CN107281619B

CN107281619B - Thrombolytic catheter

Info

Publication number: CN107281619B
Application number: CN201710657974.0A
Authority: CN
Inventors: 毕国善; 熊国祚; 宁丹
Original assignee: Second Hospital University Of South China
Current assignee: Second Hospital University Of South China
Priority date: 2017-08-03
Filing date: 2017-08-03
Publication date: 2022-12-06
Anticipated expiration: 2037-08-03
Also published as: CN107281619A

Abstract

A thrombolytic catheter relates to the technical field of medical equipment and comprises a catheter body and a joint connected to the rear end of the catheter body, wherein the catheter body comprises an outer tube and an inner tube, the outer tube is sleeved outside the inner tube, a gap between the outer tube and the inner tube is a drug injection cavity, a tube cavity of the inner tube is a drainage cavity, and the drug injection cavity and the drainage cavity are isolated from each other; the joint comprises a first interface and a second interface, the first interface is communicated with the drainage cavity, and the second interface is communicated with the injection cavity; the front end of the drainage cavity is opened, and the front end of the outer tube is welded with the peripheral surface of the inner tube together, so that the front end of the medicine injection cavity is closed; the wall of the outer tube is at least provided with a drainage hole for introducing blood into the drainage cavity and a plurality of medicine outlet holes communicated with the medicine injection cavity, the drainage hole is arranged behind the medicine outlet hole, the drainage hole is communicated with the drainage cavity through a flow guide tube, the flow guide tube penetrates through the medicine injection cavity, and the two ends of the flow guide tube are correspondingly connected with the drainage hole and the drainage cavity. The thrombolysis catheter can ensure the smooth circulation of blood and good thrombolysis effect.

Description

Thrombolysis catheter

Technical Field

The invention relates to the technical field of medical equipment, in particular to a thrombolytic catheter.

Background

Thrombi are composed primarily of insoluble fibrin, deposited platelets, accumulated white blood cells, and entrapped red blood cells. When blood flows through the thrombus, the blood is blocked by the thrombus, the local pressure of the blood vessel is increased, the thrombus is serious, and even thrombotic occlusion can occur, so that the life of a patient is threatened.

At present, three methods for treating thrombus are commonly used clinically, the first method is an artificial mechanical method, and thrombus in a blood vessel is taken out through a surgical operation or a suction device. The second is to implant a stent to enlarge the lumen of the vessel. The third one is thrombolytic medicine therapy, which is to inject thrombolytic medicine to dissolve thrombus gradually to reach the aim of dredging blood vessel.

Thrombolytic drug therapy usually needs to use a thrombolytic catheter, most of the existing thrombolytic catheters (such as UniFuse thrombolytic catheters) adopt a single-cavity structure, a plurality of side holes are cut on the wall of the perfusion section of the catheter by laser, and drugs in the lumen are sprayed into thrombus through the side holes, so that thrombolytic is realized. Such thrombolytic catheters suffer from the following problems: for the case of a large amount of thrombus in the blood vessel, as shown in fig. 1, the space between the thrombus can be used for blood to pass through, and after the catheter is inserted, the space for blood to pass through is blocked by the catheter, so that the condition of the patient is aggravated, and even the life risk of the patient is brought.

Chinese patent document CN104436417A discloses a thrombolysis catheter with a brand new structure, which adopts a three-cavity structure and comprises a guide wire cavity, a thrombolysis cavity and a perfusion cavity, wherein the guide wire cavity is used for matching with a guide wire to guide a cannula, the thrombolysis cavity is used for injecting thrombolysis medicine, and the perfusion cavity is used for ensuring blood circulation. After the intubation, the blood enters from the side port of the perfusion cavity and flows out from the outlet at the far end of the perfusion cavity, and the thrombolytic drug flows to the far end of the catheter along the thrombolytic cavity and flows out from the outlet at the far end of the thrombolytic cavity to be dispersed around the near end of the thrombus, so that thrombolysis is realized. The thrombolytic catheter has the following defects in use: 1. only one distal outlet of the thrombolytic cavity is arranged in front of the thrombus, and the drug cannot be directly contacted with the thrombus after being sprayed out from the distal outlet of the thrombolytic cavity and can be mixed in the blood for dilution, so that the concentration of the drug contacted with the thrombus is lower, and the thrombolytic effect is not ideal. 2. The thrombolysis chamber outlet is arranged on one side of the perfusion chamber, and because the liquid medicine is mixed in blood for dilution after being sprayed out from the thrombolysis chamber outlet, the concentration of the liquid medicine close to the thrombolysis chamber outlet can be higher than that of the liquid medicine on the other side of the perfusion chamber, the thrombolysis speed on the side with high liquid medicine concentration can be higher than that of the thrombolysis on the side with low liquid medicine concentration theoretically, namely, one side close to the thrombolysis chamber outlet can form a passage firstly, the medicine can flow away from the passage at the moment, and thus the situation of incomplete thrombolysis on the other side (the side with low liquid medicine concentration) of the perfusion chamber can be caused.

Disclosure of Invention

The invention aims to provide a thrombolysis catheter which can ensure the smooth circulation of blood and also can ensure good thrombolysis effect.

In order to solve the technical problem, the invention adopts the following technical scheme: a thrombolytic catheter comprises a catheter body and a joint connected to the rear end of the catheter body;

the catheter body comprises an outer tube and an inner tube, the outer tube is sleeved outside the inner tube, a gap between the outer tube and the inner tube is a medicine injection cavity, a tube cavity of the inner tube is a drainage cavity, and the medicine injection cavity and the drainage cavity are isolated from each other;

the joint comprises a first interface and a second interface, the first interface is communicated with the drainage cavity, and the second interface is communicated with the injection cavity;

the front end of the drainage cavity is open, and the front end of the outer tube and the peripheral surface of the inner tube are welded together, so that the front end of the medicine injection cavity is closed;

the utility model discloses a drainage hole, including the drainage hole, drainage hole and drainage chamber, the drainage hole is located a medicine hole rear, through the honeycomb duct intercommunication between drainage hole and the drainage chamber, the honeycomb duct passes and its both ends link to each other with drainage hole and drainage chamber respectively from the medicine chamber, set up at least on the pipe wall of outer tube and be arranged in introducing the drainage hole in the drainage chamber and a plurality of with the communicating medicine hole of injection chamber, the drainage hole is located a medicine hole rear, communicate through the honeycomb duct between drainage hole and the drainage chamber, the honeycomb duct passes and its both ends link to each other with drainage hole and drainage chamber respectively from the medicine chamber.

The drug injection cavity comprises a rear-section cavity and a front-section cavity which are communicated with each other, the flow guide pipe penetrates through the rear-section cavity, a plurality of strip-shaped diaphragms are arranged in the front-section cavity at annular intervals, the diaphragms extend from back to front and divide the front-section cavity into a plurality of independent lattice cavities, and each lattice cavity is correspondingly communicated with one drug outlet hole.

Preferably, the medicine outlet holes communicated with the medicine injection cavity are spirally arranged at intervals.

Or the medicine injection cavity comprises a rear-section cavity and a front-section cavity which are communicated with each other, the flow guide pipe penetrates through the rear-section cavity, a plurality of strip-shaped diaphragms are annularly arranged in the front-section cavity at intervals, the diaphragms extend from back to front and divide the front-section cavity into a plurality of independent grid cavities, and the grid cavities are respectively correspondingly communicated with a plurality of medicine outlet holes which are arranged from back to front at intervals.

Furthermore, a plurality of spacers are arranged in the lattice cavity at intervals in parallel, the spacers are perpendicular to the axis direction of the catheter body, the top ends of the spacers are connected to the inner wall of the outer tube, a gap for the thrombolytic liquid medicine to pass through is reserved between the bottom end of the spacer and the inner tube, and a medicine outlet is correspondingly arranged between every two adjacent spacers.

Wherein, the distance between the medicine outlet hole and the spacer positioned at the rear part of the medicine outlet hole is larger than the distance between the medicine outlet hole and the spacer positioned at the front part of the medicine outlet hole.

The connector is a Y-shaped connector, and an external thread used for connecting a heparin cap is arranged on the Y-shaped connector.

The thrombolytic catheter provided by the invention adopts a double-cavity structure, the drainage cavity can also be used as a guide wire cavity when the catheter is inserted into a blood vessel, the blood on the rear side of the thrombus (the front end of the thrombolytic catheter is equivalent to the far end in the background technical document CN104436417A, and the rear end is equivalent to the near end in the background technical document) can firstly enter the drainage cavity from the drainage hole after the guide wire is extracted from the catheter, and then flows out through the opening at the front end of the drainage cavity (the opening at the front end of the drainage cavity is positioned on the front side of the thrombus), so that the function of conducting blood flow is achieved; after the intubation is finished, thrombolytic liquid medicine is injected into the medicine injection cavity, and the front end of the medicine injection cavity is closed, so that the liquid medicine in the medicine injection cavity can be discharged from the medicine outlet, and thrombus around the medicine outlet is gradually dissolved and disappears under the action of the liquid medicine. When a part of thrombus is dissolved and a passage is formed outside the catheter, the medicine outlet hole is formed in the wall of the outer tube, the spraying direction of the medicine liquid is perpendicular to the wall of the blood vessel, and compared with the situation that the medicine liquid is directly sprayed to the far end in the background technical document CN104436417A, the design can prolong the retention time of the medicine liquid in the thrombus section, so that the thrombus is dissolved more completely. In conclusion, the thrombolysis catheter provided by the invention not only ensures smooth circulation of blood, but also ensures good thrombolysis effect.

Drawings

FIG. 1 is a schematic view of the whole construction of the thrombolytic catheter of the present invention;

FIG. 2 is a schematic view showing the internal structure of the thrombolytic catheter of the present invention;

FIG. 3 is a schematic view of the thrombolytic catheter inserted into a blood vessel for perfusion thrombolysis in accordance with the present invention;

FIG. 4 isbase:Sub>A cross-sectional view taken along line A-A of FIG. 2;

FIG. 5 is a partial enlarged view of the portion B in FIG. 2;

FIG. 6 is a schematic view of the internal structure of a single cell cavity in accordance with the present invention;

in the figure:

1-catheter body 2-joint

3-medicine injection cavity 4-drainage cavity

5-honeycomb duct 6-diaphragm

7-spacer 1 a-outer tube

1 b-inner tube 2 a-first connection

2 b-second interface 3 a-rear chamber

3 b-front chamber 1a 1-drainage hole

1a 2-medicine outlet holes 3b 1-grid cavities.

Detailed Description

In the description of the present invention, it is to be understood that the terms "front", "back", "inside", "outside", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In order that those skilled in the art will better understand the improvement of the present invention over the prior art, the present invention will now be described in further detail with reference to specific embodiments and the accompanying drawings.

As shown in fig. 1 to 6, a thrombolysis catheter comprises a catheter body 1 and a connector 2 connected to the rear end of the catheter body 1;

the catheter body 1 comprises an outer tube 1a and an inner tube 1b, the outer tube 1a is sleeved outside the inner tube 1b, a gap between the outer tube 1a and the inner tube 1b is a medicine injection cavity 3, a tube cavity of the inner tube 1b is a drainage cavity 4, and the medicine injection cavity 3 and the drainage cavity 4 are isolated from each other;

the joint 2 comprises a first interface 2a and a second interface 2b, the first interface 2a is communicated with the drainage cavity 4, and the second interface 2b is communicated with the medicine injection cavity 3;

the front end of the drainage cavity 4 is opened, and the front end of the outer tube 1a and the peripheral surface of the inner tube 1b are welded together, so that the front end of the medicine injection cavity 3 is closed;

the wall of the outer tube 1a is provided with at least one drainage hole 1a1 for introducing blood into the drainage cavity 4 and a plurality of medicine outlet holes 1a2 communicated with the medicine injection cavity 3, the drainage hole 1a1 is positioned behind the medicine outlet holes 1a2 (namely positioned between the medicine outlet holes 1a2 and the connector 2), the drainage hole 1a1 is communicated with the drainage cavity 4 through a flow guide tube 5, the flow guide tube 5 penetrates through the medicine injection cavity 3, and two ends of the flow guide tube 5 are respectively connected with the drainage hole 1a1 and the drainage cavity 4.

The thrombolytic catheter adopts a double-cavity structure, the drainage cavity 4 can also be used as a guide wire cavity when the catheter is inserted into a blood vessel, the drainage cavity is used for guiding the catheter to be inserted into the blood vessel along the guide wire, and after the guide wire is drawn out after the catheter is inserted into the blood vessel, as shown in figure 3, blood on the rear side of thrombus can firstly enter the drainage cavity 4 from the drainage hole 1a1 and then flows out through an opening at the front end of the drainage cavity 4 (the opening at the front end of the drainage cavity 4 is positioned on the front side of the thrombus), so that the function of conducting blood flow is achieved; the thrombolytic liquid medicine is injected into the medicine injection cavity 3 after the intubation is finished, and the front end of the medicine injection cavity 3 is closed, so that the liquid medicine in the medicine injection cavity 3 can be discharged only from the medicine outlet hole 1a2, and thrombus around the medicine outlet hole 1a2 is gradually dissolved and disappears under the action of the liquid medicine. When a part of thrombus is dissolved to form a passage outside the catheter, since the medicine outlet holes 1a2 are formed on the wall of the outer tube 1a in the above embodiment, and the spraying direction of the liquid medicine is perpendicular to the wall of the blood vessel, compared with the case of directly spraying the liquid medicine to the far end in the background art document CN104436417A, the design can prolong the retention time of the liquid medicine in the thrombus section, so that the thrombolysis is more thorough.

As a preferable scheme, in the thrombolytic catheter, as shown in fig. 2, 4 and 5, the drug injection cavity 3 comprises a rear-section cavity 3a and a front-section cavity 3b which are communicated with each other, the flow guide tube 5 penetrates through the rear-section cavity, a plurality of strip-shaped diaphragms 6 are arranged in the front-section cavity 3b at annular intervals, the diaphragms 6 extend from back to front and divide the front-section cavity 3b into a plurality of independent lattice cavities 3b1, and each lattice cavity 3b1 is correspondingly communicated with one drug outlet 1a2. In the preferred scheme, the rear-section chamber 3a is communicated with the front-section chamber 3b, and the front-section chamber 3b is divided into a plurality of independent lattice chambers 3b1 by the diaphragm 6, that is, the lattice chambers 3b1 are directly communicated with the rear-section chamber 3a, so that the liquid medicine pressure in each lattice chamber 3b1 is equal to that of the rear-section chamber 3a, and as each independent lattice chamber 3b1 is correspondingly communicated with one medicine outlet hole 1a2, theoretically, the liquid medicine pressure at each medicine outlet hole 1a2 is equal, that is, the liquid outlet speed of each medicine outlet hole 1a2 is the same, and the design can avoid the situation of uneven liquid output caused by the positions of the medicine outlet holes 1a2 in sequence, so that the liquid medicine can be more uniformly dispersed to thrombus positions, and the thrombolytic effect is better guaranteed. Further, the medicine outlet holes 1a2 communicating with the medicine injection cavity 3 are preferably arranged at intervals in a spiral shape.

As another preferable scheme, different from the aforementioned preferable scheme, in the present preferable scheme, each grid cavity 3b1 is correspondingly communicated with a plurality of medicine outlet holes 1a2 which are arranged from back to front at intervals. For the longer condition of thrombus length in the blood vessel, because the check chamber 3b1 quantity that separates out through diaphragm 6 is limited, if every check chamber 3b1 only corresponds a medicine hole 1a2, then the length of going out the medicine section is just very limited, can't be applied to the longer condition of thrombus length, if a check chamber 3b1 corresponds a plurality of medicine holes 1a2 that set up from back to front interval, then can increase the length of going out the medicine section. Certainly, if a check cavity 3b1 corresponds a plurality of medicine outlet holes 1a2 that set up by back-to-front interval, then it is different to probably lead to the liquid medicine pressure that each medicine outlet hole 1a2 discharges, in order to let each medicine outlet hole 1a2 discharge liquid medicine pressure be close as far as possible, can be provided with a plurality of spacers 7 in every check cavity 3b1 parallel interval, spacer 7 should be perpendicular to the axis direction setting of pipe body 1, connect the top of spacer 7 in the inner wall of outer tube 1a, and leave the space that supplies the thrombolysis liquid medicine to pass through between the bottom of spacer 7 and inner tube 1b, every two adjacent spacers 7 all correspond and are provided with a medicine outlet hole 1a2. In this case, it can be understood that the spacers 7 further divide each cell cavity 3b1 into a plurality of chambers which are communicated with each other but have smaller volumes, theoretically, such a design can make the pressure of the liquid medicine in each medicine outlet hole 1a2 more consistent, thereby improving the uniformity of medicine outlet and better ensuring the thrombolytic effect. As shown in FIG. 6, the distance between the medicine outlet 1a2 and the septum 7 located at the rear thereof is preferably larger than the distance between the septum 7 located at the front thereof. That is, in practical use, the medicine outlet 1a2 is preferably provided near the front spacer 7.

Finally, in the present invention, the connector 2 is a Y-type connector, on which an external thread for connecting a heparin cap is provided.

The above embodiments are preferred implementations of the present invention, and besides, the present invention can be implemented in other ways, and any obvious substitutions without departing from the concept of the present invention are within the protection scope of the present invention.

Some of the drawings and descriptions of the present invention have been simplified to facilitate the understanding of the improvements over the prior art by those skilled in the art, and some other elements have been omitted from this document for the sake of clarity, and it should be appreciated by those skilled in the art that such omitted elements may also constitute the subject matter of the present invention.

Claims

1. Thrombolytic catheter, including catheter body (1) and connect in the joint (2) of catheter body (1) rear end, its characterized in that:

the catheter body (1) comprises an outer tube (1 a) and an inner tube (1 b), the outer tube (1 a) is sleeved outside the inner tube (1 b), a gap between the outer tube (1 a) and the inner tube (1 b) is a medicine injection cavity (3), a tube cavity of the inner tube (1 b) is a drainage cavity (4), and the medicine injection cavity (3) and the drainage cavity (4) are isolated from each other;

the joint (2) comprises a first interface (2 a) and a second interface (2 b), the first interface (2 a) is communicated with the drainage cavity (4), and the second interface (2 b) is communicated with the medicine injection cavity (3);

the front end of the drainage cavity (4) is open, and the front end of the outer tube (1 a) and the outer peripheral surface of the inner tube (1 b) are welded together, so that the front end of the medicine injection cavity (3) is closed;

the utility model discloses a blood transfusion drainage tube, including outer tube (1 a), drainage hole (1 a 1) and a plurality of medicine outlet hole (1 a 2) that communicate with each other with injection chamber (3) that are arranged in introducing blood in drainage chamber (4) have been seted up at least on the pipe wall of outer tube (1 a), drainage hole (1 a 1) is located medicine outlet hole (1 a 2) rear, communicate through honeycomb duct (5) between drainage hole (1 a 1) and the drainage chamber (4), honeycomb duct (5) are followed and are passed in injection chamber (3) and its both ends link to each other with drainage hole (1 a 1) and drainage chamber (4) respectively.

2. The thrombolytic catheter of claim 1, wherein: the injection cavity (3) comprises a rear-section cavity (3 a) and a front-section cavity (3 b) which are communicated with each other, the guide pipe (5) penetrates through the rear-section cavity, a plurality of strip-shaped diaphragms (6) are arranged in the front-section cavity (3 b) at annular intervals, the diaphragms (6) extend from back to front and divide the front-section cavity (3 b) into a plurality of independent grid cavities (3 b 1), and each grid cavity (3 b 1) is correspondingly communicated with one medicine outlet hole (1 a 2).

3. The thrombolytic catheter of claim 2, wherein: the medicine outlet holes (1 a 2) communicated with the medicine injection cavity (3) are arranged at intervals in a spiral shape.

4. The thrombolytic catheter of claim 1, wherein: injection chamber (3) are including back end cavity (3 a) and anterior segment cavity (3 b) that communicate each other, honeycomb duct (5) pass in the back end cavity, annular interval is provided with diaphragm (6) of multi-disc rectangular shape in anterior segment cavity (3 b), diaphragm (6) are extended the setting and are separated into a plurality of independent check chambeies (3 b 1) with anterior segment cavity (3 b) by back forward, check chamber (3 b 1) correspond respectively and communicate with each other with a plurality of play medicine hole (1 a 2) that set up by back forward interval.

5. The thrombolytic catheter of claim 4, wherein: the parallel interval is provided with a plurality of spacers (7) in check cavity (3 b 1), the axis direction setting of spacer (7) perpendicular to pipe body (1), the inner wall in outer tube (1 a) is connected on the top of spacer (7), leave the space that supplies the thrombolysis liquid medicine to pass through between the bottom of spacer (7) and inner tube (1 b), all correspond between per two adjacent spacers (7) and be provided with one and go out medicine hole (1 a 2).

6. The thrombolytic catheter of claim 5, wherein: the distance between the medicine outlet hole (1 a 2) and the spacer (7) positioned at the rear part is larger than the distance between the medicine outlet hole and the spacer (7) positioned at the front part.

7. The thrombolytic catheter of claim 1, wherein: the connector (2) is a Y-shaped connector, and an external thread used for connecting a heparin cap is arranged on the Y-shaped connector.