CN107308132A - 一种磷脂壳聚糖药物递送***及其制备方法和用途 - Google Patents
一种磷脂壳聚糖药物递送***及其制备方法和用途 Download PDFInfo
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- CN107308132A CN107308132A CN201610265188.1A CN201610265188A CN107308132A CN 107308132 A CN107308132 A CN 107308132A CN 201610265188 A CN201610265188 A CN 201610265188A CN 107308132 A CN107308132 A CN 107308132A
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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Abstract
Description
指标 | 0个月 | 1个月 | 3个月 |
外观 | 淡黄色澄明溶液 | 淡黄色澄明溶液 | 淡黄色澄明溶液 |
平均粒径(nm) | 170~185nm | 170~185m | 170~185m |
Zeta电位(mV) | 33~36 | 33~36 | 33~36 |
含量(%) | 100% | 102% | 100% |
包封率(%) | 83% | 82% | 82% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 200~215nm | 200~215m | 200~215m |
Zeta电位(mV) | 40~45 | 40~45 | 40~45 |
含量(%) | 100% | 100% | 103% |
包封率(%) | 92% | 91% | 92% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 150~180nm | 150~180m | 150~180m |
Zeta电位(mV) | 39~43 | 39~43 | 39~43 |
含量(%) | 100% | 98% | 102% |
包封率(%) | 93% | 94% | 94% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 170~185nm | 170~185m | 170~185m |
Zeta电位(mV) | 32~35 | 32~36 | 32~36 |
含量(%) | 100% | 101% | 99% |
包封率(%) | 90% | 89% | 92% |
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110939458.3A CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
CN201610265188.1A CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
PCT/CN2017/081486 WO2017186065A1 (zh) | 2016-04-26 | 2017-04-21 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
Applications Claiming Priority (1)
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CN201610265188.1A CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
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CN202110939458.3A Division CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN107308132A true CN107308132A (zh) | 2017-11-03 |
CN107308132B CN107308132B (zh) | 2021-08-17 |
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CN201610265188.1A Active CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
CN202110939458.3A Active CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
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CN202110939458.3A Active CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送***及其制备方法和用途 |
Country Status (2)
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CN (2) | CN107308132B (zh) |
WO (1) | WO2017186065A1 (zh) |
Cited By (9)
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CN108620428A (zh) * | 2018-04-08 | 2018-10-09 | 杨大伟 | 一种基于离子液体的土壤重金属淋洗液及其制备方法 |
CN110151691A (zh) * | 2019-06-19 | 2019-08-23 | 宁夏医科大学 | 一种千金藤素纳米混悬液及其制备方法 |
CN111077247A (zh) * | 2019-12-24 | 2020-04-28 | 广西五和博澳药业有限公司 | 一种植物提取物或其制剂的检测方法 |
CN111281871A (zh) * | 2018-12-10 | 2020-06-16 | 赵美淇 | 一种含千金藤碱的药用组合物 |
CN112043670A (zh) * | 2019-10-08 | 2020-12-08 | 中国药科大学 | 一种线粒体靶向型外用药物制剂 |
CN114403267A (zh) * | 2022-01-24 | 2022-04-29 | 浙江欣诺医药有限公司 | 一种莓茶活性粉及其固体饮料 |
CN115212182A (zh) * | 2022-07-01 | 2022-10-21 | 广州长生康生物科技有限公司 | 一种大豆磷脂软胶囊及其制备方法和应用 |
CN116617220A (zh) * | 2023-07-26 | 2023-08-22 | 南京农业大学 | 抗青霉素类耐药菌的绿原酸-小檗碱纳米药物、药物组合物及其制备方法 |
US11771660B2 (en) | 2019-04-09 | 2023-10-03 | Beijing Wehand-Bio Pharmaceutical Co., Ltd. | Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof |
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CN115444835B (zh) * | 2022-09-05 | 2023-11-24 | 中国海洋大学 | 壳聚糖-磷脂复合纳米铁补铁剂及其制备方法 |
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Citations (2)
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CN102988484A (zh) * | 2006-06-12 | 2013-03-27 | 北京五和博澳医药科技发展有限公司 | 黄芩天然活性成分的磷脂复合物及其制备方法和制剂 |
CN105250244A (zh) * | 2014-07-18 | 2016-01-20 | 西南大学 | 一种肺部吸入的姜黄素磷脂复合物壳聚糖微球及其制备方法 |
Family Cites Families (3)
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US11771660B2 (en) | 2019-04-09 | 2023-10-03 | Beijing Wehand-Bio Pharmaceutical Co., Ltd. | Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof |
CN110151691A (zh) * | 2019-06-19 | 2019-08-23 | 宁夏医科大学 | 一种千金藤素纳米混悬液及其制备方法 |
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