CN107224444A - A kind of solid gum medicines of Xi Payi and its application in Retinoids, Retin-A, Renova, Accutane is prepared - Google Patents
A kind of solid gum medicines of Xi Payi and its application in Retinoids, Retin-A, Renova, Accutane is prepared Download PDFInfo
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Abstract
The present invention is a kind of solid gum medicines of Xi Payi and its application in Retinoids, Retin-A, Renova, Accutane is prepared, and belongs to the field of Chinese medicines.A kind of solid gum medicines of Xi Payi, the solid gum medicines of the Xi Payi are included：Nutgall.The present invention also disclosed solid applications of the gum medicine in Retinoids, Retin-A, Renova, Accutane is prepared of Xi Payi.The solid gum medicines of Xi Payi of the present invention contain middle medicine nutgall, and composition is simple, and toxic side effect is small, can effectively treat acne, and applied to the medicine for preparing treatment acne；The medicine of the solid gum medicines of Xi Payi of the present invention and its treatment acne being prepared into, can be made pharmaceutically acceptable preparation, be easy to according to administration object difference, using different formulations.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Xi Payi consolidates gum medicine and its in Retinoids, Retin-A, Renova, Accutane is prepared
Application.
Background technology
Acne, is commonly called as whelk, acne, dark sore, and traditional Chinese medical science ancient times claim face sore, acne.It is dermatology common disease, frequently-occurring disease.
Counted according to scholars, have 95% in Adolescent male, women has 85% to suffer from different degrees of acne, so everybody is called
" whelk " is very proper, to noticing that the people of image bring puzzlement.Acne is pilosebaceous unit chronic inflammation disease
Disease, is mainly in Head And Face, neck, and the abundant position of the sebaceous glands such as shirtfront back, pathogenesis is not illustrated completely yet.Heredity, hero
The sebum of hormone induction is largely secreted, the breeding of pilosebaceous duct angling, propionibacterium acnes, inflammation and immune response etc. because
Element all may be associated.
At present in the clinical treatment of acne, mainly there are topical Retinoids class medicine, benzoyl peroxide, antibiotic etc., but
Often there is mild skin stimulate the reaction in topical Retinoids, such as local erythema, furfur, tight and burn feeling occur, need small range lucifuge
Use；Benzoyl peroxide is peroxide, but stimulate the reaction occurs in sensitive skin；Topical antibiotic include erythromycin,
Lincomycin and its derivative clindamycin, chloramphenicol or clindamycin etc., it is adaptable to dry skin and sensitivity
Patients with acne, but topical antibiotic easily induces propionibacterium acnes resistance；Anti-androgens medicine can cause human hormone's level disorderly
Disorderly, especially influence feminine menstrual regular, severe patient can cause infertile.
The solid gum liquid of Xi Payi is tradition dimension medicine, and its property is dry cold, and eliminating dampness convergence can treat tooth acid caused by periodontal disease
Soft, masticatory atonia, loose shift, bleeding gums and aphthae, abscess of throat, halitosis cigarette is smelly.Inventor anticipates under study for action
Outer to find, the solid gum medicines of Xi Payi can be used for treating acne, especially, to propionibacterium acnes caused by acne, there is notable suppression
Make and use, also, the solid gum drug ingedient letters of Xi Payi are worked as, and toxic side effect is small.
In view of this, it is necessary to propose a kind of solid gum medicines of Xi Payi and its application in Retinoids, Retin-A, Renova, Accutane is prepared.
The content of the invention
It is an object of the invention to provide a kind of solid gum medicines of Xi Payi and its application in Retinoids, Retin-A, Renova, Accutane is prepared,
The solid gum drug ingedients of the Xi Payi are simple, and toxic side effect is small, can effectively treat acne.
To achieve these goals, the technical scheme used is：
A kind of solid gum medicines of Xi Payi, the solid gum medicines of the Xi Payi are included：Nutgall.
Further, the solid gum medicines of the Xi Payi also contain pharmaceutically acceptable auxiliary material；
Wherein, the auxiliary material is gelatum skeleton material, NMF, preservative, penetrating agent, flavouring, antioxidant, emulsification
One or more in agent, surfactant, propellant, thickener, ethanol and purified water.
Further, gallic acid 0.001-20.0mg is contained in the solid gum medicines of the Xi Payi of unit dose.
Further, the formulation of the solid gum medicines of the Xi Payi be powder, liniment, mixture, gel, lotion, paint,
One kind in ointment, cream, paste, patch, aerosol and spray.
Further, the formulation of the solid gum medicines of the Xi Payi is one kind in mixture and ointment.
It is a further object to provide application of the said medicine in medicine is prepared.
Solid applications of the gum medicine in Retinoids, Retin-A, Renova, Accutane is prepared of above-mentioned Xi Payi.
Further, gallic acid 0.001-20.0mg is contained in the medicine of the treatment acne of unit dose.
Further, it is described treatment acne medicine formulation for powder, liniment, mixture, gel, lotion, paint,
One kind in ointment, cream, paste, patch, aerosol and spray.
Further, the formulation of the medicine of the treatment acne is one kind in mixture and ointment.
Compared with prior art, the beneficial effects of the present invention are：
1st, the solid gum medicines of Xi Payi of the present invention contain middle medicine nutgall, and composition is simple, so toxic side effect is small.
2nd, the solid gum medicines of Xi Payi of the present invention, inventor has found that the solid gum medicines of Xi Payi are to acne under study for action
Caused propionibacterium acnes significantly inhibits effect, therefore can effectively treat acne, and treats acne applied to preparing
Medicine.
3rd, the solid gum medicines of Xi Payi of the present invention and its medicine for the treatment acne being prepared into, can be made pharmaceutically
Acceptable preparation, is easy to according to administration object difference, using different formulations.
Embodiment
In order to which a kind of solid gum medicines of Xi Payi of the invention and its application in Retinoids, Retin-A, Renova, Accutane is prepared is expanded on further,
Reach expected goal of the invention, below in conjunction with preferred embodiment, to according to a kind of solid gum medicines of Xi Payi proposed by the present invention and its
Application in Retinoids, Retin-A, Renova, Accutane is prepared, its embodiment, structure, feature and its effect are described in detail as after.Under
State it is bright in, what different " embodiment " or " embodiment " referred to is not necessarily same embodiment.In addition, one or more embodiments
In special characteristic, structure or feature can be combined by any suitable form.
One aspect of the present invention, the invention provides a kind of solid gum medicines of Xi Payi.Embodiments in accordance with the present invention, institute
The solid gum medicines of Xi Payi are stated to include：Nutgall, the solid gum medicines of the Xi Payi are used to treat acne.
Inventor has surprisingly found that the solid gum medicine of Xi Payi of the invention has preferable therapeutic effect to acne, especially right
Propionibacterium acnes caused by acne significantly inhibits effect, also, the composition letter of the solid gum medicines of the Xi Payi is worked as, toxic side effect
It is small.
In addition, the solid gum medicines of Xi Payi according to the above embodiment of the present invention, can also have technology additional as follows special
Levy：
Embodiments in accordance with the present invention, the solid gum medicines of the Xi Payi further comprise pharmaceutically acceptable auxiliary material；Its
In, the auxiliary material is gelatum skeleton material, NMF, preservative, penetrating agent, flavouring, antioxidant, emulsifying agent, surface work
One or more in property agent, propellant, thickener, ethanol and purified water.
Embodiments in accordance with the present invention, the quality that the solid gum medicine of the Xi Payi of unit dose contains gallic acid is
0.001-20.0mg.Thus, in the solid gum medicines of the Xi Payi of unit dose, no food of effective therapeutic component containing sufficient dosage
Sub- acid, so that, it is ensured that the solid gum medicines of Xi Payi have good therapeutic effect to acne.
Embodiments in accordance with the present invention, the formulation of the solid gum medicines of the Xi Payi is selected from powder, liniment, mixture, gel
One kind in agent, lotion, paint, ointment, cream, paste, patch, aerosol and spray.Thus, be easy to according to
Medicine object is different, using different formulations.
Handkerchief is according to solid gum mixture and the solid gum ointment of Xi Payi to the west of embodiments in accordance with the present invention, the solid gum medicines of the Xi Payi
The form of at least one of agent is provided.Thus, existing Chinese patent drug is utilized, you can treatment acne, also, the curative effect of medicine
Good, toxic side effect is small.
According to another aspect of the invention, treatment acne is being prepared present invention also offers the solid gum medicines of foregoing Xi Payi
Application in medicine.Embodiments in accordance with the present invention, the medicine of the preparation is used to treat acne.
Embodiments in accordance with the present invention, medicine of the invention can apply to the treatment of acne, and with preferably treatment
Effect, especially, effect is significantly inhibited to propionibacterium acnes caused by acne, also, the composition letter of the medicine is worked as, and poison is secondary to be made
With small.
The quality containing gallic acid is in embodiments in accordance with the present invention, the system treatment Cuo of unit dose medicine
0.001-20.0mg.Thus, in the medicine of unit dose, the gallic acid of effective therapeutic component containing sufficient dosage, so that,
Ensure that medicine has good therapeutic effect to acne.
Embodiments in accordance with the present invention, the formulation of the medicine of the treatment acne be selected from powder, liniment, mixture, gel,
One of lotion, paint, ointment, cream, paste, patch, aerosol and spray.Thus, it is easy to according to administration object
Difference, using different formulations.
Embodiments in accordance with the present invention, the medicine of the treatment acne is in the form of at least one of mixture and ointment
There is provided.Thus, existing Chinese patent drug is utilized, you can treatment acne, also, the good effect of medicine, toxic side effect are small.
Consolidate gum medicine and its before the application in preparing Retinoids, Retin-A, Renova, Accutane elaborating a kind of Xi Payi of the invention,
It is necessary to be described further material for referring in the present invention etc., to reach more preferable effect.
Unreceipted particular technique or condition in embodiment, according to the technology or condition described by document in the art or
Person is carried out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can be by the normal of acquisition purchased in market
Advise product.
The invention provides a kind of solid gum medicines of Xi Payi, embodiments in accordance with the present invention, the solid gum medicine bags of the Xi Payi
Contain：Nutgall, also, the solid gum medicines of the Xi Payi can be used for treatment acne.
Inventor has surprisingly found that the solid gum medicine of Xi Payi of the invention has preferable therapeutic effect to acne, especially, right
Propionibacterium acnes caused by acne, significantly inhibits effect, also, the composition letter of the solid gum medicines of the Xi Payi is worked as, and poison is secondary to be made
With small.
According to a particular embodiment of the invention, the solid gum medicines of the Xi Payi are included：Nutgall.Thus, composition in the party
Letter is worked as, safe, good effect, acts on more notable, especially, the therapeutic effect to acne is good.
Embodiments in accordance with the present invention, the solid gum medicines of the Xi Payi further comprise pharmaceutically acceptable auxiliary material.By
This, it is safe in the party, act on more notable, to the therapeutic effect of acne more preferably.
According to some embodiments of the present invention, the specific species of pharmaceutically acceptable auxiliary material is not particularly limited, ability
Field technique personnel can flexibly select according to actual needs.In some embodiments of the invention, the auxiliary material of use includes being selected from
Gelatum skeleton material, NMF, preservative, penetrating agent, flavouring, antioxidant, emulsifying agent, surfactant, propellant, increasing
Thick dose, at least one of ethanol and purified water etc..Thus, beneficial to shaping, divided dose of the solid gum medicines of Xi Payi etc..
The specific species of embodiments in accordance with the present invention, filler and diluent is not particularly limited, and for example NMF is
Glycerine, preservative is at least one of ethylparaben, sodium benzoate, sorbic acid and its esters；Penetrating agent is azone, peppermint
At least one of alcohol, borneol.
In the specific example of the present invention, the solid gum medicines of the Xi Payi can contain Galla halepensis extract and flavoring
Agent.Specifically, nutgall can be added water to cook, and obtained decocting liquid is filtered, then nutgall decocting liquid, flavouring, anti-corrosion
Agent is prepared, filling, is produced.
Embodiments in accordance with the present invention, the solid gum medicines of Xi Payi of unit dose contain the quality of gallic acid not by special
Limitation, have therapeutic action to acne.According to some currently preferred embodiments of the present invention, the solid gums of the Xi Payi of unit dose
The quality that medicine contains gallic acid is 0.001-20.0mg.Thus, in the solid gum medicines of the Xi Payi of unit dose, containing enough
Effective therapeutic component gallic acid of dosage, reaches the drug dose requirement for the treatment of acne, so that, it is ensured that the solid gum medicines of Xi Payi
There is good therapeutic effect to acne.
Term used herein " unit dose " refers to the drug dose of single administration, i.e., using western handkerchief once of the invention
During according to solid gum medicine, the dosage of the solid gum medicines of the Xi Payi can be determined corresponding single according to the formulation of the solid gum medicines of Xi Payi
The organization of position dosage.
According to some embodiments of the present invention, the formulation of the solid gum medicines of the Xi Payi is selected from powder, liniment, mixture, gel
One of agent, lotion, paint, ointment, cream, paste, patch, aerosol and spray.
According to some embodiments of the present invention, handkerchief coagulates according to solid gum mixture and the solid gums of Xi Payi to the west of the solid gum medicines of the Xi Payi
What the form of at least one of jelly was provided.Thus, the existing commercially available solid gum mixture of dimension medicine Xi Payi is utilized, you can treatment Cuo
Sore, meanwhile, relative to the medicine of some existing treatment acnes, the therapeutic effect of the medicine is good, especially, to Cuo caused by acne
Sore Propionibacterium significantly inhibits effect, and the toxic side effect of the medicine is small.
According to another aspect of the invention, present invention also offers the solid gum medicines of foregoing Xi Payi in medicine is prepared
Purposes.Embodiments in accordance with the present invention, the medicine of the preparation is used to treat acne, wherein, the solid gum medicines of the Xi Payi are included：Not yet
Infanticide.
Embodiments in accordance with the present invention, medicine prepared by the present invention can apply to the treatment of acne, and with preferable
Therapeutic effect, especially, effect is significantly inhibited to propionibacterium acnes caused by acne, also, party's composition letter is worked as, and poison is secondary to be made
With small.
According to a particular embodiment of the invention, the solid gum medicines of the Xi Payi are included：Nutgall, the especially treatment to acne
Effect is good.
According to a preferred embodiment of the invention, the solid gum medicines of the Xi Payi further comprise pharmaceutically acceptable auxiliary
Material.Thus, it is safe in the party, act on more notable, to the therapeutic effect of acne more preferably.The specific species of auxiliary material and
Select and described above consistent, this is no longer going to repeat them.
According to some embodiments of the present invention, the formulation of the medicine of the preparation is selected from powder, liniment, mixture, gel, washed
One of agent, paint, ointment, cream, paste, patch, aerosol and spray.Thus, it is easy to according to administration object not
Together, using different formulations.For example, for the ease of administration, liniment, mixture, gel can be used, and it is possible to according to medicine
The absorption site of thing and the release demand of medicine, the formulation to medicine are adjusted, so as to improve the bioavilability of medicine, prolonged
The release time of long medicine.For serious patient, parenteral solution can be used, and then realizes heavy dose of administration requirements, also,
Avoid influence of the gastrointestinal circulation to effective ingredient.
According to a particular embodiment of the invention, handkerchief is soft according to solid gum mixture and the solid gums of Xi Payi to the west of the solid gum medicines of the Xi Payi
The form of at least one of paste is provided.Thus, the existing commercially available solid gum mixture of dimension medicine Xi Payi is utilized, you can treatment Cuo
Sore, meanwhile, relative to the medicine of some existing treatment acnes, the therapeutic effect of the medicine is good, especially, to Cuo caused by acne
Sore Propionibacterium, significantly inhibits effect, also, the toxic side effect of the medicine is small.
After above-mentioned material has been understood, below in conjunction with specific embodiments, to a kind of solid gum medicines of Xi Payi of the invention
Thing and its application in Retinoids, Retin-A, Renova, Accutane is prepared are further described in detail：
One embodiment
Embodiment 1.
The purified water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；To nutgall
20g Mint Essence, 2g honey element, 4g sodium benzoate is added in decocting liquid, is stirred, the solid gum medicines of get Xi Payi.
Xi Payi is consolidated into gum medicine and propellant is filled into aerosol bottle, the solid gum medicines of Xi Payi of aerosol-type are obtained；
Xi Payi is consolidated into gum medicine to be filled into aerosol container, the solid gum medicines of Xi Payi of spray-type are obtained.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Zhang, female, 20 years old, first visit time：On May 6th, 2016, face acnes are I degree of acne, are sprayed using said medicine
To affected part, containing gallic acid 10.0mg in the solid gum medicines of Xi Payi of unit dose, 3 times/day, further consultation in 4 days, face almost without
Acne.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is mixture, the solid gum medicines of aerosol-type and spray-type Xi Payi can be made, medicine can directly arrive work
With position or absorption site, action speed is fast, and drug pack is in closed container, can keep cleaning and germ-free condition,
Reduce the contaminated chance of medicine.Further, since container is opaque, lucifuge is not contacted directly with the oxygen and moisture in air,
Therefore be conducive to improving the stability of medicine.The solid gum medicines of Xi Payi described in the embodiment of the present invention contain nutgall, and composition is simple,
Toxic side effect is small, can effectively treat acne, and can be prepared into the medicine for the treatment of acne.
Embodiment 2.
The clear water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；Filtrate is concentrated
To the medicinal extract that relative density is 1.2-1.3, by medicinal extract, 200g glycerine, 4g menthol, 2g sorbic acid and 50g poly- second
Glycol, is made ointment, the solid gum medicines of get Xi Payi.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Mr. Wang, male, 27 years old, first visit time：On December 6th, 2016, face acnes are II degree of acne, and said medicine is smeared
To affected part, gallic acid 3.0mg is contained in the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 5 days, face substantially subtracts
Gently.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is ointment, medicament plaster is rapid-action on skin；And the solid gum medicines of Xi Payi described in the embodiment of the present invention
Containing nutgall, composition is simple, and toxic side effect is small, can effectively treat acne.
Embodiment 3.
The clear water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；Filtrate is concentrated
To the medicinal extract that relative density is 1.2-1.3, the glycerin monostearate of 10g borneol, 25g glycerine and 60g is added into medicinal extract,
Cream, the solid gum medicines of get Xi Payi is made.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
2g ethylparaben is added into the solid gum medicines of above-mentioned Xi Payi, cream is made, the medicine of acne must be treated.
Contain gallic acid 0.001-20.0mg in the treatment acne of unit dose.
Model case：
Ma, female, 33 years old, first visit time：On September 5th, 2016, neck acne is I degree of acne, by above-mentioned treatment acne
Medicine be applied in affected part, the medicine of the treatment acne of unit dose containing gallic acid 0.001mg, 3 times/day, 8 days are multiple
Examine, neck is clearly better.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is ointment, medicament plaster is rapid-action on skin；And the solid gum medicines of Xi Payi described in the embodiment of the present invention
Containing nutgall, composition is simple, and toxic side effect is small, can effectively treat acne, and can be prepared into the medicine for the treatment of acne.
Embodiment 4.
The clear water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Liquid is prepared into dry extract and is ground into fine powder, obtains extract powder；The ethylparaben of extract powder, 50g glycerine and 1g is mixed and stirred
Mix uniform, be tuned into pasty state, the solid gum medicines of Xi Payi of paste type are made.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Mr. Li, female, 25 years old, first visit time：On October 15th, 2016, neck acne is I degree of acne, by above-mentioned treatment Cuo
The medicine of sore is applied in affected part, the medicine of the treatment acne of unit dose containing gallic acid 0.05mg, and 3 times/day, 5 days multiple
Examine, neck is almost without acne.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is paste, medicament plaster is on skin and is kept for the long period, rapid-action；And the west described in the embodiment of the present invention
Handkerchief contains nutgall according to solid gum medicine, and composition is simple, and toxic side effect is small, can effectively treat acne.
Embodiment 5.
The clear water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Liquid is dried, and obtains nutgall decocting liquid dried powder；Nutgall decocting liquid dried powder and 50g starch are well mixed, and are made powder,
The solid gum medicines of get Xi Payi.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Party, man, 28 years old, first visit time：On June 27th, 2016, face acnes are I degree of acne, by above-mentioned treatment acne
Medicine stick in affected part, the medicine of the treatment acne of unit dose containing gallic acid 1.0mg, 3 times/day, further consultation in 8 days,
Face is almost without acne.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is powder, medicine can take orally, can also external application；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain
There is nutgall, composition is simple, and toxic side effect is small, can effectively treat acne.
Embodiment 6.
The clear water that 100g nutgall adds 4000g is decocted 2 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Gel, the solid gum medicines of get Xi Payi is made in liquid, 300g xanthans, 6g Mint Essence and 2g sodium benzoate.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
It is high certain, man, 32 years old, first visit time：On July 21st, 2016, face acnes are II degree of acne, by above-mentioned treatment acne
Medicine be applied in affected part, the medicine of the treatment acne of unit dose containing gallic acid 3.0mg, 3 times/day, further consultation in 5 days,
It is facial substantially to mitigate.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is gel, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain
Nutgall, composition is simple, and toxic side effect is small, can effectively treat acne.
Embodiment 7.
The clear water that 100g nutgall adds 4000g is decocted 2 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Lotion, the solid gum medicines of get Xi Payi is made in liquid, 400g purified water and 0.5g sodium benzoates.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
20g ethanol is added into the solid gum medicines of above-mentioned Xi Payi, the medicine of the treatment acne of lotion is made；Unit dose
Treat and contain gallic acid 0.001-20.0mg in acne.
Model case：
Tan, man, 35 years old, first visit time：On April 20th, 2016, face acnes are I degree of acne, use above-mentioned treatment Cuo
Smeared outside the medicine of sore, containing gallic acid 20.0mg in the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 4 days, face
Almost without acne.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is lotion, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain not
Infanticide, composition is simple, and toxic side effect is small, can effectively treat acne, can be also used for preparing the medicine for the treatment of acne.
Embodiment 8.
The clear water that 100g nutgall adds 4000g is decocted 2 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Liniment, the solid gum medicines of get Xi Payi is made in liquid, 500g ethanol, 4g Mint Essence and 2g sodium benzoate.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Liu so-and-so, female, 34 years old, first visit time：On May 18th, 2016, face acnes are II degree of acne, use above-mentioned treatment
Containing gallic acid 10.0mg in the medicine of acne, the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 8 days, face is bright
It is aobvious to take a turn for the better.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is liniment, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain not
Infanticide, composition is simple, and toxic side effect is small, can effectively treat acne, can be also used for preparing the medicine for the treatment of acne.
Embodiment 9.
The clear water that 100g nutgall adds 4000g is decocted 1.5 hours, filtering obtains nutgall decocting liquid；Nutgall is decocted
Liquid is prepared into dry extract and is ground into fine powder, obtains extract powder；The ethylparaben of extract powder, 50g glycerine and 1g is mixed and stirred
Mix uniform, be tuned into pasty state, obtain pasty medicament；The pasty medicament of one unit dose is applied on medical non-woven fabrics, heating is dried
After dry, protective layer is capped, the solid gum medicines of Xi Payi of patch type are made.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Poplar, man, 28 years old, first visit time：On July 19th, 2016, face acnes are I degree of acne, use above-mentioned treatment Cuo
Containing gallic acid 5.0mg in the drug external of sore, the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 4 days, face
Almost without acne.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is patch, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain not
Infanticide, composition is simple, and toxic side effect is small, can effectively treat acne, can be also used for preparing the medicine for the treatment of acne.
Embodiment 10.
The clear water that 100g nutgall adds 4000g is decocted 2 hours, filtering obtains nutgall decocting liquid；By nutgall decocting liquid
Powder is dried to, drug powder is obtained；After the ethanol of drug powder, 0.5g ethylparaben and 50g is well mixed, add
50ml purified water, is made the solid gum medicines of Xi Payi for applying formulation.
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum medicine is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Chen, female, 26 years old, first visit time：On August 29th, 2016, face acnes are II degree of acne, use above-mentioned treatment Cuo
The medicine of sore is applied outside, containing gallic acid 3.0mg in the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 8 days, face
Acne substantially mitigates.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is paint, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain not
Infanticide, composition is simple, and toxic side effect is small, can effectively treat acne, can be also used for preparing the medicine for the treatment of acne.
Embodiment 11.
The solid gum liquid of Xi Payi is prepared according to technical method disclosed in those skilled in the art.
Contain gallic acid 0.001-20.0mg in the solid gum liquid of the Xi Payi of above-mentioned unit dose.
Above-mentioned Xi Payi, which consolidates in the medicine that gum liquid is treatment acne, the treatment acne of unit dose, contains gallic acid
0.001-20.0mg。
Model case：
Mr. Wang, man, 25 years old, first visit time：On November 6th, 2016, face acnes are II degree of acne, solid using Xi Payi
Gum liquid is applied outside, containing gallic acid 1.0mg in the medicine of the treatment acne of unit dose, 3 times/day, further consultation in 5 days, and face is substantially
Take a turn for the better.
The solid gum medicines of a kind of Xi Payi described in the present embodiment and its application in Retinoids, Retin-A, Renova, Accutane is prepared, Xi Payi
Gu gum medicine is paint, rapid-action by percutaneous drug delivery；And the solid gum medicines of Xi Payi described in the embodiment of the present invention contain not
Infanticide, composition is simple, and toxic side effect is small, can effectively treat acne, can be also used for preparing the medicine for the treatment of acne.
Two experiment tests
1st, experiment material
Instrument：Constant temperature biochemical cultivation case；Digital display gas bath constant temperature oscillator；Pressure steam sterilizer；Electronic balance；Anaerobism
Box；Nephelometer.
Reagent and medicine：Agar, Anaerobic indicator, propionibacterium acnes freezes bacterial strain reference culture, the solid gum medicines of Xi Payi
Thing (i.e. embodiment 1).Acne ointment, Guizhou Baihua Pharmaceutical Co., Ltd.
2nd, experimentation
2.1 method for preparation of drug：
2.1.1 Xi Payi consolidates gum liquid：
Using tube dilution method.The solid gum medicines of Xi Payi are adjusted to equivalent to crude drug concentration 160mg/mL, taking 11 sterilizings
Test tube adds nutrient broth 1.0mL, pipettes the solid gum medicine 1mL of Xi Payi, adds in the 1st pipe, 1mL is taken after being fully mixed evenly,
The 2nd pipe is added, by that analogy, therefrom takes 1mL to discard during to the 10th test tube, any medicine is not added with last root test tube, only
As medium controls, dilution ratio and relative medicine content are shown in Table 1.
The solid gum liquid diluted concentrations of the Xi Payi of table 1
| Test tube | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
| Drug dilution ratio | 1:2 | 1:4 | 1:8 | 1:16 | 1:32 | 1:64 | 1:128 | 1:256 | 1:512 | 1:1024 | - |
| Content of dispersion (mg/ml) | 80 | 40 | 20 | 10 | 5 | 2.5 | 1.25 | 0.65 | 0.325 | 0.163 | - |
2.1.2 comparison medicine compound method：
Using tube dilution method.Acne ointment is adjusted to concentration 160mg/mL, takes 11 sterilizing test tubes to add nutrient broth
1.0mL, pipettes acne ointment solution 1mL, adds in the 1st pipe, and 1mL is taken after being fully mixed evenly, and adds the 2nd and manages, by that analogy,
Therefrom take 1mL to discard during to the 10th test tube, be not added with any medicine in last root test tube, be only used as medium controls, it is dilute
Release ratio and relative medicine content is shown in Table 2.
The acne ointment diluted concentration of table 2.
| Test tube | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
| Drug dilution ratio | 1:2 | 1:4 | 1:8 | 1:16 | 1:32 | 1:64 | 1:128 | 1:256 | 1:512 | 1:1024 | - |
| Content of dispersion (mg/ml) | 80 | 40 | 20 | 10 | 5 | 2.5 | 1.25 | 0.65 | 0.325 | 0.163 | - |
The recovery of 2.2 propionibacterium acneses and the preparation of bacteria suspension
115 DEG C of autoclaving 15min of agar medium pour plate, are used as lyophilized bacterial strain recovery flat board.In microbial limit room,
By whole thalline suspensions, transplant in being placed in after agar medium, horizontal sliding in Anaerobic culturel box, 37 DEG C of Anaerobic culturel 48h, picking list
The individual bacterium colony that grows is to broth bouillon.
2.3 colony counting
The bacteria suspension 1mL being already equipped with is extracted, is added in test tubes of the 9mL equipped with physiological saline, it is possible to diluted
10 times of bacterium solution.1mL is pipetted into 9mL physiological saline from the bacteria suspension for diluting 10 times, so as to obtain the bacterium of 100 times of dilution
Liquid.By that analogy, dilute successively, until obtaining the bacterium solution of 1010 times of dilution, therefrom respectively pipette 0.5,1mL to plating medium
On, then even spread, 37 DEG C of Anaerobic culturel 48h count to the bacterium colony of growth, make the growth standard curve of bacterium.
Bacterial concentration is adjusted to 106, it is stand-by.
2.4 drug sensitive test：The above-mentioned fresh configuration μ L of bacterium solution 100 are added in every pipe with the quantitative sample loading guns of 100 μ L, are shaken up,
Plus 2-3mL atoleines, it is placed in 37 DEG C of constant temperature oscillators and cultivates 48h, observes result.
2.5 result judgement：After constant temperature oscillator culture 48h, often pipe draws the inoculation of 0.5mL suspensions, pours plate, is placed in 37 DEG C
48h is cultivated in constant temperature, anaerobic environment, flat board is placed on no-reflection, dark-coloured body surface and observes whether each flat board has bacterium
Fall to produce, this method can exclude the infection that Chinese medicine color bathozone is come, can intuitively observe experimental result.Testing
The drug concentration of the growth of acne skin bacillus can be completely inhibited in journey, for the minimum antibacterial medicines concentration (MIC) to bacterium,
Above experimental procedure is repeated 3 times.
3rd, result
Table 3
| Test tube | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
| The solid gum medicines of Xi Payi | — | — | — | — | — | — | — | + | + | + | + |
| Acne ointment | — | — | — | — | — | + | + | + | + | + | + |
Note："-" represents to have no the bacterium colony of propionibacterium acnes, and "+" represents the bacterium colony it is observed that propionibacterium acnes.
Observation has bacterium colony generation in blank control test tube, has no that other bacterium in the visual field, are not contaminated.The solid gums of Xi Payi
Medicine and acne ointment are shown in Table 3 to the MI of propionibacterium acnes.As a result show the solid gum liquid of Xi Payi in concentration as little as 0.65mg/
During mL, flat board visible propionibacterium acnes bacterium colony during higher than this concentration, is showed no propionibacterium acnes bacterium colony, illustrates Xi Payi
Gu gum liquid has in good inhibiting effect, erythromycin lactobionate culture plate to the Main Pathogenic Bacteria propionibacterium acnes of acne
Have no the bacterium colony of propionibacterium acnes.And comparison medicine acne ointment then just has inhibitory action in 5mg/ml.
4. conclusion
The solid each dosage of gum extract of Xi Payi (80,40,20,5,2.5,1.25mg/ml) group shown to acne propionic acid bar
The inhibitory action of bacterium, effect is better than reference product acne ointment.In addition, the present inventor is used by Xinjiang Qi Kanghabowei
The solid gum liquid of the commercially available Xi Payi of medicine company limited by shares carries out above-mentioned experiment, and result of the test and the solid gum extracts of Xi Payi are real
Test result consistent.
It is described above, only it is the preferred embodiment of the embodiment of the present invention, not makees any shape to the embodiment of the present invention
Limitation in formula, according to the embodiment of the present invention technical spirit above example is made any simple modification, equivalent variations
With modification, in the range of still falling within technical scheme of the embodiment of the present invention.
Claims (9)
1. the solid gum medicines of a kind of Xi Payi, it is characterised in that the solid gum medicines of the Xi Payi are included：Nutgall.
2. the solid gum medicines of Xi Payi according to claim 1, it is characterised in that wherein,
The solid gum medicines of the Xi Payi also contain pharmaceutically acceptable auxiliary material；
Wherein, the auxiliary material be gelatum skeleton material, NMF, preservative, penetrating agent, flavouring, antioxidant, emulsifying agent,
One or more in surfactant, propellant, thickener, ethanol and purified water.
3. the solid gum medicines of Xi Payi according to claim 1, it is characterised in that wherein,
Contain gallic acid 0.001-20.0mg in the solid gum medicines of the Xi Payi of unit dose.
4. the solid gum medicines of Xi Payi according to claim 2, it is characterised in that wherein,
The formulation of the solid gum medicines of the Xi Payi is powder, liniment, mixture, gel, lotion, paint, ointment, cream,
One kind in paste, patch, aerosol and spray.
5. the solid gum medicines of Xi Payi according to claim 4, it is characterised in that wherein,
The formulation of the solid gum medicines of the Xi Payi is one kind in mixture and ointment.
6. solid applications of the gum medicine in Retinoids, Retin-A, Renova, Accutane is prepared of any one of the claim 1-5 Xi Payi.
7. application according to claim 6, it is characterised in that wherein,
Contain gallic acid 0.001-20.0mg in the medicine of the treatment acne of unit dose.
8. application according to claim 7, it is characterised in that wherein,
It is described treatment acne medicine formulation for powder, liniment, mixture, gel, lotion, paint, ointment, cream,
One kind in paste, patch, aerosol and spray.
9. application according to claim 8, it is characterised in that wherein,
The formulation of the medicine of the treatment acne is one kind in mixture and ointment.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448575A (en) * | 2019-09-09 | 2019-11-15 | 新疆奇沐医药研究院（有限公司） | Xi Payi consolidates application of the gum drug in preparation treatment diabetic foot ulcer drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102590435A (en) * | 2012-03-05 | 2012-07-18 | 新疆奇康哈博维药有限公司 | Xipayi mouth rinse quality detection method |
| CN105592892A (en) * | 2011-12-21 | 2016-05-18 | 高露洁-棕榄公司 | Compositions comprising gallates and gallamides |
| CN105640994A (en) * | 2016-02-01 | 2016-06-08 | 新疆奇康哈博维药股份有限公司 | Method for preparing active polyphenol from xipayi mouth rinse decoction dregs |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105592892A (en) * | 2011-12-21 | 2016-05-18 | 高露洁-棕榄公司 | Compositions comprising gallates and gallamides |
| CN102590435A (en) * | 2012-03-05 | 2012-07-18 | 新疆奇康哈博维药有限公司 | Xipayi mouth rinse quality detection method |
| CN105640994A (en) * | 2016-02-01 | 2016-06-08 | 新疆奇康哈博维药股份有限公司 | Method for preparing active polyphenol from xipayi mouth rinse decoction dregs |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448575A (en) * | 2019-09-09 | 2019-11-15 | 新疆奇沐医药研究院（有限公司） | Xi Payi consolidates application of the gum drug in preparation treatment diabetic foot ulcer drug |
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Address after: 830000 Yinteng Street, North District, Urumqi High-tech Zone, Xinjiang Uygur Autonomous Region, 1375 Applicant after: XINJIANG QIMU PHARMACEUTICAL RESEARCH INSTITUTE (Co.,Ltd.) Address before: 830000 the Xinjiang Uygur Autonomous Region Urumqi hi tech Zone (new urban area) Yingbin Road No. 625 Applicant before: XINJIANG QIKANG HABOWEI MEDICAL RESEARCH INSTITUTE (Co.,Ltd.) |
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Application publication date: 20171003 |