CN107257627A - Antimicrobial copper composition and its purposes in the processing on food and surface - Google Patents

Antimicrobial copper composition and its purposes in the processing on food and surface Download PDF

Info

Publication number
CN107257627A
CN107257627A CN201580064154.XA CN201580064154A CN107257627A CN 107257627 A CN107257627 A CN 107257627A CN 201580064154 A CN201580064154 A CN 201580064154A CN 107257627 A CN107257627 A CN 107257627A
Authority
CN
China
Prior art keywords
composition
acid
salt
seconds
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201580064154.XA
Other languages
Chinese (zh)
Other versions
CN107257627B (en
Inventor
约翰·梅恰
罗恩·沙皮拉
弗朗西斯·多特尤尔
詹姆斯·迪特里希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cms Technology Co ltd
Original Assignee
Cms Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cms Technologies filed Critical Cms Technologies
Publication of CN107257627A publication Critical patent/CN107257627A/en
Application granted granted Critical
Publication of CN107257627B publication Critical patent/CN107257627B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B4/00—General methods for preserving meat, sausages, fish or fish products
    • A23B4/14—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12
    • A23B4/18—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12 in the form of liquids or solids
    • A23B4/20—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B5/00—Preservation of eggs or egg products
    • A23B5/08—Preserving with chemicals
    • A23B5/12—Preserving with chemicals in the form of liquids or solids
    • A23B5/14—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
    • A23B7/153—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
    • A23B7/154—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B9/00—Preservation of edible seeds, e.g. cereals
    • A23B9/16—Preserving with chemicals
    • A23B9/24—Preserving with chemicals in the form of liquids or solids
    • A23B9/26—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/358—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Detergent Compositions (AREA)
  • Toxicology (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Present disclose provides the composition of antimicrobial purposes, it includes inorganic acid, organic acid or its combination；Copper (II) salt；With buffer salt, detergent or its combination.The method that the disclosure additionally provides by the way that the composition of the disclosure is put on into surface to reduce pathogen quantity on the surface.

Description

Antimicrobial copper composition and its purposes in the processing on food and surface
The cross reference of related application
The U.S. Provisional Application No.62/084 submitted this application claims on November 25th, 2014,278 rights and interests, the Shen Please overall herein by being incorporated by.
Technical field
The disclosure belongs to the field for carrying out antimicrobial treatment to food and crust using composition, the composition bag Containing inorganic acid, organic acid or its combination；Copper (II) salt；With buffer salt, detergent or its combination.
Background technology
Bacterium, virus and pollution of the parasite (" pathogen ") to surface of toxic level are a great misgivings.Food The antimicrobial compositions used in product industry must can not only reduce the quantity of surface pathogens, and they must also be to the mankind It is safe for consumption.In addition, antimicrobial compositions should not deleteriously influence the quality on processed food or surface.With Antimicrobial compositions on food and surface should also easily apply and relatively cheap, to ensure them for expected production It is economical for going out.
Therefore, for safely, effectively, be easier to apply and in economic/viable commercial antimicrobial compositions, deposit In demand.This disclosure relates to these and other important demands.
The content of the invention
Present disclose provides composition, it includes inorganic acid, organic acid or its combination；Copper (II) salt；With buffer salt, washing Agent or its combination.Also describe the method that pathogen quantity on surface is reduced using these compositions.
Generality explanation and exemplary and explanatory rather than restricted, this hair simply of the invention described further below It is bright as defined in the claims.In view of detailed description of the invention provided herein, other aspects of the present invention are to this It will be apparent for art personnel.
Brief description of the drawings
Fig. 1 depicts each result tested of the washing water sample prepared with the composition of the disclosure under pH 2.2 (214 data points).
Fig. 2 depicts the result in 45 °F of lower accelerating storage phase tests.It is antimicrobial with the composition containing the disclosure Solution processing, compared with the processing of standard hypochlorous acid, realizes (active decay) reduction about 30% of actively rotting.
Fig. 3 depicts organic negative on the actual lettuce leaf surface for 250 chance samples taken come six time-of-weeks of hanging oneself The measurement result of lotus (in terms of APC CFU).Leaf lettuce sample is carried out with the composition of the disclosure or with the processing of standard hypochlorous acid Processing, standard hypochlorous acid processing is generally used in agribusiness, and the combination comprising citric acid and chlorine.
Embodiment
Drawings and examples by combining to form a part of this disclosure can be easier to manage with reference to described further below The solution present invention.It is appreciated that the invention is not restricted to the specific device for being described herein and/or showing, method, using, condition Or parameter, and terminology used in this article is simply for the purpose for describing particular implementation by way of example, and It is not intended to limit claimed invention.Further, in use, the finger of incalculability limitation in specification (including claims) Claim thing to include plural form, and the particular value is at least included to the denotion of special value, unless the context clearly determines otherwise. When the scope of statement value, another embodiment is included from a particular value and/or to another particular value.Similarly, when When value being expressed as into approximation by using antecedent " about ", it should be appreciated that the particular value formation another embodiment.It is all Scope is all inclusive and can be combined.
Understand, what is for the sake of clarity described herein under the background of separated embodiment is of the invention some Feature, can also combine offer in single embodiment.On the contrary, being retouched for simplicity under the background of single embodiment The various features of the invention stated, can also separate or be provided with any sub-portfolio.In addition, to the denotion for the value stated with scope Including each and each value within the range.
When used herein, " food " refers to the mankind or the edible solid of domestic animal and liquid food.Solid food Including but not limited to meat products such as poultry products (such as chicken, duck and turkey product), egg, beef product, pork product and sea Product (such as fish, shellfish, crustacean, mollusk, echinoderm, marine alga).Solid food also includes agricultural product, such as water Fruits and vegetables, algae, seed, cereal, young shoot, beanpod, soybean and nut.Solid food also include dairy products it is for example hard, soft half Soft cheese.Liquid food may include beverage (such as fruit juice, soda water), liquid dairy products (such as milk and cream), fermentation drink Expect that (such as beer and grape wine) and liquid feed composition and liquid feed as animal feed (for example raise farm man Poultry and the fermented liquid feed of poultry).
When used herein, " crust " refers to including but not limited to following surface：Wooden (hardwood and engineered wood), lime China, MDF (medium density fibre board (MDF)), glued board, pottery, concrete, porcelain, malthoid, laminated material, granite, marble, quartz, soap Stone, stainless steel, copper, metal alloy, iron, plastics, brick, other stone materials, sheetrock, plaster, glass, card stock, watt Stupefied fiberboard, cardboard, rubber, latex, plastics, the composite, etc. that may include two or more above-mentioned materials.
When used herein, " pathogen " includes bacterium, virus and parasite.It is thin that the composition of the energy disclosure is reduced The example of bacterium includes gram-positive bacterium and gramnegative bacterium, for example, Salmonella enteritidis (Salmonella Enterica), listeria monocytogenes (Listeria monocytogenes), Escherichia coli (Escherichia Coli), clostridium botulinum (Clostridium botulinum), Clestridium difficile (Clostridium Difficile), campylobacter (Campylobacter), Bacillus cereus (Bacillus cereus), vibrio parahaemolytious (Vibrio parahaemolyticus), comma bacillus (Vibrio cholerae), Vibrio vulnificus (Vibrio Vulnificus), staphylococcus aureus (Staphylococcus aureus), YE (Yersinia Enterocolitica), Shigella (shigella), and combinations thereof.The enteron aisle of the composition reduction of the energy disclosure is husky Door Salmonella serotype mutation (Salmonella enterica serovars) includes, for example, Bacterium enteritidis (Salmonella Enteriditis), salmonella typhimurium (Salmonella Typhimurium), moscow' poona (Salmonella Poona), Heidelberg salmonella (Salmonella Heidelberg) and Salmonella anatis (Salmonella Anatum).The viral example of the composition reduction of the energy disclosure include enterovirus, norovirus, Influenza virus, rotavirus or its combination.The example of parasite includes Cryptosporidium (Cryptosporidium), just bent Shape worm (Toxoplasma gondii), giardia duodenalis (Giardia duodenalis), circle sporozoite (Cyclospora cayetanensis), trichina(Trichinella spiralis) (Trichinella spiralis), taeniarhynchus saginatus (Taenia Saginata), taeniasis suis (Taenia solium) or its combination.
In one aspect, present disclose provides composition, it includes inorganic acid, organic acid or its combination；Copper (II) salt；With Buffer salt, detergent or its combination.In a preferred embodiment, these compositions do not include chlorine and chlorine source.For example, the present invention Preferred composition does not include hypochlorite such as sodium hypochlorite and calcium hypochlorite.
It is preferred that inorganic acid be known in the art.To have available for the inorganic acid in the composition and method of the disclosure PKa less than or equal to 1.It is preferred that inorganic acid include, for example, sulfuric acid, phosphoric acid, hydrochloric acid, nitric acid, boric acid, hydrobromic acid, high chlorine Acid, hydroiodic acid, and combinations thereof.In some respects, the inorganic acid is sulfuric acid.In other respects, the inorganic acid is phosphoric acid. Further aspect, the inorganic acid is hydrochloric acid.The inorganic acid can be to reach any of predetermined pH as described herein Amount is present.In some embodiments, the weight based on the composition, the inorganic acid between about 0.1 and about 3wt%, Concentration between preferably from about 0.1 and about 1wt% is present.
It is preferred that organic acid be known in the art.To have available for the organic acid in the composition and method of the disclosure PKa between 1 and 7.Organic acid include citric acid, ascorbic acid, lactic acid, acetic acid, peracetic acid, formic acid, propionic acid, butyric acid, valeric acid, Caproic acid, oxalic acid, malic acid, benzoic acid, carbonic acid, phenol, uric acid, taurine, p-methyl benzenesulfonic acid, trifluoromethanesulfonic acid, aminomethyl phosphine Acid, and combinations thereof.In some respects, the organic acid is citric acid.In other respects, the organic acid is ascorbic acid. Further aspect, the organic acid is lactic acid.In some respects, the organic acid is acetic acid.In some respects, the organic acid is Peracetic acid.The organic acid can exist with any amount for reach predetermined pH as described herein.In some embodiment party In formula, based on the weight of the composition, the organic acid between about 0.1 and about 3wt% or between about 0.1 and about 2wt%, Concentration between preferably from about 0.1 and about 1wt% is present.
The composition of the disclosure may include the combination of inorganic acid or inorganic acid.The composition of the disclosure may include organic acid or The combination of organic acid.The composition of the disclosure may include the mixture of inorganic acid and organic acid.The mixture comprising inorganic acid, In those embodiments of the mixture or inorganic acid of organic acid and the mixture of organic acid, sour total amount is sufficiently achieved such as this Predetermined pH described in text.In some embodiments, the weight based on the composition, the sour combination is in about 0.1 He Between about 3wt%, about 0.1 and about 2wt% between, preferably from about 0.1 and about 1wt% between concentration under.
It is preferred that copper (II) salt include copper sulphate (II), copper chloride (II), copper bromide (II) etc..It is preferred that copper (II) salt be Copper sulphate (II), particularly preferably Salzburg vitriol (II).In some respects, copper (II) salt is copper chloride (II). In other respects, copper (II) salt is copper bromide (II).The combination of copper (II) salt is also in the scope of the present disclosure.
Concentration for the mantoquita in the composition of the disclosure can be determined by those skilled in the art and be can The effective dose of pathogen reduction is reached in processed particular surface.For example, the concentration of the mantoquita can be highest 1000ppm, between 500 and 1000ppm, 100 and 500ppm between or 1 and 100ppm between.According to the disclosure, for this The concentration of the mantoquita in disclosed composition is between about 1ppm and about 80ppm, between about 1ppm and about 70ppm, about Between 1ppm and about 60ppm, between about 1ppm and about 50ppm, between about 1ppm and about 40ppm, about 1ppm and about 30ppm it Between, between about 1ppm and about 20ppm, between about 1ppm and about 15ppm, between about 1ppm and about 10ppm, about 3ppm peace treaties Between 10ppm or between about 35ppm and about 40ppm.Other preferred compositions of the disclosure are comprising about 0.1,0.2,0.3,0.4, 0.5、0.6、0.7、0.8、0.9、1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、 23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、 48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、 73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、96、97、 98th, 99, the or 100ppm copper (II) salt.In some embodiments, the concentration of copper (II) salt is to fruits and vegetables For between about 1 and 19ppm, or about 1 and less than between 60ppm for being applied to meat, seafood and/or poultry.
For the disclosure preferred buffer salt include ammonium sulfate, sodium sulphate, sodium chloride, calcium sulfate, and combinations thereof.Sulfuric acid Sodium, ammonium sulfate and calcium sulfate are particularly preferred buffer salts.In some respects, the buffer salt is ammonium sulfate.In other respects, The buffer salt is sodium sulphate.In some respects, the buffer salt is sodium chloride.In other respects, the buffer salt is sulfuric acid Calcium.
It is preferred that detergent be included in food and medicine Surveillance Authority of the U.S. (U.S.Food and Drug Administration) the composition preferably under generally recognized as safe concentration.In the scope of the present disclosure, " detergent " refers to The mixture of surfactant or surfactant.Particularly preferred detergent for the composition of the disclosure includes dodecane Base sulfate, alkyl benzene lauryl sulfate, alkyl poly glucoside, NaLS, polysorbate are (for example, poly- mountain Pears alcohol ester 20, polysorbate40, polysorbate60 and polysorbate80), and combinations thereof.Particularly preferred alkyl polysaccharide Glycosides include alkyl polyglucoside, decyl polyglucose, lauryl polydextrose, and combinations thereof.
The composition of the disclosure can be comprising inorganic acid, organic acid or its combination, copper (II) salt and buffer salt, while not Include detergent.Other compositions of the disclosure can include inorganic acid, organic acid or its combination；Copper (II) salt；And detergent, Simultaneously not comprising buffer salt.Other composition of the disclosure can include inorganic acid, organic acid or its combination；Copper (II) salt；It is slow Rush salt；And detergent.
According to the disclosure, based on the weight of the composition, the buffer salt and/or detergent are each in the composition From between 0.01wt% and 0.5wt%, between 0.01wt% and 0.4wt%, between 0.01wt% and 0.3wt%, Between 0.01wt% and 0.25wt%, between 0.01wt% and 0.20wt%, between 0.01wt% and 0.15wt% or Concentration between 0.01wt% and 0.10wt% is present.The preferred amounts of buffer salt and/or detergent are by the aqueous combination of the disclosure The pH of thing is maintained in the range of pre-selection.The preferred amounts of buffer salt and/or detergent can also control surface tension variation so that Allow the reduction for improving pathogen on surface.Other preferred compositions of the disclosure include the weight based on the composition, respectively Leisure about 0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.11,0.12,0.13,0.14, 0.15、0.16、0.17、0.18、0.19、0.20、0.21、0.22、0.23、0.24、0.25、0.26、0.27、0.28、0.29、 0.30th, 0.31,0.32,0.33,0.34,0.35,0.36,0.37,0.38,0.39,0.40,0.5,0.6,0.7,0.8,0.9 or Buffer salt and/or detergent under 1wt% concentration.The preferred amounts of buffer salt and/or detergent can be carried under low ph level Being damaged for the sense organ of reduction and can providing causticity reduction, toxicity reduces and the safer operation of human work person, and these are not yet Observed in the existing composition used in the art.
The some compositions of the disclosure substantially by inorganic acid as described herein, copper (II) salt and buffer salt and/ Or detergent composition.That is, the disclosure contemplates composition, its comprising inorganic acid as described herein, copper (II) salt, With buffer salt and/or detergent, and the only basic and novel feature of not significant impact invention disclosed herein that A little additional materials, such as water.Preferably, these compositions do not include chlorine and chlorine source such as hypochlorite.
The some compositions of the disclosure substantially by organic acid as described herein, copper (II) salt and buffer salt and/ Or detergent composition.That is, the disclosure contemplates composition, its comprising organic acid as described herein, copper (II) salt, With buffer salt and/or detergent, and the only basic and novel feature of not significant impact invention disclosed herein that A little additional materials, such as water.Preferably, these compositions do not include or containing micro chlorine and chlorine source such as hypochlorite.
In some embodiments, the disclosure composition comprising organic acid such as ascorbic acid will have inoxidizability Matter.In other embodiments, the composition can also include non-organic acid antioxidant.FDA is generally recognized as safe anti- Oxidant is as known in the art, and including such as plant extracts.Can with about 0.01wt% and about 1.0wt% it Between, between about 0.01wt% and about 0.2wt%, between about 0.01wt% and about 0.15wt%, about 0.01wt% peace treaties Concentration between 0.10wt% or between about 0.01wt% and about 0.05wt% includes the antioxidant.
In some embodiments, preferred composition of the invention is non-oxidizing, it is possible to do not included or containing micro- Ozone, peracetic acid, chlorine dioxide and the hypochlorite of amount.The non-oxidizable composition of the disclosure is for water recycle applications It is favourable, it is possible to produce significant water saving.
In particularly preferred embodiments, the composition of the disclosure is Aquo-composition.Based on the use aqueous solution Application-specific, the inorganic acid and/or organic acid, the mantoquita and the buffer salt and/or detergent are in the aqueous solution In concentration can change.In some embodiments, the ratio of water and other composition components is about 1:1.In other implementations In mode, the ratio of water and other composition components is 1:1 and 2:Between 1.In other embodiments, water and other compositions The ratio of component is about 1:1 and about 20:Between 1 or about 1:1 and about 500:Between 1.In some embodiments, water and other groups The ratio of polymer component is about 20:1 to about 500:1.The concentration available for final application can be less than original in aqueous Concentration in solid form, the latter can be diluted about 500 times, about 450 times, about 400 times, about 350 times, about 300 times, about 250 Times, about 200 times, about 150 times, about 100 times, about 90 times, about 80 times, about 70 times, about 60 times, about 50 times, about 40 times, about 30 times, About 20 times, about 10 times, about 5 times, about 4 times, about 3 times or even about 2 times.Appropriate amount of dilution can based on concentrate intensity and The expection pathogen load of the article that will be handled is selected.
The aqueous solution of the disclosure can be neutral pH (about pH 7) or acid pH (pH is less than 7) or alkalescent pH (pH highests About 9).In a preferred embodiment, pH is between about 1 and 7.In some embodiments, pH is between about 2 and 7.In other realities Apply in mode, pH is between about 3 and 7.In other embodiment, pH is between about 4 and 7.Preferably, the aqueous solution of the disclosure PH be about 1,1.1,1.2,1.3,1.4,1.5,1.6., 1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6, 2.7th, 2.8,2.9,3,3.1,3.2,3.3,3.4,3.5,4,4.5,5,5.5,6,6.5,7,7.5,8,8.5 or about 9.Other In embodiment, the pH of the aqueous solution of the disclosure is between 1.6 and 6.5, between 2.1 and 6.5, between 1.6 and 4.5,1.6 and Between 3.5 or between 2.0 and 3.0.According to the disclosure, depending on selected application, using methods known in the art, about 5 DEG C or about 22 DEG C at test the pH of the aqueous solution.Those skilled in the art are comprehensible, and the pH of the aqueous solution of the disclosure can be with Adjusted by adjusting the sour amount in the solution.
In some embodiments of the disclosure, the composition or can be solid form, and can be ball Grain, particle, powder, pod (pods), other dissolvable/water-solubility membranes or packaging or tablet.These compositions include 10 weight % Or less water/moisture.The composition can be wrapped in water-solubility membrane.Water-solubility membrane can be by such as polyvinyl alcohol Film, aliphatic polyether film or polyethylene glycol film are formed.Such film is known in the art.Suitable film will be completely solvable or can divide Dissipate in water of the temperature more than about 5 DEG C.The film is by the thickness with about 0.5 mil to about 5 mils, preferably from about 1 to 3 mil. The water-solubility membrane can be sealed using thermally or ultrasonically Sealing Method for example known in the art.
In other respects, present disclose provides the method for reducing pathogen quantity on surface, methods described is included this public affairs Any composition opened puts on surface.The surface can be foodstuff surface or crust.Preferably, for methods described In composition be the aqueous solution.The surface can be handled via any means known in the art.For example, being preferable to carry out In mode, any combinations thing of the disclosure can put on the food via sprinkling, spraying, rinsing, immersion, dipping, washing etc. The surface of thing.It can use and dip processing, and including being totally submerged, whether through mechanically or manually addition, in single groove still In multiple-grooved design.Spraying can be used to apply, and the spraying application can be spilt device and be constituted by single or multiple nozzle or drop.One In a little embodiments, spraying application can using ultrasonic spray nozzle or can with abrasion is combined is connect with improving surface area Touch.
Can be with commercially viable and do not injure the aqueous solution and will apply for the aqueous solution in methods described Surface any temperature under, for example, between about 32 °F (0 DEG C) and 212 °F (100 DEG C) or about 32 °F (0 DEG C) and 135 °F Between (57 DEG C).The solution can be cold, e.g., from about 32 °F or about 38 °F (about 3 DEG C), or warm, e.g., from about 135 °F. In other embodiments, these solution can be about 32,33,34,35,36,37,38,39,40,41,42,43,44,45, 46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、 71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、 96、97、98、99、100、101、102、103、104、105、106、107、108、109、110、111、112、113、114、115、 116、117、118、119、120、121、122、123、124、125、126、127、128、129、130、131、132、133、134、 135th, 136,137,138,139 or 140 °F., can be about for the aqueous solution in methods described in other embodiment At a temperature of between 140 and about 212 °F.For the use on crust, higher temperature is probably preferred.
In a preferred embodiment, applying includes submerging time enough to ensure the composition in institute by the surface State on surface and/or interior abundant covering and/or infiltration.Immersion time can be at most such as 5 minutes, most about 4 minutes, most It is many about 3 minutes, most about 2 minutes, or most about 1 minute.Immersion time is also contemplated less than 1 minute, and some relatively low Can be with short up to two seconds under pH levels.It is preferred that Immersion time between about 2 seconds and about 180 seconds, between about 2 seconds and about 120 seconds, about Between 2 seconds and about 90 seconds, between about 2 seconds and about 60 seconds, between about 2 seconds and about 45 seconds, or between about 2 seconds and about 30 seconds.
The composition of the disclosure effectively reduces the quantity of pathogen i.e. microorganism on surface, virus or parasite.Also To say, compared with the surface of the compositions-treated without the use disclosure, reduced with the compositions-treated surface of the disclosure bacterium, Virus and/or parasite growth on said surface and/or breeding (for example, by kill such bacterium, virus and/or Parasite or the growth for slowing down the bacterium, virus and/or parasite significantly).For example, with the composition without the use disclosure The surface of reason is compared, and pathogen quantity is effectively reduced about 10% by the composition of the disclosure.In other embodiments, when with When not compared with the surface of the compositions-treated of the disclosure, in terms of the pathogen of the composition of the disclosure on surface is reduced Validity is high by about 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%th, 150%, 160%, 170%, 180%, 190%, 200%, 300%, 400%, 500% or higher.Marked with using Accurate chlorine is compared with the surface that citric acid treatment is handled, and the composition of the disclosure is effectively reduced pathogen quantity about 10%th, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90%.
Muddy condition increase pathogen produces the risk of food origin disease.The composition of the disclosure effectively reduces pathogen number Amount, under the conditions of muddiness, such as at food processing facilities.
Following examples are provided to illustrate composition described herein, method and property.The embodiment is only Bright property, it is therefore intended that material, condition or the method parameter for being confined to wherein illustrate by the disclosure.
Embodiment
Embodiment 1：Universal bacterial determination method
Vivione is carried out using the specification (Vivione Biosciences, LLC, Pine Bluff, AR) of manufacturer RAPID-B instruments start.The problem of specification according to manufacturer carries out performance verification to verify performance and differentiate any potential. Then Rapid-B systems are ready for operation universal bacterial master plate and count determination method.It is then based on testing scheme preparation Processing solution.Solution is with 99:1 inoculation；Mean the bacterium fowl of 99mL processing solutions and 1mL drenching Xian's liquid (bacterial bird Rinse) combine, produce 10-2Dilution.Serial dilution is carried out (usually using 10 using sterile buffer peptone water-3Dilution) with Amplify extension rate.By by 570 μ l sterile buffer peptone water, 330 μ l TPC (master plate counting) reagents and coming from 100 μ l of dilution tube to be tested are combined in reaction tube, to prepare sample.This process is by sample additional dilution 10-1(therefore 10-4It is the total dilution factor tested).Example reaction pipe is placed 15 minutes, is periodically vortexed.Open in the Vivione machines On universal bacterial scheme, and according in Vivione Biosciences handbooks instruction confirm operation setting.After 15 minutes, The reaction tube is placed in sample arm and run location is moved to start analysis.Once after sample operation, the arm is returned Flush position is returned to allow to be rinsed in the completed.
Embodiment 2：The processing of green vegetable makes delay of rotting
Washings are prepared with the antimicrobial compositions of the disclosure, hereon referred to as composition A or composition PS+, and in leaching It is used to handle the green vegetable after harvest in groove.The washings that are handled with standard chlorine and citric acid treatment are also tested for enter Row compares.The washing water sample is each used in immersion trough at a temperature of about 38 °F, and is used in turbulent water to greenery Vegetables handled for 30 (30) seconds, directly took more than 250 samples to obtain result from the surface of the green vegetable.
Composition A includes the inorganic acid (sulfuric acid) of low pka values, Salzburg vitriol (the copper ion 9- with 35-40ppm 10ppm), buffer salt (0.5% ammonium sulfate) is combined under 38 °F in water.The pH of the wash water solution is 2.2.
Composition PS+ includes the inorganic acid (sulfuric acid) of low pka values, Salzburg vitriol (the copper ion 9- with 35-40ppm 10ppm), buffer salt (0.05% ammonium sulfate) and surfactant (alkyl poly glucoside) are combined under 38 °F in water.It is described to wash The pH for washing the aqueous solution is 2.2.
Green vegetable is handled with composition A or with standard chlorine and citric acid treatment.After processing, check described green The organoleptic feature of leaf vegetables and it is visible rot and via master plate count (TPC) measurement microbial load.As a result it is summarised in In table 1.
Table 1
For the product handled with composition A, the TPC levels at the 0th day substantially reduce (7,268 contrast 208, 217).At the 7th day, the TPC is still significantly less than standard processing, while providing improved relative texture, color and smell.The At 15 days, TPC keep be substantially less than standard processing, and quality, color, smell, rot and business application acceptability Aspect has the difference substantially improved.After 14 to 16 days, it is seen that rotten increase, mainly in the uneven and extruded leaf of otch Cut end, but level is still relatively low, and with excellent quality, color, smell and rot.In the leaf being without damage Oxidation stain significantly reduce.The leaf of standard chlorine processing started to show overall decay and accompanied by tissue damage at 10 to 14 days Wound.The secondary rotten nest rapid progression in the product of standard chlorine processing, and rotting in the product handled with composition A (when the 20th day) is still only related to indivedual leaves.
Handled with the composition PS+ washing water samples prepared under pH 2.2.Follow-up experiment shows master plate meter Number (TPC) is substantially reduced.The result (214 data points) in 2.2 times each experiments of pH is shown in Fig. 1.As a result prove, phase Than the optimization chlorination processing in 20ppm chlorine under pH 6.0, the TPC reductions by 92% in all experiments.The reduction is generally in food It is highest during the most muddy condition of source property disease risks highest.
Fig. 2 shows the result for accelerating storage life test under 45 °F.At the antimicrobial solutions containing composition PS+ Reason, compared with the processing of standard hypochlorous acid, realizes reduction about 30% of actively rotting.While not wishing to by any particular theory about Beam, but it is assumed that this reduction can give the credit to the pathogen load being greatly decreased in start to process.
Embodiment 3：There is no organism in the washings prepared with the antimicrobial compositions of the disclosure
After green vegetable after processing harvest, ferment is carried out to the washings containing composition PS+ used in embodiment 2 The test of female and mould and master plate count (TPC) test.For yeast and mould, measurement colony forming unit (CFU)/mL. The detection used is limited to 1CFU/mL.With in the individual washing water sample in 30 (30) of composition PS+ processing, 29 produce<1CFU/ ML detection, 1 produces the report result for being equal to test limit 1CFU/mL.Standard chlorine processing washings show, yeast< 10CFU/mL, mould is average 55CFU/mL, and TPC is average 3,172.
Embodiment 4：By the antimicrobial compositions exposed to the disclosure, pathogenic organism is substantially reduced
Culture will be attacked the composition A and composition that are used in embodiment 2 are exposed to predetermined concentration and open-assembly time PS+, is then counted.The colony of the challenge organism before exposure is compared with the colony that exists after exposure, with true The sterilizing ability of fixed each composition.
Evaluate following attack micro organisms：
Staphylococcus aureus (ATCC#6538)
Listeria monocytogenes (ATCC#7646)
Escherichia coli O 157：H7(ATCC#35150)
The mutation of Salmonella enteritidis duck serotype (Salmonella enterica serovar Anatum) (ATCC# 9270)
Methicillin-resistant staphylococcus aureus (" MRSA ") (ATCC#33592)
From specification (American type culture collection (American Type of the freeze-dried products according to manufacturer Culture Collection) (" ATCC "), Manassas, VA) or from the flat board of storage prepare the culture.By the training Foster thing is transferred in trypticase soya broth (Tryptic Soy Broth) (TSB, Neogen, Lansing, MI) and 35 ± 2 DEG C incubate 24 ± 2 hours.After incubation, by the culture centrifugation (Multifuge X1R, ThermoScientific, Waltham, MA), washing, which is laid equal stress on, in sterile peptone water is suspended into its initial volume.By the culture in trypsase With appropriate dilution factor bed board on soy agar (Tryptic Soy Agar) (TSA, Neogen), to determine that the end of reality is dense Degree.
The culture is exposed to each disinfectant, composition A and composition PS+, it is diluted to pH with sterile DI water 2.2 or 1.3.Prepare the single 250mL conical flasks containing each disinfectants of 99mL, and contain 99mL ButterfieldShi The identical flask of phosphate dilution (BPB) is used as control.Disinfectant flask is gently rotated to produce residual liquid Motion, the test cultures of 1mL equal portions are then added in the center of each flask, neck and the side of the flask are avoided during inoculation At face two.Each flask is rotated 1 minute to be thoroughly mixed content, 1mL parts of the mixture are then added to 9mL ovum In phosphatide and in solution conduit, with solution according to international (Rockville, the MD) official methods of AOAC in the lecithinSM 960.09 Prepared by (sterilization of Disinfectant and purifying sterilizing effect), methods described is for all purposes herein by being incorporated by.It is right In BPB controls, the program is repeated using identical attack inoculum.
After processing and neutralization, with tryptone grape sugar extract agar (Tryptone Glucose Extract Agar) (TGEA, Neogen), by sample with until 10-6Serial dilution degree topple over bed board (neutralize pipe as 10-1Processing).Will TGEA plates are incubated 27 ± 3 hours at 36 ± 1 DEG C.After incubation, Quebec colonometers (#3325 types, Reichert are utilized Technologies, Depew, NY) flat board is counted.Record the colony counts observed to processing and untreated samples.
By each sample observation to original count be converted into log10CFU/mL.It will be attacked present in the processing sample Hit the amount of organism with amount present in control sample to be compared, reduced with the logarithm for determining each challenge organism.
Test result is shown in table 2.
Table 2
Test confirms significant antimicrobial reduction, wherein when copper ion and detergent addition are combined, seeing Cooperative effect is observed.When being combined with copper and detergent, inorganic acid or organic acid are generated significantly with when combining salt buffer Anti-microbe ability without sense organ damage.
Embodiment 5-and compared to traditional composition method, swashed by using composition disclosed by the invention control organic loading Increase
Compared to traditional processing, the composition of the disclosure shows significant organic loading surge and suppressed.Fig. 3 is shown The measurement result of organic loading on the actual lettuce leaf surface for 250 chance samples taken come six time-of-weeks of hanging oneself is (with APC CFU is counted).Leaf lettuce sample is handled with the composition PS+ of embodiment 2 or with the processing of standard hypochlorous acid.This is for reduction It is especially important that can cause for the unexpected possibility increased sharply of high-level pathogen, and the high-level pathogen may be led Cause food origin disease.
When using scope to physical property such as molecular weight or chemical property such as chemical formula herein, it is intended that including All combinations and sub-portfolio for the scope of embodiment therein.
Each patent for quoting or describing in this document, the disclosure of patent application and publication herein with its entirely through In being incorporated herein by reference.
Skilled artisans will appreciate that, many can be made to the preferred embodiment of the present invention and changed and modifications, and Such change and modifications can be made under the spirit without departing substantially from the present invention.Therefore, claims are intended to covering and fallen in this hair All this equivalent modifications in bright true spirit and scope.

Claims (54)

1. a kind of composition, it is included：
Inorganic acid, organic acid or its combination；
Copper (II) salt；With
Buffer salt, detergent or its combination.
2. the composition of claim 1, wherein the copper (II) salt is copper sulphate (II).
3. the composition of any one of preceding claims, wherein the concentration of the copper (II) salt about 1ppm and about 100ppm it Between, between about 1ppm and about 80ppm, or between about 1ppm and about 60ppm.
4. the composition of any one of preceding claims, wherein the concentration of the copper (II) salt about 10ppm and about 50ppm it Between.
5. the composition of any one of preceding claims, wherein the concentration of the copper (II) salt about 20ppm and about 45ppm it Between.
6. the composition of any one of preceding claims, it includes inorganic acid, wherein the inorganic acid is sulfuric acid, phosphoric acid, hydrochloric acid Or its combination.
7. the composition of any one of preceding claims, it includes organic acid, wherein the organic acid is citric acid, Vitamin C Acid, lactic acid, acetic acid, peracetic acid or its combination.
8. the composition of any one of preceding claims, it includes buffer salt, wherein the buffer salt be ammonium sulfate, sodium sulphate, Sodium chloride, calcium sulfate or its combination.
9. the composition of any one of preceding claims, wherein the concentration of the buffer salt is between 0.01% and 0.5%.
10. the composition of any one of preceding claims, wherein the concentration of the buffer salt is between 0.01% and 0.4%.
11. the composition of any one of preceding claims, wherein the concentration of the buffer salt is between 0.01% and 0.3%.
12. the composition of any one of preceding claims, wherein the concentration of the buffer salt is between 0.01% and 0.25%.
13. the composition of any one of preceding claims, it includes detergent, wherein the detergent includes dodecyl sulphate Salt, alkyl benzene lauryl sulfate, NaLS, polysorbate or its combination.
14. the composition of any one of preceding claims, it includes detergent, wherein the detergent includes alkyl poly glucoside.
15. the composition of any one of preceding claims, it also includes antioxidant.
16. the composition of claim 15, wherein the concentration of the antioxidant is between 0.01% and 1% or 0.01% He Between 0.05%.
17. the composition of any one of preceding claims, wherein the composition is the aqueous solution.
18. the ratio of the composition of claim 17, its reclaimed water and remaining composition component is about 1:1 and about 500:Between 1 or About 50:1 and about 500:Between 1.
19. the composition of claim 17 or 18, wherein the pH of the aqueous solution is between about 1 and about 7.
20. the composition of any one of claim 17 to 19, wherein the pH of the aqueous solution is between 1.6 and 6.5.
21. the composition of any one of claim 18 to 20, wherein the pH of the aqueous solution is between 2.1 and 6.5.
22. the composition of any one of claim 18 to 21, wherein the pH of the aqueous solution is between 1.6 and 3.5.
23. the composition of any one of claim 1 to 16, wherein the composition be the pill of solid form, particle, powder, Pod or tablet.
24. the composition of claim 23, wherein the solid is wrapped in water-solubility membrane or packaging.
25. the composition of claim 24, wherein the solid is wrapped in polyvinyl alcohol film, aliphatic polyether film or poly- second two In alcohol film.
26. a kind of method of the pathogen quantity on reduction surface, methods described include to the surface apply claim 1 to Any one of 25 composition.
27. the method for claim 26, wherein the surface is foodstuff surface.
28. the method for claim 27, wherein the food is meat products.
29. the method for claim 28, wherein the meat products is poultry products, egg, beef product, pork product or marine products Product.
30. the method for claim 27, wherein the food is agricultural product.
31. the method for claim 30, wherein the agricultural product be water fruits and vegetables, it is algae, seed, cereal, young shoot, beanpod, big Beans or nut.
32. the method for claim 27, wherein the food is dairy products.
33. the method for claim 26, wherein the surface is crust.
34. the method for any one of claim 26 to 33, wherein the pathogen is bacterium.
35. the method for claim 34, wherein the bacterium is Salmonella enteritidis (Salmonella enterica), monokaryon Cell proliferative Listeria (Listeria monocytogenes), Escherichia coli (Escherichia coli), meat poisoning shuttle It is shape bacillus (Clostridium botulinum), Clestridium difficile (Clostridium difficile), curved Curved bar Pseudomonas (Campylobacter), Bacillus cereus (Bacillus cereus), vibrio parahaemolytious (Vibrio Parahaemolyticus), comma bacillus (Vibrio cholerae), Vibrio vulnificus (Vibrio vulnificus), golden yellow Color staphylococcus (Staphylococcus aureus), YE (Yersinia Enterocolitica), Shigella (shigella) or its combination.
36. the method for any one of claim 26 to 33, wherein the pathogen is virus.
37. the method for claim 36, wherein the virus be enterovirus, norovirus, influenza virus, rotavirus or It is combined.
38. the method for any one of claim 26 to 33, wherein the pathogen is parasite.
39. the method for claim 38, wherein the parasite is Cryptosporidium (Cryptosporidium), firm ground arch Worm (Toxoplasma gondii), giardia duodenalis (Giardia duodenalis), circle sporozoite (Cyclospora cayetanensis), trichina(Trichinella spiralis) (Trichinella spiralis), taeniarhynchus saginatus (Taenia Saginata), taeniasis suis (Taenia solium) or its combination.
40. the method for any one of claim 26 to 39, wherein the composition is between about 32 °F and about 212 °F or about The aqueous solution at a temperature of between 32 °F and about 135 °F.
41. the method for claim 40, wherein described apply comprising the Immersion time between about 2 seconds and about 180 seconds.
42. the method for claim 39 or 41, wherein described apply comprising the Immersion time between about 2 seconds and about 120 seconds.
43. the method for any one of claim 39 to 42, wherein described apply comprising the Immersion time between 2 seconds and about 90 seconds.
44. the method for claim 43, wherein described apply comprising the Immersion time between about 2 seconds and about 60 seconds.
45. the method for claim 43 or 44, wherein described apply comprising the Immersion time between about 2 seconds and about 30 seconds.
46. the method for any one of claim 26 to 45, wherein it is described apply comprising sprinkling, spraying, rinsing, immersion, dipping or Washing.
47. the method for any one of claim 26 to 46, wherein the application includes the surface impregnation including described group In the immersion trough of compound.
48. a kind of method of the pathogen quantity in liquid food for reducing certain volume, methods described is included to described certain The composition of any one of the liquid food addition claim 1 to 25 of volume.
49. the method for claim 48, wherein the pathogen is bacterium.
50. the method for claim 49, wherein the bacterium be Salmonella enteritidis, it is listeria monocytogenes, big Enterobacteria, clostridium botulinum, Clestridium difficile, campylobacter, Bacillus cereus, vibrio parahaemolytious, Comma bacillus, Vibrio vulnificus, staphylococcus aureus, YE, Shigella or its combination.
51. the method for claim 48, wherein the pathogen is virus.
52. the method for claim 51, wherein the virus be enterovirus, norovirus, influenza virus, rotavirus or It is combined.
53. the method for claim 48, wherein the pathogen is parasite.
54. the method for claim 53, wherein the parasite is Cryptosporidium, toxoplasma gondii, duodenum merchant's whip Caterpillar, circle sporozoite, trichina(Trichinella spiralis), taeniarhynchus saginatus, taeniasis suis or its combination.
CN201580064154.XA 2014-11-25 2015-11-25 Antimicrobial copper compositions and their use in the treatment of food and surfaces Active CN107257627B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084278P 2014-11-25 2014-11-25
US62/084,278 2014-11-25
PCT/US2015/062586 WO2016086087A1 (en) 2014-11-25 2015-11-25 Antimicrobial copper compositions and their use in treatment of foodstuffs and surfaces

Publications (2)

Publication Number Publication Date
CN107257627A true CN107257627A (en) 2017-10-17
CN107257627B CN107257627B (en) 2021-05-04

Family

ID=55024227

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580064154.XA Active CN107257627B (en) 2014-11-25 2015-11-25 Antimicrobial copper compositions and their use in the treatment of food and surfaces

Country Status (14)

Country Link
US (2) US10264793B2 (en)
EP (1) EP3223629B1 (en)
JP (1) JP6804444B2 (en)
KR (1) KR102298372B1 (en)
CN (1) CN107257627B (en)
AR (1) AR102790A1 (en)
AU (2) AU2015353556A1 (en)
BR (1) BR112017010669B1 (en)
CA (1) CA2968965C (en)
EA (1) EA201791140A1 (en)
MA (1) MA41021A (en)
MX (1) MX2017006674A (en)
NZ (1) NZ732089A (en)
WO (1) WO2016086087A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3684178A4 (en) * 2017-09-21 2021-07-07 Contact Organics Technologies Pty Ltd Acetic acid-based herbicide composition
WO2019140481A1 (en) * 2018-01-19 2019-07-25 Legioguard Pty Ltd Cleaning and/or disinfecting compositions
MX2018002983A (en) * 2018-03-09 2019-09-10 Inst Tecnologico Jose Mario Molina Pasquel Y Henriquez Enhancing antiviral suspension for treatment of fibres and preparation method thereof.
US10506811B1 (en) 2018-11-21 2019-12-17 Pur Products LLC Anti-microbial solution for seeds, crops, livestock and processed foods
US11441000B2 (en) 2019-04-11 2022-09-13 Iti Technologies, Inc. Plastic modifying compositions and enhanced carbonate compositions
US11432569B2 (en) 2019-10-31 2022-09-06 Iti Technologies, Inc. Domestic animal water and feed modifying compositions
US20210381169A1 (en) 2020-06-09 2021-12-09 Iti Technologies, Inc. Paper enhancing compositions, uses thereof and enhanced paper
KR102516405B1 (en) * 2021-01-27 2023-04-03 (주)피스코 Transparent antimicrobial composition having excellent formulation stability

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997911A (en) * 1996-08-27 1999-12-07 Brinton Veterinary Supply, Inc. Composition and method for reducing diarrhea in poultry and swine
CN1376036A (en) * 1999-08-31 2002-10-23 药物研究有限公司 Metal-containing compositions, preparations and uses
US20070269563A1 (en) * 2006-05-17 2007-11-22 Tasker Products, Inc. Compositions and methods for reducing microbial contamination in meat processing
US20080292673A1 (en) * 2007-05-18 2008-11-27 Crudden Joseph J Bioactive agrichemical compositions and use therreof
CN102065696A (en) * 2008-05-01 2011-05-18 万灵杀菌消毒剂股份有限公司 Versatile disinfectant
CN102317429A (en) * 2008-10-30 2012-01-11 欧赫索清洁股份有限公司 Antimicrobial foamable soaps
US20120060258A1 (en) * 2009-05-29 2012-03-15 Stewart Neal G Composition for use in decreasing the transmission of human pathogens
US20140322352A1 (en) * 2011-12-22 2014-10-30 Cms Innovative Technologies, Inc. Antimicrobial Composition for Animal Welfare

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06153744A (en) 1992-09-25 1994-06-03 Riyouyou Sangyo Kk Method for diminishing parasite of fishes and bacterium and removing living thing attached to crawl net
DE10015126B4 (en) * 2000-03-28 2006-04-27 Henkel Kgaa Cleaning fruits and vegetables
GB0112939D0 (en) 2001-05-29 2001-07-18 Mini Agriculture & Fisheries Anti-microbials
JP2012131836A (en) * 2010-12-17 2012-07-12 Lion Corp Granular detergent composition

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997911A (en) * 1996-08-27 1999-12-07 Brinton Veterinary Supply, Inc. Composition and method for reducing diarrhea in poultry and swine
CN1376036A (en) * 1999-08-31 2002-10-23 药物研究有限公司 Metal-containing compositions, preparations and uses
US20070269563A1 (en) * 2006-05-17 2007-11-22 Tasker Products, Inc. Compositions and methods for reducing microbial contamination in meat processing
US20080292673A1 (en) * 2007-05-18 2008-11-27 Crudden Joseph J Bioactive agrichemical compositions and use therreof
CN102065696A (en) * 2008-05-01 2011-05-18 万灵杀菌消毒剂股份有限公司 Versatile disinfectant
CN102317429A (en) * 2008-10-30 2012-01-11 欧赫索清洁股份有限公司 Antimicrobial foamable soaps
US20120060258A1 (en) * 2009-05-29 2012-03-15 Stewart Neal G Composition for use in decreasing the transmission of human pathogens
US20140322352A1 (en) * 2011-12-22 2014-10-30 Cms Innovative Technologies, Inc. Antimicrobial Composition for Animal Welfare

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KANSENSHOGAKU ZASSHI ET AL.: ""Inactivation of Cryptosporidium parvum Oocysts by Copper Ions"", 《JOURNAL OF THE JAPANESE ASSOCIATION OF INFECTIOUS DISEASES》 *
刘慧: ""壳聚糖及其表面活性剂复合物的抗菌性与抗菌机理的研究"", 《中国优秀博硕士学位论文全文数据库 (硕士) 工程科技 Ⅰ辑》 *
王青宁 等: ""淀粉基烷基多糖苷的抑菌研究"", 《环境与健康杂志》 *

Also Published As

Publication number Publication date
BR112017010669A2 (en) 2018-02-14
JP6804444B2 (en) 2020-12-23
MX2017006674A (en) 2018-01-11
NZ732089A (en) 2022-01-28
US20170258093A1 (en) 2017-09-14
EP3223629A1 (en) 2017-10-04
WO2016086087A1 (en) 2016-06-02
AU2015353556A1 (en) 2017-06-15
KR102298372B1 (en) 2021-09-07
EP3223629B1 (en) 2023-08-23
AU2020201702A1 (en) 2020-03-26
CN107257627B (en) 2021-05-04
EA201791140A1 (en) 2017-09-29
BR112017010669B1 (en) 2022-06-28
US20200000095A1 (en) 2020-01-02
AU2020201702B2 (en) 2020-05-28
AR102790A1 (en) 2017-03-22
CA2968965C (en) 2021-10-19
JP2017536376A (en) 2017-12-07
KR20170106956A (en) 2017-09-22
US10264793B2 (en) 2019-04-23
CA2968965A1 (en) 2016-06-02
MA41021A (en) 2017-10-03

Similar Documents

Publication Publication Date Title
Duan et al. Chitosan as a preservative for fruits and vegetables: a review on chemistry and antimicrobial properties
CN107257627A (en) Antimicrobial copper composition and its purposes in the processing on food and surface
Hafdani et al. A review on application of chitosan as a natural antimicrobial
EP1793692B1 (en) Antimicrobial composition
US20110054026A1 (en) Antimicrobial composition and use
AU2015314884C1 (en) Antimicrobial compositions and methods of their use
US20120148716A1 (en) Antimicrobial Composition and Use as Food Treatment
Duran et al. The use of chitosan as a coating material
Chen et al. Organic acids, detergents, and their combination for inactivation of foodborne pathogens and spoilage microorganisms
Pramono Application of Chitosan to Prolong the Shelf Life of Smoked Milk Fish (ChanosChanos) in Room Temperature Storage
US20120071553A1 (en) Chlorine-free water treatment
Omogbai et al. Survival of some food-borne pathogenic microorganisms in ozonated tropical fruits juices treated with chitosan
Edalatpanah et al. INVESTIGATING THE ANTIBACTERIAL ACTIVITY OF ZNO NANO-PARTICLES SUSPENSION CONTAINING ACETIC ACID AGAINST STAPHYLOCOCCUSAUREUS IN MANGO JUICE
AU2013268382B2 (en) Method for producing disinfected liver
CN117256665A (en) Natural preservative based on plant extracts and preparation method and application thereof
EA041635B1 (en) ANTIMICROBIAL COMPOSITION AND METHOD FOR TREATMENT OF FOOD PRODUCTS AND HARD SURFACES
US20120129928A1 (en) Chlorine-Free Liquid Microbicide Treatment
CN116439280A (en) Melon and fruit preservative and preparation method thereof
Dina et al. Alexandria Journal of Veterinary Sciences

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: New York, United States

Patentee after: CMS Technology Co.,Ltd.

Country or region after: U.S.A.

Address before: New York, United States

Patentee before: CMS TECHNOLOGY, Inc.

Country or region before: U.S.A.