CN107233509A - 一种治疗牙周炎的汤剂药物及其制备方法 - Google Patents
一种治疗牙周炎的汤剂药物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗牙周炎的认识机理而提供的一种治疗牙周炎的汤剂药物,所述药物的各个组分及其质量份比如下:知母6~15g、栀子10~26g、黄芩5~18g、谷精草5~12g、细辛5~16g、金银花15~28g、连翘15~28g、花椒3~8g、淡竹叶6~12g、玄参16~26g、川芎5~12g、猪苓6~15g、泽泻6~12g、荆芥8~16g、地榆6~15g、白扁豆9~18g、延胡索8~16g、甘草3~13g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗牙周炎的汤剂药物,特别是供牙周炎患者使用的汤剂药物及其制备方法的领域。
背景技术
牙周炎,牙周炎主要是由局部因素引起的牙周支持组织的慢性炎症。发病年龄以35岁以后较为多见。如龈炎未能及时治疗,炎症可由牙龈向深层扩散到牙周膜、牙槽骨和牙骨质而发展为牙周炎。由于早期多无明显自觉症状而易被忽视,待有症状时已较严重,甚至已不能保留牙齿。
临床表现:早期症状不太明显,患者常只有继发性牙龈出血或口臭的表现,与龈炎症状相似。检查时可见龈缘、龈***和附着龈的肿胀、质松软,呈深红色或暗红色,探诊易出血。随着炎症的进一步扩散,出现下列症状:
a.牙周袋形成
由于炎症的扩展,牙周膜被破坏,牙槽骨逐渐吸收,牙龈与牙根分离,使龈沟加深而形成牙周袋。可用探针测牙周袋深度。
b.牙周溢脓
牙周袋壁有溃疡及炎症性肉芽组织形成,袋内有脓性分泌物存留,故轻按牙龈,可见溢脓。并常有口臭。
c.牙齿松动
由于牙周组织被破坏,特别是牙槽骨吸收加重时,支持牙齿力量不足,出现牙齿松动、移位等现象。此时患者常感咬合无力、钝痛,牙龈出血和口臭加重。
当机体抵抗力降低、牙周袋渗液引流不畅时,可形成牙周脓肿,是牙周炎发展到晚期,出现深牙周袋的一个常见的伴发症状。此时牙龈呈卵圆形突起,发红肿胀,表面光亮;牙齿松动度增加,有叩痛;患者伴有局部剧烈跳痛。同时,患者可有体温升高、全身不适,颌下***肿大、压痛等症状。
那么,就如何找到一种可有效治疗牙周炎的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗牙周炎上,人们逐渐意识到了中医治疗牙周炎的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗牙周炎的现状,本发明的目的是在于提供一种治疗牙周炎的汤剂药物,以解决牙周炎患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述牙周炎。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗牙周炎的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母6~15g、栀子10~26g、黄芩5~18g、谷精草5~12g、细辛5~16g、金银花15~28g、连翘15~28g、花椒3~8g、淡竹叶6~12g、玄参16~26g、川芎5~12g、猪苓6~15g、泽泻6~12g、荆芥8~16g、地榆6~15g、白扁豆9~18g、延胡索8~16g、甘草3~13g。
一种治疗牙周炎的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母8~13g、栀子12~23g、黄芩6~16g、谷精草6~11g、细辛6~14g、金银花18~25g、连翘18~25g、花椒4~7g、淡竹叶7~11g、玄参18~23g、川芎6~11g、猪苓7~13g、泽泻7~11g、荆芥9~14g、地榆7~13g、白扁豆10~16g、延胡索10~14g、甘草5~12g。
一种治疗牙周炎的汤剂药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
知母12g、栀子20g、黄芩14g、谷精草10g、细辛12g、金银花22g、连翘22g、花椒6g、淡竹叶10g、玄参20g、川芎10g、猪苓12g、泽泻10g、荆芥12g、地榆12g、白扁豆14g、延胡索12g、甘草11g。
一种治疗牙周炎的汤剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡40min,然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内,注入过药62mm的冷开水进行第一次武火煎煮,待煎煮到15min时,转文火熬制38 min,滤取药液;②药渣中再次注入过药58mm的微温开水进行第二次武火煎煮,待煎煮到8min时,转文火熬制35 min,滤取药液;③将两次药液混合浓缩成50%的中药液320ml(毫升),密封备用。
一种治疗牙周炎的汤剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的中药液以一天服用,每日一剂,早晚分服,给药量160ml/次,趁温服,7天为1 个疗程。服药2~4个疗程,症状消失,病获痊愈。三月后随访,未见复发。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
知母,性味:苦、甘、寒,具有清热泻火,生津润燥之功效,用于治疗外感热病、高热烦渴、肺热燥咳、骨蒸潮热、内热消渴、肠燥便秘;
栀子,性味:苦、寒,具有泻火除烦、清热利湿、凉血解毒之功效,用于治疗热病心烦、肝火目赤、头痛、湿热黄疳、淋证、吐血衄血、血痢尿血、口舌生疮、疮疡肿毒、扭伤肿痛;
黄芩,性味:味苦、性寒,具有清热泻火、燥湿解毒、止血、安胎之功效,用于治疗肺热咳嗽、热病高热神昏、肝火头痛、目赤肿痛、湿热黄疸、泻痢、热淋、吐衄血、崩漏、胎热不安、痈肿疔疮;
谷精草,性味:辛、甘、平,具有疏散风热、明目、退翳之功效,用于治疗风热目赤、肿痛羞明、眼生翳膜、风热头痛;
细辛,性味:辛、温,具有祛风散寒、通窍止痛、温肺化饮之功效,用于治疗风寒感冒、头痛、牙痛、鼻塞鼻渊、风湿痹痛、痰饮喘咳;
金银花,性味:甘、寒,具有清热解毒之功效,用于治疗温病发热、热毒血痢、痈肿疔疮、喉痹及多种感染性疾病;
连翘,性味:苦、凉,具有清热、解毒、散结、消肿之功效,用于治疗温热、丹毒、斑疹、痈疡肿毒、瘰疬、小便淋闭等症;
花椒,性味:辛、温,具有温中止痛、杀虫止痒之功效,用于治疗脘腹冷痛、呕吐泄泻、虫积腹痛、蛔虫症,外治湿疹瘙痒;
淡竹叶,性味:甘、淡、寒,具有清热除烦、利尿之功效,用于治疗热病烦渴、小便赤涩淋痛、口舌生疮;
玄参,性味:味甘、苦、咸、性微寒,具有清热凉血、滋阴降火、解毒散结之功效,用于治疗温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、***、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛;
猪苓,性味:甘、淡、平,具有利水渗湿之功效,用于治疗小便不利、水肿、泄泻、淋浊、带下等症;
泽泻,性味:甘、寒,具有利小便、清湿热之功效,用于治疗小便不利、水肿胀满、泄泻尿少、痰饮眩晕、热淋涩痛、高血脂;
荆芥,性味:辛,温,具有发表、祛风、理血、炒炭止血之功效,用于治疗感冒发热、头痛、咽喉肿痛、中风口噤、吐血、衄血、便血、崩漏、产后血晕、痈肿、疮疥、瘰疬;
地榆,性味:苦酸、寒,无毒,具有凉血止血、清热解毒、消肿敛疮之功效,用于治疗吐血、咯血、衄血、尿血、便血、痔血、血痢、崩漏、赤白带下、疮痈肿痛、湿疹、阴痒、水火烫伤、蛇虫咬伤等病症;
白扁豆,性味:甘、微温,具有健脾化湿、和中消暑之功效,用于治疗脾胃虚弱、食欲不振、大便溏泻、白带过多、暑湿吐泻、胸闷腹胀;炒扁豆:健脾化湿,用于脾虚泄泻、白带过多;
延胡索,性味:辛、苦、温,无毒,具有活血、散瘀、理气、止痛之功效,用于治疗心腹腰膝诸痛、***、症瘕、崩中、产后血晕、恶露不尽、跌打损伤;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒。
本发明药物是基于中医治疗牙周炎的原则,从依据牙周炎的病理机制及药理作用认为:就牙周炎一证,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述牙周炎的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母12g、栀子20g、黄芩14g、谷精草10g、细辛12g、金银花22g、连翘22g、花椒6g、淡竹叶10g、玄参20g、川芎10g、猪苓12g、泽泻10g、荆芥12g、地榆12g、白扁豆14g、延胡索12g、甘草11g。
实施例2:
一种治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母13g、栀子23g、黄芩16g、谷精草11g、细辛14g、金银花25g、连翘25g、花椒7g、淡竹叶11g、玄参23g、川芎11g、猪苓13g、泽泻11g、荆芥14g、地榆13g、白扁豆16g、延胡索14g、甘草12g。
实施例3:
一种治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母15g、栀子26g、黄芩18g、谷精草12g、细辛16g、金银花28g、连翘28g、花椒8g、淡竹叶12g、玄参26g、川芎12g、猪苓15g、泽泻12g、荆芥16g、地榆15g、白扁豆18g、延胡索16g、甘草13g。
典型病例
经临床诊断治疗牙周炎患者共1180例,年龄为46岁以上的740例,只有440例为46岁以下。1180例患者中痊愈的1100例,有效的80例,总有效率达100%。
Claims (3)
1.一种治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母6~15g、栀子10~26g、黄芩5~18g、谷精草5~12g、细辛5~16g、金银花15~28g、连翘15~28g、花椒3~8g、淡竹叶6~12g、玄参16~26g、川芎5~12g、猪苓6~15g、泽泻6~12g、荆芥8~16g、地榆6~15g、白扁豆9~18g、延胡索8~16g、甘草3~13g。
2.根据权利要求1所述的治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母8~13g、栀子12~23g、黄芩6~16g、谷精草6~11g、细辛6~14g、金银花18~25g、连翘18~25g、花椒4~7g、淡竹叶7~11g、玄参18~23g、川芎6~11g、猪苓7~13g、泽泻7~11g、荆芥9~14g、地榆7~13g、白扁豆10~16g、延胡索10~14g、甘草5~12g。
3.根据权利要求1至2所述的治疗牙周炎的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母12g、栀子20g、黄芩14g、谷精草10g、细辛12g、金银花22g、连翘22g、花椒6g、淡竹叶10g、玄参20g、川芎10g、猪苓12g、泽泻10g、荆芥12g、地榆12g、白扁豆14g、延胡索12g、甘草11g。
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