CN107320428A - A kind of toothpaste for being used to balance Oral health behaviours - Google Patents
A kind of toothpaste for being used to balance Oral health behaviours Download PDFInfo
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- CN107320428A CN107320428A CN201710582355.XA CN201710582355A CN107320428A CN 107320428 A CN107320428 A CN 107320428A CN 201710582355 A CN201710582355 A CN 201710582355A CN 107320428 A CN107320428 A CN 107320428A
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- toothpaste
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- oral health
- propolis
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of toothpaste for being used to balance Oral health behaviours, it is characterised in that includes following components by mass parts：15~20 parts of dicalcium phosphate dihydrate, 20~30 parts of hydrated silica, 20~30 parts of D-sorbite, 10~20 parts of glycerine, 1~3 part of laruyl alcohol sodium sulfovinate, 0.1~1 part of cellulose gum, 0.1~1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01~0.5 part of tetrasodium pyrophosphate, 0.5~2 part of active compound, appropriate amount of deionized water, wherein sodium monofluorophosphate mass parts are in terms of fluorine；The active compound is made up of Panax quinquefolium root extract, propolis extract, carboxymethyl chitosan, and three's mass ratio is 11~16：5~9：0.5~0.9.The toothpaste efficiency comprehensively and significantly, with good biocompatibility, Oral health behaviours, full maintenance oral health can be balanced.
Description
Technical field
The present invention relates to a kind of toothpaste for being used to balance Oral health behaviours.
Background technology
Toothpaste is as common oral cleaning supplies, and its composition includes common rubbing agent, NMF, thickener, surface work
Property agent etc., with cleaning oral cavity, reduce the basic functions such as soft dirt.With increasingly increased operating pressure, bad diet and clear
Easily there is the oral problems, shadow such as swelling and aching of gum, bleeding, sensitive, halitosis cold to acid and canker sore in the influence of clean custom, people
Quality of life is rung, periodontitis is such as developed into if not handling well in time and can aggravate oral problem or even falls tooth.
The reach of science is benefited from, increasing research shows that the main blasting fuse of oral problem is that oral cavity flora loses
Adjust.Porphyromonas gingivalis, treponema dentium, the general bacterium of blackening, enterobacteria, streptococcus mutans, actinomyces viscosus and tool core shuttle bar
The oral microorganisms such as bacterium have been considered to relevant with gingivitis, canker sore, halitosis.Much add on the market all kinds of
The toothpaste of additive, but effect is comprehensively and notable, and the toothpaste with good biocompatibility is few again.Therefore focus on
Improve Oral health behaviours, the toothpaste of people's life and work custom, pole are complied with while researching and developing a energy full maintenance oral health
Has market value.
The content of the invention
It is an object of the invention to overcome the deficiencies in the prior art part to be used to balance Oral health behaviours there is provided a kind of
Toothpaste, solves the problems such as effect in above-mentioned background technology is single and not notable, biocompatibility is relatively low, the quality guarantee period is short.
The technical solution adopted for the present invention to solve the technical problems is：1. a kind of tooth for being used to balance Oral health behaviours
Cream, it is characterised in that include following components by mass parts：15~20 parts of dicalcium phosphate dihydrate, 20~30 parts of hydrated silica,
20~30 parts of D-sorbite, 10~20 parts of glycerine, 1~3 part of laruyl alcohol sodium sulfovinate, 0.1~1 part of cellulose gum, ethoxy is fine
0.1~1 part of dimension element, 0.1 part of sodium monofluorophosphate, 0.01~0.5 part of tetrasodium pyrophosphate, 0.5~2 part of active compound is gone in right amount
Ionized water, wherein sodium monofluorophosphate mass parts are in terms of fluorine；
The active compound includes Panax quinquefolium root extract, propolis extract, carboxymethyl chitosan, the carboxymethyl shell
Polysaccharide molecular weight is 20,000~50,000.
In a preferred embodiment of the present invention, the Panax quinquefolium root extract, propolis extract, the matter of carboxymethyl chitosan
Amount is than being 11~16：5~9：0.5~0.9.
In a preferred embodiment of the present invention, the preparation method of the American ginseng extract is：American Ginseng is extracted after saponin(e
It is fitted into after dry, crushing in fermentation tank, addition is appropriate dissolved with the aqueous solution of ammonium sulfate and dipotassium hydrogen phosphate, mixes, sterilizing is inoculated with
Aspergillus niger and the mixed fermentation bacterium seed liquor of bacillus subtilis, ferment 20 days, terminate fermentation, gained after sterilizing.
In a preferred embodiment of the present invention, the preparation method of the propolis extract is：Thick propolis is put into the boiling of 7 times of amounts
3h is sufficiently stirred in water, 22-25 DEG C is cooled to, wax layer and water layer is removed, obtains paraffin removal propolis；Wax propolis is removed in 60 DEG C of bars of constant temperature
Under part, 70% alcohol steep is measured 3 times with 8 times, each 2h.Merge 3 leaching liquors, by propolis leaching liquor：Water quality compares 1:10 systems
Into propolis extract.
In a preferred embodiment of the present invention, in addition to 0.01~0.1 part of saccharin sodium.
In a preferred embodiment of the present invention, in addition to 0.05~0.5 part of preservative.
In a preferred embodiment of the present invention, in addition to 0.01~0.05 part of essence.
In a preferred embodiment of the present invention, the Panax quinquefolium root extract, propolis extract, the matter of carboxymethyl chitosan
Amount is than being 11：5：0.5.
The technical program is compared with background technology, and it has the following advantages that：
1. American Ginseng is used widely in the whole world as rare traditional Chinese medicine, but is more to be directed to its contained soap
The application of glucoside.But American Ginseng also has other beneficiating ingredients such as carbohydrate in addition to saponin, it has been investigated that extracting after saponin component
American Ginseng can obtain American Ginseng oligosaccharide active component through specifically fermentation condition, and the composition has prebiotics effect through experiment test,
Promote the beneficial bacteria growing in oral cavity, while suppressing the propagation of harmful bacteria, be conducive to Oral health behaviours to balance.
2. propolis extract and carboxymethyl chitosan collocation American ginseng extract are used, enhanced products are to Candida albicans
Fungistatic effect.Propolis extract and the carboxymethyl chitosan of low molecule amount have bacteriostasis to Candida albicans, but the former is most
Low Mlc is higher than the latter and taste is not pleasant, it has been investigated that the two, which is used in combination, can improve bacteriostasis, therefore collocation
Use.Three through testing repeatedly, and ratio matches well, and considerably increases the comprehensive and conspicuousness of toothpaste efficiency.
3. described in active compound combination modern biotechnology, from the Nature, animal and plant body extract, with good life
Biodegradable and biocompatibility, ratio match well, and considerably increase the comprehensive and conspicuousness of toothpaste efficiency.
Embodiment
Present disclosure is illustrated below by embodiment：
Embodiment 1
A kind of toothpaste for being used to balance Oral health behaviours, including dicalcium phosphate dihydrate 18%, hydrated silica 25%, mountain
Pears sugar alcohol 23%, glycerine 12%, laruyl alcohol sodium sulfovinate 1%, cellulose gum 0.3%, hydroxyethyl cellulose 0.3%, saccharin sodium
0.06%, sodium monofluorophosphate 0.1% (in terms of fluorine), tetrasodium pyrophosphate 0.05%, active compound 1%, essence 0.05%, benzene first
Sour sodium 0.4%, surplus is deionized water.Wherein Panax quinquefolium root extract：Propolis extract：Carboxymethyl chitosan mass ratio is
11：5：0.5.
1) in terms of 1000g, raw material is weighed respectively according to above-mentioned formula consumption, it is standby；
2) D-sorbite, glycerine, cellulose gum, hydroxyethyl cellulose are put into glue pot, wetting stirring is added
The former materials such as saccharin sodium, the deionized water dissolved, continue to stir, and it is in uniform translucent viscous shape liquid to make the glue being made, and is then store
Deposit, allow it to be used after fully dissolving expansion；
3) by active compound and above-mentioned various solid, powdery raw materials and the glue, the essence that prepare etc. are by formula and grasp
It is required, input is blocked in conjunction pot, is stirred by mechanical mixture, is made with certain sticky, lotion that dilute cylinder is appropriate；
4) lotion is ground by grinder, can be levigate by excessively thick, really up to the mark particle, is made lotion fine and smooth, uniform, stably, is ground
Vacuum outgas is carried out after mill, a period of time is stood afterwards, product is obtained.
The present embodiment toothpaste is taken to carry out evaluation and test experiment：
(1) suppress bacterial plaque, mitigate the clinic evaluation and test of gingivitis toothpaste efficiency.
Using random, double blinding test method, test group is toothpaste manufactured in the present embodiment (being designated as A groups), and control group is
The double calcium mothproof toothpastes (being designated as B groups) of China that Co., Ltd of Uniliver produces.Clinical examination index has bacterial plaque (Q-H bacterial plaques
Index, PLI) and gingivitis (gingival index, GI), done some training very often by identical two, the oral cavity attending doctor of skilled operation enters
Row examination of mouth.Through the screening selected experiment of totally 150 people, subject each used corresponding toothpaste and toothbrush, respectively at 1 week, 3
Month and check above-mentioned corresponding index, Evaluated effect after 6 months.
14 people by test requirements document using toothpaste because not being removed in process of the test, and finally totally 136 people complete whole process 6
The experiment of the moon, includes statistical analysis.Result of the test is shown in Tables 1 and 2.
The evaluation of the bacterial plaque of table 1
As a result show, the mean of subject's dental plaque index has system using the difference between two groups of the present embodiment and control
Meter learns meaning (P ＜ 0.05).
The evaluation of the gingivitis of table 2
As a result show, at the 3rd month, the 6th month, the mean of subject's gingival index is using the present embodiment and control
Difference is statistically significant (P ＜ 0.05).
It was found from above-mentioned two result, the toothpaste that the present embodiment is prepared reduces bacterial plaque, effect of mitigation gingivitis and is better than
Chinese double calcium mothproof toothpastes.Analyze the formula table of the two and understand that, except the formula of both active component beyond the region of objective existences is basically identical, explanation adds
Active compound has been added to significantly improve toothpaste efficiency.
(2) halitosis and the evaluation and test of canker sore effect.
Because the change of halitosis and canker sore judges that subjectivity is strong, therefore the evaluation and test is judged using subjects subjective.Halitosis
The people of personnel 25, the people of canker sore personnel 31, it is desirable to 5 times tongues of toothbrush brush when brushing teeth and brush teeth sooner or later, judge after 10 days.As a result
It is shown in Table 3.
The halitosis of table 3 and canker sore effect
| It is effective | It is effective but unobvious | To no effect | |
| Improve halitosis | 19 | 3 | 3 |
| Improve canker sore | 26 | 2 | 3 |
As a result show, subjects more than half think that the toothpaste that the present embodiment is prepared can improve halitosis and canker sore.This
Product are confirmed as a kind of product effect of regular maintenance oral health.
Embodiment 2
The difference of embodiment 2 and embodiment 1 is：The present embodiment toothpaste includes dicalcium phosphate dihydrate 20%, hydration
Silica 20%, D-sorbite 30%, glycerine 20%, laruyl alcohol sodium sulfovinate 2%, cellulose gum 0.1%, hydroxyethyl cellulose
0.1%, saccharin sodium 0.03%, sodium monofluorophosphate 0.1% (in terms of fluorine), tetrasodium pyrophosphate 0.0.01%, active compound
0.5%, essence 0.03%, sodium benzoate 0.5%, surplus is deionized water.The active compound by Panax quinquefolium root extract,
Propolis extract, carboxymethyl chitosan composition, three's mass ratio is 13:9:0.7.
Through clinic evaluation and test, the present embodiment toothpaste can suppress bacterial plaque, mitigation gingivitis toothpaste, reduction halitosis and oral cavity and burst
Ulcer.
Embodiment 3
The difference of embodiment 3 and embodiment 1 is：The present embodiment toothpaste dicalcium phosphate dihydrate 15%, hydrated silica
30%, D-sorbite 20%, glycerine 10%, laruyl alcohol sodium sulfovinate 3%, cellulose gum 1%, hydroxyethyl cellulose 1%, saccharin
Sodium 0.05%, sodium monofluorophosphate 0.1% (in terms of fluorine), tetrasodium pyrophosphate 0.5%, active compound 2.0%, essence 0.05%,
Sodium benzoate 0.5%, surplus is deionized water.The active compound is by Panax quinquefolium root extract, propolis extract, carboxymethyl
Chitin is constituted, and three's mass ratio is 16:7:0.9.
Through clinic evaluation and test, the present embodiment toothpaste can suppress bacterial plaque, mitigation gingivitis toothpaste, reduction halitosis and oral cavity and burst
Ulcer.
Skilled person will appreciate that, when the technical parameter of the present invention changes in following scope, it is contemplated that obtain
Technique effect same as the previously described embodiments or close：
Dicalcium phosphate dihydrate and hydrated silica replace with calcium carbonate, calcium monohydrogen phosphate, dioxy as the rubbing agent of toothpaste
At least one of SiClx, aluminium hydroxide etc..
Glycerine, D-sorbite replace with propane diols etc. as toothpaste NMF.
Saccharin sodium is sweetener, replaces with xylitol etc..
The effect of following experimental examples can be achieved in above-described embodiment：
Effectively suppress bacterial plaque, Q-H plaque indexs Mean ± SD are significantly reduced after use in one week；Improve gingivitis,
Gingival index Mean ± SD are effectively improved with the increase of use time；Most of subject's halitosis and canker sore symptom are delayed
Solution.
It is described above, only present pre-ferred embodiments, therefore the scope that the present invention is implemented can not be limited according to this, i.e., according to
The equivalent changes and modifications that the scope of the claims of the present invention and description are made, all should still belong in the range of the present invention covers.
Claims (7)
1. a kind of toothpaste for being used to balance Oral health behaviours, it is characterised in that include following components by mass parts：Calcium monohydrogen phosphate two
15~20 parts of hydrate, 20~30 parts of hydrated silica, 20~30 parts of D-sorbite, 10~20 parts of glycerine, laruyl alcohol sodium sulfovinate 1
~3 parts, 0.1~1 part of cellulose gum, 0.1~1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, tetrasodium pyrophosphate 0.01~
0.5 part, 0.5~2 part of active compound, appropriate amount of deionized water, wherein sodium monofluorophosphate mass parts are in terms of fluorine；
The active compound is made up of Panax quinquefolium root extract, propolis extract, carboxymethyl chitosan, and the carboxymethyl shell is more
Glycan molecule amount is 20,000~50,000, the Panax quinquefolium root extract, propolis extract, the mass ratio of carboxymethyl chitosan for 11~
16：5~9：0.5~0.9.
2. a kind of toothpaste for being used to balance Oral health behaviours according to claim 1, it is characterised in that：The American Ginseng is carried
The preparation method for taking thing is：American Ginseng is extracted to be fitted into fermentation tank after saponin(e after dry, crushing, is added dissolved with ammonium sulfate and phosphoric acid
The aqueous solution of hydrogen dipotassium is appropriate, mixes, sterilizing, the mixed fermentation bacterium seed liquor of inoculated aspergillus niger and bacillus subtilis, fermentation
20 days, fermentation is terminated, gained after sterilizing.
3. a kind of toothpaste for being used to balance Oral health behaviours according to claim 1, it is characterised in that：The propolis is extracted
The preparation method of thing is：Thick propolis, which is put into the boiling water of 7 times of amounts, is sufficiently stirred for 3h, is cooled to 22-25 DEG C, removes wax layer and water
Layer, obtains paraffin removal propolis；Wax propolis is removed under the conditions of 60 DEG C of constant temperature, 70% alcohol steep is measured 3 times with 8 times, each 2h.Merge 3
Secondary leaching liquor, by propolis leaching liquor：Water quality compares 1:10 are made propolis extract.
4. a kind of toothpaste for being used to balance Oral health behaviours according to claim 1, it is characterised in that：Also include saccharin sodium
0.01~0.1 part.
5. a kind of toothpaste for being used to balance Oral health behaviours according to claim 1, it is characterised in that：Also include preservative
0.05~0.5 part.
6. a kind of toothpaste for being used to balance Oral health behaviours according to claim 1, it is characterised in that：Also include essence
0.01~0.05 part.
7. a kind of toothpaste for being used to balance Oral health behaviours according to any one of claim 1-6, it is characterised in that：Institute
It is 11 to state Panax quinquefolium root extract, propolis extract, the mass ratio of carboxymethyl chitosan：5：0.5.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582355.XA CN107320428B (en) | 2017-07-17 | 2017-07-17 | Toothpaste for balancing oral micro-ecology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582355.XA CN107320428B (en) | 2017-07-17 | 2017-07-17 | Toothpaste for balancing oral micro-ecology |
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| CN107320428A true CN107320428A (en) | 2017-11-07 |
| CN107320428B CN107320428B (en) | 2020-07-28 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090188A (en) * | 2019-05-08 | 2019-08-06 | 广州淡韵生物科技有限公司 | A kind of Chinese medicinal toothpaste and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN102283794A (en) * | 2011-08-22 | 2011-12-21 | 昆明振华制药厂有限公司 | Toothpaste including radix notoginseng and propolis and preparation method thereof |
| CN104013657A (en) * | 2014-01-16 | 2014-09-03 | 金日制药（中国）有限公司 | Post-fermentation extracting method of extracting saponin from American ginseng medicinal material |
-
2017
- 2017-07-17 CN CN201710582355.XA patent/CN107320428B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN102283794A (en) * | 2011-08-22 | 2011-12-21 | 昆明振华制药厂有限公司 | Toothpaste including radix notoginseng and propolis and preparation method thereof |
| CN104013657A (en) * | 2014-01-16 | 2014-09-03 | 金日制药（中国）有限公司 | Post-fermentation extracting method of extracting saponin from American ginseng medicinal material |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090188A (en) * | 2019-05-08 | 2019-08-06 | 广州淡韵生物科技有限公司 | A kind of Chinese medicinal toothpaste and preparation method thereof |
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