CN107260187B - Method and system for inducing craving for addictive drugs in virtual reality environment - Google Patents
Method and system for inducing craving for addictive drugs in virtual reality environment Download PDFInfo
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Abstract
The invention discloses a method and a system for inducing craving of addictive drugs in a virtual reality environment, and a multidimensional addictive memory characteristic database with explicit memory and implicit memory is established; examining the relevant life memory of the addiction of the target sample group, and extracting multidimensional clue stimulation characteristic materials with common memory corresponding to the tested target sample addiction group from an established addiction memory characteristic database; converting the multidimensional clue stimulation characteristic materials with the common memory into a virtual reality environment with a psychological model and a cognitive map, and simulating a medication scene and a scene clue of the addict; the tested craving response test is carried out in the established virtual reality environment, and craving response of the tested to the addictive drugs is induced; measuring physiological and behavioral responses of the subject while inducing craving for addiction; an craving response assessment is made for the subject based on the measured response data. The invention realizes the interactive experience of the addiction test and the virtual reality environment, and induces the medicine craving through a multi-sense channel.
Description
Technical Field
The invention belongs to the technical field of craving induction of patients with substance use disorder, and particularly relates to a method and a system for inducing craving of addictive drugs in a virtual reality environment, which provide a technical approach with higher ecological effectiveness for clinical intervention treatment of addicted patients.
Background
Substance use disorder (substance use disorders, SUD) is clinically defined as a chronic recurrent brain disease, manifested by increased intake, uncontrolled compulsive foraging and medication behavior, tolerance to medications, reduced appearance of negative emotions after use, and severe withdrawal symptoms, and is strongly desired. The use of psychoactive substances such as nicotine, alcohol, ***e and methamphetamine, results in pathological changes in the structure and function of the brain, which are the root cause of SUD production. The control of SUD is a global public health problem that is to be addressed. The root cause of the addict's relapse is not physiological dependence, but rather is a persistent psychological dependence. The long-term existence of pathological addictive memory is a key to psychological dependence development. Repeated use of addictive drugs results in adaptive changes in the nervous system, thereby affecting the formation, consolidation, maintenance and extraction of positive rewarding memory and negative emotion memory, producing long-term pathological addiction-related memory, and enabling addicts to stimulate psychological craving and re-inhalation behavior of the drug when contacting the drug and related environmental cues. Therefore, in SUD therapy, the use of behavioral therapy techniques such as cue exposure in combination with other methods such as drug therapy can effectively reduce the response of an individual to an addictive-related cue, cue Exposure Therapy (CET) is based on the classical conditional reflex principle of pavlov, which results in a strong emotional and motivational responsiveness to CS due to repeated matching of the multi-environmental cue (conditioned stimulus, CS) to the reward effect (unconditioned stimulus, US) of the drug during substance use.
Studies have shown that CET can alleviate symptoms in SUD patients. While capable of reducing re-absorption behavior, conventional CETs also have some limitations (1) they do not provide comprehensive complex cues (e.g., social scenes and interactions, emotional experiences, physical cues, etc.); (2) Traditional CETs have limitations in mimicking an individual's real life experience, thus limiting the ecological effectiveness of the treatment (ecological validity). The ecological efficiency refers to the similarity degree of experimental variables and real situations in the research process, the degree of popularization of research results to real living environments is applied, and the ecological efficiency is an important index for measuring whether the research has practical value. Traditional CET therapies generally mimic only a portion of the real environment during treatment, have relatively limited efficacy, and are prone to relapse.
Disclosure of Invention
Therefore, in order to solve the problem that the traditional two-dimensional and three-dimensional clue exposure method cannot provide comprehensive complex clues, limit the evaluation problem of the craving response of the craving for relapse caused by the factors of the social living environment and improve the measurement reliability and effectiveness, the invention provides a method and a system for inducing craving for addictive drugs in the virtual reality environment.
The technical scheme adopted is as follows:
in one aspect, the present invention provides a method of inducing craving for addictive drugs in a virtual reality environment, the method comprising the steps of:
step 1, establishing a multidimensional addictive memory characteristic database with an explicit memory and an implicit memory;
step 2, examining the relevant life memories of the addiction of the target sample group, and extracting multidimensional clue stimulating characteristic materials with common memories corresponding to the addiction groups of the tested target sample in an established addiction memory characteristic database;
step 3, converting the multidimensional clue stimulation characteristic materials with the common memory into a virtual reality environment with a psychological model and a cognitive map, and simulating a medication scene and a scene clue of the addict;
step 4, the tested person carries out craving response test on addiction in the established virtual reality environment, and craving response of the tested person to the addictive drugs is induced;
step 5, measuring response data of the physiology and behavior of the tested person while inducing craving for addiction;
and 6, carrying out craving response assessment on the tested addiction according to the tested response data.
And in the step 2, extracting multidimensional clue stimulation characteristic materials with common memory from the established addictive memory characteristic database, wherein the multidimensional clue stimulation characteristic materials specifically comprise six-dimensional characteristic contents of a medication process, social relations, environmental factors, mood factors, physical factors and cognitive factors.
The measuring of the response data of the subject physiology and behavior in step 5 includes: one or more of skin electrical data, heart rate variability data, brain electrical data and eye electrical data.
The test in the step 4 further comprises the following steps before the craving response test of addiction is performed in the established virtual reality environment:
preparing the tested before testing, and removing interference factors influencing the testing process of the tested; pre-test physiological and behavioral data acquisition was performed on the test.
The evaluation of craving response to the test includes, in particular, evaluation of physical arousal, psychological craving, emotional stress, cognitive expectancy, and self-control feeling, comparison of pre-and post-test physiological and behavioral data, and judgment of craving induction of the test.
The step 5 also comprises the step of carrying out post-test structured interview questionnaires on the tested person, and the step is used for examining test experiences of the tested person including physical, emotion, cognition and psychological motivation.
The method further comprises the step 7 of verifying the craving response data of the tested person, wherein the data before and after the tested person are extracted and compared with the withdrawal symptom characteristics of the healthy people or the patients in daily life, and whether the craving response data of the tested person are consistent with the extracted characteristics of the smoking experience of the target sample is verified.
In another aspect, the present invention also provides a system for inducing craving for addictive drugs in a virtual reality environment, the system comprising: a drug addiction database module containing relevant life data with the apparent memory and the implicit memory of the addict;
the commonality memory extraction module is connected with the drug addiction database module and is used for extracting addiction commonality memory data from the established virtual reality environment;
the VR clue addiction psychological characterization module is connected with the commonality memory extraction module and is used for extracting addiction sample commonality memories in the drug addiction database module and converting addiction memory characteristic database information into virtual reality scene experiences with psychological models and cognitive map psychological characterization forms;
the VR clue reaction test platform is integrated in a computer and is used for simulating the medication scene and scene clues of an addict, and a tested person performs an addiction craving reaction test in a virtual reality environment to induce craving reaction of the tested person to medicines;
the physiological, psychological and behavioral measuring equipment is connected with the VR clue reaction testing platform and is used for detecting physiological, psychological and behavioral data of a tested person in an induced state;
and the thread response evaluation analysis module is used for receiving the measurement data of the VR thread response test platform on the tested person and evaluating the craving for addiction of the tested person.
The VR clue reaction test platform comprises:
the scene presenting device is connected with the commonality memory extracting module and is used for presenting the medication scene and scene clues of the simulated addicts;
the physiological monitoring equipment interface and clock synchronous control module is embedded in the scene presenting device and electrically connected with the physiological, psychological and behavioral measuring equipment, and is used for synchronously controlling a software and hardware interface driving program and an operation clock of the measuring equipment;
the data recording module is connected with the clue reaction evaluation analysis module and is used for recording the outputted scene animation file, the roaming path recording file and the action interaction file of the tested and specific objects in the tested VR roaming process.
The scene presentation device is multimedia equipment, and the addiction commonality memory data extracted from the drug addiction database module presents drug scenes and scene clues of addicts through the multimedia equipment.
The physiological, psychological and behavioral measuring equipment comprises one or a combination of more than one of a skin electricity data acquisition sensor, a heart rate variability data acquisition sensor, an electroencephalogram data acquisition sensor, an electrooculogram data acquisition sensor and an interview questionnaire module.
And the system is also provided with a verification module which is connected with the VR clue reaction test platform and is used for verifying whether the tested craving reaction data is consistent with the extracted characteristics of the target sample sucking experience.
The technical scheme of the invention has the following advantages:
A. the invention is based on the virtual reality system to induce craving for addictive drugs. Compared with the traditional craving induction method using pictures or videos, the virtual reality system integrates multiple sensory channels, including vision, hearing and smell related to addiction memory, and achieves interactive experience of an addicted tested person and a virtual reality environment, so that the tested person induces medicine craving through the multiple sensory channels under the condition of immersion of a main body.
B. The virtual reality system for inducing addiction craving is based on a multidimensional database of pathological substance addiction memory characteristics, extracts common characteristics of pathological addiction memories on the basis of interviews, questionnaires and experiments, and forms an addiction memory stimulation material suitable for VR according to the common characteristics. The design of the virtual reality stimulation material is not to simply take care of the contents of the addiction memory database, but rather to further abstract the virtual reality stimulation material into VR stimulation materials which can be suitable for the addicts to extract the psychological experience form of the addiction memory (psychological model and cognitive map of the addiction memory).
C. In the process of inducing addiction craving, the invention monitors physiological, psychological and behavioral indexes simultaneously, obtains multidimensional indexes of medicine craving, and can realize mutual verification among indexes of different dimensions, thereby extracting the physiological indexes of addiction memory specificity independent of subjective report.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a block diagram of a method for inducing craving for addictive drugs in a virtual reality environment in accordance with the present invention;
FIG. 2 is a classification chart of VR substance addiction cue characteristic elements provided by the present invention;
FIG. 3 is a block diagram of a system for eliciting an craving response in accordance with the present invention;
FIG. 4 is a block diagram showing the structure of the VR cue response test platform of FIG. 3.
Detailed Description
The following description of the embodiments of the present invention will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1, the present invention provides a method for inducing craving for addictive drugs in a virtual reality environment, comprising the steps of:
s1, establishing a multidimensional addictive memory characteristic database with the explicit memory and the implicit memory.
Wherein the implicit memory comprises: medication physical experience, medication emotional experience, medication habituation behavior, and medication background and events; the explicit memory includes categorization and hierarchy of medication related concepts.
The method of clue-induced craving response is to induce the conditional reflex effect of drug-related clues in addicted patients (implicit memory) using VR clue features. The clue stimulation features are extracted by structuring interviews to obtain the declarative (explicit memory) medication experience of addicts. The addictive memory characteristic database comprises the content of the external memory and the internal memory of the dependence relationship between the addicted patient and the drug administration. The external memory mainly reflects the psychological, behavioral, physiological phenomena and processes of drug addiction of a subject which can be observed and actively realized, and the internal memory reveals the inherent correlation (including physiological, psychological and behavioral reactions) between two or more external memory phenomena and behaviors.
S2, examining the relevant life memories of the addiction of the target sample group, and extracting multidimensional clue stimulation characteristic materials with common memories corresponding to the tested target sample addiction group from an established addiction memory characteristic database.
The systematic method for extracting the common memory characteristics of the patients with substance addiction comprises the following steps:
first, the essential difference between the addicted target group and the general person (non-substance addiction) is the core feature of the 'person-drug dependence'.
Then, on the basis of defining the common characteristics, a systematic structuring method is designed to extract six-dimensional specific characteristic contents of the common addictive memory contents, namely: the course of administration, social relationships, environmental factors, mood factors, physical factors, cognitive factors.
(1) Is the medication detail process validated? What kind of appliances are commonly used are personal liked? Is other tobacco, wine or beverage, food, etc. used to the habit of drug administration? What are everything used to before and after administration? Identifying video data or picture material, etc.
(2) Social relationship — and who is inhaling? Where to obtain drugs? "isit usual and who is it taken together? Is one taking a drug? Is two people taking medicine? Is the medication of multiple people? Is toxic friend? Is a poison vendor? What is social stress or other stress related to drug use?
(3) Environmental factors-where is sucking? What time is there sucked? ", time of administration? Sites? Is other food and drink accompanied by a drug? Sites (bars, hotels, bedrooms, toilets, bathrooms, streets, dances, recreational places, in cars, worn buildings); medicine and medicine-related appliance.
(4) Mood factor-sensation before and after drug absorption? "? Is an active or passive emotional state? Excitement, execution, hallucination, sadness, anger, anxiety, frustration, depression, boredom.
(5) Cognition factors-thought before and after drug absorption? "including the idea often before the use of icetoxin? What is the idea changed before and after the medication process? Is there a hallucination after administration?
(6) Physical factors-what is most preferred to do when taking the drug? How does the physical sensation? As a substance, a specific physical state or sense of aura is used.
The layered multidimensional addictive memory feature database of the studied target group is abstracted by the six-dimensional field interview, observation and sufficient sample size investigation statistical questionnaire method. In the manufacturing link of VR material, according to the memory characteristic database of addiction as the design demand, finish the standardized stimulating clue material which embodies the commonality characteristic.
And S3, converting the multidimensional clue stimulation characteristic materials with the common memory into a virtual reality environment with a psychological model and a cognitive map, and simulating a medication scene and a scene clue of the addict.
The invention further abstracts the psychological model and the cognitive map which are suitable for the addict to be tested to extract the psychological experience form of the addicted memory, namely the addicted memory (thinking appearance). The mental model is composed of dynamic system drawings and expectations for system operation (e.g., correctness, integrity), as well as special event memory (using repetitive combinations of drawings and scripts and mental models).
The drawings and scripts herein are information stored in long-term memory, knowledge organized in terms of a central concept or topic (the drawings are generally composed of objects, backgrounds, people; the scripts are descriptions of the drawings). The cognitive map is a psychological representation of information representing objects and scene space, such as a city, a room, for example, the layout of addicts' medication sites, for representing the long-term memory of a visual space template associated with the working memory process. And the addiction memory characteristic database information is further abstracted and converted into psychological characterization forms of virtual reality scene experience, namely a psychological model and a cognitive map, and finally, the final matching of the integration of the tested perception experience in the test site is completed.
In terms of virtual cue combination feature classification, on the basis of near-end object, background object and complex object classification in the current field, independent branches of person objects are additionally added, and two-stage classification content is refined, as shown in fig. 2. The invention uses the element classification of VR substance addiction clue characteristics in figure 2 as a basic clue making attribute unit, and the extracted common memory characteristic materials can be flexibly combined into multidimensional clues approaching to the living environment of addicts under the guidance of the element classification in figure 2, so as to meet the application requirements of different experimental designs and clinical application interventions.
Wherein the character object comprises: a plurality of character scales, only a first scale, a second scale, and a third scale are shown in fig. 2, each including, but not limited to, an emotional state, a physical state, a motivational requirement, and a sequence of actions, respectively.
Included in the proximal object are: drug-absorbing tools, drugs, drug-accompanying articles and the like;
among the background objects are: sites, objects, time and atmosphere, etc.
S4, the test is carried out in the established virtual reality environment to test craving response of addiction, and craving response of the test to addictive drugs is induced.
The method for testing the craving response of addiction in the established virtual reality environment comprises the following steps: preparing the tested before testing, and removing interference factors influencing the testing process of the tested; pre-test physiological and behavioral data acquisition was performed on the test.
[ S5 ] measurement of response data of the physiology and behavior of the subject while inducing craving for addiction.
Measuring response data for the physiology and behavior of the subject includes: one or more of skin electrical data, heart rate variability data, brain electrical data and eye electrical data.
Further preferably, the step 5 further comprises performing a post-test structured interview questionnaire on the subject for examining the test experience of the subject including physical, emotional, cognitive, psychological motivation aspects.
The data can be evaluated from the following five dimensions by the measured reaction data:
(1) the tested real-time craving report; (2) physiological index: skin electricity, heart rate variability; (3) whether the response data of the specific area of the electroencephalogram detection index exceeds a threshold limit or not; (4) the tested attention bias and consciousness process interaction behavior reaction records (containing electrooculography) of the test process; (5) structured interview questionnaires are performed after testing to directly investigate the experience of the test being engaged in the test, including physical, emotional, cognitive, psychomotor perception.
Through the evaluation of the five-dimensional data, a sample case information base of the study is further expanded, and the evaluation of the craving response of the tested addiction is accurately completed.
[ S6 ] an craving response assessment for addiction is made to the subject based on the measured response data.
The evaluation of craving response to the test includes, in particular, evaluation of physical arousal, psychological craving, emotional stress, cognitive expectancy, and self-control feeling, comparison of pre-and post-test physiological and behavioral data, and judgment of craving induction of the test.
[ S7 ] verification of the craving reaction data for the test.
By extracting data before and after the test and comparing with the characteristics of withdrawal symptoms of the healthy people or the patients in daily life, whether the craving response data of the test is consistent with the extracted characteristics of the smoking experience of the target sample is verified.
The invention adopts the following two verification methods:
the first verification method comprises the following steps: the large-scale statistical requirement samples of addicts are tested, the test is carried out to examine the change of the tested test in the group before and after the test, the test is compared with the healthy control group, and whether the sensitivity and the specificity of the data response characteristics in the group are consistent or not is verified, so that the test has ecological effectiveness and action mechanism effectiveness.
The second verification method is as follows: whether the data in the addiction memory characteristic database is consistent with the front and rear characteristic information of the test response data or not takes the withdrawal symptom characteristics of patients in daily life, the published research result data in the field and the related measurement scales as evaluation reference calibration marks.
As shown in fig. 3, the present invention also provides a system for eliciting an craving response for addiction, the system comprising: the system comprises a drug addiction database module, a commonality memory extraction module, a clue addiction psychological characterization module, a VR clue reaction test platform, physiological, psychological and behavioral measuring equipment and a clue reaction evaluation analysis module.
The drug addiction database module contains relevant life data with the external memory and the internal memory of the addict, and the common memory extraction module is connected with the drug addiction database module and is used for extracting the addiction common memory data from the established virtual reality environment; the clue addiction psychological characterization module is connected with the common memory extraction module and is used for extracting the addiction sample common memory in the drug addiction database module and further abstracting and converting the addiction memory characteristic database information into virtual reality scene experience with psychological model and cognitive map psychological characterization modes.
VR clue response test platform integrated in a computer, as shown in fig. 4, comprising: the system comprises a scene presentation device, a physiological monitoring equipment interface, a clock synchronous control module and a data recording module. The scene presentation device is connected with the common memory extraction module and is used for presenting the medication scene and scene clues of the simulated addicts; the physiological monitoring equipment interface and the clock synchronous control module are embedded in the scene presentation device and are electrically connected with the physiological, psychological and behavioral measuring equipment, and are used for synchronously controlling the software and hardware interface driving program and the running clock of the measuring equipment, and meanwhile, the physiological monitoring equipment interface and clock synchronous control module has the transmission and conversion functions of standard interface data such as test time, experimental tested and the like; the data recording module is connected with the clue reaction evaluation analysis module and is used for recording the outputted scene animation file, the roaming path recording file and the action interaction file of the tested and specific objects in the tested VR roaming process. The preferred scene presentation device in the invention is multimedia equipment, and the addictive commonality memory data extracted from the drug addiction database module is used for presenting the medication scene and scene clues of addicts through the multimedia equipment.
The platform of the invention also has a management control function for psychological experiment programs, and is used for completing the generation, operation and output of experiment results of the experiment programs of specific test tasks.
The test is used for carrying out addiction craving reaction (namely user immersion) test in a virtual reality environment, and inducing craving reaction of the test on the medicine; the physiological, psychological and behavioral measuring equipment is connected with the VR clue reaction testing platform and is used for detecting physiological, psychological and behavioral data of a tested person in an induced state; the physiological, psychological and behavioral measuring equipment is a multi-perception sensing device and is used for presenting and feeding back the immersion degree of a tested body, collecting roaming action information of the tested body and forming real-time interaction of scene immersion with the scene presenting device, and the physiological, psychological and behavioral measuring equipment specifically comprises one or a combination of more of a skin-to-electricity data acquisition sensor, a heart rate variability data acquisition sensor, an electroencephalogram data acquisition sensor, an electrooculogram data acquisition sensor and an interview questionnaire module.
The thread response evaluation analysis module receives measurement data of the VR thread response test platform on a tested person and evaluates addiction craving of the tested person.
And the system is also provided with a verification module which is connected with the VR clue reaction test platform and is used for verifying whether the tested craving reaction data is consistent with the characteristics of the extracted target sample sucking experience or not, so that the whole craving reaction system forms a closed loop.
The invention extracts from semantic expression information collection and structural organization common characteristics, establishes an addiction memory database in a classified way, abstracts and converts the addiction memory database into a tested psychological characterization form in a virtual design stage, and obtains consistency verification of the addiction memory collected by investigation and analysis through integrating regular perception information processing from bottom to top and top to top in a clue scene of psychological characterization element integration presented by a tested VR virtual reality environment in a test process. The method is the whole operation process of the whole system, and is also a closed loop verifiable pseudo logic design idea for the system to verify correctness by itself.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.
Claims (10)
1. A method of inducing craving for addictive drugs in a virtual reality environment, the method comprising the steps of:
step 1, establishing a multidimensional addictive memory characteristic database with an explicit memory and an implicit memory; wherein the implicit memory is the conditional reflex effect of drug related clues of addicts induced by utilizing VR clue characteristics, and the explicit memory is the declarative medication experience of addicts obtained through structural interviews, and clue stimulation characteristics are extracted; the addiction memory characteristic database comprises the content of the external memory and the internal memory of the dependence relationship between the addicted patient and the drug administration; wherein the implicit memory comprises: medication physical experience, medication emotional experience, medication habituation behavior, and medication background and events; the external memory includes categorization and hierarchy of medication related concepts;
step 2, examining the relevant life memories of the addiction of the target sample group, and extracting multidimensional clue stimulation characteristic materials with common memories corresponding to the addiction groups of the tested target sample group from an established addiction memory characteristic database, wherein the multidimensional clue stimulation characteristic materials specifically comprise six-dimensional characteristic contents of a medication process, a social relationship, an environmental factor, a mood factor, a physical factor and a cognitive factor;
step 3, converting the multidimensional clue stimulation characteristic materials with the common memory into a virtual reality environment with a psychological model and a cognitive map, and simulating a medication scene and a scene clue of the addict;
step 4, the tested person carries out craving response test on addiction in the established virtual reality environment, and craving response of the tested person to the addictive drugs is induced;
step 5, measuring physiological and behavioral responses of the test while inducing craving for addiction, and simultaneously carrying out post-test structured interview questionnaires on the test for examining test experience of the test including physical, emotional, cognitive and psychological motivation aspects;
and 6, carrying out craving response assessment on the tested addiction according to the tested response data.
2. The method of claim 1, wherein measuring response data of the subject physiology and behavior in step 5 comprises: one or more of skin electrical data, heart rate variability data, brain electrical data and eye electrical data.
3. The method of claim 1, wherein the test of step 4 further comprises the steps of, prior to the craving reaction test in the established virtual reality environment:
preparing the tested before testing, and removing interference factors influencing the testing process of the tested; pre-test physiological and behavioral data acquisition was performed on the test.
4. The method of claim 3, wherein the assessment of craving response to craving for an addictive drug in a virtual reality environment comprises assessment of physical arousal, psychological craving, emotional stress, cognitive desire, and self-control feeling, comparison of pre-and post-test physiological and behavioral data, and determination of craving for an addictive drug in a test.
5. The method of any one of claims 1-4, further comprising the step of 7 validating the craving response data of the subject by extracting data before and after the test and comparing with the characteristics of withdrawal symptoms of the healthy population or the patient in daily life, and validating whether the craving response data of the subject is consistent with the extracted characteristics of the target sample intake experience.
6. A system for inducing craving for addictive drugs in a virtual reality environment, the system comprising: an addiction database module containing relevant life data with the apparent memory and the implicit memory of the addict;
the commonality memory extraction module is connected with the addiction database module and is used for extracting addiction commonality memory data from the established virtual reality environment;
the VR clue addiction psychological characterization module is connected with the commonality memory extraction module and is used for extracting addiction sample commonality memories in the addiction database module and converting addiction memory characteristic database information into virtual reality scene experiences with psychological models and cognitive map psychological characterization forms;
the VR clue reaction test platform is integrated in a computer and is used for simulating the medication scene and scene clues of an addict, and a tested person performs an addiction craving reaction test in a virtual reality environment to induce craving reaction of the tested person to medicines;
the physiological, psychological and behavioral measuring equipment is connected with the VR clue reaction testing platform and is used for detecting physiological, psychological and behavioral data of a tested person in an induced state;
a structured interview questionnaire coupled to said VR clue response test platform for examining test experiences including physical, emotional, cognitive, psychological motivation after being tested;
and the thread response evaluation analysis module is used for receiving the measurement data of the VR thread response test platform on the tested person and evaluating the craving for addiction of the tested person.
7. The system for inducing craving for addictive drugs in a virtual reality environment of claim 6, wherein the VR clue response test platform comprises:
the scene presenting device is connected with the commonality memory extracting module and is used for presenting the medication scene and scene clues of the simulated addicts;
the physiological monitoring equipment interface and clock synchronous control module is embedded in the scene presenting device and electrically connected with the physiological, psychological and behavioral measuring equipment, and is used for synchronously controlling a software and hardware interface driving program and an operation clock of the measuring equipment;
the data recording module is connected with the clue reaction evaluation analysis module and is used for recording the outputted scene animation file, the roaming path recording file and the action interaction file of the tested and specific objects in the tested VR roaming process.
8. The system for inducing craving for addictive drugs in a virtual reality environment according to claim 7, wherein the scene presenting means is a multimedia device through which the addicted common memory data extracted from the addictive database module is presented as a medication scene and a scene clue for the addict.
9. The system for inducing craving for addictive drugs in a virtual reality environment of any one of claims 6-7, wherein the physiological, psychological and behavioral measuring device comprises one or a combination of more of a picoelectrical data acquisition sensor, a heart rate variability data acquisition sensor, an electroencephalogram data acquisition sensor, an electrooculogram data acquisition sensor, and an interview questionnaire module.
10. The system for inducing craving for addictive drugs in a virtual reality environment of claim 8,
and the system is also provided with a verification module which is connected with the VR clue reaction test platform and is used for verifying whether the tested craving reaction data is consistent with the extracted characteristics of the target sample sucking experience.
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Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108109673A (en) * | 2018-01-22 | 2018-06-01 | 阿呆科技（北京）有限公司 | A kind of human body data measurin system and method |
| CN108735291A (en) * | 2018-05-21 | 2018-11-02 | 上海青研科技有限公司 | Drug addiction personnel's drugs craving degree assessment method based on interior hidden test and device |
| CN109300529B (en) * | 2018-09-12 | 2021-09-21 | 阿呆科技（北京）有限公司 | Drug addiction craving targeted intervention correction system based on artificial intelligence and virtual reality/augmented reality |
| CN109316196B (en) * | 2018-12-12 | 2022-07-19 | 上海市精神卫生中心（上海市心理咨询培训中心） | Amphetamine stimulant craving assessment method based on virtual reality and electroencephalogram monitoring |
| CN109727659B (en) * | 2018-12-28 | 2020-11-06 | 中国科学院心理研究所 | Addiction auxiliary treatment technology platform based on virtual reality and using method |
| CN110111873B (en) * | 2019-03-20 | 2023-10-20 | 中国科学院心理研究所 | VR clue craving response measurement system for inducing addiction based on addiction memory-motivation incentive model |
| CN110123342B (en) * | 2019-04-17 | 2021-06-08 | 西北大学 | Internet addiction detection method and system based on brain waves |
| CN110192873A (en) * | 2019-04-21 | 2019-09-03 | 浙江省十里坪强制隔离戒毒所 | Method and device for testing psychological craving degree of drugs of drug addicts |
| CN110496291B (en) * | 2019-07-10 | 2023-11-21 | 广州韬锐科技有限公司 | Drug rehabilitation system combining virtual reality technology and psychological coaching |
| CN111035840B (en) * | 2019-12-20 | 2022-10-21 | 上海大学 | VR closed-loop drug addiction self-control force training system |
| CN111012360B (en) * | 2019-12-30 | 2023-06-09 | 中国科学院合肥物质科学研究院 | Device and method for collecting nervous system data of drug addiction stopping personnel |
| CN114903006A (en) * | 2021-02-09 | 2022-08-16 | 中国科学院脑科学与智能技术卓越创新中心 | Construction method and application of non-human primate substance addiction model |
| CN113116350A (en) * | 2021-04-19 | 2021-07-16 | 上海市精神卫生中心（上海市心理咨询培训中心） | Depression disorder cognitive reconstruction training method, system, equipment and storage medium |
| CN113413155A (en) * | 2021-05-20 | 2021-09-21 | 浙江警察学院 | Psychophysical testing method, equipment and medium for negative emotion of drug addict |
| CN113693596A (en) * | 2021-07-30 | 2021-11-26 | 阿呆科技（北京）有限公司 | Game addiction degree and addiction risk assessment method and system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101169850A (en) * | 2006-10-25 | 2008-04-30 | 姜伟 | OTC detoxification drug vending system and its usage method |
| US9302179B1 (en) * | 2013-03-07 | 2016-04-05 | Posit Science Corporation | Neuroplasticity games for addiction |
| CN106803017A (en) * | 2017-01-13 | 2017-06-06 | 杭州赛翁思科技有限公司 | A kind of craving degree appraisal procedure of amphetamines habituation personnel |
| CN106938118A (en) * | 2017-04-28 | 2017-07-11 | 中国科学院心理研究所 | A kind of aggressive interference method of indignation based on crystal methamphetamine addict |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040087576A1 (en) * | 2002-11-05 | 2004-05-06 | Haracz John L. | Antimnemonic therapy for hypermemory syndromes |
-
2017
- 2017-07-24 CN CN201710607815.XA patent/CN107260187B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101169850A (en) * | 2006-10-25 | 2008-04-30 | 姜伟 | OTC detoxification drug vending system and its usage method |
| US9302179B1 (en) * | 2013-03-07 | 2016-04-05 | Posit Science Corporation | Neuroplasticity games for addiction |
| CN106803017A (en) * | 2017-01-13 | 2017-06-06 | 杭州赛翁思科技有限公司 | A kind of craving degree appraisal procedure of amphetamines habituation personnel |
| CN106938118A (en) * | 2017-04-28 | 2017-07-11 | 中国科学院心理研究所 | A kind of aggressive interference method of indignation based on crystal methamphetamine addict |
Non-Patent Citations (1)
| Title |
|---|
| 虚拟现实技术在物质滥用治疗中的研究进展;周力丹等;《科学通报》;第第62卷卷(第第9期期);第888-896页 * |
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