CN107184614B - A kind of Chinese medicine impalpable powder medicine materical crude slice and preparation method thereof - Google Patents
A kind of Chinese medicine impalpable powder medicine materical crude slice and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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Abstract
The invention discloses a kind of Chinese medicine impalpable powder medicine materical crude slice and preparation method thereof, method is first by the Chinese medicine after drying, carry out coarse crushing, then brittle processing is carried out to medicinal material coarse powder, to destroy the toughness of net medicinal material coarse powder, to shorten the finely divided time, reduce Chinese medicine the moisture absorption possibility, and then ensure prepare tcm and herbal slice there is not the problem of caking.The method, dissociation processing has been carried out to the plant fiber in tcm and herbal slice, keep tcm and herbal slice loosely organized, reduce the hardness of tcm and herbal slice, be conducive to follow-up finely divided progress, shorten the finely divided time, reduce the possibility of tcm and herbal slice moisture absorption during finely divided, ensures that the problem of caking does not occur in the tcm and herbal slice prepared.Preparation method shown in the embodiment of the present application shortens the finely divided time, reduces the possibility of the finely divided tcm and herbal slice moisture absorption in the process, saves the pelletization in traditional preparation methods, the release rate of the active ingredient for the tcm and herbal slice prepared is high.
Description
Technical field
The present invention relates to Chinese medicine technical field, more particularly to a kind of Chinese medicine impalpable powder medicine materical crude slice and preparation method thereof.
Background technology
Effective ingredient in Chinese medicine is mainly distributed on into the cell, conventional medicine materical crude slice, by Chinese medicine reserve at fine powder, is eaten
When, the effective ingredient of storage in the cell is released by the method for decoction.In decoction process, intracellular effective ingredient
It must pass through even tens cell walls that can just release.The onset time of usual effective ingredient is long, and utilization rate is low.Ultra micro
Crushing technology is the new technology to grow up in the past 20 years.Substance can be ground into impalpable powder by superfine communication technique, be made
The cell wall percentage of damage of Chinese medicine is up to 86% or more.
Superfine communication technique was combined by some researchers with tcm and herbal slice in recent years, to improve the thin of Chinese medicine
Cell wall percentage of damage.Such as application No. is：The patent of CN200610122171.7 shows a kind of processing method of traditional Chinese herbs broken wall powder,
Its process the step of be：(1) medicinal material processing：It includes sorting, being sliced, obtaining net medicinal material after drying；(2) it crushes：With above-mentioned net
Medicinal material is crushed with the Universalpulverizer that 100 mesh sieve, and broken wall crushes, and obtains the above coarse powder of 60 mesh；(3) broken wall crushes：It will be obtained as above
Coarse powder flour, be crushed to 300 mesh or more through broken wall, obtain superfine powder；(4) it pelletizes：Superfine powder obtained as above is taken, slot is set
In shape mixing and blending machine, softwood is made with water or ethyl alcohol, the oscillating granulator through 30 mesh sieve is pelletized, and wet granular obtained sets heat
It is dried in wind cycle baking oven；(5) whole grain, screening：With 40 mesh of upper layer, the oscillation pelletizing machine of lower layer's 80 mesh sieve is by above-mentioned granulation whole grain
Screening 1-3 times, is made particle between -80 mesh of 40 mesh.(6) it dispenses and packs：Take qualified sub-micron-powder, packing and outer packing
Obtain finished product.
Superfine communication technique is combined by the prior art with tcm and herbal slice, although improving Chinese medicine to a certain extent
Cell wall percentage of damage.But asking for " caking " occurs for the tcm and herbal slice that the preparation process of the prior art is prepared in order to prevent
Topic, the tcm and herbal slice after usually after Chinese medicine crushing needing that water or alcohol granulation is added to be pelletized, the Chinese medicine drink after granulation
Piece generates the release rate of the active ingredient of Chinese medicine certain influence.
Invention content
The goal of the invention of the present invention is to provide a kind of Chinese medicine impalpable powder medicine materical crude slice and preparation method thereof, the preparation method
Improve the release rate of active ingredient in Chinese medicine.
A kind of preparation method of Chinese medicine impalpable powder medicine materical crude slice is provided according to an embodiment of the invention, including：
Chinese medicine after drying is dry-cleaned, mechanical crushing obtains net medicinal powder to -20 mesh of 10 mesh；
The net medicinal powder low temperature brittleness is handled, the Chinese medicine after embrittlement is obtained；
Chinese medicine after the embrittlement is placed under mechanical oscillation wave energy environment and is dissociated, the Chinese medicine after being dissociated
Material；
By -60 irradiation sterilization 8h-10h of Chinese medicine timber-used cobalt after the dissociation, Chinese medicine sterilizing coarse powder is obtained；
By Chinese medicine sterilizing coarse powder, it is crushed to -300 mesh of 200 mesh through broken wall, obtains Chinese medicine superfine powder；
The Chinese medicine fine powder is packed, is examined, through examining qualified Chinese medicine superfine powder, outer packing that Chinese medicine is made
Material impalpable powder medicine materical crude slice.
Selectable, the broken wall crushing process crushes under -10 DEG C of states.
Selectable, described by Chinese medicine sterilizing coarse powder, the step that -300 mesh of 200 mesh is crushed to through broken wall includes：
Chinese medicine is sterilized coarse powder, broken wall isolates the Chinese medicine coarse powder of 40 mesh during crushing；
By the Chinese medicine coarse powder of 40 mesh, broken wall crushes again, isolates the Chinese medicine fine powder of 80 mesh；
By the Chinese medicine fine powder of 80 mesh, broken wall crushes again, isolates the Chinese drugs powder of 160 mesh；
By the Chinese drugs powder of 160 mesh, broken wall crushes again, isolates the Chinese medicine impalpable powder drink of -300 mesh of 200 mesh
Piece.
Selectable, the mechanical oscillation wave energy vibration frequency is 50Hz-1000Hz.
Selectable, the temperature of the low temperature brittleness processing is -40 DEG C~-50 DEG C.
Selectable, the Chinese medicine by after drying is dry-cleaned, and mechanical crushing obtains net medicinal material to -20 mesh of 10 mesh
The step foregoing description method of coarse powder further includes：
Selectable, the Chinese medicine by after drying is dry-cleaned, and mechanical crushing obtains net medicinal material to -20 mesh of 10 mesh
The step foregoing description method of coarse powder further includes：
Fresh Chinese medicine is subjected to freeze-drying process, the Chinese medicine after being dried.
Selectable, the Chinese medicine by after drying is dry-cleaned, and mechanical crushing obtains net medicinal material to -20 mesh of 10 mesh
The step foregoing description method of coarse powder further includes：
Fresh Chinese medicine is subjected to microwave drying treatment, the Chinese medicine after being dried.
By above technical scheme it is found that the embodiment of the present application shows a kind of preparation method of Chinese medicine impalpable powder medicine materical crude slice, packet
It includes：Chinese medicine after drying is dry-cleaned, mechanical crushing obtains net medicinal material coarse powder to -20 mesh of 10 mesh；The net medicinal material is thick
The processing of powder low temperature brittleness, obtains the Chinese medicine after embrittlement；Chinese medicine after the embrittlement is placed under mechanical oscillation wave energy environment
It is dissociated, the Chinese medicine after being dissociated；By -60 irradiation sterilization 8h-10h of Chinese medicine timber-used cobalt after the dissociation, in obtaining
Medicinal material sterilizing coarse powder；By Chinese medicine sterilizing coarse powder, it is crushed to -300 mesh of 200 mesh through broken wall, obtains Chinese medicine superfine powder；
The Chinese medicine fine powder is packed, is examined, chooses and examines qualified Chinese medicine superfine powder, it is superfine that Chinese medicine is made in outer packing
Powder medicine materical crude slice.Preparation method shown in the embodiment of the present application carries out coarse crushing first by the Chinese medicine after drying, then thick to medicinal material
Powder carries out brittle processing, to destroy the toughness of net medicinal material coarse powder, to shorten fine powder during subsequent Chinese medicine is finely divided
The broken time reduces Chinese medicine in the possibility of the moisture absorption, and then ensures what luming did not occurred in tcm and herbal slice prepared by the application
Problem.Further, the preparation method shown in the embodiment of the present application has carried out dissociation processing to the plant fiber in Chinese medicine, into
One step makes the loosely organized of Chinese medicine, reduces the hardness of Chinese medicine, and then is conducive to follow-up finely divided progress, shortens fine powder
The broken time reduces the possibility of Chinese medicine moisture absorption during finely divided, and then ensures tcm and herbal slice prepared by the application
There is not the problem of caking.Preparation method shown in the embodiment of the present application shortens the finely divided time, reduces finely divided mistake
The possibility of the Chinese medicine moisture absorption in journey.The preparation method shown in the application is saved in traditional preparation methods compared with prior art
Pelletization, the release rate of the active ingredient for the tcm and herbal slice prepared is high.
Description of the drawings
It in order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, below will be to institute in embodiment
Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only some implementations of the present invention
Example, for those of ordinary skill in the art, without creative efforts, can also obtain according to these attached drawings
Obtain other attached drawings.
Fig. 1 is the flow chart for the preparation method that a kind of Chinese medicine impalpable powder medicine materical crude slice exemplified is preferably implemented according to one.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Whole description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Fig. 1 is a kind of flow chart of the preparation method of Chinese medicine impalpable powder medicine materical crude slice shown in the embodiment of the present application；The system
Preparation Method includes：
S101 dry-cleans the Chinese medicine after drying, and mechanical crushing obtains net medicinal material coarse powder to -20 mesh of 10 mesh；
The net medicinal material coarse powder, can be directly used for the Chinese medicine of tcm clinical practice.
The net medicinal material coarse powder low temperature brittleness is handled, the Chinese medicine after embrittlement is obtained；It is made it is to be noted that due to Chinese medicine
Material；
Coarse crushing process, coarse crushing use the mode of shearing to achieve the effect that Chinese medicine crushes.Crushing process is at low cost,
Chinese medicine treating capacity is big, and the traditional Chinese medicine powder after drying can be broken to the net medicinal material coarse powder of -20 purpose of 10 mesh in the shorter time,
It is effective to avoid during Chinese medicine is in crushing that there is a phenomenon where the moisture absorptions.Mechanical crushing is suitable for various types drug simultaneously
Coarse crushing, including carbohydrate contains oils, contains aromatics, the processing and production of volatility class Chinese medicine.
Further, Chinese medicine mechanical crushing first to -20 purpose of 10 mesh is further to remove the miscellaneous of Chinese medicine surface
Matter.
Specifically：Chinese medicine is mostly the root of plant.Such as：Ginseng, rheum officinale, Radix Astragali etc.；These Chinese medicine long term growths
In soil；Meanwhile covered on the root of these Chinese medicines must, must be with the soil of the junction of root during early period is with processing
It is not easy to remove.
The embodiment of the present application is crushed to -20 mesh of 10 mesh after in advance dry-cleaning Chinese medicine, obtain net medicinal material coarse powder, at this time must be with
The junction of root is destroyed, and the soil of corresponding junction is exposed to the surface of net medicinal material coarse powder.During coarse crushing, net medicine
Material coarse powder under gravitational and centrifugal forces, scrolls up and down, and exposes further removed with the soil on Chinese medicine surface at this time.
Obtain net medicinal material coarse powder.The medicinal material coarse powder can be directly used for the Chinese medicine of tcm clinical practice.
S102 handles the net medicinal material coarse powder low temperature brittleness, obtains the Chinese medicine after embrittlement；The net medicinal material of -20 purpose of 10 mesh
Coarse powder；Then low temperature brittleness processing is carried out to net medicinal material coarse powder.
Known Chinese medicine is mostly toughness plant, after finely divided process using the impact force between Chinese medicine by Chinese medicine into one
Step crushes, and due to the toughness of Chinese medicine, generates certain influence to subsequent finely divided process, extends the finely divided time, increases
The possibility for adding the Chinese medicine moisture absorption to lump.
For destroy Chinese medicine toughness, shorten the finely divided time, reduce the Chinese medicine moisture absorption caking possibility, this Shen
Please embodiment net medicinal material coarse powder low temperature brittleness is handled, to destroy the toughness of net medicinal material coarse powder, shorten the finely divided time, reduce
The possibility of Chinese medicine moisture absorption caking.
Chinese medicine after the embrittlement is placed under mechanical oscillation wave energy environment and is dissociated by S103, after being dissociated in
Medicinal material；
Contain a large amount of plant fiber in Chinese medicine, since plant fiber itself compatibility in Chinese medicine is preferable, in nothing
Under the action of external force, the plant fiber in Chinese medicine is wrapped around one another, so that the hardness of Chinese medicine increases.For subsequent Chinese medicine
The finely divided process of material increases certain difficulty, has accordingly increased the Chinese medicine finely divided time, has accordingly increased Chinese medicine
The possibility of material moisture absorption caking.
The problem of in order to reduce the grinding time of Chinese medicine, prevent the tcm and herbal slice prepared from luming.
It is known.Plant fiber in Chinese medicine is all to have intrinsic resonant frequency and energy absorption peak, in mechanical vibration wave
In the environment of plant fiber in Chinese medicine can resonate so that the plant fiber in Chinese medicine is in the state of " dissociation ",
So that the hardness of Chinese medicine reduces.
For having：Chinese medicine after the embrittlement is placed under mechanical oscillation wave energy environment and is dissociated, at this point, brittle
Plant fiber in Chinese medicine afterwards absorbs mechanical oscillation wave energy and generates fierce resonance, the plant in Chinese medicine after embrittlement
Destructurized in fiber, the hardness of Chinese medicine reduces.The hardness for reducing Chinese medicine shortens the subsequent finely divided time.
- 60 irradiation sterilization 8h-10h of Chinese medicine timber-used cobalt after the dissociation is obtained Chinese medicine sterilizing coarse powder by S104；
The embodiment of the present application is sterilized using cobalt -60, and the sterilizing of cobalt -60 first can delay the certain physiology course hairs of Chinese medicine
Exhibition, delays the shelf-life of Chinese medicine, and the gamma-radiation and electron ray that cobalt -60 radiates have stronger penetration power, can will deposit
The disease pest being inside the Chinese medicine after dissociating, bacterium kill；
Further, cobalt -60 sterilize after Chinese medicine from find no radioactive substance residual, can protect Chinese medicine it is original effectively at
Point and color, smell and taste.
It is made it is noted that the embodiment of the present application ensures that the active ingredient of Chinese medicine is not destroyed using the sterilizing of cobalt -60.
It is made it is noted that sterilizing after Chinese medicine dissociation in the preparation method shown in the embodiment of the present application.If
Sterilize after Chinese medicine is finely divided, during sterilizing Chinese medicine be easy the moisture absorption and there is a phenomenon where luming, if will
The process of sterilizing after step S102, can introduce some bacteriums during dissociation, cause the effect of sterilizing undesirable, this
Application embodiment takes into account the effect of sterilizing and prevents the aspect of the Chinese medicine moisture absorption two, by sterilization process prevent with dissociation process it
Afterwards.
Prevent the Chinese medicine moisture absorption specifically present：It is known that the grain size of Chinese medicine is smaller, specific surface area is bigger, and mobility change is got over
Difference, moisture absorption is bigger, and stripping property is bigger.The grain size of Chinese medicine after dissociation is in -20 mesh of 10 mesh.The grain of Chinese medicine after finely divided
Diameter is in -300 mesh of 200 mesh, and the moisture absorption of the Chinese medicine of -20 mesh of 10 mesh is significantly less than 200 mesh -300 in identical sterilization time
The moisture absorption of mesh Chinese medicine.
Therefore, the Chinese medicine after dissociation is carried out sterilization treatment by the embodiment of the present application, in can reducing to a certain extent
The possibility of medicinal material moisture absorption caking.
Chinese medicine sterilizing coarse powder is crushed to -300 mesh of 200 mesh through broken wall, obtains Chinese medicine superfine powder by S105；
The broken wall crushing carries out in supersonic jet mill system, the crushing speed of supersonic jet mill system
Soon, moment can be completed, and retain the bioactive ingredients of Chinese medicine to the maximum extent.
S106 packs the Chinese medicine fine powder, examines, and chooses and examines qualified Chinese medicine superfine powder, outer packing system
Obtain Chinese medicine impalpable powder medicine materical crude slice.
Further, the step foregoing description method of S101 further includes：
Fresh Chinese medicine is subjected to freeze-drying process, the Chinese medicine after being dried；
Fresh Chinese medicine is first frozen into eutectic temperature hereinafter, the moisture in fresh Chinese medicine becomes solid
Then ice will be packed by the fresh Chinese medicine of pre-freeze in dryness storehouse, under cryogenic vacuum state, by heating plate with heat conduction or
Radiation mode heat supply makes the moisture in fresh Chinese medicine directly be sublimed into vapor by ice.The constantly water of distillation out
Steam is evacuated to by vacuum pump group in water catching bin, and then removes the moisture in fresh Chinese medicine.
Entire drying process carries out at low temperature, and is in vacuum state.Therefore, especially suitable for high-thermosensitive and easily
Aoxidize the drying of Chinese medicine.It can retain the color of fresh Chinese medicine in drying process and effective ingredient is not lost.
Meanwhile the tcm and herbal slice prepared has good instant capacity.Since Chinese medicine first freezes before distillation, shape
At the solid skeletal stablized, so solid skeletal is held essentially constant after water sublimed.During lyophilization, solid ice
Crystalline substance is sublimed into after vapor leaves a large amount of gaps in food material so that the Chinese medicine of freeze-drying has spongy porosity knot
Structure, tcm and herbal slice prepared by the Chinese medicine after being dried using the method have ideal instant capacity.Tcm and herbal slice after rehydration
No matter its appearance and form and taste all with before freeze-drying without much difference.
Further, the Chinese medicine by after drying is dry-cleaned, and it is thick to obtain net medicinal material to -20 mesh of 10 mesh for mechanical crushing
The step foregoing description method of powder further includes：
Fresh Chinese medicine is subjected to microwave drying treatment, the Chinese medicine after being dried.
Although freeze-drying process can retain the color, smell and taste and active ingredient of Chinese medicine, it is particularly suitable for some thermal sensitivity
And the drying of oxidizable Chinese medicine.But the drying time of freeze-drying is long, for the strong Chinese medicine of some stability using cold
Freeze the time for being dried and will extending entire technique, influences the efficiency of technique.
Therefore, such as the good Chinese medicine of some thermal stability：Cow-bezoar.The embodiment of the present application is using at micro-wave vacuum
Reason improves the efficiency of entire production technology to shorten the time of Chinese medicine drying.
The embodiment of the present application microwave drying treatment is microwave frequency control in 300MHz-300KMHz.Fresh Chinese medicine
In moisture under the action of electromagnetic field of high frequency, hydrone is from original random distribution state shift according to the pole of electromagnetic field of high frequency
Property oriented.Under the action of electromagnetic field of high frequency, the moisture in this fresh Chinese medicine is orientated the variation by electromagnetic field of high frequency
And change, this process makes that relative motion and mutual friction effect occurs between hydrone, to generate heat.At this point, alternation is electric
The electromagnetic energy in magnetic field is the kinetic energy in hydrone, and kinetic energy is then converted into thermal energy, and the temperature of fresh Chinese medicine constantly increases.
This mode does not need the process of heat transfer, and electromagnetic wave passes through Chinese medicine from surrounding or specific direction so that each in Chinese medicine
Part is heated up in acquisition thermal energy in a flash, therefore, can be reached within a short period of time and is evenly heated.At this point, due in fresh
Removing superficial moisture on medicinal materials evaporates, and fresh Chinese medicine surface temperature is made to reduce, to cause a low inside and high outside temperature gradient, this
The direction of a gradient is just consistent with the direction of moisture evaporation so that evaporation is accelerated, so the efficiency of moisture evaporation improves.Then
Improve the efficiency of entire technique.
Simultaneously because generating heat inside fresh Chinese medicine, so that steam inside generates rapidly, barometric gradient is formed,
If the initial aqueous rate of fresh Chinese medicine is very high, the very fast raising of the internal pressure of fresh Chinese medicine, moisture can be
It is discharged and excludes from the surface of fresh Chinese medicine under the action of barometric gradient.
Under vacuum conditions, the boiling point of water reduces, to make fresh Chinese medicine at relatively low temperature
Explosive evaporation.Vacuum can not only be such that material is evaporated in the case where keeping low-temperature condition, moreover it is possible to generate barometric gradient and improve drying efficiency.
Further, described that Chinese medicine sterilizes coarse powder, the step that -300 mesh of 200 mesh is crushed to through broken wall includes：
Chinese medicine is sterilized coarse powder, broken wall isolates the Chinese medicine of 40 mesh during crushing；
By the Chinese medicine of 40 mesh, broken wall crushes again, isolates the Chinese medicine of 80 mesh；
By the Chinese medicine of 80 mesh, broken wall crushes again, isolates the Chinese medicine of 160 mesh；
By the Chinese medicine of 160 mesh, broken wall crushes again, isolates the Chinese medicine of -300 mesh of 200 mesh；
The embodiment of the present application carries out classification grinding until traditional Chinese medicine powder is broken to target grain size to Chinese medicine sterilizing coarse powder.
In order to ensure the tcm and herbal slice uniform particle diameter prepared, the quality of tcm and herbal slice, the embodiment of the present application are improved
Chinese medicine sterilizing coarse powder is crushed to by target grain size using classification grinding process.
The process of classification grinding is specially：By Chinese medicine sterilizing coarse powder by the Venturi nozzle of supersonic jet mill system
Crushing chamber is added, high pressure draught sprays into the track type circulating tube type crushing chamber of not isometrical variable curvature through one group of nozzle, accelerates Chinese medicine
The particle of material sterilizing coarse powder is allowed to mutually impact, collision, rubs and crush.Simultaneously eddy flow also drives be crushed particle along pipeline to
It is upper to enter graded region, so that intensive stream is shunted under the action of graded region centrifugal force field, fine grained is in internal layer through venetian blind type
The Chinese medicine of 40 mesh is discharged after the classification of inertial classification device.Chinese medicine sterilizing coarse powder continues cycling through powder in outer layer along down pipe return
It is broken.Until the grain size of all Chinese medicine sterilizing coarse powder reaches 40 mesh, then proceed to crush the Chinese medicine of 40 mesh, point
It is the Chinese medicine for isolating 80 mesh to separate out grain size, then proceedes to crush the Chinese medicine of 80 mesh, and it is separation to isolate grain size
Go out the Chinese medicine of 160 mesh, finally according to the corresponding target grain size of Chinese medicine, the traditional Chinese medicine powder of 160 mesh is broken to target grain size.
The corresponding target grain size of each Chinese medicine is different.Such as the target grain size of the Chinese medicines such as safflower, rheum officinale, Radix Notoginseng, Radix Astragali, fritillaria thunbergii
For 200 mesh.
Such as the Chinese medicines moisture absorption such as safflower, rheum officinale, Radix Notoginseng, Radix Astragali, fritillaria thunbergii increases with the intensification of degree of grinding,
When inciting somebody to action pulverizing medicinal materials to 200 mesh among the above, the cell-wall breaking ratio of above-mentioned medicinal material has reached 90% or more.If continuing to be crushed to
The moisture absorption of the above-mentioned Chinese medicine of 300 purposes sharply increases, and above-mentioned Chinese medicine will be tied during subsequent packages at this time
The phenomenon that block.
Again for example：The moisture absorption of the Chinese medicines powder such as the rhizome of davallia and rheum officinale is unrelated with degree of grinding, when the grain size of Chinese medicine
Reach 300 mesh, the sporoderm-broken rate of Chinese medicine can reach 96% or more at this time, and grain size reaches 300 mesh after pulverizing medicinal materials among the above, i.e.,
Make to continue to crush above-mentioned Chinese medicine, the release of the active ingredient of finished product tcm and herbal slice be improved without apparent, therefore
Set the target grain size of above-mentioned Chinese medicine to 300 mesh.
The experimental results showed that even if the above-mentioned preparation method using shown in the embodiment of the present application is by above-mentioned Chinese medicine, (bone is broken
Mend and Chinese medicine that the moisture absorption of the Chinese medicines powder such as rheum officinale is unrelated with degree of grinding) be crushed to 300 mesh, packed subsequent
The problem of being not in still caking in journey.
Further, the mechanical oscillation wave energy vibration frequency is 50Hz-1000Hz.
Further, the temperature of low temperature brittleness processing is -40 DEG C~-50 DEG C.
Embodiment 1：
Fresh Radix Angelicae Sinensis is placed in drying in microwave vacuum dryer, until water content is less than or equal to 3%, after being dried
Radix Angelicae Sinensis.
Then the Radix Angelicae Sinensis after drying is placed in mechanical crushing device, carries out mechanical crushing, motor driven impeller is by Radix Angelicae Sinensis
Cut into the Radix Angelicae Sinensis coarse granule of -20 mesh of 10 mesh.
The process Radix Angelicae Sinensis of coarse crushing simultaneously is detached with Radix Angelicae Sinensis, but Radix Angelicae Sinensis and the soil of Radix Angelicae Sinensis junction are exposed to Radix Angelicae Sinensis
Surface, at this time under the brushing of compressed air, soil and Radix Angelicae Sinensis are detached from.
The Radix Angelicae Sinensis coarse granule of -20 mesh of 10 mesh is subjected to brittle processing, the temperature of embrittlement processing is maintained at -40-50 DEG C, embrittlement
The toughness of Radix Angelicae Sinensis changes after processing, and the toughness of Radix Angelicae Sinensis disappears, and Radix Angelicae Sinensis becomes fragile or even vitrifying.
Radix Angelicae Sinensis after embrittlement is placed under mechanical oscillation wave energy environment and is dissociated, mechanical oscillation wave energy vibration frequency is
50Hz-1000Hz handle 10min, with this condition the plant fiber in Radix Angelicae Sinensis can resonate, the plant fiber in Radix Angelicae Sinensis with
Loose structure exists.
By the Radix Angelicae Sinensis after the dissociation with -60 irradiation sterilization 8h of cobalt, the Radix Angelicae Sinensis after being sterilized.
Radix Angelicae Sinensis after sterilizing is transferred to classification grinding in supersonic jet mill system, obtains the Radix Angelicae Sinensis fine powder of 200 mesh,
By the superfine powder packaging of Radix Angelicae Sinensis, examines, choose and examine qualified Chinese medicine superfine powder, outer packing that Chinese medicine is made
Impalpable powder medicine materical crude slice, i.e. angelica sinensis.
When edible, angelica sinensis is added 60 DEG C -100 DEG C of water brew 5-10 minutes it is i.e. direct-edible.
The embodiment of the present application directly prepares the angelica sinensis of 200 mesh, and whole preparation process does not occur angelica sinensis
The problem of not luming, while applying for the preparation method for implementing to exemplify, the pelletization of traditional preparation methods is omitted, carries
The release rate of high Radix Angelicae Sinensis active ingredient.
Embodiment 2：
Fresh rheum officinale is placed in drying in microwave vacuum dryer, until water content is less than or equal to 3%, after being dried
Rheum officinale.
Then the rheum officinale after drying is placed in mechanical crushing device, carries out mechanical crushing, motor driven impeller is by rheum officinale
Cut into the rheum officinale coarse granule of -20 mesh of 10 mesh.
The process rheum officinale of coarse crushing simultaneously must be detached with rheum officinale, but rheum officinale and the soil of rheum officinale palpus junction are exposed to rheum officinale
Surface, at this time under the brushing of compressed air, soil and rheum officinale are detached from.
The rheum officinale coarse granule of -20 mesh of 10 mesh is subjected to brittle processing, the temperature of embrittlement processing is maintained at -40-50 DEG C, embrittlement
The toughness of rheum officinale changes after processing, and the toughness of rheum officinale disappears, and rheum officinale becomes fragile or even vitrifying.
Rheum officinale after embrittlement is placed under mechanical oscillation wave energy environment and is dissociated, mechanical oscillation wave energy vibration frequency is
50Hz-1000Hz handle 10min, with this condition the plant fiber in rheum officinale can resonate, the plant fiber in rheum officinale with
Loose structure exists.
By -60 irradiation sterilization of cobalt 10 hours of the rheum officinale after the dissociation, the rheum officinale after being sterilized.
Rheum officinale after sterilizing is transferred to classification grinding in supersonic jet mill system, obtains the rheum officinale fine powder of 200 mesh,
Chinese rhubarb fine powder body is packed, is examined, chooses and examines qualified Chinese medicine superfine powder, Chinese medicine impalpable powder drink is made in outer packing
Piece, i.e. rhubarb decoction pieces.
When edible, rhubarb decoction pieces are added 60 DEG C -100 DEG C of water brew 5-10 minutes it is i.e. direct-edible.
The embodiment of the present application directly prepares the rhubarb decoction pieces of 200 mesh, and whole preparation process does not occur rhubarb decoction pieces
The problem of not luming, while applying for the preparation method for implementing to exemplify, the pelletization of traditional preparation methods is omitted, carries
The release rate of high effective rhubarb component.
By above technical scheme it is found that the embodiment of the present application shows a kind of preparation method of Chinese medicine impalpable powder medicine materical crude slice, packet
It includes：Chinese medicine after drying is dry-cleaned, mechanical crushing obtains net medicinal material coarse powder to -20 mesh of 10 mesh；The net medicinal material is thick
The processing of powder low temperature brittleness, obtains the Chinese medicine after embrittlement；Chinese medicine after the embrittlement is placed under mechanical oscillation wave energy environment
It is dissociated, the Chinese medicine after being dissociated；By -60 irradiation sterilization 8h-10h of Chinese medicine timber-used cobalt after the dissociation, in obtaining
Medicinal material sterilizing coarse powder；By Chinese medicine sterilizing coarse powder, it is crushed to -300 mesh of 200 mesh through broken wall, obtains Chinese medicine superfine powder；
The Chinese medicine fine powder is packed, is examined, chooses and examines qualified Chinese medicine superfine powder, it is superfine that Chinese medicine is made in outer packing
Powder medicine materical crude slice.Preparation method shown in the embodiment of the present application carries out coarse crushing first by the Chinese medicine after drying, then thick to medicinal material
Powder carries out brittle processing, to destroy the toughness of net medicinal material coarse powder, to shorten fine powder during subsequent Chinese medicine is finely divided
The broken time reduces Chinese medicine in the possibility of the moisture absorption, and then ensures what luming did not occurred in tcm and herbal slice prepared by the application
Problem.Further, the preparation method shown in the embodiment of the present application has carried out dissociation processing to the plant fiber in Chinese medicine, into
One step makes the loosely organized of Chinese medicine, reduces the hardness of Chinese medicine, and then is conducive to follow-up finely divided progress, shortens fine powder
The broken time reduces the possibility of Chinese medicine moisture absorption during finely divided, and then ensures tcm and herbal slice prepared by the application
There is not the problem of caking.Preparation method shown in the embodiment of the present application shortens the finely divided time, reduces finely divided mistake
The possibility of the Chinese medicine moisture absorption in journey.The preparation method shown in the application is saved in traditional preparation methods compared with prior art
Pelletization, the release rate of the active ingredient for the tcm and herbal slice prepared is high.
Those skilled in the art after considering the specification and implementing the invention disclosed here, will readily occur to its of the present invention
Its embodiment.This application is intended to cover the present invention any variations, uses, or adaptations, these modifications, purposes or
Person's adaptive change follows the general principle of the present invention and includes undocumented common knowledge in the art of the invention
Or conventional techniques.The description and examples are only to be considered as illustrative, and true scope and spirit of the invention are by following
Claim is pointed out.
It should be understood that the invention is not limited in the precision architectures for being described above and being shown in the accompanying drawings, and
And various modifications and changes may be made without departing from the scope thereof.The scope of the present invention is limited only by the attached claims.
Claims (4)
1. a kind of preparation method of Chinese medicine impalpable powder medicine materical crude slice, which is characterized in that including：
Chinese medicine after drying is dry-cleaned, mechanical crushing obtains net medicinal material coarse powder to -20 mesh of 10 mesh；
The net medicinal material coarse powder low temperature brittleness is handled, the tcm and herbal slice after embrittlement is obtained；
Tcm and herbal slice after the embrittlement is placed under mechanical oscillation wave energy environment and is dissociated, the Chinese medicine after being dissociated
Medicine materical crude slice；
By -60 irradiation sterilization 8h-10h of cobalt of the tcm and herbal slice after the dissociation, the Chinese medicine sterilizing coarse powder after being sterilized；
By the Chinese medicine sterilizing coarse powder after the sterilizing, it is crushed to -300 mesh of 200 mesh through broken wall, obtains Chinese medicine superfine powder；
The Chinese medicine fine powder is packed, is examined, chooses and examines qualified Chinese medicine superfine powder, outer packing that Chinese medicine is made
Impalpable powder medicine materical crude slice；
The broken wall crushing process crushes under -10 DEG C of states；
The Chinese medicine sterilizing coarse powder by after sterilizing, the step that -300 mesh of 200 mesh is crushed to through broken wall include：
Chinese medicine is sterilized coarse powder, broken wall isolates the net medicinal powder of 40 purposes during crushing；
By the net medicinal powder of 40 purpose, broken wall crushes again, isolates the net medicinal powder of 80 purposes；
By the net medicinal powder of 80 purpose, broken wall crushes again, isolates the net medicinal powder of 160 purposes；
By the net medicinal powder of 160 purpose, broken wall crushes again, isolates the Chinese medicine superfine powder of -300 mesh of 200 mesh；
The temperature of the low temperature brittleness processing is -40 DEG C~-50 DEG C.
2. preparation method according to claim 1, which is characterized in that the mechanical oscillation wave energy vibration frequency is 50Hz-
1000Hz。
3. preparation method according to claim 1, which is characterized in that the Chinese medicine by after drying is dry-cleaned, machine
Tool is crushed to -20 mesh of 10 mesh, and the step foregoing description method for obtaining net medicinal material coarse powder further includes：
Fresh Chinese medicine is subjected to freeze-drying process, the Chinese medicine after being dried.
4. preparation method according to claim 1, which is characterized in that the Chinese medicine by after drying is dry-cleaned, machine
Tool is crushed to -20 mesh of 10 mesh, and the step foregoing description method for obtaining net medicinal material coarse powder further includes：
Fresh Chinese medicine is subjected to microwave drying treatment, the Chinese medicine after being dried.
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