CN107280012A - It is a kind of that there is dietary product of cardiovascular opsonic action and preparation method thereof - Google Patents
It is a kind of that there is dietary product of cardiovascular opsonic action and preparation method thereof Download PDFInfo
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- CN107280012A CN107280012A CN201610191933.2A CN201610191933A CN107280012A CN 107280012 A CN107280012 A CN 107280012A CN 201610191933 A CN201610191933 A CN 201610191933A CN 107280012 A CN107280012 A CN 107280012A
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- 235000005911 diet Nutrition 0.000 title claims abstract description 39
- 230000000378 dietary effect Effects 0.000 title claims abstract description 39
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 30
- 230000001662 opsonic effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000007787 solid Substances 0.000 claims abstract description 27
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 22
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 22
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims abstract description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 12
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 9
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 9
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 9
- 229960002675 xylitol Drugs 0.000 claims abstract description 9
- 235000010447 xylitol Nutrition 0.000 claims abstract description 9
- 239000000811 xylitol Substances 0.000 claims abstract description 9
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 8
- 239000003826 tablet Substances 0.000 claims description 12
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 8
- 238000009501 film coating Methods 0.000 claims description 8
- 239000007888 film coating Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 13
- 241000361919 Metaphire sieboldi Species 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 7
- 230000036541 health Effects 0.000 abstract description 7
- 235000013305 food Nutrition 0.000 abstract description 5
- 230000005800 cardiovascular problem Effects 0.000 abstract description 2
- 238000007873 sieving Methods 0.000 abstract 2
- 229960003563 calcium carbonate Drugs 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 abstract 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 239000011248 coating agent Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 229920001661 Chitosan Polymers 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000009492 tablet coating Methods 0.000 description 3
- 239000002700 tablet coating Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
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- 230000036407 pain Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
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- 102000004190 Enzymes Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003130 cardiopathic effect Effects 0.000 description 1
- 230000005961 cardioprotection Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940001501 fibrinolysin Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 108010070324 lumbrokinase Proteins 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000018338 positive regulation of fibrinolysis Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of dietary product with cardiovascular opsonic action and preparation method thereof, belongs to dietary product technical field, is made up of the chitosan oligosaccharide of 1.1~12.7 parts by weight, the ground dragon protein of 10~25 parts by weight and auxiliary material；Preparation method comprises the following steps：Each component is taken, crushes, sieves for subsequent use；Weigh by weight the chitosan oligosaccharide after crushing, dragon protein, maltodextrin, calcium carbonate, xylitol and ethanol, it is well mixed after sieving solid base is made；0.5~7.6 part of solid base is weighed, ethanol solution is added and stirs to obtain wet grain；Dry particl is made in drying；Dry particl and remaining solid base are mixed, magnesium stearate and silica is added, stirring sieving, tabletting is produced.Two kinds of functional components are combined in the present invention, not only enhanced assimilation effect but also preferably cardiovascular problems can be nursed one's health.Reasonable recipe, effect are that China traditional Chinese medicine earthworm has made good try and contribution in the application of field of food significantly.
Description
Technical field
The present invention relates to dietary product technical field, more particularly to a kind of dietotherapy with cardiovascular opsonic action
Product and preparation method thereof.
Background technology
Chitosan oligosaccharide is called Chitosan poly oligosaccharide, chitosan oligomer, be by chitosan through special biological enzyme technology (
Have using chemical degradation, the report of microwave degradation technology) a kind of obtained degree of polymerization of degrading widow between 2~20
Sugar product, molecular weight≤3200Da is the water-soluble preferable, low molecule that function is big, bioactivity is high
Volume production product.It has the unexistent higher solubility of chitosan, and water is dissolved in entirely, easily absorbs profit by organism
With etc. many unique functions, it act as 14 times of chitosan.Chitosan oligosaccharide is (such as double as beneficial bacteria of intestinal tract
Qi bacillus) activation factor, promote the absorption of calcium and mineral matter.
Earthworm protein extraction contains clostridiopetidase A, fibrinolysin, Lumbrokinase, activation of fibrinolysis albumen (FA from earthworm
Albumen), nucleic acid, the Multiple components such as trace element, its molecular weight belongs to short chain small molecule in 5000-10000
Material, can smoothly enter capilary.No. 18 bulletin batch of Ministry of Health of the People's Republic of China 2009 year
Quasi- ground dragon protein is new resource food.
Contained activated protein lyase and other active materials can dissolve atherosis blood vessel wall in ground dragon protein
The upper netted thing of fibrin, eliminates the pathological products such as cholesterol plaques attached thereto, promotes blood vessel endothelium thin
Born of the same parents DNA synthesis, promotes the injury repair of vascular wall, expands blood vessel, recovers blood vessel elasticity, makes blood smooth
It is logical, change and prevent the natural history of artery sclerosis to a certain extent.
Cardiovascular disease incidence factor is various, and pathomechanism is numerous and diverse, treats very intractable, with coronary heart disease and the heart
The cardiovascular disease obstructed for representative is the first killer of human health, and is referred to as human death's by modern medicine
One of the main reasons, so the cardiopathic medicine of research treatment is also a lot, treats cardiovascular in existing technology
In the Chinese medicine of disease, Western medicine medicine, it can reach that effectively, the medication duration is very long, it is also difficult to
Angiocardiopathy, and there's no such thing as a totally safe medicine are thoroughly cured, the harm that medicine is caused to human body when taking medicine can not
Look down upon.Therefore, cardioprotection, advocates prevention and conditioning after being ill before disease and is combined, using drug therapy and drink
Food therapy is combined more and more welcomed by the people, with fast development and the living standard of social economy
Rapid to improve, people increasingly pay attention to health and health care, various for the medicine of prevention and cure of cardiovascular disease, but
It is both food and the product of medicine is rare, the dietary product that angiocardiopathy is nursed one's health in the market is rare,
Some products include chitosan oligosaccharide or ground dragon protein, though having certain effect, it is low all to deposit bioavilability, takes
Band drinks inconvenience, and human intake's amount is few to wait not enough, it is therefore necessary to according to the integration of drinking and medicinal herbs of the traditional Chinese medical science it is theoretical and
Diet-therapy health-preserving is theoretical, develops a kind of suitable people's needs, can improve bioavilability, edible side
Just, new type functional modernization industry processing the cardiovascular food of conditioning.
The content of the invention
The invention provides a kind of dietary product with cardiovascular opsonic action and preparation method thereof, solve existing
The problem of health food bioavilability containing chitosan oligosaccharide or ground dragon protein having is low.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of dietary product with cardiovascular opsonic action, be by 1.1~12.7 parts by weight chitosan oligosaccharide, 10~
The ground dragon protein and auxiliary material of 25 parts by weight are made.
Wherein it is preferred to, the formulation of the dietary product is tablet, capsule or granule.
Wherein it is preferred to, the formulation of the dietary product is tablet, and the auxiliary material includes following weight parts
Component：5.5~41.4 parts of maltodextrin, 10.5~20 parts of calcium carbonate, 5~15 parts of xylitol, magnesium stearate 0.2~
2 parts, 0.1~1.4 part of silica.
Wherein it is preferred to, the auxiliary material includes following components in parts by weight：30~41.4 parts of maltodextrin, carbon
Sour 12~18 parts of calcium, 8~12 parts of xylitol, 0.5~1.5 part of magnesium stearate, silica 1~2 part.
A kind of preparation method of the dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 60~300 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after chitosan oligosaccharide, dragon protein, maltodextrin, calcium carbonate, xylose
Alcohol and 1~5 part 50% of ethanol, cross 60~150 mesh sieves after being well mixed and solid base are made；
(3) 0.5~7.6 part of solid base is weighed, the ethanol solution for adding 1~5 part 50% stirs
Wet grain；
(4) the wet grain is dried into 30~60min under the conditions of 30 DEG C~60 DEG C, relative humidity 10%~40%
Dry particl is made；
(5) dry particl and remaining solid base are mixed, add magnesium stearate and silica,
Stir and 20~40 mesh sieves are crossed after 30min, tabletting is produced.
Wherein it is preferred to, the step of also including film coating after the step (5).
Beneficial effects of the present invention：
This product is using earthworm albumen powder and chitosan oligosaccharide as main composition, and preferred other customary adjuvants are obtained
The dietary product with cardiovascular opsonic action, two kinds of functional components combine, not only enhanced assimilation effect but also
Preferably cardiovascular problems can be nursed one's health.Reasonable recipe, effect are that China traditional Chinese medicine earthworm is eating significantly
Good try and contribution have been made in the application in product field.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described
Embodiment be only a part of embodiment of the invention, rather than whole embodiment.Based in the present invention
Embodiment, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
A kind of dietary product with cardiovascular opsonic action, be by 1.1~12.7 parts by weight chitosan oligosaccharide, 10~
The ground dragon protein and auxiliary material of 25 parts by weight are made.
A kind of preparation method of the dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 60~300 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after chitosan oligosaccharide, dragon protein, maltodextrin, calcium carbonate, xylose
Alcohol and 1~5 part 50% of ethanol, cross 60~150 mesh sieves after being well mixed and solid base are made；
(3) 0.5~7.6 part of solid base is weighed, the ethanol solution for adding 1~5 part 50% stirs
Wet grain；
(4) the wet grain is dried into 30~60min under the conditions of 30 DEG C~60 DEG C, relative humidity 10%~40%
Dry particl is made；
(5) dry particl and remaining solid base are mixed, adds 0.2~2 part of magnesium stearate and two
20~40 mesh sieves are crossed after 0.1~1.4 part of silica, stirring 30min, tabletting is produced.
Embodiment 1
The present embodiment provides a kind of dietary product with cardiovascular opsonic action, is few by the shell of 8 parts by weight
Sugar, the ground dragon protein of 20 parts by weight and auxiliary material are made.
The preparation method of the above-mentioned dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 100 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after 8 parts of chitosan oligosaccharide, earthworm protein 20 part, 25 parts of maltodextrin,
The ethanol of 15 parts of calcium carbonate, 10 parts and 3 part 50% of xylitol, crosses 100 mesh sieves after being well mixed and solid-based is made
Material；
(3) 4 parts of solid base is weighed, 3 part 50% of ethanol solution is added and stirs to obtain wet grain；
(4) the wet grain is dried into 45min under the conditions of 45 DEG C, relative humidity 10%~40% and is made dry
Grain；
(5) dry particl and remaining solid base are mixed, adds 1.1 parts of magnesium stearate and titanium dioxide
30 mesh sieves are crossed after 0.8 part of silicon, stirring 30min, tabletting produces the tablet that specification is 0.5g/ pieces..
(6) 1 part of film coating material is weighed, the film coating material is made into concentration with 60% ethanol is
10% coating solution, after by compress tablet coating 150min, during coating control coating pan rotating speed 5r/min, atomization pressure
Power is 0.7MPa.
Embodiment 2
The present embodiment provides a kind of dietary product with cardiovascular opsonic action, is few by the shell of 1.1 parts by weight
Sugar, the ground dragon protein of 25 parts by weight and auxiliary material are made.The above-mentioned dietary product with cardiovascular opsonic action
Preparation method, comprises the following steps：
(1) each component is taken, is crushed, 60 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after 1.1 parts of chitosan oligosaccharide, earthworm protein 25 part, 5.5 parts of maltodextrin,
The ethanol of 20 parts of calcium carbonate, 5 parts and 5 part 50% of xylitol, crosses 60 mesh sieves after being well mixed and solid base is made；
(3) 7.6 parts of solid base is weighed, 5 part 50% of ethanol solution is added and stirs to obtain wet grain；
(4) the wet grain is dried into 30min under the conditions of 60 DEG C, relative humidity 10%~40% and is made dry
Grain；
(5) dry particl and remaining solid base are mixed, adds 2 parts of magnesium stearate and titanium dioxide
20 mesh sieves are crossed after 0.1 part of silicon, stirring 30min, tabletting produces the tablet that specification is 0.5g/ pieces..
Embodiment 3
The present embodiment provides a kind of dietary product with cardiovascular opsonic action, is few by the shell of 12.7 parts by weight
Sugar, the ground dragon protein of 10 parts by weight and auxiliary material are made.
The preparation method of the above-mentioned dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 300 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after 1.7 parts of chitosan oligosaccharide, earthworm protein 10 part, 41.4 parts of maltodextrin,
The ethanol of 10.5 parts of calcium carbonate, 15 parts and 1 part 50% of xylitol, crosses 150 mesh sieves after being well mixed and solid base-material is made；
(3) 0.5 part of solid base is weighed, 1 part 50% of ethanol solution is added and stirs to obtain wet grain；
(4) the wet grain is dried into 60min under the conditions of 30 DEG C, relative humidity 10%~40% and is made dry
Grain；
(5) dry particl and remaining solid base are mixed, adds 0.2 part of magnesium stearate and titanium dioxide
40 mesh sieves are crossed after 1.4 parts of silicon, stirring 30min, tabletting produces the tablet that specification is 0.5g/ pieces..
Embodiment 4
The present embodiment provides a kind of dietary product with cardiovascular opsonic action, is few by the shell of 8 parts by weight
Sugar, the ground dragon protein of 20 parts by weight and auxiliary material are made.
The preparation method of the above-mentioned dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 100 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after 10 parts of chitosan oligosaccharide, earthworm protein 25 part, 30 parts of maltodextrin,
The ethanol of 18 parts of calcium carbonate, 8 parts and 3 part 50% of xylitol, crosses 100 mesh sieves after being well mixed and solid base is made；
(3) 4 parts of solid base is weighed, 3 part 50% of ethanol solution is added and stirs to obtain wet grain；
(4) the wet grain is dried into 45min under the conditions of 45 DEG C, relative humidity 10%~40% and is made dry
Grain；
(5) dry particl and remaining solid base are mixed, adds 1.5 parts of magnesium stearate and titanium dioxide
30 mesh sieves are crossed after 1 part of silicon, stirring 30min, tabletting produces the tablet that specification is 0.5g/ pieces..
(6) 1 part of film coating material is weighed, the film coating material is made into concentration with 60% ethanol is
10% coating solution, after by compress tablet coating 150min, during coating control coating pan rotating speed 5r/min, atomization pressure
Power is 0.7MPa.
Embodiment 5
The present embodiment provides a kind of dietary product with cardiovascular opsonic action, is few by the shell of 6 parts by weight
Sugar, the ground dragon protein of 16 parts by weight and auxiliary material are made.
The preparation method of the above-mentioned dietary product with cardiovascular opsonic action, comprises the following steps：
(1) each component is taken, is crushed, 100 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after 6 parts of chitosan oligosaccharide, earthworm protein 16 part, 41.4 parts of maltodextrin,
The ethanol of 12 parts of calcium carbonate, 8 parts and 3 part 50% of xylitol, crosses 100 mesh sieves after being well mixed and solid base is made；
(3) 4 parts of solid base is weighed, 3 part 50% of ethanol solution is added and stirs to obtain wet grain；
(4) the wet grain is dried into 45min under the conditions of 45 DEG C, relative humidity 10%~40% and is made dry
Grain；
(5) dry particl and remaining solid base are mixed, adds 0.5 part of magnesium stearate and titanium dioxide
30 mesh sieves are crossed after 2 parts of silicon, stirring 30min, tabletting produces the tablet that specification is 0.5g/ pieces.
(6) 1 part of film coating material is weighed, it is 10% that the film coating material is made into concentration with 60% ethanol
Coating solution, after by compress tablet coating 150min, coating pan rotating speed 5r/min is controlled during coating, atomizing pressure is
0.7MPa。
In the above-described embodiments, the dietary product with cardiovascular opsonic action of the present invention can be also made
Granula or capsule.
The Application Example of the dietary product of the cardiovascular opsonic action of the present invention：
1. a ××, female, nineteen sixty life, Qingdao people from city is dizzy all day with hypertension, patient
Body is poor, takes the dietary product of the embodiment of the present invention 1, and 3 times a day, 2 tablets once (specification 0.5g/ pieces),
Have pains all over after taking 30 days, soreness of waist symptom has taken a turn for the better, and takes after one month, from head to foot pain, soreness of waist symptom
The spirit that all disappeared takes a turn for the better, and is further continued for taking two weeks, dizziness makes moderate progress, and muscle power increase feels good
It is good.
2. Lee's ××, female, life in 1956, Shandong people from Shouguang City has hypertension, high fat of blood, it is impossible to from
Reason life, 2015, family members required to take the dietary product of the embodiment of the present invention 1,3 times a day, every time
2 (specification 0.5g/ pieces), takes aftersensation in one week and obtains that sb.'s illness took a favorable turn, breathes smooth, can arrive outdoor activity, with
After continue to take one month, 3 times a day, 2 tablets once, can be taken a walk daily to outside, and can do housework work.
3. horse ××, man, life in 1954, Qingdao city people, August is suffered from examination in hospital on the 15th within 2013
Coronary heart disease, frequent angina pectoris, expiratory dyspnea, by taking the dietary product of the embodiment of the present invention 1, daily 3
Secondary, 2 tablets once (specification 0.5g/ pieces), takes aftersensation in three weeks and obtains that sb.'s illness took a favorable turn, breathes smooth, the current heart is twisted
The symptom of pain has taken a turn for the better.
The dietary product of the present invention passes through clinical verification, and blood fat (blood after dietary product of the invention is taken in invention
Clear TC, TG, HDL-C) efficiency index improves significantly, and this product is safe and reliable, in the observation period
Between do not find obvious adverse reaction and toxic side effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in this hair
Within bright spirit and principle, any modification, equivalent substitution and improvements made etc. should be included in this hair
Within bright protection domain.
Claims (6)
1. a kind of dietary product with cardiovascular opsonic action, it is characterised in that be by 1.1~12.7 parts by weight
Chitosan oligosaccharide, the ground dragon protein of 10~25 parts by weight and auxiliary material are made.
2. a kind of dietary product with cardiovascular opsonic action according to claim 1, it is characterised in that
The formulation of the dietary product is tablet, capsule or granule.
3. a kind of dietary product with cardiovascular opsonic action according to claim 2, it is characterised in that
The formulation of the dietary product is tablet, and the auxiliary material includes following components in parts by weight：Maltodextrin 5.5~
41.4 parts, 10.5~20 parts of calcium carbonate, 5~15 parts of xylitol, 0.2~2 part of magnesium stearate, silica 0.1~
1.4 part.
4. a kind of dietary product with cardiovascular opsonic action according to claim 3, it is characterised in that
The auxiliary material includes following components in parts by weight：30~41.4 parts of maltodextrin, 12~18 parts of calcium carbonate, xylose
8~12 parts of alcohol, 0.5~1.5 part of magnesium stearate, silica 1~2 part.
5. a kind of preparation method of the dietary product with cardiovascular opsonic action described in claim 3, it is special
Levy and be to comprise the following steps：
(1) each component is taken, is crushed, 60~300 mesh sieves are crossed, it is standby；
(2) by weight weigh crush after chitosan oligosaccharide, dragon protein, maltodextrin, calcium carbonate, xylose
Alcohol and 1~5 part 50% of ethanol, cross 60~150 mesh sieves after being well mixed and solid base are made；
(3) 0.5~7.6 part of solid base is weighed, the ethanol solution for adding 1~5 part 50% stirs
Wet grain；
(4) the wet grain is dried into 30~60min under the conditions of 30 DEG C~60 DEG C, relative humidity 10%~40%
Dry particl is made；
(5) dry particl and remaining solid base are mixed, add magnesium stearate and silica,
Stir and 20~40 mesh sieves are crossed after 30min, tabletting is produced.
6. a kind of preparation method of dietary product with cardiovascular opsonic action according to claim 5,
Characterized in that, the step of also including film coating after the step (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191933.2A CN107280012A (en) | 2016-03-30 | 2016-03-30 | It is a kind of that there is dietary product of cardiovascular opsonic action and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191933.2A CN107280012A (en) | 2016-03-30 | 2016-03-30 | It is a kind of that there is dietary product of cardiovascular opsonic action and preparation method thereof |
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|---|---|
| CN107280012A true CN107280012A (en) | 2017-10-24 |
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ID=60087157
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610191933.2A Pending CN107280012A (en) | 2016-03-30 | 2016-03-30 | It is a kind of that there is dietary product of cardiovascular opsonic action and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239706A (en) * | 2013-05-13 | 2013-08-14 | 肖梅芬 | Earthworm protein for reducing blood glucose, improving microcirculation and eliminating diabetic complication and application thereof |
| CN104839680A (en) * | 2015-04-13 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Medical formula food for people with cardiovascular diseases |
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|---|---|---|---|---|
| CN103239706A (en) * | 2013-05-13 | 2013-08-14 | 肖梅芬 | Earthworm protein for reducing blood glucose, improving microcirculation and eliminating diabetic complication and application thereof |
| CN105360789A (en) * | 2014-08-18 | 2016-03-02 | 天津鑫泽众生物技术有限公司 | Edible earthworm protein nutrition granules and processing process thereof |
| WO2016029113A1 (en) * | 2014-08-22 | 2016-02-25 | Abbott Laboratories | Methods of increasing endogenous production of beta-hydroxy-beta-methylbutyrate |
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Application publication date: 20171024 |