CN107233504A - It is a kind of that there is pharmaceutical preparation of raising immunity antitumor efficacy and preparation method and application - Google Patents
It is a kind of that there is pharmaceutical preparation of raising immunity antitumor efficacy and preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical preparation for having and improving immunity antitumor efficacy, it is made up of the bulk drug of following parts by weight:The Radix Astragali 6, the stem of noble dendrobium, the bighead atractylodes rhizome, umbellate pore furgus, safflower, the red sage root, pseudo-ginseng, dandelion, Chinese fan palm, subprostrate sophora, kuh-seng, the root of fangji, camplotheca acuminata, Centipeda minima, Java brucea, short-tube lycoris, cow-bezoar, leech, stiff silkworm, ground bettle, centipede, cinnabar, Toad Skin are made.The present invention is according to traditional Chinese medical theory, theoretical using diagnosis and treatment carries out Chinese prescription screening, Chinese medicine composition proportioning is scientific and reasonable, test result indicates that, the Chinese medicine composition that the present invention is provided has to be suppressed growth of tumour cell and can promote the effect of apoptosis of tumor cells well, and strong killing action is respectively provided with to Several Kinds of Malignancy cell, have wide range of applications;Immunity can be substantially provided, built up health, and show that the Chinese medicine composition that the present invention is provided is safe, and toxic side effect is low, can be developed into as new antineoplastic through long-term experiment research.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, and in particular to a kind of to have the medicine system for improving immunity antitumor efficacy
Agent, belongs to medical pharmaceutical technology field.
Background technology
Tumour has turned into the number one killer for 21 century threatening human survival, and China is one of world's cancer country occurred frequently, and
And present a rapidly rising trend every year.Clinically the medicine for the treatment of tumour mainly has chemicals at present, but due to chemotherapeutics poison
Property big, also human autoimmune's cell such as kill leucocyte, lymphocyte of non-selectivity while tumour cell is killed, lead
Pathogenic people because of autoimmunity inferior capabilities accompanying infection, patient usually due to using erious adverse reaction, and survival rate is low, and expense
It is high.
Traditional Chinese medicine has unique advantage in terms of tumour is treated, and the natural class medicine by representative of Chinese medicine has poison is secondary to make
With small, action target spot is various, better tolerance the features such as, be more and more taken seriously in terms of tumour is treated.
Therefore, it is necessary on the basis of existing technology, it is good to research and develop a kind of antitumous effect, equal to kinds of tumors
With good therapeutic effect, and adverse reaction is low, can obviously improve the Traditional Chinese medicine compound composition of Quality of Life of Tumor Patients.
The content of the invention
Goal of the invention:Present invention aims to solve the deficiencies of the prior art, and provides a kind of one kind proportioning it is scientific and reasonable, curative effect is true
Cut, Clinical practice safety, the low pharmaceutical preparation with raising immunity antitumor efficacy of adverse reaction, another mesh of the invention
Be to provide this there is the preparation method of pharmaceutical preparation for improving immunity antitumor efficacy to be applied with it.
Technical scheme:In order to realize the above object the technical solution used in the present invention is:
A kind of to have the pharmaceutical preparation for improving immunity antitumor efficacy, it is made up of the bulk drug of following parts by weight:
60~120 parts of the Radix Astragali, 20~45 parts of the stem of noble dendrobium, 20~60 parts of the bighead atractylodes rhizome, 30~90 parts of umbellate pore furgus, 5~15 parts of safflower, the red sage root 15~60
Part, 10~40 parts of pseudo-ginseng, 10~30 parts of dandelion, 10~30 parts of Chinese fan palm, 5~25 parts of subprostrate sophora, 10~30 parts of kuh-seng, the root of fangji 10
~30 parts, 5~25 parts of camplotheca acuminata, 5~20 parts of Centipeda minima, 5~15 parts of Java brucea, 10~20 parts of short-tube lycoris, 3~9 parts of cow-bezoar, leech
4~16 parts, 5~25 parts of stiff silkworm, 5~25 parts of ground bettle, 2~10 parts of centipede, 1~3 part of cinnabar, 1~4 part of Toad Skin.
Preferably, above-described to have the pharmaceutical preparation for improving immunity antitumor efficacy, it is by following heavy
The bulk drug of amount number is made:80~120 parts of the Radix Astragali, 20~30 parts of the stem of noble dendrobium, 30~60 parts of the bighead atractylodes rhizome, 40~90 parts of umbellate pore furgus, safranine
Spend 10~15 parts, 30~60 parts of the red sage root, 20~40 parts of pseudo-ginseng, 10~20 parts of dandelion, 10~20 parts of Chinese fan palm, subprostrate sophora 5~15
Part, 10~20 parts of kuh-seng, 10~20 parts of the root of fangji, 5~15 parts of camplotheca acuminata, 10~20 parts of Centipeda minima, 10~15 parts of Java brucea, short-tube lycoris
10~20 parts, 3~6 parts of cow-bezoar, 4~6 parts of leech, 5~15 parts of stiff silkworm, 10~25 parts of ground bettle, 2~10 parts of centipede, cinnabar 1~
2 parts, 1~2 part of Toad Skin.
Preferably, above-described to have the pharmaceutical preparation for improving immunity antitumor efficacy, it is by following heavy
The bulk drug of amount number is made:120 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 60 parts of the bighead atractylodes rhizome, 80 parts of umbellate pore furgus, 10 parts of safflower, 60 parts of the red sage root,
40 parts of pseudo-ginseng, 10 parts of dandelion, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 10 parts of kuh-seng, 10 parts of the root of fangji, 15 parts of camplotheca acuminata, Centipeda minima 10
Part, 15 parts of Java brucea, 10 parts of short-tube lycoris, 3 parts of cow-bezoar, 4 parts of leech, 10 parts of stiff silkworm, 25 parts of ground bettle, 4 parts of centipede, 2 parts of cinnabar, toad
3 parts of bufonid toad skin.
Preparation method of the present invention with the pharmaceutical preparation for improving immunity antitumor efficacy, it includes following step
Suddenly:
(1) parts by weight as described in any one of claims 1 to 3 take the Radix Astragali, the stem of noble dendrobium, the bighead atractylodes rhizome, umbellate pore furgus, safflower, pellet
Ginseng, pseudo-ginseng, dandelion, Chinese fan palm, subprostrate sophora, kuh-seng, the root of fangji, camplotheca acuminata, Centipeda minima, Java brucea and short-tube lycoris, add medicinal material total amount 6
The ethanol of~15 times of amounts extract 1~3 time, 1~3 hour every time, reduced vacuum concentration, and adding ethanol makes the volumetric concentration of ethanol be
70~85%, stand, filtering takes filtrate, obtains concentrate;
(2) parts by weight as described in any one of claims 1 to 3 take cow-bezoar, leech, stiff silkworm, ground bettle, centipede, Zhu
Sand and Toad Skin, beat powder, cross 80 mesh and shine, standby;
(3) medicinal powder for taking step (1) concentrate and step (2) to obtain, is well mixed, and pharmaceutically acceptable load
Body is prepared into oral liquid, pill, micropill, granule, capsule or tablet.
Preferably, it is above-described that there is the pharmaceutical preparation for improving immunity antitumor efficacy, by each bulk drug
Extract and pharmaceutically acceptable carrier be prepared into oral liquid, pill, micropill, granule, capsule or tablet.
The extraction for each raw material with the pharmaceutical preparation for improving immunity antitumor efficacy that the present invention provides the present invention
When oral liquid is made in thing, add distilled water to dissolve the extract of each raw material, filter, add syrup, adjust pH value, be made oral
Liquid.
The extract for each raw material with the pharmaceutical preparation for improving immunity antitumor efficacy that the present invention is provided is made
During tablet, the extract and lactose or cornstarch of each raw material, it is necessary to when add magnesium stearate lubricant, be well mixed, it is whole
Tablet is made in grain, then tabletting.
Glue is made in the extract for each raw material with the pharmaceutical preparation for improving immunity antitumor efficacy that the present invention is provided
The extract and carrier lactose or cornstarch of each raw material are well mixed during wafer, whole grain is then encapsulated that capsule is made.
The extract for each raw material with the pharmaceutical preparation for improving immunity antitumor efficacy that the present invention is provided is made
During granula, the extract and diluent lactose or cornstarch of each raw material are well mixed, whole grain, dry, granule is made.
It is of the present invention that there is the pharmaceutical preparation for improving immunity antitumor efficacy answering in antineoplastic is prepared
With.
It is of the present invention have improve immunity antitumor efficacy pharmaceutical preparation prepare anti-liver cancer and anti-, stomach cancer, lung cancer,
Application in breast cancer, prostate cancer, intestinal cancer or leukemia medicament.
Preferably, it is above-described that there is the pharmaceutical preparation for improving immunity antitumor efficacy, the described Radix Astragali
For Radix Astragali (processed).
What the present invention was provided has the pharmaceutical preparation for improving immunity antitumor efficacy, and prescription is screened by many experiments,
In prescription, using the great Radix Astragali of consumption as monarch drug in a prescription, Radix Astragali tonifying Qi key medicine, can work(mend three burnt, solid just to help, beneficial internal organs work(
Reused in effect, we, many effects for improving tumor patient immunity can be obtained.
The compatibility stem of noble dendrobium in our side, with reinforcing stomach reg fluid, nourishing Yin and clearing heat, Gu just helping this effect, with anti-aging, raising is exempted from
Epidemic disease power, with good antineoplastic effect.
Our the compatibility bighead atractylodes rhizome and umbellate pore furgus in addition, can improve body immunity, and conditioning viscera is comprehensive to improve body metabolism energy
Power, mutual compatibility has the effects such as improving constitution, pre- preventing tumor.
Our compatibility safflower, the red sage root and pseudo-ginseng have good promoting blood circulation and removing blood stasis, dredging collateral, relieve the pain, and disappear the effects such as tying, therefrom
Doctor's angle eliminating blood stasis and smoothing collaterals dissipating bind relieves the pain.
Our compatibility dandelion, Chinese fan palm, subprostrate sophora, kuh-seng, the root of fangji, camplotheca acuminata, Centipeda minima, Java brucea and short-tube lycoris etc. have
Well removing toxic substances disappear cancer and attack poison disappear cancer the effects such as.
We screen especially through many experiments, the cow-bezoar of addition preferable amount, leech, stiff silkworm, ground bettle, centipede, Zhu
Sand and Toad Skin have good removing toxic substances, stagnation resolvation, dredging collateral, relieve the pain, the activity of dissipating bind anticancer.
Rationally, tonification and purgation in combination for complete square compatibility 5 of the present invention, play altogether " Gu sheet, supplementing qi and nourishing yin, activating collaterals and eliminating stagnation, promoting blood circulation and pain relieve are just being helped,
Poison is attacked to disappear cancer " work(, clinic improves immunity and active anticancer clearly, evident in efficacy.
Beneficial effect:Compared to the prior art what the present invention was provided has the pharmaceutical preparation of raising immunity antitumor efficacy
With advantages below:
1st, the present invention is according to traditional Chinese medical theory, using diagnosis and treatment it is theoretical carry out Chinese prescription screening there is provided have
The pharmaceutical preparation proportioning for improving immunity antitumor efficacy is scientific and reasonable, test result indicates that, what the present invention was provided has raising
The pharmaceutical preparation of immunity antitumor efficacy, not only has effects that to consolidate well and is just helping sheet, supplementing qi and nourishing yin to improve immunity, and
And also there is activating collaterals and eliminating stagnation, promoting blood circulation and pain relieve and the malicious cancer that disappears is attacked.Suppress growth of tumour cell with good and can promote
The effect of apoptosis of tumor cells, and strong killing action is respectively provided with to Several Kinds of Malignancy cell, have wide range of applications;And through length
Phase experimental study shows that what the present invention was provided has the pharmaceutical preparation for improving immunity antitumor efficacy safe, and poison is secondary to be made
With low.
2nd, the extract with the pharmaceutical preparation for improving immunity antitumor efficacy that the present invention is provided, can facilitate and medicine
Learn carrier and be prepared into a variety of formulations, it is clinically convenient to take.
Embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application appended claims limited range.
Implement row 1
1st, a kind of bulk drug with the pharmaceutical preparation for improving immunity antitumor efficacy is constituted:
2nd, 120 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 60 parts of the bighead atractylodes rhizome, 80 parts of umbellate pore furgus, 10 parts of safflower, 60 parts of the red sage root, 40 parts of pseudo-ginseng,
10 parts of dandelion, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 10 parts of kuh-seng, 10 parts of the root of fangji, 15 parts of camplotheca acuminata, 10 parts of Centipeda minima, Java brucea
15 parts, 10 parts of short-tube lycoris, 3 parts of cow-bezoar, 4 parts of leech, 10 parts of stiff silkworm, 25 parts of ground bettle, 4 parts of centipede, 2 parts of cinnabar, 3 parts of Toad Skin.
2nd, the preparation method of the present invention with the pharmaceutical preparation for improving immunity antitumor efficacy, it includes following
Step:
(1) by above-mentioned parts by weight take 120 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 60 parts of the bighead atractylodes rhizome, 80 parts of umbellate pore furgus, 10 parts of safflower,
60 parts of the red sage root, 40 parts of pseudo-ginseng, 10 parts of dandelion, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 10 parts of kuh-seng, 10 parts of the root of fangji, 15 parts of camplotheca acuminata,
10 parts of Centipeda minima, 15 parts of Java brucea, 10 parts of short-tube lycoris, the ethanol for adding 12 times of amounts of medicinal material total amount are extracted 3 times, 2 hours every time, are subtracted
Pressure is concentrated in vacuo, and adding ethanol makes the volumetric concentration of ethanol be 85%, stands, and filtering takes filtrate, obtains concentrate;
(2) 3 parts of cow-bezoar, 4 parts of leech, 10 parts of stiff silkworm, 25 parts of ground bettle, 4 parts of centipede, 2 parts of cinnabar, 3 parts of Toad Skin are taken, is beaten
Powder, crosses 80 mesh and shines, standby;
(3) medicinal powder for taking step (1) concentrate and step (2) to obtain, is well mixed, and adds lubricant stearic acid
Magnesium, is well mixed, tablet is made in whole grain, then tabletting.
Implement row 2
1st, with the pharmaceutical preparation for improving immunity antitumor efficacy, it is made up of the bulk drug of following parts by weight:
80 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 30 parts of the bighead atractylodes rhizome, 40 parts of umbellate pore furgus, 10 parts of safflower, 30 parts of the red sage root, 20 parts of pseudo-ginseng, Pu Gong
10 parts of English, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 15 parts of kuh-seng, 10 parts of the root of fangji, 10 parts of camplotheca acuminata, 10 parts of Centipeda minima, Java brucea 10
Part, 10 parts of short-tube lycoris, 3 parts of cow-bezoar, 4 parts of leech, 5 parts of stiff silkworm, 10 parts of ground bettle, 2 parts of centipede, 1 part of cinnabar, 1 part of Toad Skin.
2nd, the preparation method with the pharmaceutical preparation preparation for improving immunity antitumor efficacy:
(1) by above-mentioned parts by weight take 80 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 30 parts of the bighead atractylodes rhizome, 40 parts of umbellate pore furgus, 10 parts of safflower,
30 parts of the red sage root, 20 parts of pseudo-ginseng, 10 parts of dandelion, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 15 parts of kuh-seng, 10 parts of the root of fangji, 10 parts of camplotheca acuminata,
10 parts of Centipeda minima, 10 parts of Java brucea, 10 parts of short-tube lycoris, the ethanol for adding 10 times of amounts of medicinal material total amount are extracted 2 times, 3 hours every time, are subtracted
Pressure is concentrated in vacuo, and adding ethanol makes the volumetric concentration of ethanol be 75%, stands, and filtering takes filtrate, obtains concentrate;
(2) 3 parts of cow-bezoar, 4 parts of leech, 5 parts of stiff silkworm, 10 parts of ground bettle, 2 parts of centipede, 1 part of cinnabar, 1 part of Toad Skin are taken, is beaten
Powder, crosses 80 mesh and shines, standby;
(3) medicinal powder for taking step (1) concentrate and step (2) to obtain, is well mixed, and then adds diluent lactose
Or cornstarch is well mixed, whole grain is dried, granule is made.
Implement row 3
A kind of to have the pharmaceutical preparation for improving immunity antitumor efficacy, it is made up of the bulk drug of following parts by weight:
60 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 20 parts of the bighead atractylodes rhizome, 30 parts of umbellate pore furgus, 5 parts of safflower, 15 parts of the red sage root, 10 parts of pseudo-ginseng, Pu Gong
10 parts of English, 10 parts of Chinese fan palm, 5 parts of subprostrate sophora, 10 parts of kuh-seng, 10 parts of the root of fangji, 5 parts of camplotheca acuminata, 5 parts of Centipeda minima, 5 parts of Java brucea, stone
10 parts of garlic, 3 parts of cow-bezoar, 4 parts of leech, 5 parts of stiff silkworm, 5 parts of ground bettle, 2 parts of centipede, 1 part of cinnabar, 1 part of Toad Skin.
Then and lactose (3) medicinal powder for taking step (1) concentrate and step (2) to obtain, is well mixed, and corn forms sediment
Powder mixing with whole grain is then encapsulated that capsule is made.
Implement the antitumor pharmacological evaluation of row 4
1st, anticancer experiment in vitro
With human lung cancer (MCF-7), breast cancer (A-5408), human liver cancer cells Hep G2, human gastric cancer (SGC-7901),
The 6 kinds of knurl strains of human leukemia cell line HL-60 and people's casing slime gland cancer, carry out extracorporeal anti-tumor real using tetrazolium bromide reducing process (MTT)
Test, the embodiment of the present invention 1, embodiment 2, the extract for the Chinese medicine composition that embodiment 3 is prepared is test medicine, with cis-platinum
For positive controls, the solvent using sample is physiological saline as negative control group.Specific experiment result is as shown in table 1:
Inhibitory action (IC of the Chinese medicine composition of table 1 to tumour cell50For half inhibiting rate)
Shown by the anticancer experiment in vitro result of table 1, the Chinese medicine composition that the present invention is provided is equal to a variety of human tumor cells
With stronger inhibitory action, and many cells of resistant tumors also have suppression and killing action, can be used for malignancy disease
Treatment.Implement experiment of the Chinese medicine compound prescription of row 5 to immunoregulation effect
1st, experiment material
1.1 experimental animal
ICR mouse 300, male and female half and half, body weight 18-22g, (SPF grades) offers of Nanjing University of Traditional Chinese Medicine.Animal feeding in
In animal center SPF grades of mouse experiment room of Nanjing University of Traditional Chinese Medicine, 23 DEG C ± 2 DEG C of temperature, humidity 55 ± 5%, pellet (point
Wei soup mountain dragon's fountain board experimental mouse pellet and rabbit pellet) feed, free water.
1.2 medicines and reagent
The Chinese medicinal compound extract that embodiment 1 and embodiment 2 are prepared;Sheep red blood cell (SRBC) (Guangzhou stamen spy's biotechnology
Co., Ltd provides);Guinea pig serum (offer of Guangzhou Rui Te bio tech ltd);Kit builds up bioengineering by Nanjing
Research institute provides;Other reagents are that domestic analysis is pure.
1.3 laboratory apparatus
Freeze drier (LABCONCO companies of the U.S.), ultraviolet specrophotometer (the limited public affairs of Beijing LabTech instrument
Department), ELIASA (PerkinElmer limited companies), Automatic Blood Cell Analyzer (Japanese Sysmex company), electronics
Balance (Sai Duolisi scientific instrument Co., Ltd).
2nd, experimental method
2.1 hypoimmunity mice modelings and administration
Mouse 70, male and female half and half, numbering of weighing is randomly divided into 4 groups, if blank group, model group, embodiment 1 and implementation
The Chinese medicinal compound extract that example 2 is prepared.3d, the daily gavage CMC-Na solution 0.4mL of blank group and intraperitoneal injection physiology
Salt solution 0.4mL, the daily gavage CMC-Na solution 0.4mL of model group and intraperitoneal injection of cyclophosphamide (CTX) 50mg/kg.Each group is every
Its administration 2 times (10mg/kg), continuous 5d, the continuous modeling 3d of model group administration group.Chinese medical extract group daily give respectively by gavage
Medicine, while CTX 50mg/kg are injected intraperitoneally.
The measure of 2.2 macrophage phagocytic functions
Using Carbon grain Kuo clear law, after last dose 30min, the india ink of 3 times of dilutions is injected through mouse tail vein
0.05mL/10g.The μ L of blood 20 are taken after eye socket respectively at 30s and 360s, and add it to 0.1%Na2CO3Shaken in solution 2mL
Even, the densitometric value at spectrophotometer 680nm wavelength, OD1 represents 30s OD value, and OD2 represents 360s optical density
Value.Calculated according to formula and clean up index K, K value after body weight and the conversion of liver and spleen weight, obtain phagocytic index α.
Clean up index K=(lgOD1-lgOD2)/(t2-t1)
Phagocytic index α=body weight/liver and spleen weight × 3K
Experimental data withRepresent, compare between group and examined using t, with P<0.05 is with statistical significance.
3rd, experimental result
The influence of 3.1 pairs of hypoimmunity mice mononuclear-macrophage phagocytic functions
By table 1 test result indicates that, compared with blank group, the phagocytic index of model group mouse and phagocytosis coefficient conspicuousness subtract
Small (P<0.01);Compared with model group, the phagocytic index for the Chinese medical extract that embodiment 1 and embodiment 2 are prepared and phagocytosis
Increase (the P of coefficient conspicuousness<0.01).As a result show, Chinese medical extract of the present invention can dramatically increase hypoimmunity mice list
Core macrophage phagocytic function.
The each group of table 1 to hypoimmunity mice mononuclear-macrophage phagocytic function influence (N=10)
Group | Medicine | Phagocytic index K | Swallow factor alpha |
Blank group | - | 0.0403±0.0051 | 5.4236±0.1976 |
Model group | - | 0.0121±0.0023## | 4.0321±0.2871## |
Chinese medical extract | Embodiment 1 | 0.0199±0.0023* | 8.5345±0.2581** |
Chinese medical extract | Embodiment 2 | 0.0183±0.0021** | 7.6261±0.2179** |
Note:Compared with blank group,##P<0.01, compared with model group,*P<0.05,**P<0.01。
The Chinese medicine compound prescription that the present invention is provided is remarkably improved the macrophage phagocytic function of mouse, can improve immunity.
The present invention is according to traditional Chinese medical theory, and theoretical using diagnosis and treatment carries out proportioning prescription, passes through above experimental result
Show, what the present invention was provided has not only with the pharmaceutical preparation for improving immunity antitumor efficacy has raising well immune
Effect of power, and have strong suppression to kinds of tumor cells and kill effect, achieve significantly enter compared with prior art
Step!.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of have the pharmaceutical preparation for improving immunity antitumor efficacy, it is characterised in that it includes following parts by weight
Bulk drug:60~120 parts of the Radix Astragali, 20~45 parts of the stem of noble dendrobium, 20~60 parts of the bighead atractylodes rhizome, 30~90 parts of umbellate pore furgus, 5~15 parts of safflower, pellet
15~60 parts of ginseng, 10~40 parts of pseudo-ginseng, 10~30 parts of dandelion, 10~30 parts of Chinese fan palm, 5~25 parts of subprostrate sophora, kuh-seng 10~30
Part, 10~30 parts of the root of fangji, 5~25 parts of camplotheca acuminata, 5~20 parts of Centipeda minima, 5~15 parts of Java brucea, 10~20 parts of short-tube lycoris, cow-bezoar 3
~9 parts, 4~16 parts of leech, 5~25 parts of stiff silkworm, 5~25 parts of ground bettle, 2~10 parts of centipede, 1~3 part of cinnabar, Toad Skin 1~4
Part.
2. according to claim 1 have the pharmaceutical preparation for improving immunity antitumor efficacy, it is characterised in that it is under
The bulk drug of row parts by weight is made:80~120 parts of the Radix Astragali, 20~30 parts of the stem of noble dendrobium, 30~60 parts of the bighead atractylodes rhizome, 40~90 parts of umbellate pore furgus,
10~15 parts of safflower, 30~60 parts of the red sage root, 20~40 parts of pseudo-ginseng, 10~20 parts of dandelion, 10~20 parts of Chinese fan palm, subprostrate sophora 5
~15 parts, 10~20 parts of kuh-seng, 10~20 parts of the root of fangji, 5~15 parts of camplotheca acuminata, 10~20 parts of Centipeda minima, 10~15 parts of Java brucea,
10~20 parts of short-tube lycoris, 3~6 parts of cow-bezoar, 4~6 parts of leech, 5~15 parts of stiff silkworm, 10~25 parts of ground bettle, 2~10 parts of centipede, Zhu
1~2 part of sand, 1~2 part of Toad Skin.
3. according to claim 2 have the pharmaceutical preparation for improving immunity antitumor efficacy, it is characterised in that it is under
The bulk drug of row parts by weight is made:120 parts of the Radix Astragali, 20 parts of the stem of noble dendrobium, 60 parts of the bighead atractylodes rhizome, 80 parts of umbellate pore furgus, 10 parts of safflower, the red sage root 60
Part, 40 parts of pseudo-ginseng, 10 parts of dandelion, 10 parts of Chinese fan palm, 10 parts of subprostrate sophora, 10 parts of kuh-seng, 10 parts of the root of fangji, 15 parts of camplotheca acuminata, sandwort
10 parts of grass, 15 parts of Java brucea, 10 parts of short-tube lycoris, 3 parts of cow-bezoar, 4 parts of leech, 10 parts of stiff silkworm, 25 parts of ground bettle, 4 parts of centipede, cinnabar 2
Part, 3 parts of Toad Skin.
4. the preparation method with the pharmaceutical preparation for improving immunity antitumor efficacy described in any one of claims 1 to 3, its
It is characterised by comprising the following steps:
(1) parts by weight as described in any one of claims 1 to 3 take the Radix Astragali, the stem of noble dendrobium, the bighead atractylodes rhizome, umbellate pore furgus, safflower, the red sage root, three
7th, dandelion, Chinese fan palm, subprostrate sophora, kuh-seng, the root of fangji, camplotheca acuminata, Centipeda minima, Java brucea and short-tube lycoris, add medicinal material total amount 6~15
The ethanol of times amount extracts 1~3 time, 1~3 hour every time, reduced vacuum concentration, add ethanol make the volumetric concentration of ethanol for 70~
85%, stand, filtering takes filtrate, obtains concentrate;
(2) parts by weight as described in any one of claims 1 to 3 take cow-bezoar, leech, stiff silkworm, ground bettle, centipede, cinnabar and
Toad Skin, beats powder, crosses 80 mesh and shines, standby;
(3) medicinal powder for taking step (1) concentrate and step (2) to obtain, is well mixed, and pharmaceutically acceptable carrier system
It is standby into oral liquid, pill, micropill, granule, capsule or tablet.
5. having the pharmaceutical preparation for improving immunity antitumor efficacy according to any one of claims 1 to 3, its feature exists
In the extract and pharmaceutically acceptable carrier of each bulk drug are prepared into oral liquid, pill, micropill, granule, capsule
Or tablet.
6. described in any one of claims 1 to 3 have improve immunity antitumor efficacy pharmaceutical preparation prepare it is antitumor
Application in medicine.
7. the pharmaceutical preparation that having described in any one of claims 1 to 3 improves immunity antitumor efficacy is preparing anti-liver cancer and anti-,
Application in stomach cancer, lung cancer, breast cancer, liver cancer, prostate cancer, intestinal cancer or leukemia medicament.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108936846A (en) * | 2018-04-25 | 2018-12-07 | 四川生命源健康管理有限公司 | The U.S. corselet for preventing breast cancer |
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2017
- 2017-07-28 CN CN201710628142.6A patent/CN107233504A/en active Pending
Non-Patent Citations (1)
Title |
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王辉武: "《中药临床新用》", 31 January 2001, 人民卫生出版社 * |
Cited By (1)
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CN108936846A (en) * | 2018-04-25 | 2018-12-07 | 四川生命源健康管理有限公司 | The U.S. corselet for preventing breast cancer |
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