CN107157872A - A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof - Google Patents
A kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing and preparation method thereof Download PDFInfo
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- CN107157872A CN107157872A CN201710316690.5A CN201710316690A CN107157872A CN 107157872 A CN107157872 A CN 107157872A CN 201710316690 A CN201710316690 A CN 201710316690A CN 107157872 A CN107157872 A CN 107157872A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing, it is made up of component A and B component, the dendrobium candidum alcohol plastid contained in B component has good superdeformable, under skin hydration pressure, alcohol plastid can carry content tranmittance its own small 1/5 ~ 1/10 aperture, deep skin can be rapidly entered, it is to facilitate dendrobium candidum extract solution active ingredient to penetrate to the skin interior effective transport vehicle, the problem of solving the penetrating power difference of existing skin care item generally existing, improves the transdermal penetration effect of dendrobium candidum active ingredient;The active component accumulation of the dendrobium candidum facial treatment milk is high, preparation technology is simple, materials safety, it is non-stimulated to skin, with significantly maintenance or recovery skin elasticity, reduction or deposition, ultra-violet radiation resisting and slowing down skin aging effect for repairing the microgroove of skin generation, suppression lipofuscin, it can effectively suppress the formation that ultraviolet irradiates caused skin photoage and daylight sunburn.
Description
Technical field
The present invention relates to cosmetics and its preparing technical field, specifically a kind of oxidation resistant dendrobium candidum skin care milk of moisturizing
Liquid and preparation method thereof.
Background technology
The mistake of wrinkle, freckle, excessively calm melanin, tarnish and elasticity reduction caused by clinical ultraviolet irradiation
Journey is referred to as light aging, and it is mainly due to the ultraviolet B radiation (UVB) and long wave ultraviolet in solar UV (UV)
(UVA) caused by.Modern science experimental studies have found that, UVB irradiations induction body skin first produces substantial amounts of free radical, from
By base by a series of reaction, and then damage body skin histology.In addition to said process, UVB can also cause body protein,
A series of reaction of functional mass such as enzyme, ultimately results in body cell damage, and it is even more the key factor for inducing cutaneum carcinoma.UVA
Biological effect is although small, but it can penetrate skin histology, reaches skin corium, and then cause dermal tissue collagenous fibres and elastic force
The damage of fiber, its light aging morbidity triggered effect is also gradually taken seriously.It is substantial amounts of that ultraviolet also results in skin generation
ROS, has broken the anti-oxidant balance of body, and activate upstream kinases activation activation MAPK (MAPK),
And then the expression of c-Jun genes is raised, improve MMPs genetic transcription and suppress the synthesis of skin collagen.It is above-mentioned a series of
Approach causes the change of body skin, that is, the skin photoage phenomenon known to us.
With the lifting of science beautifying technique, people can carry out reparation to the light injury caused by light aging and control
Treat.At this stage, the major measure of the damage caused by reply light aging has drug therapy, laser, intense pulsed light, radio frequency, light to move
Power therapy, injection cosmetology and operation.Some common antioxidants such as vitamin C, vitamin E etc., by removing body
Free radical reaches the purpose for repairing damage.And be also current preventing/treating by way of painting for oral administration, outer and drug combination
Important means.In addition, drug therapy is also by the Chinese medicine of Chemical peeling agent, chemical sunscreen agents and anti-aging, to ultraviolet
Caused light aging is prevented and treated.
At present, the relatively effective medicine of reply light aging is main based on Chemical peeling agent, chemical sunscreen agents, but these
Chemical composition often brings allergic adverse side effect of Denging.China's Traditional Chinese Medicine recognizes long history for daylight light poison,
Numerous studies show that some Chinese medicines have preferable light aging protective effect simultaneously, therefore are developed from the wide Chinese medicine of China
Satisfactory Related product has wide DEVELOPMENT PROSPECT.Dendrobium candidum has long as the typical Chinese medicine of China
Medication history, but there is not been reported for its related uvioresistant light injury.In consideration of it, the present invention proposes that a kind of moisturizing is oxidation resistant
Dendrobium candidum facial treatment milk and preparation method thereof.
The content of the invention
The technical problems to be solved by the invention, which are to provide one kind, to be had significantly maintenance or recovers skin elasticity, reduces or repair
The moisturizing antioxygen of microgroove, the deposition for suppressing lipofuscin, ultra-violet radiation resisting and slowing down skin aging effect that multiple skin is produced
Dendrobium candidum facial treatment milk of change and preparation method thereof.
The present invention solve the technical scheme that is used of above-mentioned technical problem for:A kind of oxidation resistant dendrobium candidum skin care of moisturizing
Emulsion, is made up of component A and B component, and the volume ratio of described component A and described B component is (0.5-1):(3-5);It is described
Component A mass percent composition include:Cetearyl glucoside 1-5wt%, methyl glucoside dioleate 1-
5wt%, cetostearyl alcohol 1-3wt%, tristerin l-5wt%, saualane 2-5wt%, nutmeg isopropyl propionate 0-
5wt%, isononyl isononanoate 0-10wt%, lanolin derivative 0.1-2wt%, olive oil 1-8wt%, Sweet Almond Oil 1-
8wt%, vitamin E 0.1-1wt%, glycerine 5-10wt%, plants essential oil 0.1-0.3wt%, preservative 0.05-0.5wt%,
Surplus is the aqueous solution of dendrobium candidum extract solid content, in terms of the quality of the aqueous solution, contains 2-4wt%'s in the aqueous solution
Dendrobium candidum extract solid content;Described B component is dendrobium candidum alcohol plastid suspension, and described dendrobium candidum alcohol plastid is mixed
The mass percent composition of suspension includes:Dendrobium candidum extract solid content 0.5-5wt%, lecithin 1-8wt%, cholesterol 0-
0.3wt%, ethanol 25-45wt%, vitamin E 0-0.1wt%, emulsifying agent 0-0.5wt%, surplus is water.
Preferably, the preparation process of described dendrobium candidum alcohol plastid suspension is:Each raw material is weighed, by described ovum
Phosphatide, cholesterol, vitamin E and emulsifying agent are dissolved in acetone, are formed uniformly by depressurizing rotary evaporation removing organic solvent
Film, then immobilized artificial membrane is obtained after thoroughly waving most organic solvent in vacuum drying chamber;Then by dendrobium candidum extract solid content
25-45% ethanol water is dissolved in, is then added in described immobilized artificial membrane and carries out aquation, formation is encapsulated with dendrobium candidum alcohol matter
After the dispersion liquid of body, ultrasonic disperse, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation obtains described iron sheet
Stem of noble dendrobium alcohol plastid suspension.Or, the preparation process of described dendrobium candidum alcohol plastid suspension is:Each raw material is weighed, by institute
Lecithin, cholesterol, vitamin E and the emulsifying agent stated are dissolved in 75-95% ethanol, obtain mixed liquor;By dendrobium candidum
Extract solid content is soluble in water, obtains dendrobium candidum aqueous phase, then at room temperature, under confined conditions while stirring by described mixing
Liquid is slowly injected into described dendrobium candidum aqueous phase, stirring, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation, i.e.,
Obtain described dendrobium candidum alcohol plastid suspension.The dendrobium candidum alcohol plastid contained in dendrobium candidum alcohol plastid suspension is in capsule
Blister, outward appearance is in the spheroid or spheroid of rule, and particle diameter is between 30-300nm.
Preferably, described emulsifying agent is Montanov 82, Montanov 202, Prolipid 131 and E-
At least one of Inspire 343.
Preferably, the preparation process of described dendrobium candidum extract solid content is:By the fresh bar of dendrobium candidum with it is pure
Water is according to 1:After 15 weight is than mixing, extracts three times, centrifuged every time under 4500r/min rotating speeds through multi-functional wall-breaking machine
20min, merges after extraction and extracts supernatant, obtain dendrobium candidum extract solution, obtained after being dried to the dendrobium candidum extract solution
Described dendrobium candidum extract solid content.The present invention prepares dendrobium candidum with dendrobium candidum all herbal medicine using extraction process by water
Extract solution, it is intended to farthest retain the effective active compositions such as dendrobium polysaccharide and dendrobine, and then play its maximum skin care work(
Effect.Operation is simple for the extraction of the dendrobium candidum extract solution, recovery rate is high, impurity is few in extract solution, is effectively reduced sensitization
The source of material, it is ensured that dendrobium candidum facial treatment milk of the present invention is safer on skin, non-stimulated.
The dendrobium candidum extract solution that water extraction is obtained is not easy to preserve, and the different drying process of present invention selection, is the later stage
Processing provides selection gist.Specifically, the drying process to described dendrobium candidum extract solution is:By described dendrobium candidum
Extract solution is divided into ceramic whiteware disk, then ceramic whiteware disk is placed in baking oven carries out heated-air drying, and drying temperature is 90 DEG C, drying time
For 4h.Or, the drying process to described dendrobium candidum extract solution is:Described dendrobium candidum extract solution is divided to ceramic whiteware
In disk, in the environment of vacuum is 0.9MPa, 24h is dried in vacuo with 60 DEG C of drying temperature.Or, to described iron sheet stone
The drying process of dry measure used in former times extract solution is:Described dendrobium candidum extract solution is divided to surface plate, is placed at -80 DEG C and is freeze-dried
72h.Or, the drying process to described dendrobium candidum extract solution is:By described dendrobium candidum extract solution dilute after 4 times
It is spray-dried in spray dryer, the EAT of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C.
A kind of preparation method of the oxidation resistant dendrobium candidum facial treatment milk of above-mentioned moisturizing, comprises the following steps:
(1) the various raw materials of preparation are weighed;
(2) take dendrobium candidum extract solid content soluble in water, obtain dendrobium candidum extract solid content for 2-
The aqueous solution of 4wt% dendrobium candidum extract solid content, then the addition water soluble ingredient cetearyl Portugal into the aqueous solution
Glucosides, methyl glucoside dioleate and glycerine, are heated to 70-80 DEG C after stirring, obtain aqueous phase;By cetearyl alcohol
Alcohol, tristerin, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative, olive oil, dessert almond
Oil, vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 70-80 DEG C, are stirred, and obtain oil phase, stand-by;So
Described aqueous phase is poured slowly into described oil phase afterwards, component A is obtained, 10-30min is stirred clockwise, treat the temperature of the component A
Degree is when being down to 45-55 DEG C, adds B component dendrobium candidum alcohol plastid suspension, and the volume ratio of component A and B component is (0.5-1):
(3-5), stirs and obtains the oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
Compared with prior art, the advantage of the invention is that:
(1) the oxidation resistant dendrobium candidum facial treatment milk of moisturizing disclosed by the invention, active component accumulation is high, preparation technology
Simply, materials safety, it is non-stimulated to skin, with it is notable maintain or recover skin elasticity, reduce or repair that skin produces it is thin
Line, deposition, ultra-violet radiation resisting and the slowing down skin aging effect for suppressing lipofuscin, it can effectively suppress ultraviolet irradiation institute
The skin photoage caused and the formation of daylight sunburn.
(2) dendrobium candidum alcohol plastid is contained in dendrobium candidum facial treatment milk disclosed by the invention, it is a kind of superminiature capsule
Carrier is steeped, the alcohol plastid has good superdeformable, under skin hydration pressure, and alcohol plastid can carry content tranmittance
Its own small 1/5~1/10 aperture, can rapidly enter deep skin, be to facilitate dendrobium candidum extract solution active ingredient to permeate
Effective transport vehicle in skin, the problem of solving the penetrating power difference of existing skin care item generally existing, improves iron sheet
The transdermal penetration effect of stem of noble dendrobium active ingredient.
Brief description of the drawings
Fig. 1 is Scavenging activity testing result of the dendrobium candidum facial treatment milk in embodiment to DPPH free radicals;
Fig. 2 is Scavenging activity testing result of the dendrobium candidum facial treatment milk in embodiment to ABTS free radicals;
Fig. 3 be in embodiment at the end of light aging model modeling after six groups of mouse skin HE sections tissue morphology (×
200);
Fig. 4 is investigation result of the dendrobium candidum facial treatment milk in embodiment to moisture of skin moisture-keeping function;
The investigation result that Fig. 5 is acted on skin oil holding for dendrobium candidum facial treatment milk in embodiment.
Embodiment
The present invention is described in further detail below in conjunction with accompanying drawing embodiment.
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing of embodiment one, is made up of, component A and B groups component A and B component
The volume ratio divided is 0.8:5;The mass percent composition of component A includes:Cetearyl glucoside 1.5wt%, methyl glucose
Glucosides dioleate 1.2wt%, cetostearyl alcohol 2wt%, tristerin 2.2wt%, saualane 3wt%, nutmeg acid
Isopropyl ester 2wt%, isononyl isononanoate 1.8wt%, lanolin derivative 1.6wt%, olive oil 3wt%, Sweet Almond Oil
5wt%, vitamin E 0.5wt%, glycerine 5wt%, plants essential oil 0.2wt%, preservative 0.25wt%, surplus is dendrobium candidum
The aqueous solution of extract solid content, in terms of the quality of the aqueous solution, the dendrobium candidum extract containing 3wt% is consolidated in the aqueous solution
Shape thing;B component is dendrobium candidum alcohol plastid suspension, and the mass percent composition of dendrobium candidum alcohol plastid suspension includes:Iron
Skin Herba Dendrobii extract solid content 2.5wt%, lecithin 5wt%, cholesterol 0.2wt%, ethanol 32wt%, vitamin E
The emulsifying agent 0.28wt% of 0.06wt%, Montanov 82, surplus is water;The oxidation resistant dendrobium candidum facial treatment milk of the moisturizing
Preparation method comprises the following steps:
(1) the various raw materials of preparation are weighed;
(2) preparation of dendrobium candidum extract solid content:By the fresh bar of dendrobium candidum and pure water according to 1:15 weight ratio
After mixing, extracted three times through multi-functional wall-breaking machine, centrifuge 20min under 4500r/min rotating speeds every time, merged after extraction and extract
Clear liquid, obtains dendrobium candidum extract solution, and dendrobium candidum extract solution is divided into ceramic whiteware disk, then ceramic whiteware disk is placed in baking oven
Row heated-air drying, drying temperature is 90 DEG C, and drying time is 4h, and dendrobium candidum extract solid content is obtained after drying;
(3) preparation of dendrobium candidum alcohol plastid suspension:Weigh each raw material, by lecithin, cholesterol, vitamin E and
Montanov82 emulsifying agents are dissolved in acetone, and uniform film is formed by depressurizing rotary evaporation removing organic solvent, then true
Immobilized artificial membrane is obtained after thoroughly waving most organic solvent in empty drying box;Then dendrobium candidum extract solid content is dissolved in 24-45%
Ethanol water in, be then added in immobilized artificial membrane and carry out aquation, formed and be encapsulated with the dispersion liquid of dendrobium candidum alcohol plastid, ultrasound
After scattered, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation obtains dendrobium candidum alcohol plastid suspension;
(4) take dendrobium candidum extract solid content soluble in water, obtain dendrobium candidum extract solid content for 3wt%
Dendrobium candidum extract solid content the aqueous solution, then add into the aqueous solution water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerine, are heated to 80 DEG C, obtain aqueous phase after stirring;By cetostearyl alcohol, stearic acid
Glyceride, methyl glucoside dioleate, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative,
Olive oil, Sweet Almond Oil, vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 80 DEG C, are stirred, obtain oil
Phase, it is stand-by;Then aqueous phase is poured slowly into oil phase, obtains component A, 10-30min is stirred clockwise, treat the temperature of the component A
When being down to 50 DEG C, B component dendrobium candidum alcohol plastid suspension is added, the volume ratio of component A and B component is 0.8:5, stir
Obtain the oxidation resistant dendrobium candidum facial treatment milk of moisturizing of embodiment one.
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing of embodiment two, is made up of, component A and B groups component A and B component
The volume ratio divided is 1:5;The mass percent composition of component A includes:Cetearyl glucoside 1.3wt%, methyl glucoside
Glycosides dioleate 2.7wt%, cetostearyl alcohol 1wt%, tristerin 3.5wt%, saualane 4.4wt%, different n-nonanoic acid is different
Nonyl ester 0.7wt%, lanolin derivative 0.5wt%, olive oil 1.2wt%, Sweet Almond Oil 1.5wt%, vitamin E
0.1wt%, glycerine 8wt%, plants essential oil 0.1wt%, preservative 0.5wt%, surplus are dendrobium candidum extract solid content
The aqueous solution, in terms of the quality of the aqueous solution, the dendrobium candidum extract solid content containing 2wt% in the aqueous solution;B component is iron
Skin stem of noble dendrobium alcohol plastid suspension, the mass percent composition of dendrobium candidum alcohol plastid suspension includes:Dendrobium candidum extract is consolidated
Shape thing 3wt%, lecithin 4.5wt%, ethanol 43wt%, the emulsifying agent of vitamin E 0.03wt%, Montanov 202
0.5wt%, surplus is water;The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing comprises the following steps:
(1) the various raw materials of preparation are weighed;
(2) preparation of dendrobium candidum extract solid content:By the fresh bar of dendrobium candidum and pure water according to 1:15 weight ratio
After mixing, extracted three times through multi-functional wall-breaking machine, centrifuge 20min under 4500r/min rotating speeds every time, merged after extraction and extract
Clear liquid, obtains dendrobium candidum extract solution, and dendrobium candidum extract solution is divided into ceramic whiteware disk, in the environment that vacuum is 0.9MPa
Under, 24h is dried in vacuo with 60 DEG C of drying temperature, dendrobium candidum extract solid content is obtained after drying;
(3) preparation of dendrobium candidum alcohol plastid suspension:Weigh each raw material, by lecithin, cholesterol, vitamin E and
Montanov202 emulsifying agents are dissolved in 75-95% ethanol, obtain mixed liquor;Dendrobium candidum extract solid content is dissolved in
In water, dendrobium candidum aqueous phase is obtained, then at room temperature, under confined conditions mixed liquor dendrobium candidum aqueous phase is slowly injected into while stirring
In, stir, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation obtains dendrobium candidum alcohol plastid suspension;
(4) take dendrobium candidum extract solid content soluble in water, obtain dendrobium candidum extract solid content for 2wt%
Dendrobium candidum extract solid content the aqueous solution, then add into the aqueous solution water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerine, are heated to 78 DEG C, obtain aqueous phase after stirring;By cetostearyl alcohol, stearic acid
Glyceride, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 78 DEG C, are stirred, and obtain oil phase, stand-by;Then it is aqueous phase is slow
Pour into oil phase, obtain component A, 10-30min is stirred clockwise, when the temperature of the component A is down to 45 DEG C, add B component iron
The volume ratio of skin stem of noble dendrobium alcohol plastid suspension, component A and B component is 1:5, stir and obtain the moisturizing antioxygen of embodiment two
The dendrobium candidum facial treatment milk of change.
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing of embodiment three, is made up of, component A and B groups component A and B component
The volume ratio divided is 0.6:4;The mass percent composition of component A includes:Cetearyl glucoside 2.1wt%, methyl glucose
Glucosides dioleate 3wt%, cetostearyl alcohol 2.5wt%, tristerin 1.7wt%, saualane 2.9wt%, nutmeg
Isopropyl propionate 4.9wt%, lanolin derivative 1.8wt%, olive oil 4.5wt%, Sweet Almond Oil 6wt%, vitamin E
0.8wt%, glycerine 7wt%, plants essential oil 0.25wt%, preservative 0.1wt%, surplus are dendrobium candidum extract solid content
The aqueous solution, in terms of the quality of the aqueous solution, the dendrobium candidum extract solid content containing 4wt% in the aqueous solution;B component is iron
Skin stem of noble dendrobium alcohol plastid suspension, the mass percent composition of dendrobium candidum alcohol plastid suspension includes:Dendrobium candidum extract is consolidated
Shape thing 1.5wt%, lecithin 2.3wt%, cholesterol 0.3wt%, ethanol 30wt%, vitamin E 0.1wt%, Prolipid
131 emulsifying agent 0.3wt%, surplus is water;The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing includes following step
Suddenly:
(1) the various raw materials of preparation are weighed;
(2) preparation of dendrobium candidum extract solid content:By the fresh bar of dendrobium candidum and pure water according to 1:15 weight ratio
After mixing, extracted three times through multi-functional wall-breaking machine, centrifuge 20min under 4500r/min rotating speeds every time, merged after extraction and extract
Clear liquid, obtains dendrobium candidum extract solution, and dendrobium candidum extract solution is divided to surface plate, is placed at -80 DEG C and is freeze-dried
72h, dendrobium candidum extract solid content is obtained after drying;
(3) preparation of dendrobium candidum alcohol plastid suspension:Weigh each raw material, by lecithin, cholesterol, vitamin E and
The emulsifying agents of Prolipid 131 are dissolved in 75-95% ethanol, obtain mixed liquor;Dendrobium candidum extract solid content is dissolved in
In water, dendrobium candidum aqueous phase is obtained, then at room temperature, under confined conditions mixed liquor dendrobium candidum aqueous phase is slowly injected into while stirring
In, stir, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation obtains dendrobium candidum alcohol plastid suspension;
(4) take dendrobium candidum extract solid content soluble in water, obtain dendrobium candidum extract solid content for 4wt%
Dendrobium candidum extract solid content the aqueous solution, then add into the aqueous solution water soluble ingredient cetearyl glucoside,
Methyl glucoside dioleate and glycerine, are heated to 70 DEG C, obtain aqueous phase after stirring;By cetostearyl alcohol, stearic acid
Glyceride, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 70 DEG C, are stirred, and obtain oil phase, stand-by;Then it is aqueous phase is slow
Pour into oil phase, obtain component A, 10-30min is stirred clockwise, when the temperature of the component A is down to 50 DEG C, add B component iron
The volume ratio of skin stem of noble dendrobium alcohol plastid suspension, component A and B component is 0.6:4, stir obtain embodiment three moisturizing resist
The dendrobium candidum facial treatment milk of oxidation.
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing of example IV, is made up of, component A and B groups component A and B component
The volume ratio divided is 0.5:3;The mass percent composition of component A includes:Cetearyl glucoside 4.8wt%, methyl glucose
Glucosides dioleate 4.5wt%, cetostearyl alcohol 3wt%, tristerin 4.6wt%, saualane 2wt%, nutmeg acid
Isopropyl ester 3.1%, isononyl isononanoate 8.4%, lanolin derivative 0.2wt%, olive oil 8wt%, Sweet Almond Oil 7.5%,
Vitamin E 1wt%, glycerine 10wt%, plants essential oil 0.15wt%, preservative 0.45wt%, surplus are dendrobium candidum extract
The aqueous solution of solid content, in terms of the quality of the aqueous solution, the dendrobium candidum extract solid containing 2.5wt% in the aqueous solution
Thing;B component is dendrobium candidum alcohol plastid suspension, and the mass percent composition of dendrobium candidum alcohol plastid suspension includes:Iron sheet
Herba Dendrobii extract solid content 3wt%, lecithin 4.7wt%, cholesterol 0.1wt%, the breast of ethanol 35wt%, E-Inspire 343
Agent 0.2wt%, surplus is water;The preparation method of the oxidation resistant dendrobium candidum facial treatment milk of the moisturizing comprises the following steps:
(1) the various raw materials of preparation are weighed;
(2) preparation of dendrobium candidum extract solid content:By the fresh bar of dendrobium candidum and pure water according to 1:15 weight ratio
After mixing, extracted three times through multi-functional wall-breaking machine, centrifuge 20min under 4500r/min rotating speeds every time, merged after extraction and extract
Clear liquid, obtains dendrobium candidum extract solution, is spray-dried after dendrobium candidum extract solution is diluted into 4 times in spray dryer,
The EAT of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C, and dendrobium candidum extract solid content is obtained after drying;
(3) preparation of dendrobium candidum alcohol plastid suspension:Each raw material is weighed, by lecithin, cholesterol, vitamin E and E-
Inspire343 emulsifying agents are dissolved in acetone, and uniform film is formed by depressurizing rotary evaporation removing organic solvent, then true
Immobilized artificial membrane is obtained after thoroughly waving most organic solvent in empty drying box;Then dendrobium candidum extract solid content is dissolved in 24-45%
Ethanol water in, be then added in immobilized artificial membrane and carry out aquation, formed and be encapsulated with the dispersion liquid of dendrobium candidum alcohol plastid, ultrasound
After scattered, the filtering with microporous membrane whole grain through 0.45um, 0.22um after elder generation obtains dendrobium candidum alcohol plastid suspension;
(4) take dendrobium candidum extract solid content soluble in water, obtaining dendrobium candidum extract solid content is
The aqueous solution of 2.5wt% dendrobium candidum extract solid content, then the addition water soluble ingredient cetearyl into the aqueous solution
Glucoside, methyl glucoside dioleate and glycerine, are heated to 75 DEG C, obtain aqueous phase after stirring;By cetostearyl alcohol,
Tristerin, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil,
Vitamin E, plants essential oil and preservative are mixed and stirred for, and are heated to 75 DEG C, are stirred, and obtain oil phase, stand-by;Then by water
Mutually it is poured slowly into oil phase, obtains component A, 10-30min is stirred clockwise, when the temperature of the component A is down to 40 DEG C, adds B
The volume ratio of component dendrobium candidum alcohol plastid suspension, component A and B component is 0.5:3, stir and obtain example IV
The oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
DPPH generally exists in the form of stable alcohol free radical, and DPPH radical scavenging activities are also most common external
Antioxidant system.After the dendrobium candidum facial treatment milk dilution of one~example IV of embodiment, detect it to DPPH free radicals
Scavenging activity, is as a result shown in Fig. 1.It can be seen from figure 1 that the dendrobium candidum facial treatment milk of one~example IV of embodiment is to DPPH free radicals
Clearance rate general performance go out certain difference, but overall show preferable DPPH radical scavenging activities, otherness
Smaller, showing the dendrobium candidum facial treatment milk of one~example IV of embodiment has fabulous antioxidation activity.
ABTS+Stable water-soluble free radical, ABTS can be formed+Scavenging activity be external common anti-oxidant comment
Valency system.After the dendrobium candidum facial treatment milk dilution of one~example IV of embodiment, its removing to ABTS free radicals is detected
Ability, is as a result shown in Fig. 2.As shown in Figure 2, with the rise of dendrobium candidum facial treatment milk concentration, its removing to ABTS free radicals
Effect gradually rises, but the overall radical scavenging activity of the facial treatment milk of four embodiments shows certain otherness, whole
Body is shown as:The > embodiments one of three > example IV > embodiments of embodiment two.
By taking the dendrobium candidum facial treatment milk of embodiment one as an example, the experiment of anti-mouse dermal photodamage, internal water are carried out to it
Divide moisture-retaining capacity and the experiment of oil holding capacity.
1st, dermal photodamage is tested
By 54 ICR mouse, 6 groups are randomly divided into:Normal group, control group, VE smearings group, low dosage emulsion smearing group, in
Dosage emulsion smearing group, high dose emulsion smearing group, wherein:Normal group is not irradiated by ultraviolet, the irradiation of control group ultraviolet, VE
Smearing group smears VE and ultraviolet irradiation (VE applying amounts are 500mg/kg), and low dosage smearing group smears dendrobium candidum emulsion and purple
Outside line irradiation (emulsion applying amount is 100mg/kg), middle dosage smearing group smears dendrobium candidum emulsion and ultraviolet irradiation (emulsion
Applying amount is 250mg/kg), high dose smearing group smear dendrobium candidum emulsion and ultraviolet irradiation (emulsion applying amount be 500mg/
kg)。
Before experiment starts, scissors trimming mouse skin hair, depilatory cream depilation, simulation daylight is carried out to depilation ICR mouse
Ultra violet lamp, makes mouse light loss wound model, and pre-irradiation shifts to an earlier date 0.5h according to above-mentioned dosage and smeared, and exposure intensity is:It is purple
(the 2.86 μ w/cm of outside line A fluorescent tubes two2), (the 175 μ w/cm of UV-B fluorescent tube one2), irradiation time is:Initial 1h, three daily
Daily 2h after it, daily 3h, keeps daily 5h later after one week, until control group mice skin thickens, and occurs wide and deep
Wrinkle, take around Continuous irradiation 10 weeks, irradiation terminates.Raised under 25 DEG C of indoor environments, mouse is given daily and is freely drunk
Food and drinking-water, during which without death condition.Experimental animal is raised under 25 DEG C of indoor environments by group point cage, is made light aging model.
During experiment, the same free diet of mouse and drinking-water are given daily.
At the end of light aging model modeling, entire effect of the observation ultraviolet irradiation to ICR mouse backs depilation skin:See
Discovery is examined, normal group mouse skin texture is normal, and skin is ruddy glossy, no wrinkle and corresponding pigment deposition phenomenon;Control
Lumps accumulation is presented in group mouse skin, hence it is evident that visible elasticity reduction and melanin deposition, while skin is matt, shows the source of an allusion
The skin photoage clinical symptoms of type, illustrate mouse light aging model modeling success;VE smearing group mouse skins are compared with control group skin
Skin glossiness makes moderate progress, and rare wrinkle of skin lumps packing phenomenon, and surface only has a small amount of pigmentation;Low dosage breast
Liquid smearing group mouse skin is made moderate progress compared with control group skin shine, rare lumps packing phenomenon, and result phase is smeared with VE
Seemingly, also there is a little Skin pigmentation phenomenon;Middle dosage emulsion smearing group mouse skin and high dose emulsion smearing group mouse skin
Skin is significantly improved compared with control group mice skin significant improvement, mouse skin glossiness, and skin surface without conspicuousness wrinkle with
Skin lumps are accumulated, and are shown preferable photoaging damage repair, are shown the iron sheet stone of one~example IV of embodiment
Dry measure used in former times facial treatment milk has good light injury repair function.
At the end of light aging model modeling, skin HE sections are carried out to six groups of mouse, the skin group of mouse light injury is observed
Form is knitted, as a result as shown in Figure 3.In Fig. 3, a is normal group, and b is control group, and c is VE smearing groups, and d smears for low dosage emulsion
Group, e is middle dosage emulsion smearing group, and f is high dose emulsion smearing group.From the figure 3, it may be seen that each Rotating fields of normal group mouse skin are complete
It is whole, it is connected clear with corium with respect to epidermis, epidermal thickness is moderate, corium is evenly distributed without hyperplasia, and corresponding collagenous fiber bundle,
It is not broken;Control group mice epiderm skin is substantially thickened, skin texture be layered unintelligible, skin corium conspicuousness hyperplasia, this with
Above-mentioned mouse macroscopic observation result mouse skin Flexible change is consistent, and a series of histology and morphology structure shows mouse light aging
Model modeling success;VE smearing group mouse show certain compared with low dosage emulsion smearing group mouse is compared with control group mice
Light injury repair, first dermal layer of the skin thickness are substantially reduced compared with control group, at the same corresponding collagenous fiber bundle distribution compared with
Control group is also greatly improved;The skin of middle dosage emulsion smearing group mouse and high dose emulsion smearing group mouse is then shown
Preferable light injury repairing effect, also indicating that the dendrobium candidum facial treatment milk of one~example IV of embodiment has good light loss
Hinder repair function.
2nd, internal water moisture-retaining capacity is tested
By 18 ICR mouse, 2 groups are randomly divided into:Control group does not smear dendrobium candidum facial treatment milk, and experimental group smears iron sheet
Stem of noble dendrobium facial treatment milk, investigates the dendrobium candidum facial treatment milk of embodiment one to moisture of skin moisture-keeping function.Fig. 4 protects for dendrobium candidum
Investigation result of the skin emulsion to moisture of skin moisture-keeping function.As can be seen from Figure 4, initial stage, the mouse of experimental group are smeared in facial treatment milk
Skin surface moisture is significantly raised, and 30.6% before smearing rises to 61.6%, effectively improves skin moisture content, table
Reveal very strong skin moisture-keeping effect, show that dendrobium candidum facial treatment milk has good moisture moistening effect.From time shaft
See, the moisture of skin of experimental mice is consistently higher than control group mice, show stronger moisture of skin moisture-keeping efficacy.
3rd, oil holding capacity is tested
By 18 ICR mouse, 2 groups are randomly divided into:Control group does not smear dendrobium candidum facial treatment milk, and experimental group smears iron sheet
Stem of noble dendrobium facial treatment milk, the dendrobium candidum facial treatment milk for investigating embodiment one is acted on skin oil holding.Fig. 5 protects for dendrobium candidum
The investigation result that skin emulsion is acted on skin oil holding.As can be seen from Figure 5, initial stage, the mouse of experimental group are smeared in facial treatment milk
Skin surface oil content is significantly raised, and 14.8% before smearing rises to 27.7%, and the skin oil of experimental mice contains
Amount is consistently higher than control group mice, shows good skin oil and keeps effect.
Claims (10)
1. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing, it is characterised in that be made up of component A and B component, described A groups
Divide and the volume ratio of described B component is (0.5-1):(3-5);The mass percent composition of described component A includes:Spermaceti is hard
Aliphatic radical glucoside 1-5 wt%, methyl glucoside dioleate 1-5 wt%, cetostearyl alcohol 1-3 wt%, tristerin
L-5 wt%, saualane 2-5 wt%, nutmeg isopropyl propionate 0-5 wt%, isononyl isononanoate 0-10 wt%, lanolin derivative
0.1-2 wt%, olive oil 1-8 wt%, Sweet Almond Oil 1-8 wt%, vitamin E 0.1-1 wt%, glycerine 5-10 wt %, plant
Essential oil 0.1-0.3 wt%, preservative 0.05-0.5 wt%, surplus are the aqueous solution of dendrobium candidum extract solid content, with the water
Dendrobium candidum extract solid content containing 2-4 wt% in the quality meter of solution, the aqueous solution;Described B component is iron sheet stone
Dry measure used in former times alcohol plastid suspension, the mass percent composition of described dendrobium candidum alcohol plastid suspension includes:Dendrobium candidum extract
Solid content 0.5-5 wt%, lecithin 1-8 wt%, cholesterol 0-0.3 wt%, ethanol 25-45 wt%, vitamin E 0-0.1
Wt%, emulsifying agent 0-0.5 wt%, surplus is water.
2. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 1, it is characterised in that described iron
The preparation process of skin stem of noble dendrobium alcohol plastid suspension is:Each raw material is weighed, by described lecithin, cholesterol, vitamin E and emulsification
Agent is dissolved in acetone, and uniform film is formed by depressurizing rotary evaporation removing organic solvent, then in vacuum drying chamber thoroughly
Immobilized artificial membrane is obtained after waving most organic solvent;Then dendrobium candidum extract solid content is dissolved in 25-45 % ethanol water, then
It is added in described immobilized artificial membrane and carries out aquation, is formed after the dispersion liquid for being encapsulated with dendrobium candidum alcohol plastid, ultrasonic disperse, successively
Filtering with microporous membrane whole grain through 0.45 um, 0.22 um, that is, obtain described dendrobium candidum alcohol plastid suspension.
3. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 1, it is characterised in that described iron
The preparation process of skin stem of noble dendrobium alcohol plastid suspension is:Each raw material is weighed, by described lecithin, cholesterol, vitamin E and emulsification
Agent is dissolved in 75-95 % ethanol, obtains mixed liquor;Dendrobium candidum extract solid content is soluble in water, obtain iron sheet stone
Described mixed liquor, then at room temperature, is under confined conditions slowly injected into described dendrobium candidum aqueous phase by dry measure used in former times aqueous phase while stirring,
Filtering with microporous membrane whole grain through 0.45 um, 0.22 um after stirring, elder generation, that is, obtain described dendrobium candidum alcohol plastid and be suspended
Liquid.
4. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 1, it is characterised in that described breast
Agent is at least one of Montanov 82, Montanov 202, Prolipid 131 and E-Inspire 343.
5. a kind of oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to any one of claim 1-4, its feature exists
It is in the preparation process of described dendrobium candidum extract solid content:By the fresh bar of dendrobium candidum and pure water according to 1:15 weight
After mixing, extracted three times through multi-functional wall-breaking machine, centrifuge 20 min under 4500 r/min rotating speeds every time, merged after extraction and carry
Supernatant is taken, dendrobium candidum extract solution is obtained, described dendrobium candidum is obtained after being dried to the dendrobium candidum extract solution and is extracted
Thing solid content.
6. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that to described iron sheet
The drying process of dendrobium extract is:Described dendrobium candidum extract solution is divided into ceramic whiteware disk, then ceramic whiteware disk is placed in baking
Heated-air drying is carried out in case, drying temperature is 90 DEG C, and drying time is 4 h.
7. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that to described iron sheet
The drying process of dendrobium extract is:Described dendrobium candidum extract solution is divided into ceramic whiteware disk, is 0.9 MPa in vacuum
In the environment of, 24 h are dried in vacuo with 60 DEG C of drying temperature.
8. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that to described iron sheet
The drying process of dendrobium extract is:Described dendrobium candidum extract solution is divided to surface plate, is placed at -80 DEG C and freezes
Dry 72 h.
9. the oxidation resistant dendrobium candidum facial treatment milk of moisturizing according to claim 5, it is characterised in that to described iron sheet
The drying process of dendrobium extract is:Sprayed after described dendrobium candidum extract solution is diluted into 4 times in spray dryer
Dry, the EAT of spray dryer is 200 DEG C, and leaving air temp is 80 DEG C.
10. a kind of preparation method of the oxidation resistant dendrobium candidum facial treatment milk of moisturizing described in claim 1, it is characterised in that bag
Include following steps:
(1)Weigh the various raw materials of preparation;
(2)Take dendrobium candidum extract solid content soluble in water, it is 2-4 wt%'s to obtain dendrobium candidum extract solid content
The aqueous solution of dendrobium candidum extract solid content, then addition water soluble ingredient cetearyl glucoside, first into the aqueous solution
Base glucoside dioleate and glycerine, are heated to 70-80 DEG C after stirring, obtain aqueous phase;By cetostearyl alcohol, stearic acid
Glyceride, saualane, nutmeg isopropyl propionate, isononyl isononanoate, lanolin derivative, olive oil, Sweet Almond Oil, vitamin
E, plants essential oil and preservative are mixed and stirred for, and are heated to 70-80 DEG C, are stirred, and obtain oil phase, stand-by;Then will be described
Aqueous phase be poured slowly into described oil phase, obtain component A, 10-30min stirred clockwise, treat that the temperature of the component A is down to
At 45-55 DEG C, B component dendrobium candidum alcohol plastid suspension is added, the volume ratio of component A and B component is (0.5-1):(3-5),
Stir and obtain the oxidation resistant dendrobium candidum facial treatment milk of moisturizing.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114796115A (en) * | 2021-04-23 | 2022-07-29 | 四川大学华西医院 | Dendrobium officinale polysaccharide external preparation as well as preparation method and application thereof |
WO2023211829A1 (en) * | 2022-04-25 | 2023-11-02 | Access Business Group International Llc | Composition and method for inhibiting advanced glycation end products |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103585053A (en) * | 2013-10-30 | 2014-02-19 | 广州品赫化妆品有限公司 | Dendrobium-extract-containing composition and preparation method thereof |
KR20150019276A (en) * | 2013-08-13 | 2015-02-25 | 주식회사 한국화장품제조 | Cosmetic composition including an extract of the tissue-cultured dendrobium, and preparatioin method of the extract |
CN105125435A (en) * | 2015-08-18 | 2015-12-09 | 广州栋方生物科技股份有限公司 | Moisturizing composition as well as preparation method and application thereof |
US20160051463A1 (en) * | 2011-09-14 | 2016-02-25 | Nefeli Corp. | Herbal skin care composition |
CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
CN106420536A (en) * | 2016-11-25 | 2017-02-22 | 上海娇云日化有限公司 | Hydrated cream and preparation method thereof |
CN106727164A (en) * | 2017-02-16 | 2017-05-31 | 中山卡丝生物科技有限公司 | A kind of moisture-keeping composition and its preparation method and application |
-
2017
- 2017-05-08 CN CN201710316690.5A patent/CN107157872B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160051463A1 (en) * | 2011-09-14 | 2016-02-25 | Nefeli Corp. | Herbal skin care composition |
KR20150019276A (en) * | 2013-08-13 | 2015-02-25 | 주식회사 한국화장품제조 | Cosmetic composition including an extract of the tissue-cultured dendrobium, and preparatioin method of the extract |
CN103585053A (en) * | 2013-10-30 | 2014-02-19 | 广州品赫化妆品有限公司 | Dendrobium-extract-containing composition and preparation method thereof |
CN105125435A (en) * | 2015-08-18 | 2015-12-09 | 广州栋方生物科技股份有限公司 | Moisturizing composition as well as preparation method and application thereof |
CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
CN106420536A (en) * | 2016-11-25 | 2017-02-22 | 上海娇云日化有限公司 | Hydrated cream and preparation method thereof |
CN106727164A (en) * | 2017-02-16 | 2017-05-31 | 中山卡丝生物科技有限公司 | A kind of moisture-keeping composition and its preparation method and application |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114796115A (en) * | 2021-04-23 | 2022-07-29 | 四川大学华西医院 | Dendrobium officinale polysaccharide external preparation as well as preparation method and application thereof |
CN114796115B (en) * | 2021-04-23 | 2023-09-15 | 四川大学华西医院 | Dendrobium candidum polysaccharide external preparation and preparation method and application thereof |
WO2023211829A1 (en) * | 2022-04-25 | 2023-11-02 | Access Business Group International Llc | Composition and method for inhibiting advanced glycation end products |
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