CN107308332A - A kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster - Google Patents

Abstract

A kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster, the Chinese medicine composition is made up of ivy tree bark, Chinese avens herb or root, white thizoma curculiginis, short handle Oriental Bittersweet Root, Herba Serissae, flabellate hemipilia herb, lip vanilla, silk thatch seven, climbing violet herb, Herba lygodii.It can be clinically used for treating stagnated heat of liver channel type herpes zoster.

Description

A kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster

Technical field

The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese traditional medicine composition for treating stagnated heat of liver channel type herpes zoster Thing.

Background technology

Herpes zoster is the acute herpes dermatoses as caused by varicella virus, and described in TCM Document " herpes zostor ", " herpes zoster ", " herpes zoster ", " She Dan " etc. it is similar.Its feature has two：One is that patient erythema locally occurs The skin damageds such as papulovesicle；Two be that patient herpes zoster pain and post herpetic neuralgia occurs.The traditional Chinese medical science thinks that herpes zoster is more because of liver and spleen Inside accumulate damp and hot, and caused by sense evil poison.The syndrome-classification of herpes zoster has：Stagnated heat of liver channel type, insufficiency of the spleen type of latent damp, qi stagnation and blood stasis type. The Symptoms of stagnated heat of liver channel type herpes zoster are：Skin damaged is scarlet, tonic vesicle wall, scorching hot shouting pain, bitter taste in the mouth and dry throat, irritable, Stool is dry or urine is yellow, red tongue body, and thin lingual fur is yellow or yellow thick, wiry and rolling pulse number.Western medical treatment herpes zoster mainly using antibacterial, disappear Scorching, analgesic, curative effect differs and side effect is big.Drawn by the long-term practice of inventor, treatment by Chinese herbs stagnated heat of liver channel type band Shape bleb has preferable effect, obtains good effect.

The content of the invention

It is an object of the invention to provide a kind of therapeutic effect is good, efficient high, the treatment liver that is had no toxic side effect to human body Chinese medicine composition through stagnated heat type herpes zoster.

The object of the present invention is achieved like this, according to traditional Chinese medical theory, using the unique property of medicine of Chinese medicine, using Ivy Tree Bark Skin, Chinese avens herb or root, white thizoma curculiginis, short handle Oriental Bittersweet Root, Herba Serissae, flabellate hemipilia herb, lip vanilla, silk thatch seven, climbing violet herb, Hai Jin Sand-grass is according to certain compatibility requirement, by being processed into.

Chinese medicine composition of the present invention is prepared to be made up of following raw material medicaments：30-50 parts of ivy tree bark, Chinese avens herb or root 20-40 Part, white thizoma curculiginis 20-40 parts, 20-40 parts of short handle Oriental Bittersweet Root, 15-25 parts of Herba Serissae, 15-25 parts of flabellate hemipilia herb, lip vanilla 15-25 parts, 9-15 parts of silk thatch seven, 9-15 parts of climbing violet herb, 9-15 parts of Herba lygodii.

The optimum weight of traditional Chinese medicinal composition raw materials of the present invention part is：40 parts of ivy tree bark, 30 parts of Chinese avens herb or root, Bai Xian 30 parts of thatch, 30 parts of short handle Oriental Bittersweet Root, 20 parts of Herba Serissae, 20 parts of flabellate hemipilia herb, 7 12 parts of 20 part, thread thatch of lip vanilla, it is white Careless 12 parts, 12 parts of Herba lygodii.

The pharmacological action of Chinese medicine of the present invention is as follows：

Ivy tree bark：Pungent, hardship, it is cool.Relieving superficies by cooling, dispelling wind and eliminating dampness is stimulated the circulation of the blood and cause the muscles and joints to relax.Cold, fever is cured mainly, abscess of throat is scalded Wound, nameless sores or boils, herpes zoster, arthralgia pain due to rheumatism, traumatic injury, fracture.

Chinese avens herb or root：Bitter, acrid, cold.Return liver and kidney channel.Kidney tonifying soothing the liver, activating blood circulation and reducing swelling.Dizziness is cured mainly, impotence, seminal emission is empty Impairment and cough, anaemia, arthralgia pain due to rheumatism, child convulsion, irregular menstruation, women's pain of lower abdomen, acute mastitis, sore swell and ache curative, traumatic injury.

White thizoma curculiginis：Sweet, slight bitter, temperature.Beneficial lung invigorating the spleen, tonifying kidney and strengthening yang is activated blood and relaxed tendons.Cough due to deficiency of the lung is cured mainly, insufficiency of the spleen digestion is not It is good, impotence due to deficiency of the kidney, with, the prolapse of uterus, traumatic injury, fracture.

Short handle Oriental Bittersweet Root：It is pungent, put down.Dispelling wind and eliminating dampness, removing toxicity for detumescence.Cure mainly arthralgia pain due to rheumatism, traumatic injury, hernia pain, sore Ulcer pyogenic infections, herpes zoster, eczema, venomous snake bite.

Herba Serissae：It is bitter, pungent, put down.Liver soothing and depression relief, opens the sharp diaphragm of chest, menstruation regulating promoting circulation of blood, swelling and pain relieving.Cure mainly flu, chest and hypochondrium, Stomachache, abdominal distension, postpartum edema, postpartum blood stasis pain, irregular menstruation, rheumatic arthritis, snakebite, ulcer on the shank.

Flabellate hemipilia herb：Sweet, slight bitter, puts down.Nourishing Yin and moistening lung, qi-restoratives, hemostasis.Lung-heat type cough is cured mainly, consumptive disease is coughed, deficient internal lesion caused by overexertion, Abnormal heat, night sweat, lumbago due to the kidney deficiency, traumatism and bleeding.

Lip vanilla：It is micro-sweet, pungent, it is cool.Antitoxic heart-soothing and sedative, alleviating water retention heat.Palpitation and insomnia is cured mainly, oedema, cold, fever, hot eyes swells Bitterly, sore swollen toxin.

Silk thatch seven：Hardship, it is cool.It is clearing heat and detoxicating, cool blood dissipates the stasis of blood.Cure mainly anemopyretic cold, carbuncle swells serious case of furuncle, herpes zoster, menstruation is not Adjust, breast is not few smooth, traumatic injury.

Climbing violet herb：Bitter, acrid, cold.Return lung, Liver Channel.It is clearing heat and detoxicating, detumescence, cough-relieving.Treatment of ulcer pyogenic infections, eye conjunctivitis, lung Heat cough, lung carbuncle, pertussis, children's chronic cough trachyphonia, jaundice, herpes zoster is scalded, injury and bone fracture, venomous snake bite.

Herba lygodii：It is sweet, tremble with fear.Return bladder, small intestine, Liver Channel.Clearing heat and detoxicating, promoting diuresis for stranguria is promoting blood circulation and removing obstruction in channels.Cure mainly stranguria, Under oedema, gonorrhoea, band, hepatitis, diarrhea, dysentery, cold, fever, cough and asthma, abscess of throat, aphtha, red eye, swell pain, mumps, acute mastitis, Erysipelas, herpes zoster, scald, pruitus, bruise wound is swollen, arthralgia pain due to rheumatism, traumatism and bleeding.

The traditional Chinese medical science thinks that stagnated heat of liver channel type herpes zoster is more because of feelings will internal injury, and stagnation of liver qi, long strongly fragrantization is fiery, Liver Channel fiery poison, outside Caused by excessive skin.Ivy tree bark relieving superficies by cooling, dispelling wind and eliminating dampness in the present invention, stimulate the circulation of the blood and cause the muscles and joints to relax, be monarch drug in a prescription；Chinese avens herb or root kidney tonifying is put down Liver, activating blood circulation and reducing swelling, the beneficial lung invigorating the spleen of white thizoma curculiginis, tonifying kidney and strengthening yang, the dispelling wind and eliminating dampness of short handle Oriental Bittersweet Root, removing toxicity for detumescence, are ministerial drug；Hua Ze Blue liver soothing and depression relief, open the sharp diaphragm of chest, menstruation regulating promoting circulation of blood, swelling and pain relieving, flabellate hemipilia herb nourishing Yin and moistening lung, qi-restoratives hemostasis, lip vanilla calming heart Calm the nerves, alleviating water retention heat, silk thatch seven is clearing heat and detoxicating, cool blood dissipates the stasis of blood, and climbing violet herb is clearing heat and detoxicating, and Herba lygodii is clearing heat and detoxicating, Li Shui is logical Drench, it is promoting blood circulation and removing obstruction in channels.Find that there is unique curative effect to stagnated heat of liver channel type herpes zoster by clinical practice, all medicines play heat-clearing altogether Inducing diaphoresis, dispelling wind and eliminating dampness, kidney tonifying soothing the liver, beneficial lung invigorating the spleen, liver soothing and depression relief, swelling and pain relieving, nourishing Yin and moistening lung, antitoxic heart-soothing and sedative, it is clearing heat and detoxicating, Promoting blood circulation and removing obstruction in channels the effect of, reach the purpose for the treatment of stagnated heat of liver channel type herpes zoster.

First, routine test data and method

Chinese medicine composition of the present invention in 2007 to 2012 clinical observation stagnated heat of liver channel type 128 Cases with Herpes Zoster patients, Clinical report is as follows：

1st, general information

In 128 patients, male 65, women 63, age 18-70 Sui, average age 37.5 years old, the course of disease is more at 2 days By 1 month, site of pathological change concentrated on intercostal nerve, cervical nerve, trigeminal neuralgia and waist sacrum sacrum innervation region.

2nd, diagnostic criteria

Diagnosis basis State Administration of Traditional Chinese Medicine issues《Chinese medical disease Standardization of diagnosis and curative effect》：

1. skin damaged is generally the blister of mung bean size, and in groups, blister wall is more nervous, and base coat colour is red for gathering, often unilateral distribution, arrangement Become band.Severe patient, skin damaged can behave as hemorrhagic, or visible gangraenosum infringement.Skin damaged is sent out in Head And Face person, the state of an illness often compared with Weight.

2. before fash occurs, often first there are skin irritation or burning heat sensation, can be with the slight uncomfortable, heating in the whole body.

3. feel pain substantially, can there is insufferable severe pain or deflorescence postherpetic neuralgia.

And have following symptom：Skin damaged is scarlet, tonic vesicle wall, scorching hot shouting pain, bitter taste in the mouth and dry throat, irritable, and stool is dry or small Just yellow, red tongue body, thin lingual fur is yellow or yellow thick, wiry and rolling pulse number.

Include and exclusion standard：Inclusive criteria：Meet the diagnostic criteria of herpes zoster in Chinese medical disease Standardization of diagnosis and curative effect. Exclusion standard：1. previously there is the serious protopathy such as liver, kidney, brain and hemopoietic system；2. allergic constitution or to multi-medicament allergy sufferers； 3. mental patient；4. gestation or women breast-feeding their children；5. inclusive criteria is not met, it is impossible to judge or the infull person of data.

3rd, treatment method：

3.1 prescription：Ivy tree bark 40g, Chinese avens herb or root 30g, white thizoma curculiginis 30g, short handle Oriental Bittersweet Root 30g, Herba Serissae 20g, flabellate hemipilia herb 20g, lip vanilla 20g, the 12g of silk thatch seven, climbing violet herb 12g, Herba lygodii 12g.

3.2 method of preparation and use：Routinely decoction is made in technique to said medicine, and daily 1 dose, 2 times a day, is within 3 days 1 treatment Journey.

4th, treatment results：

4.1 reference《Traditional Chinese medicine Clinical Researches of New Drugs guideline》Formulate：

Cure：Deflorescence, clinical sign disappears, without pain sequelae；

Take a turn for the better：Deflorescence about 30%, pain substantially mitigates；

It is not cured：Deflorescence still has pain less than 30%.

4.2 result：In 128 patients, 104 (81.3%) is cured, take a turn for the better 17 (13.3%), not more 7 (5.4%), total effective rate is 94.6%.

2nd, check experiment data and method

1st, general information

64 stagnated heat of liver channel type Patients with Herpes Zoster during my section 2007 to 2012 are randomly divided into test group and right Each 32 according to group.All patients make a definite diagnosis all in accordance with symptom, sign.Test group：Male 17, women 15, age 18-70 Sui, Average age 43.85 ± 16.29 years old, course of disease 2-21 days.Control group：Male 16, women 16, age 18-70 Sui, average year 44.54 ± 17.19 years old age, course of disease 2-19 days.The general information no significant differences such as two groups of patient ages, courses of disease, have Comparativity (P ＞ 0.05).

2nd, diagnostic criteria

Diagnosis basis State Administration of Traditional Chinese Medicine issues《Chinese medical disease Standardization of diagnosis and curative effect》：

1. skin damaged is generally the blister of mung bean size, and in groups, blister wall is more nervous, and base coat colour is red for gathering, often unilateral distribution, arrangement Become band.Severe patient, skin damaged can behave as hemorrhagic, or visible gangraenosum infringement.Skin damaged is sent out in Head And Face person, the state of an illness often compared with Weight.

2. before fash occurs, often first there are skin irritation or burning heat sensation, can be with the slight uncomfortable, heating in the whole body.

3. feel pain substantially, can there is insufferable severe pain or deflorescence postherpetic neuralgia.

And by following symptom：Skin damaged is scarlet, tonic vesicle wall, scorching hot shouting pain, bitter taste in the mouth and dry throat, irritable, and stool is dry or small Just yellow, red tongue body, thin lingual fur is yellow or yellow thick, wiry and rolling pulse number.

Include and exclusion standard：Inclusive criteria：Meet the diagnostic criteria of herpes zoster in Chinese medical disease Standardization of diagnosis and curative effect. Exclusion standard：1. previously there is the serious protopathy such as liver, kidney, brain and hemopoietic system；2. allergic constitution or to multi-medicament allergy sufferers； 3. mental patient；4. gestation or women breast-feeding their children；5. inclusive criteria is not met, it is impossible to judge or the infull person of data.

3rd, treatment method

Test group：1. prescription：Ivy tree bark 40g, Chinese avens herb or root 30g, white thizoma curculiginis 30g, short handle Oriental Bittersweet Root 30g, China Herba Lycopi 20g, flabellate hemipilia herb 20g, lip vanilla 20g, the 12g of silk thatch seven, climbing violet herb 12g, Herba lygodii 12g.2. prepare and use Method：Routinely decoction is made in technique, and daily 1 dose, 2 times a day, is within 3 days 1 course for the treatment of, medication 14 days.

Control group：Aciclovir sustained-release tablet 0.4g, oral 3 times a day, takes medicine 7 days；Two taste sida szechuensis matsuda tea adjust external application, often Day 2 times, medication 14 days.

4th, observation index

Please patient in further consultation in the 14th day, observe and record index.Treat and evaluate within the 14th day skin damaged curative effect, pain curative effect and comprehensive Close curative effect.

5th, symptom and sign scores

Skin damaged area and pain are scored respectively, score value is recorded when first visit and during further consultation.

5.1 skin damaged

0 point-without skin damaged

2 points of body surface areas of-＜ 0.5%

4 points->=0.5%, ＜ 1% body surface areas

6 points->=1%, ＜ 5% body surface areas

8 points->=5% body surface area

5.2 pain

0 point-painless

2 points-slight pain

4 points-moderate pain

6 points-severe pain

8 points-severe pain

6th, curative effect determinate standard

6.1 skin damaged curative effect determinate standards

Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment

Recovery from illness：Fash disappears or formed a scab completely, therapeutic index >=90%；

It is effective：Fash largely disappears, therapeutic index >=60%；

Effectively：Fash partial remission, therapeutic index >=30%；

It is invalid：Fash fraction disappears, therapeutic index ＜ 30%.

It is efficient by fully recover with it is effective in terms of.

6.2 pain curative effect determinate standards

Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment

Recovery from illness：Pain is wholly absent or substantially not bitterly, therapeutic index ＜ 30%；

It is effective：Local pain substantially mitigates, therapeutic index >=30%；

Effectively：Local pain mitigates, therapeutic index >=60%；

It is invalid：Local pain is without obvious mitigation, therapeutic index >=90%.

It is efficient by fully recover with it is effective in terms of.

6.3 comprehensive therapeutic effect criterion

Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment

Recovery from illness：Fash disappears completely or incrustation is wholly absent with pain, and therapeutic index is 100%；

It is effective：Fash largely disappears, and local pain substantially mitigates, therapeutic index >=60%；

Effectively：Fash partial remission, local pain mitigates, therapeutic index >=30%；

It is invalid：Fash fraction disappears, and local pain is without obvious mitigation, therapeutic index ＜ 30%.

It is efficient by fully recover with it is effective in terms of.

7th, result

7.1 test groups and control group skin damaged comparitive study (being shown in Table 1)

Table 1

Conclusion：As it can be seen from table 1 test group is 87.5% to the effective percentage of skin damaged, effective percentage of the control group to skin damaged It is 68.8%, test group is efficient more efficient than control group high by 18.7%, illustrates this Chinese medicine composition for stagnated heat of liver channel type band The skin damaged of shape bleb has good therapeutic effect.

7.2 test groups and control group pain comparitive study (being shown in Table 2)

Table 2

Conclusion：From table 2 it can be seen that test group is 84.4% to the effective percentage of pain, effective percentage of the control group to pain It is 75.0%, test group is efficient more efficient than control group high by 9.4%, illustrates this Chinese medicine composition for stagnated heat of liver channel type banding The pain of bleb has good therapeutic effect.

7.3 test groups are compared with control group comprehensive therapeutic effect and (are shown in Table 3)

Table 3

Conclusion：From table 3 it can be seen that the effective percentage of test group comprehensive therapeutic effect is 93.8%, control group comprehensive therapeutic effect has Efficiency is 71.9%, and test group is efficient more efficient than control group high by 21.9%, illustrates this Chinese medicine composition for stagnated heat of liver channel Type herpes zoster has good therapeutic effect；Recurrence rate 3.1% after test group is discontinued 3 months, recurrence rate is extremely low, and control group is discontinued 3 Recurrence rate 37.5% after month, recurrence rate is higher.

Post herpetic neuralgia incidence is compared and (is shown in Table 4) after 7.4 test groups are discontinued 3 months with control group

Table 4

Conclusion：From table 4, it can be seen that post herpetic neuralgia incidence is 3.1%, incidence pole after test group is discontinued 3 months Low, post herpetic neuralgia incidence is 56.3% after control group is discontinued 3 months, and recurrence rate is higher.

3rd, model case

1st, Zhao, man, 33 years old.Patient's left lumbar, chest side of body portion, belly have big red of the wheat of many places slabbing distribution Spot, sharp ache, red tongue body, thick,yellow and greasy fur, slippery and rapid pulse.It is diagnosed as stagnated heat of liver channel type herpes zoster.Medicine of the present invention is taken, often After 1 dose of day, 1 course for the treatment of, erythema area is significantly reduced, and pain substantially mitigates, and continues to take 3 courses for the treatment of, recovery from illness, follow-up 3 months Occur without post herpetic neuralgia.

2nd, hole, female, 37 years old.Neck, back pain on the right side of patient, play bleb 2 days, a large amount of intensive red blebs of distribution, Bleb basal part is rubescent, tonic vesicle wall, scorching hot shouting pain, dry and hard excrement, and urine is yellow, and red tongue body, tongue is greasy, slippery.It is diagnosed as Liver Channel Stagnated heat type herpes zoster.Take medicine of the present invention, daily 1 dose, after 1 course for the treatment of, bleb area is significantly reduced, and shouting pain substantially subtracts Gently, continue to take 3 courses for the treatment of, fully recover, follow-up occurs for 3 months without post herpetic neuralgia.

3rd, it is peaceful certain, man, 35 years old.Right chest side of body portion bleb, color is scarlet, inside there is slurries, the in groups or in the form of sheets spot mound per heap 3-5 Rash, locally there is scratch, a blood stain, scorching hot shouting pain, fatigue and weak, irritable, dry and hard excrement, scanty drak urine, receives poor pale tongue, and tongue is thin Huang, floating pulse is slightly counted.It is diagnosed as stagnated heat of liver channel type herpes zoster.Take medicine of the present invention, daily 1 dose, after 1 course for the treatment of, papule face Product is significantly reduced, and shouting pain substantially mitigates, and continues to take 3 courses for the treatment of, recovery from illness, and follow-up occurs for 3 months without post herpetic neuralgia.

Embodiment

With reference to embodiment, the present invention is further illustrated, following embodiments be merely to illustrate the present invention and it is right The present invention is not limited.

Embodiment 1, a kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster is by ivy tree bark 30g, pubescence water Red bayberry 20g, white thizoma curculiginis 20g, short handle Oriental Bittersweet Root 20g, Herba Serissae 15g, flabellate hemipilia herb 15g, lip vanilla 15g, the 9g of silk thatch seven, Climbing violet herb 9g, Herba lygodii 9g are made.

Embodiment 2, a kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster is by ivy tree bark 40g, pubescence water Red bayberry 30g, white thizoma curculiginis 30g, short handle Oriental Bittersweet Root 30g, Herba Serissae 20g, flabellate hemipilia herb 20g, lip vanilla 20g, silk thatch seven 12g, climbing violet herb 12g, Herba lygodii 12g are made.

Embodiment 3, a kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster is by ivy tree bark 50g, pubescence water Red bayberry 40g, white thizoma curculiginis 40g, short handle Oriental Bittersweet Root 40g, Herba Serissae 25g, flabellate hemipilia herb 25g, lip vanilla 25g, silk thatch seven 15g, climbing violet herb 15g, Herba lygodii 15g are made.

Claims (2)

1. a kind of Chinese medicine composition for treating stagnated heat of liver channel type herpes zoster, it is characterised in that it is made up of following raw material medicaments： 30-50 parts of ivy tree bark, 20-40 parts of Chinese avens herb or root, white thizoma curculiginis 20-40 parts, 20-40 parts of short handle Oriental Bittersweet Root, Herba Serissae 15- 25 parts, 15-25 parts of flabellate hemipilia herb, 15-25 parts of lip vanilla, 9-15 parts of silk thatch seven, 9-15 parts of climbing violet herb, Herba lygodii 9-15 Part.

2. Chinese medicine composition according to claim 1, it is characterised in that it is made up of following raw material medicaments：Ivy tree bark 40 Part, 30 parts of Chinese avens herb or root, 30 parts of white thizoma curculiginis, 30 parts of short handle Oriental Bittersweet Root, 20 parts of Herba Serissae, 20 parts of flabellate hemipilia herb, lip are fragrant Careless 7 12 parts of 20 part, thread thatch, 12 parts of climbing violet herb, 12 parts of Herba lygodii.