CN107213244A - It is a kind of to help to treat chewable tablets of bleeding gums and preparation method thereof - Google Patents
It is a kind of to help to treat chewable tablets of bleeding gums and preparation method thereof Download PDFInfo
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- CN107213244A CN107213244A CN201710501771.2A CN201710501771A CN107213244A CN 107213244 A CN107213244 A CN 107213244A CN 201710501771 A CN201710501771 A CN 201710501771A CN 107213244 A CN107213244 A CN 107213244A
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- chewable tablets
- bleeding gums
- honeysuckle
- chrysanthemum
- chinese medicine
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- 230000000740 bleeding effect Effects 0.000 title claims abstract description 32
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 26
- 241001113925 Buddleja Species 0.000 claims abstract description 22
- 241000218982 Populus nigra Species 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 19
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 18
- 241000723353 Chrysanthemum Species 0.000 claims abstract description 18
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 18
- 239000004615 ingredient Substances 0.000 claims abstract description 14
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 13
- 229920002472 Starch Polymers 0.000 claims abstract description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 8
- 229930006000 Sucrose Natural products 0.000 claims abstract description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 8
- 239000008107 starch Substances 0.000 claims abstract description 8
- 235000019698 starch Nutrition 0.000 claims abstract description 8
- 239000005720 sucrose Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 3
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 abstract description 26
- 208000034158 bleeding Diseases 0.000 abstract description 26
- 230000000694 effects Effects 0.000 abstract description 12
- 208000024891 symptom Diseases 0.000 abstract description 8
- 238000011282 treatment Methods 0.000 abstract description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000000840 anti-viral effect Effects 0.000 abstract description 2
- 206010006514 bruxism Diseases 0.000 abstract description 2
- 229910052791 calcium Inorganic materials 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 abstract description 2
- 230000000857 drug effect Effects 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 206010044029 Tooth deposit Diseases 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 244000267222 Brasenia schreberi Species 0.000 description 1
- 235000006506 Brasenia schreberi Nutrition 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of chewable tablets for helping to treat bleeding gums, including following component：Traditional Chinese medicine ingredients, magnesium stearate, sucrose, starch and calcium carbonate；Traditional Chinese medicine ingredients are chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae.The present invention's contributes to the chewable tablets for the treatment of bleeding gums, using clearing heat and detoxicating chrysanthemum and honeysuckle as primary raw material, it is aided with the good radix glycyrrhizae of antibacterial, antiviral effect, and the Lindley Butterflybush Herb with dispelling wind and eliminating dampness effect and Lombardy poplar again, the symptom of bleeding gums can be just eased in the short time；And the main component of the chewable tablets is chrysanthemum and honeysuckle, the effect with fresh breath；Adding calcium carbonate not only has grinding tooth surface, strengthens the effect of drug effect, and has calcium supplementing effect concurrently, is particularly suitable for minor and takes.
Description
Technical field
The present invention relates to health product technology field, more particularly to a kind of chewable tablets and its system for helping to treat bleeding gums
Preparation Method.
Background technology
Bleeding gums are one of department of stomatology common symptons, refer to gum it is spontaneous or due to a small amount of caused by minimal irritation
Bleed.The trace of blood is carried in saliva when the lighter shows as only sucking, brushes teeth, chews harder food, severe one is in gum by slight
It is that bleeding is more or even hematostaxis during stimulation.In general, the chronic inflammation of gum is the common cause of bleeding gums, therefore
Bleeding gums are more common in periodontitis and gingivitis patients；But can also be the oral appearance of some systemic diseases sometimes, at this moment
It should give enough attention.
Issued by Asia dental aesthetics association《2014 oral health white paper and dental health guide handbook》It has been shown that, mistake
Sixty percent 6 ages virgin Primary Caries, teen-age caries prevalence rate is also close to three one-tenth within 12 years old.One of omen symptom as periodontitis, gum
The situation of bleeding is also very universal.Domestic oral health epidemiological survey data shows, 12 years old teenager's bleeding gums recall rate
It is 77.3% for the recall rate of 57.7%, 35-44 Sui a middle-aged person's bleeding gums, dental calculus recall rate is 97.3%, there is the tooth of dental calculus per capita
Number is 21.87；The periodontal health rate of 65-74 Sui the elderly is 14.1%, and the recall rate of bleeding gums is 68.0%.
Teenager carries out long-term treatment, traditional western medicine therapy due to learning tasks weight without time system to hospital
Easily recurrence, and Chinese medicine is bitter, therefore be necessary to study a kind of suitable teenager's long-term taking contribute to treatment bleeding gums
Chewable tablets.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide it is a kind of contribute to treat bleeding gums chewable tablets and its
Preparation method.
Technical scheme is as follows：
A kind of chewable tablets for helping to treat bleeding gums, including following component：Traditional Chinese medicine ingredients, magnesium stearate, sucrose, starch and
Calcium carbonate.
It is preferred that, described contributes to the chewable tablets for the treatment of bleeding gums, includes the composition of following percentage by weight：Chinese medicine
Composition 2-8%, magnesium stearate 1-2.5%, sucrose 35-50%, starch 12-20% and calcium carbonate surplus.
It is preferred that, described traditional Chinese medicine ingredients, including following component：Chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae.
It is preferred that, described traditional Chinese medicine ingredients include the composition of following percentage by weight：Chrysanthemum 65-75%, honeysuckle 8-
15%th, Lombardy poplar 2-5%, Lindley Butterflybush Herb 1-3% and radix glycyrrhizae surplus.
Lindley Butterflybush Herb dispelling wind and eliminating dampness, it is relieving cough and reducing sputum, dissipate the stasis of blood, desinsection.Bronchitis, cough, asthma, rheumatic arthritis is fallen
Play damage；Traumatic bleeding, burn and scald are controlled in external application, and are used as to kill maggot and are gone out wriggler.The difference of Lindley Butterflybush Herb and other Chinese medicines is nothing
It need to take orally, it is evident in efficacy after brushing teeth, after addition Lindley Butterflybush Herb is ground together with silica to tooth in the present invention, there is certain
The effect of dispelling wind and eliminating dampness, contributes to hemostasis.
Lombardy poplar cures mainly rheumatalgia pain, and tinea pedis swells：Bark is steep in wine clothes.With removing pattogenic heat from the blood and toxic material from the body；Effect of dispelling wind and eliminating dampness, equally
It is evident in efficacy after brushing teeth without for oral administration.
A kind of preparation method for helping to treat the chewable tablets of bleeding gums, comprises the following steps：
A, chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae weighed in proportion；
B, the method that chrysanthemum, honeysuckle and radix glycyrrhizae are respectively adopted into supercritical fluid extraction are extracted, and using spray drying
Mode obtain extract；
C, Lombardy poplar and Lindley Butterflybush Herb crushed, and ground repeatedly after it is mixed with calcium carbonate, crossed 200 mesh sieves, obtain under sieve
Thing；
D, the screenings in the extract in step B, step C and remaining raw material are mixed after tabletting, you can.
The present invention is advantageous in that：The present invention's contributes to the chewable tablets for the treatment of bleeding gums, with clearing heat and detoxicating
Chrysanthemum and honeysuckle are primary raw material, then are aided with the good radix glycyrrhizae of antibacterial, antiviral effect, and with the liquor-saturated of dispelling wind and eliminating dampness effect
Water shield and Lombardy poplar, can just be eased in the short time to the symptom of bleeding gums；And the main component of the chewable tablets is
Chrysanthemum and honeysuckle, the effect with fresh breath；Adding calcium carbonate not only has grinding tooth surface, strengthens the effect of drug effect, and
And have calcium supplementing effect concurrently, it is particularly suitable for minor and takes.
Embodiment
The application principle of the present invention is explained in detail with specific embodiment below.
Embodiment 1
A kind of chewable tablets for helping to treat bleeding gums, includes the composition of following percentage by weight：Traditional Chinese medicine ingredients 5%, tristearin
Sour magnesium 2.2%, sucrose 45%, starch 18% and calcium carbonate surplus.
Described traditional Chinese medicine ingredients, include the composition of following percentage by weight：Chrysanthemum 72%, honeysuckle 10%, Lombardy poplar
4%th, Lindley Butterflybush Herb 2% and radix glycyrrhizae surplus.
Embodiment 2
A kind of chewable tablets for helping to treat bleeding gums, includes the composition of following percentage by weight：Traditional Chinese medicine ingredients 2%, tristearin
Sour magnesium 2.5%, sucrose 35%, starch 20% and calcium carbonate surplus.
Described traditional Chinese medicine ingredients, include the composition of following percentage by weight：Chrysanthemum 65%, honeysuckle 15%, Lombardy poplar
2%th, Lindley Butterflybush Herb 3% and radix glycyrrhizae surplus.
Embodiment 3
A kind of chewable tablets for helping to treat bleeding gums, includes the composition of following percentage by weight：Traditional Chinese medicine ingredients 8%, tristearin
Sour magnesium 1%, sucrose 50%, starch 12% and calcium carbonate surplus.
Described traditional Chinese medicine ingredients, include the composition of following percentage by weight：Chrysanthemum 75%, honeysuckle 8%, Lombardy poplar 5%,
Lindley Butterflybush Herb 1% and radix glycyrrhizae surplus.
Contribute to the preparation method of the chewable tablets for the treatment of bleeding gums above, comprise the following steps：
A, chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae weighed in proportion；
B, the method that chrysanthemum, honeysuckle and radix glycyrrhizae are respectively adopted into supercritical fluid extraction are extracted, and using spray drying
Mode obtain extract；
C, Lombardy poplar and Lindley Butterflybush Herb crushed, and ground repeatedly after it is mixed with calcium carbonate, crossed 200 mesh sieves, obtain under sieve
Thing；
D, the screenings in the extract in step B, step C and remaining raw material are mixed after tabletting, you can.
The using effect to chewable tablets carries out clinical trial below, obtains following test result.
Subject Population：There is bleeding gums, the patient 200 of halitosis symptom, the age is 12-18 Sui, is divided into 1 group of embodiment
With two groups of control group；Wherein every group male 50, women 50.
3 for each person every day, the usage amount of each chewable tablets is 3g；Control group：Spiramvcin is treated.
Treatment and detection time：Continuously using after 15 days, detect for the first time；It is continuous to use 1 month, disable, second of inspection
Survey.
Efficacy evaluation：
It is invalid：Symptom is without alleviation or DeGrain.
Effectively：Symptom is significantly alleviated, and effect is obvious.
Cure：Symptom disappears, recovery from illness.
Recurrence：During second of detection, detect that the patient effectively or cured repeats bleeding gums symptom for the first time.
Table 1：The therapeutic effect of embodiment 1
By above clinical detection result it is recognised that chewable tablets not only instant effect, the good effect, and when taking one section of the present invention
Between after, recurrence can be prevented, and traditional antibiotic therapy method is very easy to recurrence.
Comparative example 1
Lombardy poplar in embodiment 1 and Lindley Butterflybush Herb are removed.
Comparative example 2
Lombardy poplar in embodiment 1 is removed.
Comparative example 3
Lindley Butterflybush Herb in embodiment 1 is removed.
Clinical trial is carried out to embodiment 1 and comparative example 1-3 sample by the above process, test crowd total number of persons is 200
Example, the age is 12-18 Sui, is divided into 4 groups.
Table 2：The contrast therapeutic effect of embodiment 1 and comparative example 1-3
By above test data it is recognised that the therapeutic effect of Lombardy poplar and Lindley Butterflybush Herb to chewable tablets in the traditional Chinese medicine ingredients of the present invention
Influence is notable, and recurrence rate is also had a certain impact, and Lombardy poplar and Lindley Butterflybush Herb have cooperative effect.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (5)
1. a kind of chewable tablets for helping to treat bleeding gums, it is characterised in that including following component：Traditional Chinese medicine ingredients, stearic acid
Magnesium, sucrose, starch and calcium carbonate.
2. the chewable tablets as claimed in claim 1 for helping to treat bleeding gums, it is characterised in that including following weight percent
The composition of ratio：Traditional Chinese medicine ingredients 2-8%, magnesium stearate 1-2.5%, sucrose 35-50%, starch 12-20% and calcium carbonate surplus.
3. the as claimed in claim 1 or 2 chewable tablets for helping to treat bleeding gums, it is characterised in that described Chinese medicine into
Point, including following component：Chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae.
4. the as claimed in claim 1 or 2 chewable tablets for helping to treat bleeding gums, it is characterised in that described Chinese medicine into
Point, include the composition of following percentage by weight：Chrysanthemum 65-75%, honeysuckle 8-15%, Lombardy poplar 2-5%, Lindley Butterflybush Herb 1-3%
With radix glycyrrhizae surplus.
5. a kind of preparation method for helping to treat the chewable tablets of bleeding gums, it is characterised in that comprise the following steps：
A, chrysanthemum, honeysuckle, Lombardy poplar, Lindley Butterflybush Herb and radix glycyrrhizae weighed in proportion；
B, the method that chrysanthemum, honeysuckle and radix glycyrrhizae are respectively adopted into supercritical fluid extraction are extracted, and using spray drying
Mode obtain extract；
C, Lombardy poplar and Lindley Butterflybush Herb crushed, and ground repeatedly after it is mixed with calcium carbonate, crossed 200 mesh sieves, obtain under sieve
Thing；
D, the screenings in the extract in step B, step C and remaining raw material are mixed after tabletting, you can.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710501771.2A CN107213244B (en) | 2017-06-27 | 2017-06-27 | Chewable tablet beneficial to treatment of gingival bleeding and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710501771.2A CN107213244B (en) | 2017-06-27 | 2017-06-27 | Chewable tablet beneficial to treatment of gingival bleeding and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107213244A true CN107213244A (en) | 2017-09-29 |
| CN107213244B CN107213244B (en) | 2020-11-24 |
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ID=59951008
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| CN201710501771.2A Active CN107213244B (en) | 2017-06-27 | 2017-06-27 | Chewable tablet beneficial to treatment of gingival bleeding and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108142944A (en) * | 2017-12-29 | 2018-06-12 | 河南健特生物科技集团有限公司 | For alleviating chewable tablets of endogenous halitosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1038935A (en) * | 1989-07-05 | 1990-01-24 | 天津市轻工业化学研究所 | Jiekouye gargle |
| CN103520554A (en) * | 2013-10-28 | 2014-01-22 | 李金媛 | Oral care composition and preparation method thereof |
| CN105685869A (en) * | 2016-01-21 | 2016-06-22 | 安徽农业大学 | Dragon fruit stem chewable tablets and preparation method thereof |
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2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038935A (en) * | 1989-07-05 | 1990-01-24 | 天津市轻工业化学研究所 | Jiekouye gargle |
| CN103520554A (en) * | 2013-10-28 | 2014-01-22 | 李金媛 | Oral care composition and preparation method thereof |
| CN105685869A (en) * | 2016-01-21 | 2016-06-22 | 安徽农业大学 | Dragon fruit stem chewable tablets and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108142944A (en) * | 2017-12-29 | 2018-06-12 | 河南健特生物科技集团有限公司 | For alleviating chewable tablets of endogenous halitosis and preparation method thereof |
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