CN107184746A - It is a kind of to be used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis - Google Patents
It is a kind of to be used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis Download PDFInfo
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- CN107184746A CN107184746A CN201710377291.XA CN201710377291A CN107184746A CN 107184746 A CN107184746 A CN 107184746A CN 201710377291 A CN201710377291 A CN 201710377291A CN 107184746 A CN107184746 A CN 107184746A
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- extract
- pharmaceutical composition
- rush
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- herba lysimachiae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
It is used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis the invention discloses a kind of, described pharmaceutical composition is (2 4) by weight by rush extract and Herba Lysimachiae extract：1 composition.Present invention firstly discovers that, rush extract and Herba Lysimachiae extract are applied in combination can be with skin care, keep moisture of skin, Skin Itch in Uremia Patients can preferably be alleviated, avoid because of skin lesion caused by dry skin, the comfort level and quality of life of uraemic patients is improved, with clinical expansion use value.
Description
Technical field
It is used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis the present invention relates to a kind of, belongs to
Technical field of medicine.
Background technology
With the development and raising of the blood purification technologies such as haemodialysis, peritoneal dialysis, the time-to-live of uraemic patients
It is obviously prolonged.But the phenomenon of dry skin often occurs in the therapeutic process of uraemic patients' haemodialysis, uremia is suffered from
The reason for person's dry skin and sweat gland and sebaceous gland atrophy, sweat gland secretion be impaired etc. that reason is relevant.Because the exhaustion of renal function,
The due function of losing, such as balancing blood pressure, the internal excessive water of regulation, excludes a large amount of toxin, green blood, acid-base balance etc..
And blood dialysis can substantial amounts of dehydration, dialysis dehydration is that to take off moisture unnecessary in blood be not the water in belly, blood
Pipe will absorb moisture in fatty, muscle and skin again, add to again in the middle of blood so that uremic patient skin sebum
Gland and eccrine gland atrophy, secretion sweat and lipid are more normally reduced, and water content of stratum corneum is reduced.And the dehydration of keratoderma,
Drying can further result in secondary skin itch, and patient is extremely painful.At present, for the skin as caused by uremia haemodialysis
Skin is dried and there is no effective ameliorative way.
Rush (Medulla Junci), the stem marrow or herb of JUNCACEAE rush platymiscium rush.Existing research
Show：The effects such as rush has clearing heart fire, inducing diuresis for treating strangurtia, cures mainly heat gonorrhea, difficult urination, jaundice with damp-heat pathogen, aphthae etc..
Desmodium (Herba Lysimachiae) is the herb of Primulaceae Lysimachia plant Lysimachia christinae.Existing research
Show：Desmodium has effects that clearing heat and promoting diuresis, Tonglin Paishi, removing toxic substances, cures mainly liver, courage and calculi in urinary system.
But being not yet related to rush and desmodium at present improves the dry skin aspect as caused by uremia haemodialysis
Report.
The content of the invention
Carried it is an object of the invention to provide a kind of improvement medicine of dry skin as caused by uremia haemodialysis that is used for
Take thing.
To achieve the above object, the present invention uses following technical proposals：
The first aspect of the present invention is being prepared for improving by uremia there is provided rush extract and Herba Lysimachiae extract
Purposes in the medicine of dry skin caused by haemodialysis.
The rush extract is prepared from by the following method：
Rush is crushed, decocting after the water of 8-10 times of weight, 0.5~1h of immersion is added and boils 0.5~1h, filtering is left and taken
Clear liquid, obtains first supernatant, and the filter residue being filtrated to get repeats the above steps twice, obtains secondary supernatant and three supernatants
Liquid, merges described first supernatant, secondary supernatant and three supernatants and obtains total supernatant, total supernatant is by steaming
Hair concentration, adds absolute ethyl alcohol and mixes, filtering obtains clear liquid after removing precipitation, and the rotated evaporimeter of the clear liquid is distilled
Remove and reclaim ethanol, produce rush extract.
The Herba Lysimachiae extract is prepared from by the following method：
Desmodium is crushed, the mass concentration that 6-8 times of weight is added every time is 70% ethanol, is extracted 3 times at 60 DEG C,
1.5 hours for the first time, second and third time each 1 hour, and filtering, merging filtrate obtains ethanol extract；Ethanol extract is in vacuum
At 0.07-0.08MPa, 50-60 DEG C of temperature, the concentrate that relative density is 1.05-1.10 is concentrated into, ethanol, concentrate is reclaimed
Be extracted with ethyl acetate 3 times, for the first time plus 3 times of volumes ethyl acetate, the 2nd, 3 times respectively plus 2 times of volumes acetic acid second
Ester, obtains acetic acid ethyl acetate extract, and at vacuum 0.07-0.8MPa, 50-60 DEG C of temperature, ethyl acetate is recovered under reduced pressure, must stay
Thing, stays thing at vacuum 0.07-0.08MPa, 50-60 DEG C of temperature, is dried under reduced pressure, produces Herba Lysimachiae extract.
The second aspect of the present invention is used to improve the medicine of the dry skin as caused by uremia haemodialysis there is provided a kind of
Composition, described pharmaceutical composition is (2-4) by weight by above-mentioned rush extract and Herba Lysimachiae extract：1 composition.
It is preferred that, described pharmaceutical composition is 3 by weight by rush extract and Herba Lysimachiae extract：1 composition.
The preparation method of the rush extract and Herba Lysimachiae extract is ibid.
Above-mentioned pharmaceutical composition can also be combined with pharmaceutically acceptable auxiliary material is prepared into various pharmaceutical dosage forms, such as solidifying
Jelly, spray, lotion, emulsifiable paste/creme, powder etc..
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, preferably glycerine, butanediol, marine alga
One or more in sugar, glycine betaine, starch, sodium carboxymethylcellulose.
Beneficial effects of the present invention：
Present invention firstly discovers that, rush extract and Herba Lysimachiae extract are applied in combination and can be kept with skin care
Moisture of skin, can preferably alleviate Skin Itch in Uremia Patients, it is to avoid because of skin lesion caused by dry skin, improve uremia
The comfort level and quality of life of patient, with clinical expansion use value.
The present invention also determines the consumption proportion between rush extract and Herba Lysimachiae extract by substantial amounts of experiment,
Said composition is set to have played good synergy.Find that rush extract and desmodium carry by experimental study repeatedly
It is (2-4) to take the weight ratio between thing：Unexpected synergy can be further produced when 1, synergy substantially, is particularly
Weight ratio between rush extract and Herba Lysimachiae extract is 3：When 1, action effect is especially pronounced.
The present invention's is used in improvement pharmaceutical composition of dry skin as caused by uremia haemodialysis, each raw material group
It is an organic whole to divide, indispensable.Inventor has found in R＆D process, reduces any in aforementioned pharmaceutical compositions
A kind of raw material components, or the raw material components of pharmaceutical composition of the present invention are replaced with the bulk drug with the similar property of medicine, then
Pharmaceutical composition is integrally significantly reduced to the action effect of dry skin caused by uremia haemodialysis；In the medicine of the present invention
Other raw material components are further added by the basis of composition, the whole structure of pharmaceutical composition does not improve significantly, even
The situation for having the whole structure reduction of pharmaceutical composition occurs.
Embodiment
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The present invention is explained, its content is not defined.
Embodiment 1：
(1) preparation of rush extract：
Rush is crushed, decocting after the water of 8-10 times of weight, 0.5~1h of immersion is added and boils 0.5~1h, filtering is left and taken
Clear liquid, obtains first supernatant, and the filter residue being filtrated to get repeats the above steps twice, obtains secondary supernatant and three supernatants
Liquid, merges described first supernatant, secondary supernatant and three supernatants and obtains total supernatant, total supernatant is by steaming
Hair concentration, adds absolute ethyl alcohol and mixes, filtering obtains clear liquid after removing precipitation, and the rotated evaporimeter of the clear liquid is distilled
Remove and reclaim ethanol, produce rush extract.
(2) preparation of Herba Lysimachiae extract
Desmodium is crushed, the mass concentration that 6-8 times of weight is added every time is 70% ethanol, is extracted 3 times at 60 DEG C,
1.5 hours for the first time, second and third time each 1 hour, and filtering, merging filtrate obtains ethanol extract；Ethanol extract is in vacuum
At 0.07-0.08MPa, 50-60 DEG C of temperature, the concentrate that relative density is 1.05-1.10 is concentrated into, ethanol, concentrate is reclaimed
Be extracted with ethyl acetate 3 times, for the first time plus 3 times of volumes ethyl acetate, the 2nd, 3 times respectively plus 2 times of volumes acetic acid second
Ester, obtains acetic acid ethyl acetate extract, and at vacuum 0.07-0.8MPa, 50-60 DEG C of temperature, ethyl acetate is recovered under reduced pressure, must stay
Thing, stays thing at vacuum 0.07-0.08MPa, 50-60 DEG C of temperature, is dried under reduced pressure, produces Herba Lysimachiae extract.
It is 3 by weight by rush extract and Herba Lysimachiae extract：1 is mixed, and is produced for improving by uremic
The pharmaceutical composition of dry skin caused by disease haemodialysis.
Then the pharmaceutical composition is combined with pharmaceutic adjuvant and gel is made in conventional manner.
Embodiment 2：
The preparation method be the same as Example 1 of rush extract and Herba Lysimachiae extract.
It is 2 by weight by rush extract and Herba Lysimachiae extract：1 is mixed, and is produced for improving by uremic
The pharmaceutical composition of dry skin caused by disease haemodialysis.
Then the pharmaceutical composition is combined with pharmaceutic adjuvant and gel is made in conventional manner.
Embodiment 3：
The preparation method be the same as Example 1 of rush extract and Herba Lysimachiae extract.
It is 4 by weight by rush extract and Herba Lysimachiae extract：1 is mixed, and is produced for improving by uremic
The pharmaceutical composition of dry skin caused by disease haemodialysis.
Then the pharmaceutical composition is combined with pharmaceutic adjuvant and gel is made in conventional manner.
Embodiment 4：
The preparation method be the same as Example 1 of rush extract and Herba Lysimachiae extract.
It is 3 by weight by rush extract and Herba Lysimachiae extract：1 is mixed, and is produced for improving by uremic
The pharmaceutical composition of dry skin caused by disease haemodialysis.
Then the pharmaceutical composition is combined with pharmaceutic adjuvant and emulsifiable paste is made in conventional manner.
Embodiment 5：
The preparation method be the same as Example 1 of rush extract and Herba Lysimachiae extract.
It is 3 by weight by rush extract and Herba Lysimachiae extract：1 is mixed, and is produced for improving by uremic
The pharmaceutical composition of dry skin caused by disease haemodialysis.
Then the pharmaceutical composition is combined with pharmaceutic adjuvant and creme is made in conventional manner.
Test example 1：Safety testing：
Using healthy rabbits as subjects, 24h cuts off family's rabbit back backbone diamond wool before administration.It is randomly divided into two groups.
During experiment, one group of animal is removed into the fur of hair-fields to sterilize sand paper abrasion, and be drawn with sterilization syringe needle to oozing of blood and is used as damaged skin
Group；Another group is intact skin group.
The left side of hair-fields is gone to apply the gel prepared by the embodiment of the present invention 1 in the rabbit of damaged skin group, right side, which is applied, assigns
Shape agent is compared.Antistaling film is covered after administration, immobilization with adhesive tape is kept medicine to contact 4h with skin, then washed away with warm water residual
Stay medicine.Daily administration 2 times, continuous 2 weeks.
Intact skin group is in kind administered.
Last removes 1,24,48 and 72h after medicine and observes and record smearing position whether there is erythema and oedema and recovery situation,
Press《Chinese medicine, natural drug local irritation and hemolytic investigative technique guideline》The pharmaceutical composition for evaluating the present invention is continuous
Administration was compared with control group stimulus intensity, the recovery situation of stimulate the reaction and the time completely with damaged skin.
As a result show：The pharmaceutical composition of the present invention is nonirritant to animal skin, and experimental animal is without red and swollen, oedema or mistake
Quick phenomenon, illustrates that the composition of the present invention, using safety, has no toxic side effect.
Test example 2：The evaluation of moisture-keeping efficacy
Choose 40 volunteers, smearing method：Left and right inner forearm skin, each to smear once daily after cleaning, left arm is applied
Blank sample control is smeared, right arm smears gel prepared by the embodiment of the present invention 1, continuous to smear 7 days, tests the 0th day respectively, the
1 day, the 3rd day, the 5th day, and data at the 7th day, test event included：Water content, fat content.
Water content, fat content tester are：German CK companies Multi-functional skin tester MPA580, test wrapper
Border：Temperature：20~22 DEG C, humidity：40%~60%.
Test result is shown in Table 1.
Table 1：
Test example 3：Clinical application effect
Test method：Choose the volunteer of 60 dry skin problems as caused by uremia haemodialysis, early daily, evening
The gel prepared after clean skin using embodiment 1 is smeared, and continues 15 days, is filled in and is used feedback opinion table.Obtained by statistical analysis
Go out conclusion as shown in table 2.
Table 2：
The preferred embodiment of the application is the foregoing is only, the application is not limited to, for the skill of this area
For art personnel, the application can have various modifications and variations.It is all within spirit herein and principle, made any repair
Change, equivalent substitution, improvement etc., should be included within the protection domain of the application.
Claims (8)
1. rush extract and Herba Lysimachiae extract are being prepared for improving the dry skin as caused by uremia haemodialysis
Medicine in purposes.
2. purposes as claimed in claim 1, it is characterised in that the rush extract is prepared from by the following method：
Rush is crushed, decocting after the water of 8-10 times of weight, 0.5~1h of immersion is added and boils 0.5~1h, supernatant is left and taken in filtering
Liquid, obtains first supernatant, and the filter residue being filtrated to get repeats the above steps twice, obtains secondary supernatant and three supernatants,
Merge described first supernatant, secondary supernatant and three supernatants and obtain total supernatant, total supernatant is through pervaporation
Concentration, adds absolute ethyl alcohol and mixes, filtering obtains clear liquid after removing precipitation, and the rotated evaporimeter distillation of the clear liquid is removed
Go and reclaim ethanol, produce rush extract.
3. purposes as claimed in claim 2, it is characterised in that the Herba Lysimachiae extract is prepared from by the following method：
Desmodium is crushed, the mass concentration that 6-8 times of weight is added every time is 70% ethanol, and 3 times, first are extracted at 60 DEG C
Secondary 1.5 hours, second and third time each 1 hour, and filtering, merging filtrate obtains ethanol extract；Ethanol extract is in vacuum 0.07-
At 0.08MPa, 50-60 DEG C of temperature, the concentrate that relative density is 1.05-1.10 is concentrated into, ethanol, concentrate acetic acid is reclaimed
Ethyl ester is extracted 3 times, for the first time plus 3 times of volumes ethyl acetate, the 2nd, 3 times respectively plus 2 times of volumes ethyl acetate, obtain second
Acetoacetic ester extract, at vacuum 0.07-0.8MPa, 50-60 DEG C of temperature, is recovered under reduced pressure ethyl acetate, must stay thing, stay thing to exist
At vacuum 0.07-0.08MPa, 50-60 DEG C of temperature, it is dried under reduced pressure, produces Herba Lysimachiae extract.
4. it is a kind of be used for improve the dry skin as caused by uremia haemodialysis pharmaceutical composition, described pharmaceutical composition by
Rush extract and Herba Lysimachiae extract described in claim 1 are (2-4) by weight：1 composition.
5. pharmaceutical composition as claimed in claim 4, it is characterised in that described pharmaceutical composition is as described in claim 1
Rush extract and Herba Lysimachiae extract are 3 by weight：1 composition.
6. a kind of be used to improve the pharmaceutical preparation of the dry skin as caused by uremia haemodialysis, it is characterised in that the medicine
Thing preparation is prepared from by the pharmaceutical composition described in claim 4 or 5 and pharmaceutically acceptable auxiliary material.
7. pharmaceutical preparation as claimed in claim 6, it is characterised in that the formulation of the pharmaceutical preparation be gel, spray,
Lotion, emulsifiable paste/creme or powder.
8. pharmaceutical preparation as claimed in claim 6, it is characterised in that the pharmaceutically acceptable auxiliary material is glycerine, fourth two
One or more in alcohol, trehalose, glycine betaine, starch, sodium carboxymethylcellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710377291.XA CN107184746A (en) | 2017-05-25 | 2017-05-25 | It is a kind of to be used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710377291.XA CN107184746A (en) | 2017-05-25 | 2017-05-25 | It is a kind of to be used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis |
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| Publication Number | Publication Date |
|---|---|
| CN107184746A true CN107184746A (en) | 2017-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710377291.XA Pending CN107184746A (en) | 2017-05-25 | 2017-05-25 | It is a kind of to be used to improve the pharmaceutical composition of the dry skin as caused by uremia haemodialysis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080112557A (en) * | 2007-06-21 | 2008-12-26 | 고연호 | A composition for the treatment or prevention of diarrhea |
| CN103005471A (en) * | 2013-01-10 | 2013-04-03 | 三门峡山水方正生物科技有限公司 | Healthcare capsule for improving skin moisture |
| CN105106094A (en) * | 2015-09-14 | 2015-12-02 | 叶芳 | Novel skin care product for preventing skin dryness and preparation method thereof |
-
2017
- 2017-05-25 CN CN201710377291.XA patent/CN107184746A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080112557A (en) * | 2007-06-21 | 2008-12-26 | 고연호 | A composition for the treatment or prevention of diarrhea |
| CN103005471A (en) * | 2013-01-10 | 2013-04-03 | 三门峡山水方正生物科技有限公司 | Healthcare capsule for improving skin moisture |
| CN105106094A (en) * | 2015-09-14 | 2015-12-02 | 叶芳 | Novel skin care product for preventing skin dryness and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| ANNELIES AVERMAETE，ET AL: "Skin changes in dialysis patients:a review", 《NEPHROL DIAL TRANSPLANT》 * |
| 中华中医药学会皮肤科专业委员会: ""特应性皮炎中医诊疗方案专家共识"", 《CHIN J DERMATO VENEROL INTEG TRAD W MED》 * |
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Application publication date: 20170922 |
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