CN107308282A - A kind of herbal mixture for improving immunologic function of livestock and birds - Google Patents
A kind of herbal mixture for improving immunologic function of livestock and birds Download PDFInfo
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- CN107308282A CN107308282A CN201710652424.XA CN201710652424A CN107308282A CN 107308282 A CN107308282 A CN 107308282A CN 201710652424 A CN201710652424 A CN 201710652424A CN 107308282 A CN107308282 A CN 107308282A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
The present invention relates to the herbal mixture for improving immunologic function of livestock and birds, potency is low during puzzlement animal husbandry control and prevention of disease can effectively be solved, maintain the problem of immunity time is short, its solve technical scheme be, the technical scheme that the present invention is solved is that the herbal mixture is made up of the material medicine of following parts by weight meter：13 parts of thizoma curculiginis, 13 parts of wilsonii and hairyvein agrimony 3 10, herbal mixture of the present invention can improve the prevention effect of livestock and poultry infectious disease, the chemicals residue for reducing animal products, improve the quality of breast meat egg, ensure food safety and promote health of people, ensure the sound development of animal husbandry, and economic and society is all of great immediate significance.
Description
Technical field
The present invention relates to Chinese medicine preparation is related to, particularly a kind of herbal mixture for improving immunologic function of livestock and birds.
Background technology
In recent years, China's livestock and poultry breeding industry large-scale degree constantly expands, the prevention and control ever more important of livestock and poultry pestilence.However,
Animal sexually transmitted disease for example bird flu, aftosa, it is the breaking out of the great animal epidemic such as newcastle disease, popular, have a strong impact on China poultry
Poultry breeding industry is produced, and causes huge economic losses, the threat of reality and potentiality has also been carried out to mankind's health care belt.Further, since
In feeding process, it is various stress, immunosupress, Mycotoxins in Feed pollution and abuse of antibiotics etc. can seriously damage poultry
The immunologic function of fowl, causes immune tolerance, immunological paralysis, does not produce immune response etc. to vaccine, cause under body's immunity
Drop is even lacked, and causes growth of animals or poultry to suppress, and influences economic benefit.
At present, people generally add some feed addictives or a certain immunopotentiator of exclusive use in feed
（Especially Chinese herbal medicine）Carry out prevention disease, alleviate immunological stress, promote growth of animal.But it is single use antigen or only applies certain
A kind of adjuvant, to improving the potency of antigen, maintaining immunity time etc. to limit.In addition.Due to abuse of antibiotics
The caused resistance to the action of a drug and residue problem have attracted worldwide attention.Therefore, characteristic determination, efficient, ideal stably, nontoxic is found to exempt from
Epidemic disease reinforcing agent is one of emphasis of current research.Chinese herbal medicine is the rarity of traditional Chinese medicine, and its aboundresources, noresidue poison are secondary
Effect, determined curative effect, have attracted increasing attention.Therefore exploitation compound natural medicine immunopotentiator is used to prevent and treat livestock and poultry disease
Disease, is very wide especially to viral, bacterial infectious disease prospect, with important scientific and technical meaning and social economy
Value.
The content of the invention
For above-mentioned situation, to solve the defect of prior art, the purpose of the present invention is just to provide a kind of raising livestock and poultry and exempted from
The herbal mixture of epidemic disease function, activates livestock and poultry immunity of organisms, improves animal health condition, can effectively solve to perplex animal husbandry epidemic disease
Potency is low during prevention and control, maintains the problem of immunity time is short.
The technical scheme that the present invention is solved is that the herbal mixture is made up of the material medicine of following parts by weight meter：It is celestial
3-10 parts of 1-3 parts of thatch, 1-3 parts of wilsonii and hairyvein agrimony.
The specific preparation method of Chinese medicine, comprises the following steps：
1）It will be fitted into after thizoma curculiginis in material medicine, wilsonii and hairyvein agrimony coarse crushing in round-bottomed flask；
2）In round-bottomed flask, plus 9 times of weight of material medicine water, soak 4h；
3）It is first boiled with high heat, 2h is heated to reflux, filters, obtains decoction；
4）The dregs of a decoction decoct secondary, the water of each plus 6 times of weight of material medicine again, are heated to reflux 1.5h, filter, and obtain decoction, merge 3
Secondary decoction, the supernatant after centrifugation, distillation and concentration to 1mL decoctions is produced equivalent to 1g crude drugs.Herbal mixture of the present invention is added
2-70% auxiliary material, routinely preparation method be made injection, oral solid formulation or oral liquid, described is oral solid
Body preparation is powder, tablet, capsule or granule, and described oral liquid is oral liquid or syrup, and described is auxiliary
Expect for one or more mixtures in filler, excipient, flavouring or preservative.
Herbal mixture of the present invention can improve livestock and poultry infectious disease prevention effect, reduce animal products chemicals it is residual
Stay, improve the quality of newborn meat egg, ensure food safety and promotes health of people, ensure the sound development of animal husbandry, to it is economical with
Society is all of great immediate significance.
Embodiment
The embodiment to the present invention is described in further detail with reference to embodiments.
Embodiment 1
In the specific implementation, the Chinese medicine can be made up the present invention of the material medicine of following parts by weight meter：1 part of thizoma curculiginis, wilsonii 1
Part and 3 parts of hairyvein agrimony, the same Summary of preparation method（Slightly）.
Embodiment 2
In the specific implementation, the Chinese medicine can be made up the present invention of the material medicine of following parts by weight meter：1 part of thizoma curculiginis, wilsonii 2
Part and 3 parts of hairyvein agrimony, the same Summary of preparation method（Slightly）.
Embodiment 3
In the specific implementation, the Chinese medicine can also be made up the present invention of the material medicine of following parts by weight meter：3 parts of thizoma curculiginis, thorn five
Plus 3 parts and 4 parts of hairyvein agrimony, the same Summary of preparation method（Slightly）.
Embodiment 4
In the specific implementation, the Chinese medicine can also be made up the present invention of the material medicine of following parts by weight meter：1 part of thizoma curculiginis, thorn five
Plus 3 parts and 6 parts of hairyvein agrimony, the same Summary of preparation method（Slightly）.
Modern pharmacology research finds, Chinese herbal medicine and its extract can by adjusting lymphocyte, it is macrophage, thin
The modes such as intracellular cytokine, antibody level and neuroendocrine-immune network produce stimulation to body immune system, can improve and exempt from
The activity of epidemic disease system organization cell, increases the synthesis of antibody, can promote the combined immune response of body.Thizoma curculiginis in prescription of the present invention
Warm kidney sun, strengthens the bone, with adjusting immune, anti-oxidant, liver protection, antihyperglycemic, tonifying kidney and strengthening yang and anti-osteoporosis, anti-inflammatory and fit
Effect should be waited as former state.Wilsonii has the effect of replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, with antitumor, anti-inflammatory, resisting stress, it is antifatigue,
The extensive pharmacological action such as immunological regulation and antibacterial, can adjust the immunologic function of body, remove free radical, promote appetite.It is celestial
Crane grass has astringing to arrest bleeding, the effect of strong righting qi-restoratives, its can tonifying Qi, can enrich blood again.Reasonable recipe compatibility of the present invention, phase
Interaction, effectively regulation animal body immunologic function, strengthen animal immune responsibility.And achieve satisfaction through repetition test
Effect, correlation test data is as follows：
Influence of the Chinese medicine preparation of the present invention to livestock and poultry specific immune function
1 material
1.1 experimental animal
1 age in days, 817 broiler chicks 125, cultivation Specialty Co-operative Organization is surely sent out purchased from Xinyang Pingqiao District；
28 ages in days " long white ternary pigs " 30, selected from Xinyang heroes' ecological cultivation farm；
1.2 test drug
1）Chinese medicine liquid of the present invention.2）Ergamisole, purchased from Shandong Kernel and Hall Pharmaceutical Industry Co., Ltd..
2 test methods
The packet of 2.1 chick and the measure of HI antibody titers:
1 age in days, 817 broiler chicks 125, during 5 age in days, are randomly divided into 5 groups, and both I group was blank group（Without medicine）, V groups are a left side
Revolve imidazoles group（10mg/kg）, II, III, IV group be respectively Chinese medicine low dose group of the present invention（0.5ml/kg）, middle dose group（1ml/
kg）, high dose group（2ml/kg）, every group 20.Each group is dripped in 7 age in days with Newcastle disease attenuated vaccine LaSota systems normal dose
Nose, eye droppings immunity inoculation.5 ages in days start, each group according to dosage drinking water administration, continuous feeding 25 days, each group respectively the age in days of chicken 9,
Venous blood collection separates ND-HI in serum, detection serum under 12 ages in days, 15 ages in days, 18 ages in days, every group of the 21 ages in days chicken of extraction 5, the wing
Antibody level.
The packet and processing of 2.2 ternary piglets:
28 ages in days " long white ternary pigs " 30, are randomly divided into 5 groups, and both I group was blank group（Without medicine）, V groups are left-handed miaow
Azoles group（10mg/kg）, II, III, IV group be respectively low dose group（0.5ml/kg）, middle dose group（1ml/kg）, high dose group
（2ml/kg）, every group 6.30 ages in days start each group, and according to dosage spice is administered, continuous feeding 14 days, and each group is respectively in 35 age in days
Inject live vaccines of hog cholera normal dose immunity inoculation.Piglet is in the 36th after vaccine inoculation, 40,45,50,55,60 ages in days difference
By each group pig ear vein blood sampling 5mL, serum is analyzed.Swine fever antibody level of serum is detected using enzyme micro-plate reader.
3 result of the tests
Influence of 3.1 Chinese medicine preparations of the present invention to ND Vaccine immune effect
As can be seen from Table 1, the trend that the antibody level of ewcastle disease rises with the inoculation presentation of vaccine in each group, after inoculation
Newcastle epidemic disease antibody level reaches peak in 8th day serum, wherein newcastle epidemic disease antibody level is highest in serum in IV group.From 15
Newcastle epidemic disease antibody level is gradually reduced age in days in each group backward.Illustrate that Chinese medicine preparation of the present invention can be to improving the anti-NDV blood of chicken body
It is solidifying to suppress antibody titer, and Chinese medicine preparation of the present invention is maintaining chicken body newcastle epidemic disease antibody valency level 26Duration above
Longer, better than levamisol group, the time that wherein maximum dose level group is maintained is most long.
Newcastle epidemic disease antibody level changes in the serum of table 1
| Age in days | Ⅰ | Ⅱ | Ⅲ | Ⅳ | V |
| 9 | 24 | 24 | 25 | 25 | 25 |
| 12 | 25 | 25 | 25 | 25 | 26 |
| 15 | 26 | 26 | 28 | 29 | 27 |
| 18 | 26 | 26 | 27 | 28 | 26 |
| 21 | 24 | 26 | 26 | 27 | 25 |
Influence of 3.2 Chinese medicine preparations of the present invention to piglet hog cholera vaccine immune effect
As shown in Table 2, during testing, the antibody level of Chinese medicine addition group and levamisol is above control group.During 40 age in days,
The antibody level difference of II group and V groups is not notable, but is all remarkably higher than I group（P<0.05）, wherein IV group of antibody level is significantly high
In II group and III group, significant difference (P<0.05), antibody level reaches highest in 45 age in days each groups, wherein IV group of antibody level
Highest, during 50 age in days, the antibody level of each group piglet has different degrees of falling, but IV group still maintains higher level,
It is significantly higher than other each groups（P<0.05）, show that Chinese traditional compound medicine of the present invention can improve hog cholera antibody level, extension antibody is high
The peak phase holds time.
Hog cholera antibody level changes in the serum of table 2
| Age in days | Ⅰ | Ⅱ | Ⅲ | Ⅳ | V |
| 36 | 0.36±0.05 | 0.40±0.02 | 0.44±0.02 | 0.45±0.07 | 0.45±0.04 |
| 40 | 0.43±0.02 | 0.51±0.05 | 0.61±0.04 | 0.68±0.03 | 0.53±0.06 |
| 45 | 0.50±0.06 | 0.65±0.07 | 0.68±0.05 | 0.74±0.08 | 0.59±0.07 |
| 50 | 0.39±0.04 | 0.58±0.03 | 0.63±0.03 | 0.69±0.05 | 0.55±0.08 |
| 55 | 0.37±0.07 | 0.56±0.02 | 0.58±0.06 | 0.63±0.03 | 0.47±0.06 |
| 60 | 0.30±0.02 | 0.49±0.03 | 0.53±0.04 | 0.59±0.06 | 0.42±0.05 |
The present invention compared with prior art, with advantages below：
1. pure Chinese medicinal preparation, with regulation animal body immunologic function, strengthens animal immune responsibility；
2. antibiotic-free residue problem, reduces environmental pollution, a series of food securities that effectively solution chemicals is brought are asked
Topic, the need for meeting present healthy living；
3. preparation technology is simple, quality standard is controllable, is adapted to large-scale production needs, is worth with good promotion and application.
Claims (8)
1. a kind of herbal mixture for improving immunologic function of livestock and birds, it is characterised in that the Chinese medicine is by the original of following parts by weight meter
Material medicine is made：3-10 parts of 1-3 parts of thizoma curculiginis, 1-3 parts of wilsonii and hairyvein agrimony.
2. the herbal mixture according to claim 1 for improving immunologic function of livestock and birds, it is characterised in that the Chinese medicine can be by following
The material medicine of parts by weight meter is made：3 parts of 1 part of thizoma curculiginis, 1 part of wilsonii and hairyvein agrimony.
3. the herbal mixture according to claim 1 for improving immunologic function of livestock and birds, it is characterised in that the Chinese medicine can be by following
The material medicine of parts by weight meter is made：3 parts of 1 part of thizoma curculiginis, 2 parts of wilsonii and hairyvein agrimony.
4. it is according to claim 1 improve immunologic function of livestock and birds herbal mixture, it is characterised in that the Chinese medicine can also by with
The material medicine of lower parts by weight meter is made：4 parts of 3 parts of thizoma curculiginis, 3 parts of wilsonii and hairyvein agrimony.
5. it is according to claim 1 improve immunologic function of livestock and birds herbal mixture, it is characterised in that the Chinese medicine can also by with
The material medicine of lower parts by weight meter is made：6 parts of 1 part of thizoma curculiginis, 3 parts of wilsonii and hairyvein agrimony.
6. the preparation method of the herbal mixture of the raising immunologic function of livestock and birds described in claim 1 or any one of 2-5, its feature exists
In comprising the following steps：
1）It will be fitted into after thizoma curculiginis in material medicine, wilsonii and hairyvein agrimony coarse crushing in round-bottomed flask；
2）In round-bottomed flask, plus 9 times of weight of material medicine water, soak 4h；
3）It is first boiled with high heat, 2h is heated to reflux, filters, obtains decoction；
4）The dregs of a decoction decoct secondary, the water of each plus 6 times of weight of material medicine again, are heated to reflux 1.5h, filter, and obtain decoction, merge 3
Secondary decoction, the supernatant after centrifugation, distillation and concentration to 1mL decoctions is produced equivalent to 1g crude drugs.
7. the herbal mixture of the raising immunologic function of livestock and birds described in claim 1 or any one of 2-5, it is characterised in that add 2-
70% auxiliary material, routinely preparation method injection, oral solid formulation or oral liquid, described oral administration solid is made
Preparation is powder, tablet, capsule or granule, and described oral liquid is oral liquid or syrup, described auxiliary material
For one or more mixtures in filler, excipient, flavouring or preservative.
8. herbal mixture prepared by preparation method according to claim 6, it is characterised in that add 2-70% auxiliary material, press
Injection, oral solid formulation or oral liquid is made in customary preparation methods, and described oral solid formulation is powder, piece
Agent, capsule or granule, described oral liquid are oral liquid or syrup, and described auxiliary material is filler, assigned
One or more mixtures in shape agent, flavouring or preservative.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728387A (en) * | 2017-02-06 | 2017-05-31 | 兰州大学 | A kind of compound medicine with promotion immunologic function and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728387A (en) * | 2017-02-06 | 2017-05-31 | 兰州大学 | A kind of compound medicine with promotion immunologic function and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| В.П.НИКОЛАЕНКО: "用刺五加浸膏预防雏鸡疫苗接种应激", 《国外畜牧学（猪与禽）》 * |
| 孟胜男: "《药剂学》", 30 September 2011, 上海科学技术出版社 * |
| 宁平: "《饲料添加剂开发加工新工艺与应用新技术实务全书》", 31 March 2004, 清华同方光盘电子出版社 * |
| 梅全喜: "《现代中药药理与临床应用手册》", 31 October 2016, 中国中医药出版社 * |
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