CN1072933C - Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof - Google Patents
Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof Download PDFInfo
- Publication number
- CN1072933C CN1072933C CN98113649A CN98113649A CN1072933C CN 1072933 C CN1072933 C CN 1072933C CN 98113649 A CN98113649 A CN 98113649A CN 98113649 A CN98113649 A CN 98113649A CN 1072933 C CN1072933 C CN 1072933C
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- albendazole
- suspension
- tween
- xanthan
- livestock
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to albendazole suspension for repelling and controlling livestock endoparasites and a preparation method thereof, which mainly overcomes the abuses of complicated production process, inconvenient administration, inaccurate dosage, poor endoparasite repelling effect, etc. of the existing tablet medicine. The suspension comprises albendazole powders, tween-80, liquid paraffin, xanthan, water and stabilizing agents. The main preparation process comprises the steps that the xanthan is prepared into xanthan solutions by adding the water; after the xanthan solutions are put in an emulsifier, paraffin oil, the tween-80, the stabilizing agents and the albendazole powders are added and sheared to prepare the albendazole suspension. The albendazole suspension has the advantages of simple production process, stable quality, simple and convenient administration operation, accurate dosage and obvious endoparasite repelling effect.
Description
The present invention relates to a kind of veterinary drug and preparation method thereof.
Pastoral area, China grassland is the pilosity district of parasitic disease.The parasitic infection of animal is the parasitic infection of domestic animal (cattle, sheep and pig etc.) particularly, and is very big for aquaculture harm, restricted Developing of Animal Industry to a certain extent.Present domestic expeling endoparasite broad-spectrum specific drug is an albendazole, and it is than other all kinds of anthelmintics wide spectrum low toxicity more, thereby makes a strong impact in the pastoral area, grassland.But it is water insoluble, generally makes tablet more, and use at present in the pastoral area, grassland is its tablet more widely, there is the very inconvenient problem of taking in tablet for domestic animal, it is loaded down with trivial details to throw the clothes operation, and easily causes the domestic animal vomiting, causes taking dose inaccurate and influence anthelminthic effect.Simultaneously, the Albenza complex manufacturing technology, price is higher, the acceptance that the herdsman can only be limited.
The object of the present invention is to provide Albendazole suspension of the expelling and controlling parasite in livestock that a kind of processing technology is simple, the throwing clothes are convenient, anthelminthic effect is good and preparation method thereof.
The object of the present invention is achieved like this: this suspension contains albendazole powder, tween 80, liquid paraffin, xanthan gum, water, stabilizing agent; Each percentages of ingredients content is: principal agent albendazole powder 10%, tween 80 are 8～12%, liquid paraffin 18～25%, xanthan gum 1～2%, water 48～62%, stabilizing agent 1～3%.
The preparation method of above-mentioned suspension is: after choosing raw material by described component and proportioning, 1) xanthan gum is added water is made into glue; 2) put and add paraffin oil, tween 80, stabilizing agent, albendazole powder after the emulsator and shear, can obtain this product.
The invention has the advantages that production technology is simple, its constant product quality can be placed the long period and be never degenerated, need not matching while using, can be mass-produced, and can satisfy the needs that pastoral area herdsman and raiser carry out the preventing and treating verminosis medication to cows, flock of sheep.This medicine is a suspension, and it is simple to throw clothes than tablet of the prior art, and dosage is accurate, adopts the dispensing of quantitative chemical dosing device, is particularly useful for the control that large tracts of land is carried out the animal parasite disease, can alleviate people's labor intensity greatly.Anthelminthic effect is remarkable, and this suspension dispersion is big, is easy to absorb, directly drop in the stomach of domestic animal by the quantitative chemical dosing device after, can be attached to more in large area equably in the stream stomach of animal, increase former medicine and gastrointestinal time of contact, thereby improve its drug effect.Its drug effect is better than tablet, using this suspension drives and controls effect observation for sheep stomach intestinal worms (by the oral medicinal liquid that contains 7 milligrams of former pharmaceutical quantities of per kilogram of body weight amount), take medicine just can present in back 24 hours and significantly kill the parasite effect, other nematicide beyond the first nematicide of defeathering and Mohs are belonged to cestode have 100% anthelminthic effect.
Below the present invention is further described.
This suspension system adopts the albendazole powder to add proper amount of paraffin oil, adds additives such as an amount of xanthan gum and emulsifying, stabilizing agent and makes.During actual production, desirable principal agent albendazole powder 10%, tween 80 is 10～12%, liquid paraffin 25%, xanthan gum 2%, water 50%, stabilizing agent 1～3%.Earlier xanthan gum is added water in the preparation and be made into glue, put and add paraffin oil, tween 80, albendazole powder after the emulsator and shear and make.Because of adding glue and, making the principal agent raw material can be made into superfine little microgranule, be evenly dispersed in the suspension in the preparation process through shearing.Be to adopt the quantitative chemical dosing device directly in the domestic animal oral cavity, to offer medicine in throwing the clothes operation, medicinal liquid is sent in the stomach of ruminants, make the throwing clothes not only convenient but also accomplish that dosage is accurate.
Claims (2)
1, a kind of Albendazole suspension of expelling and controlling parasite in livestock is characterized in that: this suspension contains albendazole powder, tween 80, liquid paraffin, xanthan gum, water, stabilizing agent; Each percentages of ingredients content is: principal agent albendazole powder 10%, tween 80 are 8～12%, liquid paraffin 18～25%, xanthan gum 1～2%, water 48～62%, stabilizing agent 1～3%.
2, the preparation method of the Albendazole suspension of the described expelling and controlling parasite in livestock of claim 1, it is characterized in that: after choosing raw material by described component and proportioning, 1) xanthan gum is added water and be mixed with glue, 2) put and add paraffin oil, tween～80, stabilizing agent, albendazole powder after the emulsator and shear, can obtain this product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113649A CN1072933C (en) | 1998-07-24 | 1998-07-24 | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113649A CN1072933C (en) | 1998-07-24 | 1998-07-24 | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1215590A CN1215590A (en) | 1999-05-05 |
| CN1072933C true CN1072933C (en) | 2001-10-17 |
Family
ID=5223358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98113649A Expired - Fee Related CN1072933C (en) | 1998-07-24 | 1998-07-24 | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1072933C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274174B (en) * | 2010-03-18 | 2013-02-13 | 中国疾病预防控制中心寄生虫病预防控制所 | Oil suspension agent of benzimidazole medicine |
| CN104382897A (en) * | 2014-11-14 | 2015-03-04 | 山西双鹰动物药业有限公司 | Medicine for treating livestock taeniasis and preparation method of medicine |
| CN105534917A (en) * | 2016-01-21 | 2016-05-04 | 陈小媚 | Albendazole dry suspension and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1653780A1 (en) * | 1988-07-25 | 1991-06-07 | Piskov Vyacheslav B | Process for preparing liquid form of anthelintics from group of benzimidazoles using organic solvent |
| CN1019768B (en) * | 1989-01-18 | 1992-12-30 | 菲利浦光灯制造公司 | Dry-shaving apparatus |
-
1998
- 1998-07-24 CN CN98113649A patent/CN1072933C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1653780A1 (en) * | 1988-07-25 | 1991-06-07 | Piskov Vyacheslav B | Process for preparing liquid form of anthelintics from group of benzimidazoles using organic solvent |
| CN1019768B (en) * | 1989-01-18 | 1992-12-30 | 菲利浦光灯制造公司 | Dry-shaving apparatus |
Non-Patent Citations (1)
| Title |
|---|
| 中国兽医科技，1993,23(1)35-36 2093.1.1 李闻等，丙硫咪唑混悬液的临床验证及推广应用 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1215590A (en) | 1999-05-05 |
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