CN107308340A - It is a kind of to treat pharmaceutical composition of wound and preparation method thereof - Google Patents
It is a kind of to treat pharmaceutical composition of wound and preparation method thereof Download PDFInfo
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- CN107308340A CN107308340A CN201710658998.8A CN201710658998A CN107308340A CN 107308340 A CN107308340 A CN 107308340A CN 201710658998 A CN201710658998 A CN 201710658998A CN 107308340 A CN107308340 A CN 107308340A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of pharmaceutical composition for treating wound, including following raw material, Radix Sambuci Chiensis, the seed of cowherb, rheum officinale, persimmon leaf, pseudo-ginseng and the bletilla striata, the parts by weight of each raw material are：30 ~ 45 parts of 100 ~ 150 parts of Radix Sambuci Chiensis, 100 ~ 150 parts of the seed of cowherb, 150 ~ 200 parts of rheum officinale, 50 ~ 70 parts of persimmon leaf, 30 ~ 45 parts of pseudo-ginseng and the bletilla striata.During preparation, comprise the following steps：Step 1: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；Step 2: mixing：The mixing charcoal of step one is crossed 80~100 mesh sieves and be made with persimmon leaf, pseudo-ginseng, bletilla striata co-grinding.The pharmaceutical composition of the present invention is applied directly on the wound of wound, can not only quick-acting haemostatic powder, while can also be carried out disinfection to wound, while increasing the quantity of leucocyte and activity in wound subrange, promote the healing of wound.Wound healing and bone regeneration effect especially for slight wound is more preferable.
Description
Technical field
The invention belongs to field of medicine preparing technology, and in particular to a kind of pharmaceutical composition for treating wound and its preparation side
Method.
Background technology
Wound refers to the outer damage that body is caused due to erosion of strike, collision or chemical substance of external object etc.,
Bullet, Jin Ren are generally comprised, traumatic injury, overloads injury, fall and flutter, or is damaged by external force collision, weapons, and insect and animal biting,
The pathogenic factors such as boiling hot, burning, frostbite cause skin and flesh muscles and bones injured.Various wounds, no matter wound size, the depth, will be carried out in time
Correct processing, if dealing with improperly, can cause wound bleeding, infection, suppurate, can seriously obtain lockjaw, amputation, or even threaten life
Life.Treatment of wounds is correct, it can be made to heal rapidly, on the contrary may suppurative infection, do not recover for a long time, in addition because concurrent general infection,
The threat to life such as emphysematous gangrene, lockjaw.The medicine of processing wound has hydrogen peroxide, the tincture of iodine, mercurochrome, gentian violet etc. at present, but
These disinfectants, can be corrupted to granulation tissue, reduce quantity of leucocyte and activity, wound healing effect is poor, while also easily making
Scar is stayed into wound.Therefore how to prepare a kind of safe and efficient family often gone with vulnerary solve this series of problems be at present urgently
To be solved.
The content of the invention
The present invention uses disinfectant when handling wound for prior art, can be corrupted to granulation tissue, reduces white blood cell
Active the problem of, there is provided a kind of pharmaceutical composition of the treatment wound after improvement.
The technical scheme is that：A kind of pharmaceutical composition for treating wound, including following raw material, Radix Sambuci Chiensis, king are not
Row, rheum officinale, persimmon leaf, pseudo-ginseng and the bletilla striata are stayed, the parts by weight of each raw material are：100 ~ 150 parts of Radix Sambuci Chiensis, the seed of cowherb 100 ~ 150
30 ~ 45 parts of part, 150 ~ 200 parts of rheum officinale, 50 ~ 70 parts of persimmon leaf, 30 ~ 45 parts of pseudo-ginseng and the bletilla striata.
Further, the parts by weight of each raw material are：100 ~ 120 parts of Radix Sambuci Chiensis, 100 ~ 120 parts of the seed of cowherb, rheum officinale 150
30 ~ 40 parts of ~ 180 parts, 50 ~ 60 parts of persimmon leaf, 30 ~ 40 parts of pseudo-ginseng and the bletilla striata.
Further, the parts by weight of each raw material are：100 parts of Radix Sambuci Chiensis, 100 parts of the seed of cowherb, 150 parts of rheum officinale, persimmon leaf
30 parts of 50 parts, 30 parts of pseudo-ginseng and the bletilla striata.
The operation principle and beneficial effect of the present invention：Radix Sambuci Chiensis of the present invention are warm-natured, bitter, and with promoting blood circulation to remove blood stasis, wind-dispelling is lived
The effect of network, sweating diuresis, it is exclusively used in traumatic injury；The seed of cowherb has the effects such as invigorating blood circulation, stimulate the menstrual flow, subsiding a swelling, stopping blooding；Rheum officinale is cool
Blood removing blood stasis and hemostasis, has the stasis of blood-haemorrhage for blood-head；Fang Zhong, for main ingredient after being mixed with Radix Sambuci Chiensis, the seed of cowherb and the medicine of rheum officinale three,
The effect of taking its quick-acting haemostatic powder, it is adjuvant astringing to arrest bleeding, detumescence and promoting granulation, to strengthen the quick extensive of wound to be equipped with persimmon leaves and the bletilla striata
It is multiple；Assistant is with pseudo-ginseng dissipate stasis of blood hemostasis again, and detumescence ding-tong is relieved pain and the scar that disappears.The pharmaceutical composition of the present invention is applied directly to wound
On wound, can not only quick-acting haemostatic powder, while can also be carried out disinfection to wound, while increasing the leucocyte in wound subrange
Quantity and activity, promote the healing of wound.Wound healing and bone regeneration effect for slight wound is more preferable.
Further, medicine is mixed and made into powder, tincture, paste or patch after being got the raw materials ready by above-mentioned number.Using
When, powder, tincture, paste or patch is made in the pharmaceutical composition of the present invention by as needed and wound site.
Further refine, the pharmaceutical composition of present invention treatment wound comprises the following steps when preparing powder：
Step 1: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 2: mixing：By the mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding cross 80~100 mesh sieves be made it is scattered
Agent.
The refinement further walked, the pharmaceutical composition of present invention treatment wound comprises the following steps when preparing tincture：
Step 1: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 2: mixing：The mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding are obtained into mixture：
Step 3: immersion：The ethanol that concentration is 55 ~ 65% is taken, is 3 ~ 4 according to mixture and ethanol ratio of weight and number:8, it will mix
Thing soaks in ethanol, soaks 12 ~ 16d, and every 4 ~ 5d stirrings once obtain soak；
Step 4: filtering：Soak is filtered, takes filtrate to stand after 7 ~ 9d, supernatant is tincture.
During preparation, either tincture or powder, the first two steps of preparation be all it is consistent, Chinese medicine is accurate in proportion
It is standby, Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are boiled in a covered pot over a slow fire and forge into charcoal, it is being produced into pharmaceutical composition with remaining medicinal material co-grinding,
When powder is made, direct No. 7 sieves of mistake（80~100 mesh sieves）, then when tincture is made, pharmaceutical composition is placed into 55
Soaked in ~ 65% ethanol, immersion a period of time, stirring is aided with during immersion, soak is filtered, until solution becomes sticky, will be soaked
Liquid filtering and standing is steeped, takes supernatant to bottle, the supernatant passes through for the Chinese medicine composition for treating slight wound of the invention, or active compound
Pulvis is made after crushing, on the wound for being sprinkling upon or being applied to slight wound, effect is equally notable.
Embodiment
Below by embodiment, the present invention is further detailed explanation：
Illustrate the embodiment of the present invention, but protection scope of the present invention by example below, be not limited to this.
Embodiment 1, treats the preparation method of the pharmaceutical composition of wound, when preparing powder, comprises the following steps：
Step 1: getting the raw materials ready：According to 100 parts of Radix Sambuci Chiensis, 100 parts of the seed of cowherb, 150 parts of rheum officinale, 50 parts of persimmon leaf, 30 parts of pseudo-ginseng and white
30 parts of splendid achnatherum is got the raw materials ready.
Step 2: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 3: mixing：By the mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding cross 80~100 mesh sieves be made it is scattered
Agent.
Embodiment 2, treats the preparation method of the pharmaceutical composition of wound, when preparing tincture, comprises the following steps：
Step 1: getting the raw materials ready：According to 100 parts of Radix Sambuci Chiensis, 100 parts of the seed of cowherb, 150 parts of rheum officinale, 50 parts of persimmon leaf, 30 parts of pseudo-ginseng and white
30 parts of splendid achnatherum is got the raw materials ready.
Step 2: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 3: mixing：The mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding are obtained into mixture：
Step 4: immersion：The ethanol that concentration is 60% is taken, is 3 according to mixture and ethanol ratio of weight and number:8, mixture is soaked
Bubble in ethanol, soaks 15d, and per 5d, stirring once obtains soak；
Step 5: filtering：Soak is filtered, takes filtrate to stand after 7 ~ 9d, supernatant is tincture.
The number for differing only in raw material of embodiment 3 and embodiment 2 is 110 parts of Radix Sambuci Chiensis, 110 parts of the seed of cowherb, big
30 parts of yellow 170 parts, 55 parts of persimmon leaf, 30 parts of pseudo-ginseng and the bletilla striata, paste is made by mixture.
The number for differing only in raw material of embodiment 4 and embodiment 2 is 120 parts of Radix Sambuci Chiensis, 120 parts of the seed of cowherb, big
40 parts of yellow 180 parts, 60 parts of persimmon leaf, 40 parts of pseudo-ginseng and the bletilla striata, patch is made by mixture.
Clinical test：
Choose the test mice of 7 group of 7 week old, every group of experiment mice 10, after test mice is removed into back hair through haircut device
Lost hair or feathers, then cleaned with running water, every doing 1cm × 4cm skin incisions after 24 hours, by embodiment 1 ~ 4 with depilatory cream back again
With other traumatics（Hydrogen peroxide and mercurochrome）Wound is applied to, another group is only used normal saline flushing, 10h, 1d, 3d observation
Wound and detection wound white blood cell concentration, it is as a result as follows：
Data above is the average value of 10 test mices, passes through above-mentioned data, compared with prior art, medicine of the invention
Compositions can stop blooding rapidly, and in the substantial amounts of leucocyte of wound rapid accumulation, while the mesh for promoting wound healing can be reached
's.
Application case：
Case 1：Mr. Liu, man, teacher leads team field to march and fallen down accidentally, and right leg knee broken skin bleeding, the two hand palms of the hand are light
Micro- scratch, bleeding part is wrapped up after being applied with pulvis with gauze, and the palm of the hand is sprayed with the tincture of embodiment 2, and the palm of the hand is abraded two days later
Position rehabilitation, knee position incrustation, edge is started shedding off, and is completely fallen off to incrustation in the 5th day, rehabilitation.
Case 2：Mr. Zhang, man, student, careless tumble injury of playing basketball was formed a scab with second day after the paste topical application of drug of embodiment 3,
Incrustation comes off rehabilitation after six days.
Case 3：Mr. Wang, man, student, go up a hill collect specimen when slip, shank by branch scratch one of 2cm length superficial
Property wound, with gauze wrapped after the powder of embodiment 1 application, remove gauze after five days and peel off incrustation, most of rehabilitation, only
Deeper, the adhesion muscle of centre position incrustation, causes neoplastic skin damaged, two days complete health after being sprayed with tincture when peeling off incrustation
It is multiple.
Case 4：Miss Wei, female, student, collect specimen of going up a hill is to slip, and dampens the centre of the palm by road surface sandstone, but do not go out
Blood, is sprayed with the tincture of embodiment 2, formed a scab after three days self falling, rehabilitation.
Above-described is only that the known general knowledge such as concrete structure and characteristic is not made herein in embodiments of the invention, scheme
Excessive description., without departing from the structure of the invention, can be with it should be pointed out that for those skilled in the art
Several modifications and improvements are made, these should also be considered as protection scope of the present invention, these are implemented all without the influence present invention
Effect and practical applicability.The scope of protection required by this application should be based on the content of the claims, in specification
Embodiment etc. records the content that can be used for explaining claim.
Claims (6)
1. a kind of pharmaceutical composition for treating wound, it is characterised in that including following raw material, Radix Sambuci Chiensis, the seed of cowherb, rheum officinale,
Persimmon leaf, pseudo-ginseng and the bletilla striata, the parts by weight of each raw material are：100 ~ 150 parts of Radix Sambuci Chiensis, 100 ~ 150 parts of the seed of cowherb, rheum officinale 150 ~
30 ~ 45 parts of 200 parts, 50 ~ 70 parts of persimmon leaf, 30 ~ 45 parts of pseudo-ginseng and the bletilla striata.
2. the pharmaceutical composition for the treatment of wound according to claim 1, it is characterised in that the parts by weight of each raw material are：
100 ~ 120 parts of Radix Sambuci Chiensis, 100 ~ 120 parts of the seed of cowherb, 150 ~ 180 parts of rheum officinale, 50 ~ 60 parts of persimmon leaf, 30 ~ 40 parts of pseudo-ginseng and the bletilla striata
30 ~ 40 parts.
3. the pharmaceutical composition for the treatment of wound according to claim 1, it is characterised in that the parts by weight of each raw material are：
30 parts of 100 parts of Radix Sambuci Chiensis, 100 parts of the seed of cowherb, 150 parts of rheum officinale, 50 parts of persimmon leaf, 30 parts of pseudo-ginseng and the bletilla striata.
4. according to the preparation method of the pharmaceutical composition of any described treatment wound of claim 1 ~ 3, it is characterised in that by upper
State after number is got the raw materials ready and medicine is mixed and made into powder, tincture, paste or patch.
5. the preparation method of the pharmaceutical composition for the treatment of wound according to claim 4, it is characterised in that prepare powder
When, comprise the following steps：
Step 1: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 2: mixing：By the mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding cross 80~100 mesh sieves be made it is scattered
Agent.
6. the preparation method of the pharmaceutical composition for the treatment of wound according to claim 4, it is characterised in that prepare tincture
When, comprise the following steps：
Step 1: charcoal processing：Mixed after Radix Sambuci Chiensis, the seed of cowherb and rheum officinale are crushed, it is stewing to forge into mixing charcoal；
Step 2: mixing：The mixing charcoal of step one and persimmon leaf, pseudo-ginseng, bletilla striata co-grinding are obtained into mixture：
Step 3: immersion：The ethanol that concentration is 55 ~ 65% is taken, is 3 ~ 4 according to mixture and ethanol ratio of weight and number:8, it will mix
Thing soaks in ethanol, soaks 12 ~ 16d, and every 4 ~ 5d stirrings once obtain soak；
Step 4: filtering：Soak is filtered, takes filtrate to stand after 7 ~ 9d, supernatant is tincture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710658998.8A CN107308340B (en) | 2017-08-04 | 2017-08-04 | A pharmaceutical composition for treating trauma, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710658998.8A CN107308340B (en) | 2017-08-04 | 2017-08-04 | A pharmaceutical composition for treating trauma, and its preparation method |
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| Publication Number | Publication Date |
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| CN107308340A true CN107308340A (en) | 2017-11-03 |
| CN107308340B CN107308340B (en) | 2020-12-08 |
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| CN201710658998.8A Active CN107308340B (en) | 2017-08-04 | 2017-08-04 | A pharmaceutical composition for treating trauma, and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108465021A (en) * | 2018-06-26 | 2018-08-31 | 王世琼 | The Chinese medicine composition and preparation method and preparation for the treatment of wound and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316255A (en) * | 2000-04-04 | 2001-10-10 | 汤仪 | Styptic powder |
| CN101249149A (en) * | 2008-04-15 | 2008-08-27 | 郭岩 | Pharmaceutical combination for intestinal tract hemostasia and method of preparing the same |
| CN202207239U (en) * | 2011-05-19 | 2012-05-02 | 中国人民解放军第二军医大学 | Novel wound plaster |
| CN104825819A (en) * | 2015-05-12 | 2015-08-12 | 朱铁海 | Traditional Chinese medicine for treating scalds and burns |
-
2017
- 2017-08-04 CN CN201710658998.8A patent/CN107308340B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316255A (en) * | 2000-04-04 | 2001-10-10 | 汤仪 | Styptic powder |
| CN101249149A (en) * | 2008-04-15 | 2008-08-27 | 郭岩 | Pharmaceutical combination for intestinal tract hemostasia and method of preparing the same |
| CN202207239U (en) * | 2011-05-19 | 2012-05-02 | 中国人民解放军第二军医大学 | Novel wound plaster |
| CN104825819A (en) * | 2015-05-12 | 2015-08-12 | 朱铁海 | Traditional Chinese medicine for treating scalds and burns |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108465021A (en) * | 2018-06-26 | 2018-08-31 | 王世琼 | The Chinese medicine composition and preparation method and preparation for the treatment of wound and application |
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