CN107232612A - A kind of B B-complex lozenge rich in high activity SOD and preparation method thereof - Google Patents
A kind of B B-complex lozenge rich in high activity SOD and preparation method thereof Download PDFInfo
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- CN107232612A CN107232612A CN201710385280.6A CN201710385280A CN107232612A CN 107232612 A CN107232612 A CN 107232612A CN 201710385280 A CN201710385280 A CN 201710385280A CN 107232612 A CN107232612 A CN 107232612A
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- 239000007937 lozenge Substances 0.000 title claims abstract description 40
- 230000000694 effects Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 102000008186 Collagen Human genes 0.000 claims abstract description 117
- 108010035532 Collagen Proteins 0.000 claims abstract description 117
- 229920001436 collagen Polymers 0.000 claims abstract description 116
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 46
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 44
- 240000000111 Saccharum officinarum Species 0.000 claims abstract description 42
- 235000007201 Saccharum officinarum Nutrition 0.000 claims abstract description 42
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims abstract description 35
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims abstract description 35
- 102000019197 Superoxide Dismutase Human genes 0.000 claims abstract description 30
- 108010012715 Superoxide dismutase Proteins 0.000 claims abstract description 30
- 239000011782 vitamin Substances 0.000 claims abstract description 25
- 229920002472 Starch Polymers 0.000 claims abstract description 23
- 239000008107 starch Substances 0.000 claims abstract description 23
- 235000019698 starch Nutrition 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 68
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 30
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 22
- 239000011265 semifinished product Substances 0.000 claims description 21
- 241000251468 Actinopterygii Species 0.000 claims description 20
- 239000012153 distilled water Substances 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 13
- 235000016709 nutrition Nutrition 0.000 claims description 12
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 11
- 229930003427 Vitamin E Natural products 0.000 claims description 11
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 11
- 238000007654 immersion Methods 0.000 claims description 11
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 11
- 239000011691 vitamin B1 Substances 0.000 claims description 11
- 239000011716 vitamin B2 Substances 0.000 claims description 11
- 229940046009 vitamin E Drugs 0.000 claims description 11
- 235000019165 vitamin E Nutrition 0.000 claims description 11
- 239000011709 vitamin E Substances 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 10
- 210000003205 muscle Anatomy 0.000 claims description 10
- 239000011715 vitamin B12 Substances 0.000 claims description 10
- 239000011726 vitamin B6 Substances 0.000 claims description 10
- 230000010355 oscillation Effects 0.000 claims description 9
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 7
- 102000002322 Egg Proteins Human genes 0.000 claims description 7
- 108010000912 Egg Proteins Proteins 0.000 claims description 7
- 235000014103 egg white Nutrition 0.000 claims description 7
- 210000000969 egg white Anatomy 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 3
- 235000011121 sodium hydroxide Nutrition 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 abstract description 15
- 235000001014 amino acid Nutrition 0.000 abstract description 14
- 150000001413 amino acids Chemical class 0.000 abstract description 14
- 229940088594 vitamin Drugs 0.000 abstract description 14
- 229930003231 vitamin Natural products 0.000 abstract description 14
- 235000013343 vitamin Nutrition 0.000 abstract description 14
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 14
- 229930091371 Fructose Natural products 0.000 abstract description 3
- 239000005715 Fructose Substances 0.000 abstract description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 3
- 229930006000 Sucrose Natural products 0.000 abstract description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 3
- 239000008103 glucose Substances 0.000 abstract description 3
- 239000005720 sucrose Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 40
- 230000000052 comparative effect Effects 0.000 description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 10
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 10
- 229930003268 Vitamin C Natural products 0.000 description 10
- 235000019154 vitamin C Nutrition 0.000 description 10
- 239000011718 vitamin C Substances 0.000 description 10
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 8
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 8
- 235000013601 eggs Nutrition 0.000 description 8
- 238000002791 soaking Methods 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000007760 free radical scavenging Effects 0.000 description 5
- 239000011708 vitamin B3 Substances 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- 239000001116 FEMA 4028 Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960004853 betadex Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- -1 hydroxypropyl Chemical group 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002927 oxygen compounds Chemical class 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of B B-complex lozenge rich in high activity SOD and preparation method thereof, it is made up of the component of following parts by weight：50 70 parts of 1 part of superoxide dismutase, 0.2~0.3 part of sialic acid, 3~4 parts of hydroxypropyl beta cyclodextrin, 12~15 parts of collagen liquid, 30~40 parts of sugar-cane juice, 15~30 parts of starch and B B-complex.The present invention is by the sugar being rich in superoxide dismutase and sugar-cane juice (sucrose, glucose and fructose etc.), amino acid and vitamin etc., included in the lump with hydroxypropyl beta cyclodextrin, the encapsulating effect of incorporating collagen albumen, SOD stability is effectively improved, higher activity can be maintained the long period.The present invention adds a small amount of sialic acid, is aided with the nutriments such as the sugar being rich in sugar-cane juice, amino acid and vitamin, can play synergistic function, strengthens the inoxidizability of superoxide dismutase.
Description
Technical field
The present invention relates to health product technology field, more particularly to a kind of B B-complex lozenge rich in high activity SOD and
Its preparation method.
Background technology
SOD, i.e. superoxide dismutase (Superoxide dismutase), are that one kind can be catalyzed superoxides and pass through
Disproportionated reaction is converted into the enzyme of oxygen and hydrogen peroxide, is widely present in animal, plant and microbial cell.
SOD belongs to metalloproteinases, different according to bind metal ion species, including following three kinds：Cupric and zinc super oxygen
Compound mutase (Cu-Zn-SOD), Mn-SOD (Mn-SOD) and Fe-contained SOD (Fe-SOD).
Three kinds of SOD are catalyzed superoxide anion radical, are disproportionated into hydrogen peroxide and oxygen.SOD is a kind of important resists
Oxidant, can protect the cell in oxygen, and SOD is continuously replenished to human body has the effect of anti-aging.
Existing antioxidant health-care product species is various, but the antioxidant health-care product based on SOD is commercially still few
See, topmost reason is among these, common SOD stability is poor, and heat is easily decomposed, and activity is had a greatly reduced quality.Although
Some resistant to elevated temperatures superoxide dismutases are have now been developed, but cost is higher, can not still realize Industry Promotion.
The content of the invention
The technical problem existed based on background technology, the present invention proposes a kind of B B-complex rich in high activity SOD
Lozenge and preparation method thereof.
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.2~0.3 part of sialic acid, 3~4 parts of hydroxypropyl-β-cyclodextrin, 12~15 parts of collagen liquid, sugar-cane juice 30
~40 parts, 50-70 parts of 15~30 parts of starch and B B-complex；Wherein, collagen liquid is made up of collagen and water,
Per 30mL collagen liquids 1g containing collagen.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, can be with
Including vitamin B3, vitamin B6And vitamin B12In any one or it is a variety of.
It is preferred that, the nutritional ingredient in the sugar-cane juice than water, and superoxide dismutase are incorporated in hydroxyl in the lump
Hydroxypropyl-beta-cyclodextrin inclusion is formed in propyl-beta-cyclodextrin.
It is further preferred that the nutritional ingredient in sugar-cane juice than water includes：Sugar (sucrose, glucose and fructose
Deng), amino acid and vitamin.
It is further preferred that the hydroxypropyl-beta-cyclodextrin inclusion and sialic acid are encapsulated in collagen in the lump.
It is preferred that, the sugar-cane juice is the juice that produces after cane milling.
It is preferred that, the collagen liquid, which is prepared by the following method, to be obtained：By fish-bone, fish-skin, fish scale or fish muscle
In a kind of 0.05mol/L sodium hydroxide solutions immersion with 3~4 times of raw materials weight after rinsed with clear water to neutrality；Then with 5~
Rinsed after the 0.05mol/L hydrochloric acid solutions stirring immersion of 8 times of raw material weights with clear water to neutrality, blend and be prepared into collagen；To
Distilled water is added in collagen, 80 DEG C of extractions filter out insoluble matter and produced, the mass volume ratio of the collagen and distilled water
For 1g：30mL.
It is further preferred that the soak time of sodium hydroxide solution is 12~24 hours.
It is further preferred that the soak time of hydrochloric acid solution is 2~3 hours.
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 20~40 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 20~40 minutes is subsequently added into glue
Former protein liquid, is persistently stirred 1~2 hour, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
The B B-complex lozenge of the present invention is adapted to directly oral.
This programme is beneficial in that compared to traditional scheme：The present invention is by superoxide dismutase and sugar-cane juice
Sugar (sucrose, glucose and fructose etc.), amino acid and vitamin for being rich in etc., are carried out with hydroxypropyl-β-cyclodextrin in the lump
Inclusion, the encapsulating effect of incorporating collagen albumen, effectively improves gained SOD stability, can remain higher the long period
Activity.The present invention adds a small amount of sialic acid, is aided with the nutriments such as the sugar being rich in sugar-cane juice, amino acid and vitamin, can
To play synergistic function, strengthen the inoxidizability of superoxide dismutase.It is of the invention last all with collagen parcel
Composition, collagen in itself have good biocompatibility, human body will not be caused stimulate, moreover, collagen is structure
Into the main component of extracellular matrix, after human body is taken, collagen can slowly degrade in vivo, form many micropores, wherein
Superoxide dismutase, sugar and sialic acid of encapsulating etc. are slowly infiltrated therewith, play the effect being sustained in similar medicine,
Can be effective in a long time after taking, it is to avoid frequently take.
Embodiment
Sialic acid of the present invention is obtained according to the method for step (1)~(5) in patent application CN104072544A.
Sugar-cane juice is the juice that produces after cane milling.
Embodiment 1：
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.2 part of sialic acid, 3 parts of hydroxypropyl-β-cyclodextrin, 12 parts of collagen liquid, 30 parts of sugar-cane juice, 15 parts of starch,
70 parts of B B-complex；Wherein, collagen liquid is made up of collagen and water, per 30mL collagen liquids egg containing collagen
White 1g.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B3, vitamin B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 12 hours with clear water；Then weighed with 5 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2 hours with clear water, is blended and is prepared into collagen；To collagen egg
Distilled water is added in white, 80 DEG C of extractions filter out insoluble matter and produced, and the mass volume ratio of the collagen and distilled water is 1g：
30mL。
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 20 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 20 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 1 hour, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Embodiment 2：
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.3 part of sialic acid, 4 parts of hydroxypropyl-β-cyclodextrin, 15 parts of collagen liquid, 40 parts of sugar-cane juice, 30 parts of starch,
50 parts of B B-complex；Wherein, collagen liquid is made up of collagen and water, per 30mL collagen liquids egg containing collagen
White 1g.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B3And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 4
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 24 hours with clear water；Then weighed with 8 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 3 hours with clear water, is blended and is prepared into collagen；To collagen egg
Distilled water is added in white, 80 DEG C of extractions filter out insoluble matter and produced, and the mass volume ratio of the collagen and distilled water is 1g：
30mL。
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 40 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 40 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 2 hours, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Embodiment 3：
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.2 part of sialic acid, 4 parts of hydroxypropyl-β-cyclodextrin, 12 parts of collagen liquid, 40 parts of sugar-cane juice, 25 parts of starch,
65 parts of B B-complex；Wherein, collagen liquid is made up of collagen and water, per 30mL collagen liquids egg containing collagen
White 1g.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B3And vitamin B6。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 24 hours with clear water；Then weighed with 8 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2 hours with clear water, is blended and is prepared into collagen；To collagen egg
Distilled water is added in white, 80 DEG C of extractions filter out insoluble matter and produced, and the mass volume ratio of the collagen and distilled water is 1g：
30mL。
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 20 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 40 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 1 hour, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Embodiment 4：
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.3 part of sialic acid, 3 parts of hydroxypropyl-β-cyclodextrin, 15 parts of collagen liquid, 30 parts of sugar-cane juice, 20 parts of starch,
55 parts of B B-complex；Wherein, collagen liquid is made up of collagen and water, per 30mL collagen liquids egg containing collagen
White 1g.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B3, vitamin B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 4
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 12 hours with clear water；Then weighed with 8 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2 hours with clear water, is blended and is prepared into collagen；To collagen egg
Distilled water is added in white, 80 DEG C of extractions filter out insoluble matter and produced, and the mass volume ratio of the collagen and distilled water is 1g：
30mL。
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 40 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 20 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 2 hours, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Embodiment 5：
A kind of B B-complex lozenge rich in high activity SOD, is made up of the component of following parts by weight：Superoxides
1 part of mutase, 0.25 part of sialic acid, 3.5 parts of hydroxypropyl-β-cyclodextrin, 13 parts of collagen liquid, 35 parts of sugar-cane juice, starch 20
Part, 60 parts of B B-complex；Wherein, collagen liquid is made up of collagen and water, contains glue per 30mL collagen liquids
Former albumen 1g.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 18 hours with clear water；Then weighed with 6 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2.5 hours with clear water, is blended and is prepared into collagen；To collagen
Distilled water is added in albumen, 80 DEG C of extractions filter out insoluble matter and produced, the mass volume ratio of the collagen and distilled water is
1g：30mL.
A kind of preparation method of above-mentioned B B-complex lozenge rich in high activity SOD, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 30 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 30 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 1.5 hours, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Comparative example 1
A kind of B B-complex lozenge, is made up of the component of following parts by weight：1 part of superoxide dismutase, hydroxypropyl
3.5 parts of group-beta-cyclodextrin, 13 parts of collagen liquid, 35 parts of sugar-cane juice, 20 parts of starch, 60 parts of B B-complex；Wherein, collagen
Protein liquid is made up of collagen and water, per 30mL collagen liquids 1g containing collagen.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.Hydroxypropyl-β-cyclodextrin
Inclusion compound is encapsulated in collagen.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 18 hours with clear water；Then weighed with 6 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2.5 hours with clear water, is blended and is prepared into collagen；To collagen
Distilled water is added in albumen, 80 DEG C of extractions filter out insoluble matter and produced, the mass volume ratio of the collagen and distilled water is
1g：30mL.
A kind of preparation method of above-mentioned B B-complex lozenge, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 30 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) collagen liquid is added into inclusion complex in solution obtained by step (1), persistently stirred 1.5 hours, concentration is obtained
Semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Comparative example 2
A kind of B B-complex lozenge, is made up of the component of following parts by weight：1 part of superoxide dismutase, saliva
0.25 part of acid, 3.5 parts of hydroxypropyl-β-cyclodextrin, 13 parts of collagen liquid, 35 parts of water, 20 parts of starch, 60 parts of B B-complex；
Wherein, collagen liquid is made up of collagen and water, per 30mL collagen liquids 1g containing collagen.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B6And vitamin B12。
Wherein, superoxide dismutase is incorporated in hydroxypropyl-β-cyclodextrin and forms hydroxypropyl-beta-cyclodextrin inclusion.
Hydroxypropyl-beta-cyclodextrin inclusion and sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 18 hours with clear water；Then weighed with 6 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2.5 hours with clear water, is blended and is prepared into collagen；To collagen
Distilled water is added in albumen, 80 DEG C of extractions filter out insoluble matter and produced, the mass volume ratio of the collagen and distilled water is
1g：30mL.
A kind of preparation method of above-mentioned B B-complex lozenge, is comprised the following steps that：
(1) it is hydroxypropyl-β-cyclodextrin is soluble in water, superoxide dismutase is then added while stirring, continues to stir
30 minutes, obtain hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 30 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 1.5 hours, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Comparative example 3
A kind of B B-complex lozenge, is made up of the component of following parts by weight：1 part of superoxide dismutase, saliva
0.25 part of acid, 13 parts of collagen liquid, 35 parts of sugar-cane juice, 20 parts of starch, 60 parts of B B-complex；Wherein, collagen liquid is
It is made up of collagen and water, per 30mL collagen liquids 1g containing collagen.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase, sialic acid are encapsulated in collagen in the lump.
Collagen liquid, which is prepared by the following method, to be obtained：One kind in fish-bone, fish-skin, fish scale or fish muscle is used 3
The 0.05mol/L sodium hydroxide solutions of times raw material weight are rinsed to neutrality after soaking 18 hours with clear water；Then weighed with 6 times of raw materials
0.05mol/L hydrochloric acid solutions stirring immersion is rinsed to neutrality after 2.5 hours with clear water, is blended and is prepared into collagen；To collagen
Distilled water is added in albumen, 80 DEG C of extractions filter out insoluble matter and produced, the mass volume ratio of the collagen and distilled water is
1g：30mL.
A kind of preparation method of above-mentioned B B-complex lozenge, is comprised the following steps that：By superoxide dismutase, sugar-cane juice
It is well mixed with sialic acid, collagen liquid is added, is persistently stirred 1.5 hours, concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Comparative example 4
A kind of B B-complex lozenge, is made up of the component of following parts by weight：1 part of superoxide dismutase, saliva
0.25 part of acid, 3.5 parts of hydroxypropyl-β-cyclodextrin, 35 parts of sugar-cane juice, 20 parts of starch, 60 parts of B B-complex.
Described B B-complex, including vitamin C, vitamin E, vitamin B1, vitamin B2, vitamine R, vitamin
B6And vitamin B12。
Wherein, in sugar-cane juice than water nutritional ingredient (including：Sugar, amino acid and vitamin), and super oxygen
Thing mutase is incorporated in hydroxypropyl-β-cyclodextrin forms hydroxypropyl-beta-cyclodextrin inclusion in the lump.
A kind of preparation method of above-mentioned B B-complex lozenge, is comprised the following steps that：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continued
Stirring 30 minutes, obtains hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) add sialic acid into inclusion complex in solution obtained by step (1), sonic oscillation 30 minutes, concentration, obtain half into
Product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
Test example
1st, for the B B-complex lozenge of embodiment 1~5 and comparative example 1~4, respectively at detection at 35 DEG C and 55 DEG C
Contained SOD half-life period (the time required to content reduces half), it the results are shown in Table 1.
Table 1.SOD half-life period compares
| Half-life period (hour) at 35 DEG C | Half-life period (hour) at 55 DEG C | |
| Embodiment 1 | ＞ 72 | ＞ 72 |
| Embodiment 2 | ＞ 72 | ＞ 72 |
| Embodiment 3 | ＞ 72 | ＞ 72 |
| Embodiment 4 | ＞ 72 | ＞ 72 |
| Embodiment 5 | ＞ 72 | ＞ 72 |
| Comparative example 1 | 32 | 24 |
| Comparative example 2 | 36 | 20 |
| Comparative example 3 | 12 | 8 |
| Comparative example 4 | 10 | 5 |
Comparative example 3 omits hydroxypropyl-β-cyclodextrin, and comparative example 4 omits collagen liquid, SOD half-life period substantially compared with
It is short, and the SOD half-life period of embodiment 1~5 is longer, illustrates that hydroxypropyl-β-cyclodextrin and collagen liquid collaboration enhance SOD's
Stability.Comparative example 1 omits sialic acid, the water consumption substitution sugar-cane juice of comparative example 2, SOD half-life period also have it is a certain degree of shorten,
Illustrate that the nutritional ingredient in sialic acid or sugar-cane juice also plays a part of collaboration enhancing stability to a certain extent.
2nd, inoxidizability is investigated
DPPH (1,1- diphenyl -2- trinitrophenyl-hydrazines) method determines inoxidizability：Methanol dilution DPPH is used, makes its concentration be
120 μm of ol/L, it is standby；Dissolve the B B-complex lozenge of embodiment 1~5 and comparative example 1~2 respectively with water so that SOD and water
Mass ratio be 0.01g：100mL.
Blank group：+ 2.0mL120 μm of ol/L of 2.0mL water DPPH methanol solutions；
Experimental group：The aqueous solution prepared by the B B-complex lozenge of 2.0mL embodiments 1~5 and comparative example 1~2+
2.0mL120 μm ol/L DPPH methanol solutions；
The control group of each experimental group：Prepared by the B B-complex lozenge of 2.0mL embodiments 1~5 and comparative example 1~2
The aqueous solution+2.0mL methanol.
Blank group, experimental group and control group react 30 minutes after under the conditions of 517nm colorimetric, according to formula calculate DPPH from
By base clearance rate, DPPH free radical scavenging activities (C)/%=(1- (A1-A2)/A0) × 100, wherein, C is DPPH radicals scavengings
Rate；A1 is each experimental group absorbance, and sample removes the absorbance after DPPH free radicals；A2 is control group absorbance, reflects sample
Contribution to absorbance in itself；A0 is blank group absorbance, and DPPH free radicals are certainly in the absorbance of specific wavelength.Result of the test
It is shown in Table 2.
The DPPH free radical scavenging activities of the embodiment 1~5 of table 2. and the B B-complex lozenge of comparative example 1~3 compare
| DPPH free radical scavenging activities (%) | |
| Embodiment 1 | 98 |
| Embodiment 2 | 98 |
| Embodiment 3 | 99 |
| Embodiment 4 | 99 |
| Embodiment 5 | 100 |
| Comparative example 1 | 58 |
| Comparative example 2 | 52 |
Comparative example 1 omits sialic acid, and the water consumption substitution sugar-cane juice of comparative example 2, DPPH free radical scavenging activities are substantially reduced, said
The nutriments such as sugar, amino acid and the vitamin being rich in bright sialic acid and sugar-cane juice have the work of collaboration enhancing inoxidizability
With, and the DPPH free radical scavenging activities of embodiment 1~5 are high, inoxidizability is strong.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (9)
1. a kind of B B-complex lozenge rich in high activity SOD, it is characterised in that be made up of the component of following parts by weight
's：1 part of superoxide dismutase, 0.2~0.3 part of sialic acid, 3~4 parts of hydroxypropyl-β-cyclodextrin, collagen liquid 12~15
50-70 parts of part, 30~40 parts of sugar-cane juice, 15~30 parts of starch and B B-complex；Wherein, collagen liquid is by collagen
Constituted with water, per 30mL collagen liquids 1g containing collagen.
2. B B-complex lozenge according to claim 1, it is characterised in that the nutrition in the sugar-cane juice than water
Composition, and superoxide dismutase are incorporated in hydroxypropyl-β-cyclodextrin form hydroxypropyl-beta-cyclodextrin inclusion in the lump.
3. B B-complex lozenge according to claim 2, it is characterised in that the hydroxypropyl-beta-cyclodextrin inclusion
It is encapsulated in the lump in collagen with sialic acid.
4. B B-complex lozenge according to claim 1, it is characterised in that described B B-complex, including dimension life
Plain C, vitamin E, vitamin B1, vitamin B2And vitamine R.
5. B B-complex lozenge according to claim 4, it is characterised in that described B B-complex, in addition to dimension
Raw element B3, vitamin B6And vitamin B12In any one or it is a variety of.
6. B B-complex lozenge according to claim 1, it is characterised in that the collagen liquid is by with lower section
What method was prepared：By a kind of 0.05mol/L sodium hydroxides with 3~4 times of raw material weights in fish-bone, fish-skin, fish scale or fish muscle
Rinsed after solution immersion with clear water to neutrality；Then used after being soaked with the 0.05mol/L hydrochloric acid solutions stirring of 5~8 times of raw material weights
Clear water is rinsed to neutrality, is blended and is prepared into collagen；Distilled water is added into collagen, 80 DEG C of extractions filter out insoluble matter
Produce, the mass volume ratio of the collagen and distilled water is 1g：30mL.
7. B B-complex lozenge according to claim 6, it is characterised in that the soak time of sodium hydroxide solution is 12
~24 hours.
8. B B-complex lozenge according to claim 6, it is characterised in that the soak time of hydrochloric acid solution is 2~3 small
When.
9. the preparation method of B B-complex lozenge any one of claim 1~8, it is characterised in that specific steps are such as
Under：
(1) hydroxypropyl-β-cyclodextrin is dissolved in sugar-cane juice, superoxide dismutase is then added while stirring, continue to stir
20~40 minutes, obtain hydroxypropyl-beta-cyclodextrin inclusion solution；
(2) sialic acid is added into inclusion complex in solution obtained by step (1), sonic oscillation 20~40 minutes is subsequently added into collagen egg
White liquor, is persistently stirred 1~2 hour, and concentration obtains semi-finished product；
(3) starch and B B-complex are added into semi-finished product obtained by step (2), after being well mixed, tabletting, you can.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107594522A (en) * | 2017-11-03 | 2018-01-19 | 襄阳星马食品有限公司 | The preparation method of the micro- SOD functional food of benefit |
| CN109105896A (en) * | 2018-07-11 | 2019-01-01 | 广州富诺营养科技有限公司 | A kind of nutrient composition being made of vitamin D, K and vitamin B12 |
| CN114766553A (en) * | 2022-05-05 | 2022-07-22 | 中国海洋大学 | Sturgeon and dragon's tendon chewable tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103844215A (en) * | 2012-11-30 | 2014-06-11 | 李良奎 | High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method |
| CN105055363A (en) * | 2015-09-06 | 2015-11-18 | 叶澄 | Acotiamide hydrochloride sustained-release drug and preparation method thereof |
| CN105288652A (en) * | 2015-10-30 | 2016-02-03 | 珠海市雅莎生物科技有限公司 | Superoxide dismutase microcapsule powder and preparation method thereof |
-
2017
- 2017-05-26 CN CN201710385280.6A patent/CN107232612A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103844215A (en) * | 2012-11-30 | 2014-06-11 | 李良奎 | High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method |
| CN105055363A (en) * | 2015-09-06 | 2015-11-18 | 叶澄 | Acotiamide hydrochloride sustained-release drug and preparation method thereof |
| CN105288652A (en) * | 2015-10-30 | 2016-02-03 | 珠海市雅莎生物科技有限公司 | Superoxide dismutase microcapsule powder and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 嘻哈花花: "长期吃燕窝，可以预防这9大疾病，难怪吃燕窝的人越来越多!", 《HTTPS://WWW.JIANSHU.COM/P/DA6D859D720E》 * |
| 韦日明等: "甘蔗汁对大鼠酒精性肝损伤的保护作用", 《安徽农业科学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107594522A (en) * | 2017-11-03 | 2018-01-19 | 襄阳星马食品有限公司 | The preparation method of the micro- SOD functional food of benefit |
| CN109105896A (en) * | 2018-07-11 | 2019-01-01 | 广州富诺营养科技有限公司 | A kind of nutrient composition being made of vitamin D, K and vitamin B12 |
| CN114766553A (en) * | 2022-05-05 | 2022-07-22 | 中国海洋大学 | Sturgeon and dragon's tendon chewable tablet and preparation method thereof |
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