CN107184918A - It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof - Google Patents

It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof Download PDF

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CN107184918A
CN107184918A CN201710644316.8A CN201710644316A CN107184918A CN 107184918 A CN107184918 A CN 107184918A CN 201710644316 A CN201710644316 A CN 201710644316A CN 107184918 A CN107184918 A CN 107184918A
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chinese medicine
chinese
heart disease
medicine composition
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韩希典
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Abstract

The invention discloses a kind of Chinese medicine composition for treating coronary heart disease, prescription is in parts by weight：10 26 parts of Radix Codonopsis, 18 34 parts of oyster, 7 15 parts of chrysanthemum, 9 21 parts of Ligusticum wallichii, 10 24 parts of root tuber of aromatic turmeric, 7 13 parts of frankincense, 6 14 parts of bulbus fritillariae cirrhosae, 8 22 parts of Radix Angelicae Sinensis, 7 15 parts of peach kernel, 8 20 parts of the seed of Oriental arborvitae, 8 22 parts of moutan bark, 8 18 parts of barrenwort, 7 17 parts of safflower, 6 14 parts of Divine Comedy, 8 14 parts of radix glycyrrhizae.Chinese medicine of the present invention has that instant effect, cure rate are high, stress to nurse one's health, treat both principal and secondary aspect of disease, the technical advantage such as uneasy to recur；Also, the finished product preparation conveniently taken can also be made in the Chinese medicine in the case where ensureing drug effect, and preparation technology simplicity, efficacy stability, medication individual difference are small, application easy to spread, benefit more patients with coronary heart disease.

Description

It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for treating coronary heart disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Coronary cardiopathy (coronary artery heart disease, CHD) abbreviation coronary heart disease, is a kind of Most common heart disease, refers to because of caused by coronary artery stenosis, blood supply insufficiency myocardial dysfunction and (or) organic Lesion, therefore also known as ischemic cardiomyopathy (IHD).CHD is the result of a variety of coronary artery diseases, but coronary atherosclerosis is accounted for Exhausted big (95% -99%) of coronary cardiopathy is most, therefore, coronary cardiopathy is traditionally considered as hat Shape atherosclerotic heart (coronary atherosclerotic heart disease) synonym.
Modern medicine is under the guidance of this theory, and the treatment means to heart disease class disease are broadly divided into two classes：One is Include expansion blood vessel class medicine and the molten lipid drug of thrombolysis using medicine；Two be support, bypass surgery.In the treatment of coronary heart disease In, intervention operation and bypass surgery belong to invasive treatment, while postoperative complication has a strong impact on the healthy of patient.This A little methods are effective particularly in the rescue sexual stage to the treatment of cardiac, and blood vessel can not be but solved from source The rubbish such as inner lipid precipitate to form new patch again, cause blood vessel restenosis, blocking, the not smooth old disease recurrence of myocardial blood supply Problem, at the same have the shortcomings that cost is high, cure the symptoms, not the disease, therapeutic process it is complicated.
The disease is generally insufficiency of vital energy and blood, and negative and positive virtual loss, qi deficiency to blood stasis, phlegm stagnation in collateral etc. causes.Clinical manifestation is common not enough and Deficient disease.Therefore, with multi-purpose tonifying Qi and blood during treatment by Chinese herbs, nourishment for vitality etc rule treatment." strengthening vital QI to eliminate pathogenic factors " principle Under guidance, the factor that first excision induces, aggravated, the sufferer of radical cure itself.Eliminating evil is warming heart yang with promoting blood circulation and removing blood stasis, slit phlegm dredging collateral, The wide chest of qi-regulating, dampness elimination dredging collateral is removed based on phlegm heat.
The content of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of coronary heart disease for the treatment of has the Chinese medicine composition of better effects.
In order to solve the technical problem, the solution of inventor is the characteristics of combining modern pharmaceutical technique, to have invented one Individual Chinese prescription, both meets the requirement for the treatment of coronary heart disease, finished product preparation can be made using the preparation technology specially developed again. The Chinese prescription is made up of the Chinese medicine of following parts by weight：
10-26 parts of Radix Codonopsis, 18-34 parts of oyster, 7-15 parts of chrysanthemum, 9-21 parts of Ligusticum wallichii, 10-24 parts of root tuber of aromatic turmeric, 7-13 parts of frankincense, tendril-leaved fritillary bulb Female 6-14 parts, 8-22 parts of Radix Angelicae Sinensis, 7-15 parts of peach kernel, 8-20 parts of the seed of Oriental arborvitae, 8-22 parts of moutan bark, 8-18 parts of barrenwort, safflower 7- 17 parts, 6-14 parts of Divine Comedy, 8-14 parts of radix glycyrrhizae.
It is following steps for the preparation technology that said preparation is specially developed：
（1）Each taste Chinese medicine is weighed by Chinese prescription of the present invention；
（2）By Radix Codonopsis, oyster, the Radix Astragali, frankincense, bulbus fritillariae cirrhosae, the bighead atractylodes rhizome, safflower, crush respectively, after mixing plus 6-10 times of weight it is dense Spend for 55-75% ethanol, soak 6-12 hour, backflow is decocted, extract 2 times, it is each 2-6 hour, filter, merging filtrate, depressurize Ethanol is distilled off, and is concentrated into the concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 7-10 times of weight is added afterwards, backflow is decocted three times, each 1-4 hours, filtering, merging filtrate is concentrated into 65 DEG C of phases It is standby to the concentrate that density is 1.20-1.25；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Gained Chinese medical concrete be made the Chinese medicine of clinical needs into Product preparation, the formulation such as granule, oral liquid, pill, capsule, syrup, tablet or powder.
The prescription analysis of Chinese prescription of the present invention：
Chinese prescription of the present invention be using oyster, Radix Codonopsis, Radix Angelicae Sinensis, the seed of Oriental arborvitae as monarch drug in a prescription, invigorating qi for strengthening superficies, stasis-dispelling and pain-killing, invigorate blood circulation, Tonifying middle-Jiao and Qi, nourishing liver and kidney；Using Ligusticum wallichii, root tuber of aromatic turmeric, moutan bark, barrenwort as ministerial drug, blood-activating and qi-promoting, The strong bone of kidney tonifying；With safflower, chrysanthemum Flower, peach kernel are adjutant, strengthening the spleen and replenishing qi, stasis eliminatings analgesic, scattered wind heat-clearing；Using frankincense, bulbus fritillariae cirrhosae, Divine Comedy as medicine is made, analgesic therapy is chased after poison, dissipated Stasis of blood analgesic, helps yang transforming qi；With radix glycyrrhizae coordinating the drug actions of a prescription, all medicines is cooperated, promote mutually, collective effect, so as to reach benefit The effects such as superficies-consolidating, promoting blood circulation and removing blood stasis, stasis-dispelling and pain-killing, invigorate blood circulation, there is significant therapeutic effect to coronary heart disease.
Compared with prior art, Chinese medicine of the present invention has instant effect, cure rate height, stresses to nurse one's health, treat both principal and secondary aspect of disease, be difficult again The technical advantages such as hair；Also, the finished product preparation conveniently taken can also be made in the Chinese medicine in the case where ensureing drug effect, and prepares Technique simplicity, efficacy stability, medication individual difference are small, application easy to spread, benefit more patients with coronary heart disease.
Embodiment
Embodiment 1
（1）Radix Codonopsis 1000g, oyster 1800g, chrysanthemum 700g, Ligusticum wallichii 900g, root tuber of aromatic turmeric 1000g, breast are weighed by Chinese prescription of the present invention Fragrant 700g, bulbus fritillariae cirrhosae 600g, Radix Angelicae Sinensis 800g, peach kernel 700g, seed of Oriental arborvitae 800g, moutan bark 800g, barrenwort 800g, safflower Each taste Chinese medicine such as 700g, Divine Comedy 600g, radix glycyrrhizae 800g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 2
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 2600g, oyster 3400g, chrysanthemum 1500g, Ligusticum wallichii 2100g, root tuber of aromatic turmeric 2400g, Frankincense 1300g, bulbus fritillariae cirrhosae 1400g, Radix Angelicae Sinensis 2200g, peach kernel 1500g, seed of Oriental arborvitae 2000g, moutan bark 2200g, barrenwort Each taste Chinese medicine such as 1800g, safflower 1700g, Divine Comedy 1400g, radix glycyrrhizae 1400g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 3
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 2600g, oyster 1800g, chrysanthemum 1500g, Ligusticum wallichii 2100g, root tuber of aromatic turmeric 1000g, It is frankincense 700g, bulbus fritillariae cirrhosae 1400g, Radix Angelicae Sinensis 800g, peach kernel 1500g, seed of Oriental arborvitae 800g, moutan bark 2200g, barrenwort 800g, red Each taste Chinese medicines such as flower 1700g, Divine Comedy 600g, radix glycyrrhizae 1400g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 4
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 2000g, oyster 2400g, chrysanthemum 1300g, Ligusticum wallichii 1700g, root tuber of aromatic turmeric 1500g, Frankincense 1100g, bulbus fritillariae cirrhosae 1100g, Radix Angelicae Sinensis 1400g, peach kernel 1200g, seed of Oriental arborvitae 1300g, moutan bark 1600g, barrenwort Each taste Chinese medicine such as 1200g, safflower 1100g, Divine Comedy 1100g, radix glycyrrhizae 1200g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 5
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 1800g, oyster 2600g, chrysanthemum 1100g, Ligusticum wallichii 1500g, root tuber of aromatic turmeric 1700g, Frankincense 1000g, bulbus fritillariae cirrhosae 1000g, Radix Angelicae Sinensis 1500g, peach kernel 1100g, seed of Oriental arborvitae 1400g, moutan bark 1500g, barrenwort Each taste Chinese medicine such as 1300g, safflower 1200g, Divine Comedy 1000g, radix glycyrrhizae 1100g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 6
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 1900g, oyster 2500g, chrysanthemum 1200g, Ligusticum wallichii 1600g, root tuber of aromatic turmeric 1600g, Frankincense 900g, bulbus fritillariae cirrhosae 900g, Radix Angelicae Sinensis 1400g, peach kernel 1200g, seed of Oriental arborvitae 1300g, moutan bark 1700g, barrenwort 1100g, Each taste Chinese medicine such as safflower 1000g, Divine Comedy 900g, radix glycyrrhizae 1100g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
Embodiment 7
（1）By Chinese prescription of the present invention weigh Radix Codonopsis 1800g, oyster 2800g, chrysanthemum 1200g, Ligusticum wallichii 1600g, root tuber of aromatic turmeric 1800g, Frankincense 1200g, bulbus fritillariae cirrhosae 1200g, Radix Angelicae Sinensis 1600g, peach kernel 1200g, seed of Oriental arborvitae 1500g, moutan bark 1500g, barrenwort Each taste Chinese medicine such as 1400g, safflower 1300g, Divine Comedy 1100g, radix glycyrrhizae 1200g；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 8 times of weight is added after mixing is 70% ethanol, Immersion 10 hours, backflow is decocted, and is extracted 2 times, 4 hours every time, filtering, merging filtrate, vacuum distillation removed ethanol, and is concentrated into The concentrate that 65 DEG C of relative densities are 1.20-1.25, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 9 times of weight is added afterwards, and backflow is decocted three times, and 2 hours every time, filtering, merging filtrate was concentrated into 65 DEG C of relative densities It is standby for 1.20-1.25 concentrate；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Granule is made in gained Chinese medical concrete, converts into crude drug 0.225g/g particles.
The animal toxicity of embodiment 8 is tested
1st, acute toxicity test
（1）Tested medicine：Granule obtained by 1-7 of the embodiment of the present invention, by 1:3 add purified water, and magma is made.
（2）Experimental animal：Regular grade NIH mouse, body weight 20g ± 5g, male and female half and half, female mice is without pregnant.
（3）The magma of mouse stomach Chinese herbal granules modulation, when given low reaches 642.5g crude drugs/kg dosage, gives There is light activity reduction in mouse after medicine, recovers within 1 hour or so normally, Continuous Observation 7 days after administration, none animal dead, its Overall health of patients, diet, to take the photograph water, urine and body weight increase normal.
（4）Result of the test shows：The maximum dosage-feeding of granule obtained by mouse stomach embodiment 1-7 for 642.5g crude drugs/ kg/d（LD50 ＞ 642.5g crude drugs/kg）.The daily clinical application total amount of Chinese medicine of the present invention is 0.15g crude drugs/kg/d to the maximum；Press Batheroom scale, the dosis tolerata of granule obtained by mouse stomach embodiment 1-7 is 4283.3 times of clinical patient.Point out the medicine acute poison Property it is extremely low, clinical application safety.
2nd, long-term toxicity test for animals
Medicine：Chinese herbal granules obtained by 1-7 of the embodiment of the present invention, by 1:3 add purified water, and magma is made.
Animal：Regular grade SD rats, body weight 220g ± 12g, male and female half and half, female rats are without pregnant.
Method and result：
（1）7 kinds of Chinese medicine magmas：High, medium and low three dosage groups are divided into, per weight dosage is respectively patient's dose 180th, 60,20 times；
（2）Experimental mouse is randomly divided into 22 groups, wherein the magma of 21 groups of difference gavages 6 kind, three dosage, remaining one group of gavage life Manage salt solution（60 times of patient's dose）；All 22 groups of equal continuous gavages 180 days, observation animal general toxic reaction and serious journey Degree, each position is checked after execution by operational procedure, and carries out hematology, and ALT, BUN and the heart, liver, spleen, lung, kidney, stomach etc. are main dirty The pathological examination of device；
（3）By long-term feeding, 22 groups of rats do not occur toxic reaction.Physically well develop.Macroscopic appearance and main organs have no It is abnormal.Peripheral hemogram and Serum ALT, BUN are compared no pathologic with control group and changed.The pathological replacement heart, liver, spleen, lung, kidney, stomach Change Deng not significant, it is therefore contemplated that through proved by pathology, 7 kinds of Chinese herbal granules are showed without chronic toxicity animal.
Pass through two above toxicity test, it was demonstrated that the present invention is safe, nothing by the embodiment 1-7 Chinese herbal granules made Toxic side effect, it can be taken by patient.
The clinical test of the Chinese herbal granules of the present invention of embodiment 9
1st, basic document is tested
Subject is provided by third party people hospital of certain city heart internal medicine, and from May, 2010 to 2 months 2014, the section office accept for medical treatment 522 patients with coronary heart disease, therefrom select 235 patients for being adapted to and being willing to participate in clinical test, wherein, man 135, year Age 41-68 Sui, female 100, age 40-66 Sui.
2nd, experiment packet
By subject with reference to factors such as age, sex, the courses of disease, 5 groups, every group of 47 people, male 27 people, the people of female 20 are divided into.This 4 Numbering is group respectively：Control group, experiment 1, experiment 2, experiment 3, experiment 4.
3rd, test drug
Comparison medicine：Isosorbide Mononitrate piece, Chinese medicines quasi-word H20093478, first sign medicine company.
Investigational agent：The granule of 4-7 of embodiment of the present invention productions（Equivalent crude drug 0.225g/g particles）.
4th, test method
The oral Isosorbide Mononitrate piece of control group, each 20mg, 2 times a day.Test group 1-4 distinguishes oral embodiment 4-7 lifes The granule of production, each 20g, 2 times a day.It is within 4 weeks a course for the treatment of, continuously treats and patient's body is recorded in 3 courses for the treatment of, therapeutic process Levy change, not body-feeling, reaction etc..
5th, test effect evaluation
Cure：Coronary heart disease related symptoms all disappear, and make a definite diagnosis and fully recovered through doctor；
Effectively：Coronary heart disease related symptoms partial disappearance makes moderate progress, it is still necessary to continual cure；
It is invalid：Coronary heart disease related symptoms do not have any improvement, even more seriously；
Adverse reaction：By in normal usage, the prevention of consumption drug application, diagnosis or treatment lysis, it there occurs and treatment mesh Unrelated adverse reaction.
6th, logging and analysis
（1）Characterize and compare after medication：Control group has 8 people to occur in that different degrees of dilatancy headache, flush, dizziness, straight The vertical adverse reaction such as property low blood pressure and reflex tachycardia；4 groups of test group are without 1 adverse reaction.Test group patient with Generally feel that qi and blood becomes vigorous, middle gas foot, body after one course for the treatment of of medicine spry and light, and control group patient does not have such sensation.
7th, conclusion (of pressure testing)
Result of the test shows that patient body is sensuously seen, Chinese herbal granules of the present invention have given full play to that Chinese herbal medicine specimen is simultaneous to be controlled, stress The technical advantage of conditioning.Test data analyzer shows that the average cure rate of test group is 65.4%, is 1.8 times of control group, experiment Group total effective rate is 95.2%, and higher than control group 12.2 percentage points, the adverse reaction rate of test group is zero, and control group is not Good reactivity is up to 17.0%.Therefore, compared with prior art, the present invention has very significant technology in terms of coronary heart disease is treated Advantage, obtains unexpected technique effect.

Claims (2)

1. a kind of Chinese medicine composition for treating coronary heart disease, it is characterised in that the Chinese prescription of the Chinese medicine composition is with parts by weight It is calculated as：10-26 parts of Radix Codonopsis, 18-34 parts of oyster, 7-15 parts of chrysanthemum, 9-21 parts of Ligusticum wallichii, 10-24 parts of root tuber of aromatic turmeric, 7-13 parts of frankincense, river 6-14 parts of fritillaria, 8-22 parts of Radix Angelicae Sinensis, 7-15 parts of peach kernel, 8-20 parts of the seed of Oriental arborvitae, 8-22 parts of moutan bark, 8-18 parts of barrenwort, safflower 7-17 parts, 6-14 parts of Divine Comedy, 8-14 parts of radix glycyrrhizae.
2. the preparation method of the Chinese medicine composition of the treatment coronary heart disease described in a kind of claim 1, it is characterised in that including following Processing step：
（1）Each taste Chinese medicine is weighed by Chinese prescription of the present invention；
（2）By Radix Codonopsis, oyster, frankincense, bulbus fritillariae cirrhosae, safflower, crush respectively, the concentration that 6-10 times of weight is added after mixing is 55-75% Ethanol, is soaked 6-12 hours, and backflow is decocted, and is extracted 2 times, each 2-6 hours, and filtering, merging filtrate, vacuum distillation removes second Alcohol, and the concentrate that 65 DEG C of relative densities are 1.20-1.25 is concentrated into, it is standby；
（3）Chrysanthemum, Ligusticum wallichii, root tuber of aromatic turmeric, Radix Angelicae Sinensis, peach kernel, the seed of Oriental arborvitae, moutan bark, barrenwort, Divine Comedy, radix glycyrrhizae are crushed respectively, mixed The purified water of 7-10 times of weight is added afterwards, backflow is decocted three times, each 1-4 hours, filtering, merging filtrate is concentrated into 65 DEG C of phases It is standby to the concentrate that density is 1.20-1.25；
（4）By step（2）With（3）In obtained concentrate merge, be well mixed, continue to be concentrated into 65 DEG C of relative densities be 1.30-1.35 thick paste, as Chinese medical concrete；
（5）Using modern general Chinese medicine composition technology, by step（4）Gained Chinese medical concrete be made the Chinese medicine of clinical needs into Product preparation.
CN201710644316.8A 2017-08-01 2017-08-01 It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof Pending CN107184918A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118021897A (en) * 2024-04-12 2024-05-14 山东新时代药业有限公司 Pharmaceutical composition and application thereof in medicines for treating coronary heart disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383115A (en) * 2014-11-27 2015-03-04 崔合芳 Traditional Chinese medicine preparation for treating coronary heart disease and preparation method of traditional Chinese medicine preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383115A (en) * 2014-11-27 2015-03-04 崔合芳 Traditional Chinese medicine preparation for treating coronary heart disease and preparation method of traditional Chinese medicine preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118021897A (en) * 2024-04-12 2024-05-14 山东新时代药业有限公司 Pharmaceutical composition and application thereof in medicines for treating coronary heart disease
CN118021897B (en) * 2024-04-12 2024-06-11 山东新时代药业有限公司 Pharmaceutical composition and application thereof in medicines for treating coronary heart disease

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Application publication date: 20170922