CN107334753B - Black plaster and preparation method thereof - Google Patents
Black plaster and preparation method thereof Download PDFInfo
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- CN107334753B CN107334753B CN201710756634.3A CN201710756634A CN107334753B CN 107334753 B CN107334753 B CN 107334753B CN 201710756634 A CN201710756634 A CN 201710756634A CN 107334753 B CN107334753 B CN 107334753B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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Abstract
The invention belongs to the field of traditional Chinese medicine preparation, and particularly relates to a black plaster and a preparation method thereof. The black plaster is prepared by refining medicinal materials, emu oil and yellow lead into paste, and spreading on a backing material. Because emu oil does not contain phosphorus, the emu oil can smoothly pass through skin barriers to reach the discomfort of human bodies, and has super-strong skin permeability, which is a characteristic that other oil does not have. And has the property of healing wounds due to the fatty acid composition, particularly high levels of gamma-linolenic acid and oleic acid. Linolenic acid is an unsaturated fatty acid, and can relieve joint pain; oleic acid is a monounsaturated fatty acid, and can be used for reducing inflammation of skin tissue and for adjuvant treatment. For the preparation of the black plaster, because the boiling point of the black plaster is lower than that of common sesame oil, tung oil or sesame oil and the like in the existing preparation, the medicine can be boiled at a relatively low temperature, the obtained medicine has more effective components, and the black plaster is not easy to lose efficacy due to high-temperature oxidation or other chemical actions.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparation, and particularly relates to a black plaster and a preparation method thereof.
Background
The plaster is one of the main methods for external treatment in traditional Chinese medicine, and has a long history in China. The plaster has the advantages of convenient use, low price, rapid action, obvious curative effect and the like, and is most suitable for people who are not allowed to take the medicine and can not take the medicine. Especially for difficult and complicated diseases which can not be cured for a long time, the traditional Chinese medicine composition can show unique work and force, and is a traditional Chinese medicine external treatment wonderful prescription which is deeply favored by the broad masses of common people.
Currently, the black paste medicament sold in domestic markets and used clinically is prepared by processing the medicaments by using vegetable oil (such as sesame oil, tung oil and the like) and yellow lead as substrates and refining the medicaments at high temperature (above 270 ℃). The specific method comprises frying the Chinese medicinal materials and vegetable oil in a frying pot at 200-220 deg.C until they are yellow, filtering to remove residues, refining at 270-350 deg.C, adding Plumbum Preparatium, removing toxic materials, and spreading on a backing material. The method has the following disadvantages in production and use: 1. after the medicine is refined at a high temperature of more than 270 ℃, the loss of active ingredients is more, and the curative effect of the medicine is influenced. 2. The vegetable oil used as the base material has poor permeability, and influences the deep absorption of the effective components of the medicine into the skin.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a black plaster and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a black plaster is prepared by mixing medicinal materials, emu oil and Plumbum Preparatium, making into paste, and spreading on backing material.
Preferably, the mass ratio of the medicinal materials, the emu oil and the yellow lead is 0.5-1: 3-1: 1.
the invention also comprises a method for preparing the black plaster, which comprises the following steps: 1) frying materials: heating emu oil to 80-125 deg.C, adding the rest materials except the valuable materials, stirring to make the materials heated uniformly, frying until the ointment turns yellow, removing residues, filtering, and cooling to obtain base ointment oil; 2) parching pill: placing Plumbum Preparatium in a clean pan, parching with slow fire until water vapor disappears, and loosening; continuously stir-frying with a shovel after the fire is turned off; 3) oil refining: putting the base cream oil obtained in the step 1) into a clean pot, decocting with strong fire until boiling, namely changing to small fire, maintaining the oil temperature at 120-195 ℃, dripping oil on cold water by using a stick, and obtaining the required oil material after the oil drops bead and the cold water are not scattered; 4) the following components: slowly adding the yellow lead obtained in the step 2) into the oil material refined in the step 3), and continuously stirring until the oil material is boiled, wherein the oil material overflows bubbles and smokes, and obtaining the oil lead when the smoke is slightly exhausted; dipping the red lead into a stainless steel plate by a wooden stick, and cooling, then, trying to pinch the red lead by a dry hand until the red lead is stuck and no red lead is left on the hand when the hand is loosened, turning off the fire at the moment, and continuing to stir until the red lead is cooled; 5) fire toxin removal: after the oil pills obtained in the step 4) are made into paste, the paste is placed into a cold water basin to be soaked for 3-5 days, and water is changed for 2-3 times every day to remove fire toxin; 6) adding fine powder; grinding the valuable medicinal materials in the medicinal materials into fine powder by using a superfine grinder, slowly adding the fine powder into the re-melted plaster obtained in the step 5), and stirring; 7) spreading plaster: spreading the fine plaster obtained in step 6) on sterilized paper or cloth, and cooling.
Preferably, the fried explosive materials in the step 1) are added and cooked firstly and secondly according to different properties of the explosive materials; firstly, putting hard plant root and stem medicinal materials into a container, soaking the medicinal materials in emu oil, boiling the medicinal materials with slow fire, and boiling the medicinal materials for 1 to 1.5 hours; simultaneously adding herbal materials such as flowers, grasses, leaves and skins which are not resistant to boiling, and boiling for 1.5-2.5 hours with medium fire to change the external color of the herbal materials in the container into dark brown and the internal color of the herbal materials into brown, stopping heating, and heating at the rest temperature until the herbal materials are boiled to dry.
Wherein, the emu oil comprises the following components in parts by weight: 0.4 part of myristic acid; 22 parts of palmitic acid; 9.6 parts of stearic acid; 3.5 parts of palmitoleic acid; 47.4 parts of oleic acid and 15.2 parts of linoleic acid; linolenic acid 0.9 part.
Compared with the prior art, the invention has the beneficial effects that:
because emu oil does not contain phosphorus, the emu oil can smoothly pass through skin barriers to reach the discomfort of human bodies, and has super-strong skin permeability, which is a characteristic that other oil does not have. And has the property of healing wounds due to the fatty acid composition, particularly high levels of gamma-linolenic acid and oleic acid. Linolenic acid is an unsaturated fatty acid, and can relieve joint pain; oleic acid is a monounsaturated fatty acid, and can be used for reducing inflammation of skin tissue and for adjuvant treatment. For the preparation of the black plaster, because the boiling point of the black plaster is lower than that of common sesame oil, tung oil or sesame oil and the like in the existing preparation, the medicine can be boiled at a relatively low temperature, the obtained medicine has more effective components, and the black plaster is not easy to lose efficacy due to high-temperature oxidation or other chemical actions.
Detailed Description
In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the following preferred embodiments.
A method for preparing the black plaster, which comprises the following steps: 1) frying materials: heating emu oil to 80-125 deg.C, adding the rest materials except the valuable materials, stirring to make the materials heated uniformly, frying until the ointment turns yellow, removing residues, filtering, and cooling to obtain base ointment oil; 2) parching pill: placing Plumbum Preparatium in a clean pan, parching with slow fire until water vapor disappears, and loosening; continuously stir-frying with a shovel after the fire is turned off; 3) oil refining: putting the base cream oil obtained in the step 1) into a clean pot, decocting with strong fire until boiling, namely changing small fire, maintaining the boiling of the base cream oil (120 plus 195 ℃ for emu oil), dripping oil on cold water by using a stick, and obtaining the required oil material after the oil material is beaded and does not disperse; 4) the following components: slowly adding the yellow lead obtained in the step 2) into the oil material refined in the step 3), and continuously stirring until the oil material is boiled, wherein the oil material overflows bubbles and smokes, and obtaining the oil lead when the smoke is slightly exhausted; dipping the red lead into a stainless steel plate by a wooden stick, and cooling, then, trying to pinch the red lead by a dry hand until the red lead is stuck and no red lead is left on the hand when the hand is loosened, turning off the fire at the moment, and continuing to stir until the red lead is cooled; 5) fire toxin removal: after the oil pills obtained in the step 4) are made into paste, the paste is placed into a cold water basin to be soaked for 3-5 days, and water is changed for 2-3 times every day to remove fire toxin; 6) adding fine powder; grinding the valuable medicinal materials in the medicinal materials into fine powder by using a superfine grinder, slowly adding the fine powder into the re-melted plaster obtained in the step 5), and stirring; 7) spreading plaster: spreading the fine plaster obtained in step 6) on sterilized paper or cloth, and cooling. Wherein the mass ratio of the medicinal materials, the emu oil and the yellow lead is 0.1-1: 3-1: 1. the emu oil comprises the following components in parts by weight: 0.4 part of myristic acid; 22 parts of palmitic acid; 9.6 parts of stearic acid; 3.5 parts of palmitoleic acid; 47.4 parts of oleic acid and 15.2 parts of linoleic acid; linolenic acid 0.9 part.
Example 1, preparation of an analgesic anti-inflammatory black plaster: the preparation method is the same as that described above, wherein the medicine material is 20 g of nux vomica; 20 g of gallnut; 10 g of litsea pungens; 28 g of hempseed; semen momordicae 15 g; 23 g of pangolin scales; 10 g of frankincense; smearing 23 g of medicine; 5 g of borneol; centipede 5 g; 1200 grams of emu oil; 800 g of yellow lead.
Comparative example 1, comparative example 1 is the same as example 1, except that emu oil is replaced by peanut oil, and the temperature of the refining in step 3) is 320 ℃.
And (3) comparison of treatment effects:
first, case
400 outpatient cases, with a maximum of 75 years and a minimum of 23 years. The main symptoms are: surgical injury, skin ulceration, muscle decay, wound suppuration, difficult wound healing, sore.
Second, therapeutic methods
The plaster prepared in the embodiment 1 and the comparative example 1 of the invention is pasted one day, and 7 days are one treatment course.
Third, evaluation of Effect
And (3) curing: the wound surface heals completely, scabs and falls off.
The method has the following advantages: the wound surface is reduced.
And (4) invalidation: those with unchanged symptoms.
Fourthly, summary of therapeutic effects
400 patients were randomized into two groups, one using example 1 and one using comparative example 1;
in example 1, 188 cases are cured, 12 cases are effective, the cure rate is 94%, and the effective rate is 100%.
Comparative example 1 has 162 cases of cure, 36 cases of effective use and 2 cases of ineffective use, the cure rate is 81 percent, and the effective rate is 96 percent.
Clinical tests prove that the traditional Chinese medicine composition has better curative effects on surgical injuries, skin ulceration, muscle decay, wound suppuration, difficult wound healing and carbuncle.
Example 2, a black plaster for treating ostealgia is prepared by the same method as described above, wherein the raw materials include zaocys dhumnade 10 g, semen strychni 1 g, scorpio 2 g, sappan wood 12 g, jowar 12 g, large-leaved gentian 6 g, asarum herb 1 g, magnolia bark 6 g, centipede 6 pieces, dahurian angelica root 4 g, ligusticum wallichii 20 g, musk 0.2 g, nodular branch of pine 10 g, dandelion 10 g, emu oil 200 g; 50 g of yellow lead.
Comparative example 2, comparative example 2 is the same as example 2 except that sesame oil is used instead of emu oil and the refining temperature of step 3) is 270 ℃.
First, case
1000 outpatient cases, with a maximum of 76 years and a minimum of 23 years. The main symptoms are: traumatic injury, fracture, and soft tissue injury.
Second, therapeutic methods
The plaster prepared in the embodiment 2 and the comparative example 2 of the invention is pasted one day, and 7 days are one treatment course.
Third, evaluation of Effect
According to the clinical healing standard, i.e. no pressure pain and no percussion pain, the X-ray shows that the fracture line is fuzzy, and the local part is stable without deformation when the external fixation is cancelled. 1000 patients are randomly divided into two groups, one group uses the example 2, one group uses the comparative example 2, 375 fresh fracture patients in the example 2 are cured in about 1 to 3 treatment courses, wherein 108 clinical heals in one treatment course, 138 clinical heals in two treatment courses, 229 clinical heals in three treatment courses, 125 old fractures heal slowly or not healed for a long time, and the healing standards are that local abnormal activities do not occur, X lines show that fracture lines disappear, the functions of limbs are basically recovered, and the like. Among 125 patients, 34 patients healed within 1 to 2 months, 68 patients healed within 2 to 4 months, and 23 patients healed within 4 months. In comparative example 2, 386 is cured in about 1 to 4 treatment courses, wherein 84 clinical heals in one treatment course, 116 clinical healers in two treatment courses, 132 clinical healers in three treatment courses and 48 clinical healers in four treatment courses. 114 cases of old fracture are delayed in healing or not healed for a long time, and the healing standard is that the local abnormal activities are not generated, the X line shows that the fracture line disappears, the limb function is basically recovered, and the like. Among 114, 22 healed within 1 to 2 months, 32 healed within 2 to 4 months, and 38 healed within 4 months.
Clinical tests prove that the invention is characterized in that: has better curative effect on traumatic injury, fracture and soft tissue injury.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (4)
1. A black plaster is characterized in that a medicinal material, emu oil and yellow lead are refined into a plaster material which is spread on a backing material to prepare the black plaster, and the preparation method of the black plaster comprises the following steps: 1) frying materials: heating emu oil at 80-125 deg.C, adding other materials except valuable materials, stirring to make the materials heated uniformly, frying until the ointment turns yellow, removing residues, filtering, and cooling to obtain base ointment oil; 2) parching pill: placing Plumbum Preparatium in a clean pan, parching with slow fire until water vapor disappears, and loosening; continuously stir-frying with a shovel after the fire is turned off; 3) oil refining: putting the base cream oil obtained in the step 1) into a clean pot, decocting with strong fire until boiling, namely changing to small fire, maintaining the oil temperature at 120-195 ℃, dripping oil on cold water by using a stick, and obtaining the required oil material after the oil drops form beads and are not scattered; 4) the following components: slowly adding the yellow lead obtained in the step 2) into the oil material refined in the step 3), and continuously stirring until the oil material is boiled, wherein the oil material overflows bubbles and smokes, and obtaining the oil lead when the smoke is slightly exhausted; dipping the red lead into a stainless steel plate by a wooden stick, and cooling, then, trying to pinch the red lead by a dry hand until the red lead is stuck and no red lead is left on the hand when the hand is loosened, turning off the fire at the moment, and continuing to stir until the red lead is cooled; 5) fire toxin removal: after the oil pills obtained in the step 4) are made into paste, the paste is placed into a cold water basin to be soaked for 3-5 days, and water is changed for 2-3 times every day to remove fire toxin; 6) adding fine powder; grinding the valuable medicinal materials in the medicinal materials into fine powder by using a superfine grinder, slowly adding the fine powder into the re-melted plaster obtained in the step 5), and stirring; 7) spreading plaster: spreading the fine plaster obtained in step 6) on sterilized paper or cloth, and cooling.
2. A black plaster according to claim 1, wherein the mass ratio of the drug substance, emu oil and yellow lead is from 0.1 to 1: 3-1: 1.
3. the black plaster of claim 1, wherein the frying materials of step 1) are decocted first and second according to different properties of the materials; firstly, putting hard plant root and stem medicinal materials into a container, soaking the medicinal materials in emu oil, boiling the medicinal materials with slow fire, and boiling the medicinal materials for 1 to 1.5 hours; adding herbal materials with unsusceptible decocting property such as flower, grass, leaf, and bark, decocting with medium fire for 1.5-2.5 hr to make the external color of the herbal materials in the container become dark brown and the internal color become brown, stopping heating, and heating at rest temperature until the herbal materials are completely decocted.
4. A black plaster according to claim 1, wherein the emu oil comprises the following components in parts by weight: 0.4 part of myristic acid; 22 parts of palmitic acid; 9.6 parts of stearic acid; 3.5 parts of palmitoleic acid; 47.4 parts of oleic acid and 15.2 parts of linoleic acid; linolenic acid 0.9 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710756634.3A CN107334753B (en) | 2017-08-29 | 2017-08-29 | Black plaster and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710756634.3A CN107334753B (en) | 2017-08-29 | 2017-08-29 | Black plaster and preparation method thereof |
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| CN107334753A CN107334753A (en) | 2017-11-10 |
| CN107334753B true CN107334753B (en) | 2020-07-24 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002324481A1 (en) * | 2001-08-24 | 2003-06-05 | Maurine Pearson | Emu-based formulations for wound treatment related application information |
| AU2006201179A1 (en) * | 1999-08-26 | 2006-04-27 | Ganeden Biotech, Inc. | Use of Emu Oil Carrier for Antifungal, Antibacterial, and Antiviral Medications |
| CN102283941B (en) * | 2011-08-31 | 2013-04-03 | 深圳市美鳄缘投资有限公司 | Crocodile emu oil scald and burn ointment and preparation method thereof |
| CN103446240A (en) * | 2013-09-19 | 2013-12-18 | 单德文 | Traditional Chinese medicine composition for rapidly healing wounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528040B1 (en) * | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
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2017
- 2017-08-29 CN CN201710756634.3A patent/CN107334753B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006201179A1 (en) * | 1999-08-26 | 2006-04-27 | Ganeden Biotech, Inc. | Use of Emu Oil Carrier for Antifungal, Antibacterial, and Antiviral Medications |
| AU2002324481A1 (en) * | 2001-08-24 | 2003-06-05 | Maurine Pearson | Emu-based formulations for wound treatment related application information |
| CN102283941B (en) * | 2011-08-31 | 2013-04-03 | 深圳市美鳄缘投资有限公司 | Crocodile emu oil scald and burn ointment and preparation method thereof |
| CN103446240A (en) * | 2013-09-19 | 2013-12-18 | 单德文 | Traditional Chinese medicine composition for rapidly healing wounds |
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