with excitement to use instead again and is cooked by slow fire 35 minutes with high heat, takes filtrate；
Then add water and do not cross 6 centimetres of powder, decoct to seething with excitement to use instead again and be cooked by slow fire 35 minutes with high heat, then remove slag and take filtrate,
Filtrate merges twice.
Embodiment 2：
A kind of Chinese medicine composition for treating diabetes, endo-medicine are made up of the component of following mass fraction：Soybean 5
Part, 5 parts of golden cypress, 3 parts of seven leaf courage, 6 parts of asparagus fern, 3 parts of turnip, 6 parts of stevia rebaudian leaf, 3 parts of fermented Chinese gall herb and tea leaves, 5 parts of Dendrobium densiflorum lindl, 3 parts of square olive, sea
6 parts of leek, 3 parts of the dried rhizome of rehmannia, 6 parts of red ginseng, 3 parts of dogwood fruit, 8 parts of Poria cocos.External used medicine is made up of the component of following mass fraction：Chinese holly
5 parts of matrimony vine, 8 parts of sweet potato leaves, 4 parts of HERBA DENDROBII, 5 parts of Radix Angelicae Sinensis, 3 parts of the root of kudzu vine, 8 parts of pollen pini, 4 parts of radix ampelopsis, 5 parts of garden burnet, forge furnace
Sweet 5 parts of stone, 5 parts of pinkflower ecdysanthera root and leaf.
Endo-medicine preparation method comprises the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4 DEG C under the conditions of refrigerate 24h, at -10 DEG C freeze 20h it is standby
With；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is
The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put at 2kg steps (1) freezing
Chinese medicine material after reason, regulation microwave power are 450w, and operation 180s carries out microwave bulking；Then it is 40-80 by temperature adjustment
DEG C, microwave power 90-120w, dry 6-9min；Chinese medicine after freezing is directly subjected to microwave bulking, using hydrone from
The strength that ice is directly changed into the distillation of gas moment completes puffing process, does not then have to take out Chinese medicine, is directly entered using microwave
Row drying, opens stirring in dry process, and Chinese medicine uniform drying and becomes during stirring because microwave bulking is dried
It is crisp, disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder
End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) Chinese medicine material after crushing is weighed in proportion and adds yeast, is 1 according to solid-liquid ratio：10 ratio add after water
24 DEG C of temperature, fermentation 90min is carried out under the conditions of relative humidity 95%；The monose decomposed in medicine etc. that fermented using yeast is easily lifted
The carbohydrate of blood glucose；
(5) zymotic fluid is according to 1:100 solid-liquid ratio soaks ultrafiltration after 24h in ethanol.Monose is not readily dissolved in ethanol, through second
Polar component sugar content after alcohol extracting is low, is readily dissolved in body fluid, is oriented to target location, quick；Ultrafiltration is further filtered
Macromolecular, what is left is biological micromolecule, is worked faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into
The destruction divided, drug effect are more preferable.
Stage drying is used after step (2) microwave bulking, i.e., it is 80 DEG C, power 110w to adjust temperature first, is dried
2min；Then it is 70 DEG C, power 100w to adjust temperature, dries 2min；It is 50 DEG C, power 100w finally to adjust temperature, is dried
2min。
The pulverization conditions of the step (3) are to shut down 3min after 15min is just being ground using ball mill, then are stopped after instead grinding 15min
Machine 3min, so repeatedly 2 times.
The molecular weight that milipore filter retains in the step (5) is 20000.It is demonstrated experimentally that molecular weight is for 15000-20000
Retain the most molecular weight of active ingredient, and it is rapid-action, effect is good.
Step (6) the microwave disinfection condition is 70 DEG C, 180 seconds time.Can be maximum on the basis of microorganism is killed
The reservation active ingredient of degree is not destroyed.
External used medicine comprises the steps of：Chinese medicine material is weighed according to formula and is added in container, adds water to cover medicine
Face is soaked 25 minutes, is added water and is not crossed 7 centimetres of powder, is decocted to seething with excitement to use instead again and is cooked by slow fire 30 minutes with high heat, takes filtrate；
Then add water and do not cross 7 centimetres of powder, decoct to seething with excitement to use instead again and be cooked by slow fire 30 minutes with high heat, then remove slag and take filtrate,
Filtrate merges twice.
Embodiment 3：
A kind of Chinese medicine composition for treating diabetes, endo-medicine are made up of the component of following mass fraction：Soybean 8
Part, 3 parts of golden cypress, 5 parts of seven leaf courage, 4 parts of asparagus fern, 5 parts of turnip, 4 parts of stevia rebaudian leaf, 5 parts of fermented Chinese gall herb and tea leaves, 3 parts of Dendrobium densiflorum lindl, 5 parts of square olive, sea
4 parts of leek, 5 parts of the dried rhizome of rehmannia, 4 parts of red ginseng, 5 parts of dogwood fruit, 5 parts of Poria cocos.External used medicine is made up of the component of following mass fraction：Chinese holly
8 parts of matrimony vine, 5 parts of sweet potato leaves, 6 parts of HERBA DENDROBII, 3 parts of Radix Angelicae Sinensis, 5 parts of the root of kudzu vine, 5 parts of pollen pini, 6 parts of radix ampelopsis, 3 parts of garden burnet, forge furnace
Sweet 8 parts of stone, 3 parts of pinkflower ecdysanthera root and leaf.
Endo-medicine preparation method comprises the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 10 DEG C under the conditions of refrigerate 12h, freeze 20h at -10 DEG C
It is standby；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, improves cellular damage rate,
Laid the first stone for the microwave bulking of next step.
(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put at 2kg steps (1) freezing
Chinese medicine material after reason, regulation microwave power are 450w, and operation 180s carries out microwave bulking；Then it is 40-80 by temperature adjustment
DEG C, microwave power 90-120w, dry 6-9min；Chinese medicine after freezing is directly subjected to microwave bulking, using hydrone from
The strength that ice is directly changed into the distillation of gas moment completes puffing process, does not then have to take out Chinese medicine, is directly entered using microwave
Row drying, opens stirring in dry process, and Chinese medicine uniform drying and becomes during stirring because microwave bulking is dried
It is crisp, disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder
End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) Chinese medicine material after crushing is weighed in proportion and adds yeast, is 1 according to solid-liquid ratio:20 ratio add after water
24 DEG C of temperature, fermentation 90min is carried out under the conditions of relative humidity 95%；The monose decomposed in medicine etc. that fermented using yeast is easily lifted
The carbohydrate of blood glucose；
(5) zymotic fluid is according to 1:500 solid-liquid ratio soaks ultrafiltration after 12h in ethanol.Monose is not readily dissolved in ethanol, through second
Polar component sugar content after alcohol extracting is low, is readily dissolved in body fluid, is oriented to target location, quick；Ultrafiltration is further filtered
Macromolecular, what is left is biological micromolecule, is worked faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into
The destruction divided, drug effect are more preferable.
Stage drying is used after step (2) microwave bulking, i.e., it is 70 DEG C, power 120w to adjust temperature first, is dried
2min；Then it is 70 DEG C, power 100w to adjust temperature, dries 3min；It is 40 DEG C, power 100w finally to adjust temperature, is dried
3min。
The pulverization conditions of the step (3) are to shut down 3min after 15min is just being ground using ball mill, then are stopped after instead grinding 15min
Machine 3min, so repeatedly 2 times.
The molecular weight that milipore filter retains in the step (5) is 15000.It is demonstrated experimentally that molecular weight is for 15000-20000
Retain the most molecular weight of active ingredient, and it is rapid-action, effect is good.
Step (6) the microwave disinfection condition is 105 DEG C, 90 seconds time.Can be maximum on the basis of microorganism is killed
The reservation active ingredient of degree is not destroyed.
External used medicine comprises the steps of：Chinese medicine material is weighed according to formula and is added in container, adds water to cover medicine
Face is soaked 30 minutes, is added water and is not crossed 5 centimetres of powder, is decocted to seething with excitement to use instead again and is cooked by slow fire 40 minutes with high heat, takes filtrate；
Then add water and do not cross 5 centimetres of powder, decoct to seething with excitement to use instead again and be cooked by slow fire 40 minutes with high heat, then remove slag and take filtrate,
Filtrate merges twice.
Claims (10)
- A kind of 1. Chinese medicine composition for treating diabetes, it is characterised in that endo-medicine by following mass fraction component group Into：Soybean 5-8 parts, golden cypress 3-5 parts, seven leaf courage 3-5 parts, asparagus fern 4-6 parts, turnip 3-5 parts, stevia rebaudian leaf 4-6 parts, fermented Chinese gall herb and tea leaves 3-5 Part, Dendrobium densiflorum lindl 3-5 parts, square olive 3-5 parts, Triglochin martimum 4-6 parts, dried rhizome of rehmannia 3-5 parts, red ginseng 4-6 parts, dogwood fruit 3-5 parts, Poria cocos 5-8 Part.
- 2. the Chinese medicine composition for the treatment of diabetes as claimed in claim 1, it is characterised in that by the group of following mass fraction It is grouped into：6 parts of soybean, 4 parts of golden cypress, 4 parts of seven leaf courage, 5 parts of asparagus fern, 4 parts of turnip, 5 parts of stevia rebaudian leaf, 4 parts of fermented Chinese gall herb and tea leaves, Dendrobium densiflorum lindl 4 Part, 4 parts of square olive, 5 parts of Triglochin martimum, 4 parts of the dried rhizome of rehmannia, 5 parts of red ginseng, 4 parts of dogwood fruit, 7 parts of Poria cocos.
- A kind of 3. Chinese medicine composition for treating diabetes, it is characterised in that external used medicine by following mass fraction component group Into：Fruit of Chinese wolfberry 5-8 parts, sweet potato leaves 5-8 parts, HERBA DENDROBII 4-6 parts, Radix Angelicae Sinensis 3-5 parts, root of kudzu vine 3-5 parts, pollen pini 5-8 parts, radix ampelopsis 4-6 parts, garden burnet 3-5 parts, calcined and quenched CALAMINA 5-8 parts, pinkflower ecdysanthera root and leaf 3-5 parts.
- 4. the Chinese medicine composition for the treatment of diabetes as claimed in claim 3, it is characterised in that by the group of following mass fraction It is grouped into：7 parts of the fruit of Chinese wolfberry, 6 parts of sweet potato leaves, 5 parts of HERBA DENDROBII, 4 parts of Radix Angelicae Sinensis, 4 parts of the root of kudzu vine, 6 parts of pollen pini, 5 parts of radix ampelopsis, garden burnet 4 parts, 7 parts of calcined and quenched CALAMINA, 4 parts of pinkflower ecdysanthera root and leaf.
- 5. a kind of preparation method of the Chinese medicine composition of the diabetes for the treatment of as claimed in claim 1, it is characterised in that by following Step forms：(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, it is cold at -10~-18 DEG C It is standby to freeze 10-20h；(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) freezing Chinese medicine material after processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking；Then temperature is adjusted Save as 40-80 DEG C, microwave power 90-120w, dry 6-9min；(3) Chinese medicine after step (2) processing is put into ball mill and crushed；(4) Chinese medicine material after crushing is weighed in proportion and adds yeast, is 1 according to solid-liquid ratio:20-1：10 ratio add after water 24-26 DEG C of temperature, carries out fermentation 30-90min under the conditions of relative humidity 95%；(5) zymotic fluid is according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol；(6) liquid after ultrafiltration is sealed after microwave disinfection.
- 6. the preparation method of the Chinese medicine composition for the treatment of diabetes as claimed in claim 5, it is characterised in that：The step (2) stage drying is used after microwave bulking, i.e., it is 70-80 DEG C, power 110-120w to adjust temperature first, dries 2-3min；So It is 50-70 DEG C, power 100-110w to adjust temperature afterwards, dries 2-3min；It is 40-50 DEG C finally to adjust temperature, power 90- 100w, dry 2-3min.
- 7. the preparation method of the Chinese medicine composition for the treatment of diabetes as claimed in claim 5, it is characterised in that：The step (3) pulverization conditions are shutting down 3min after 15Min just to be ground using ball mill, then shut down 3min after anti-mill 15min, and so repeatedly 2 It is secondary.
- 8. the preparation method of the Chinese medicine composition for the treatment of diabetes as claimed in claim 5, it is characterised in that：The step (5) molecular weight that milipore filter retains in is 15000-20000.
- 9. the preparation method of the Chinese medicine composition for the treatment of diabetes as claimed in claim 5, it is characterised in that：The step (6) microwave disinfection condition is 70 DEG C -105 DEG C, second time 90-180.
- 10. a kind of preparation method of the Chinese medicine composition of the diabetes for the treatment of as claimed in claim 3, it is characterised in that by following Step forms：Chinese medicine material is weighed according to formula and is added in container, is added water to cover powder immersion 25-30 minutes, is added water 5-7 centimetres of powder is not crossed, decocts with high heat to seething with excitement to use instead again and is cooked by slow fire 30-40 minutes, take filtrate；Then no mistake is added water 5-7 centimetres of powder, decoct with high heat to seething with excitement to use instead again and be cooked by slow fire 30-40 minutes, then remove slag and take filtrate, filtrate is closed twice And.
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| CN101843737A (en) * | 2009-11-04 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic feet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101843737A (en) * | 2009-11-04 | 2010-09-29 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating diabetic feet |
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| Title |
|---|
| 周月红: "生肌散外敷治疗糖尿病足30例", 《中国中医药现代远程教育》 * |
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Application publication date: 20171110 |