CN107296808B - 化合物埃博霉素b在制备修复角膜神经创伤的药物中的应用 - Google Patents
化合物埃博霉素b在制备修复角膜神经创伤的药物中的应用 Download PDFInfo
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- CN107296808B CN107296808B CN201610237382.9A CN201610237382A CN107296808B CN 107296808 B CN107296808 B CN 107296808B CN 201610237382 A CN201610237382 A CN 201610237382A CN 107296808 B CN107296808 B CN 107296808B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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Description
时间 | 创伤对照组 | EpoB给药组 |
2天 | 0.1137±0.0152 | 0.0864±0.0131* |
4天 | 0.0986±0.0215 | 0.0465±0.0312*** |
6天 | 0.0725±0.0132 | 0.0059±0.0033*** |
8天 | 0.0558±0.0158 | 0.0062±0.0048*** |
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CN201610237382.9A CN107296808B (zh) | 2016-04-15 | 2016-04-15 | 化合物埃博霉素b在制备修复角膜神经创伤的药物中的应用 |
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CN201610237382.9A CN107296808B (zh) | 2016-04-15 | 2016-04-15 | 化合物埃博霉素b在制备修复角膜神经创伤的药物中的应用 |
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CN107296808A CN107296808A (zh) | 2017-10-27 |
CN107296808B true CN107296808B (zh) | 2020-09-04 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113350326B (zh) * | 2021-07-28 | 2023-03-17 | 爱尔眼科医院集团股份有限公司 | 化合物lm22b-10在制备角膜上皮及神经损伤治疗药物中的应用 |
CN113974888A (zh) * | 2021-11-11 | 2022-01-28 | 苏州药明康德新药开发有限公司 | 一种神经营养性角膜炎的大鼠疾病模型的制备方法 |
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2016
- 2016-04-15 CN CN201610237382.9A patent/CN107296808B/zh active Active
Non-Patent Citations (2)
Title |
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Epothilone B Speeds Corneal Nerve Regrowth and Functional Recovery through Microtubule Stabilization and Increased Nerve Beading;Hanqing Wang等;《Scientific Reports》;20180208;第82卷 * |
Microtubule stabilization opposes the (TNF-a)-induced loss in the barrier integrity of corneal endothelium;Mahesh Shivanna等;《Experimental Eye Research》;20090818;第89卷;第950–959页 * |
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