CN107157461A - Noninvasive continuous BP measurement method based on photoplethysmographic - Google Patents
Noninvasive continuous BP measurement method based on photoplethysmographic Download PDFInfo
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- CN107157461A CN107157461A CN201710546746.6A CN201710546746A CN107157461A CN 107157461 A CN107157461 A CN 107157461A CN 201710546746 A CN201710546746 A CN 201710546746A CN 107157461 A CN107157461 A CN 107157461A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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Abstract
The present invention relates to blood pressure measurement technical field, specifically, it is related to a kind of noninvasive continuous BP measurement method based on photoplethysmographic.It comprises the following steps：Step 1: the volume pulsation wave of collection measurement object, obtains digital volume pulse wave；Step 2: extracting maximum amplitude Hp, minimum amplitude Ht and the heart beat cycles T of digital volume pulse wave, and then obtain pulse waveform area Aarea and pulse wave average amplitude Have of the digital volume pulse wave in a heart beat cycles T；Step 3: obtaining second-order differential volume pulsation wave, extract first rising fulcrum P1 and second of the second-order differential volume pulsation wave in a heart beat cycles T and rise fulcrum P2, and then pulse wave translation time PWTT is obtained, pulse wave translation time PWTT is the time difference between the first rising fulcrum P1 and the second rising fulcrum P2；Step 4: obtaining pulse pressure difference DP；Step 5: obtaining systolic pressure SBP；Step 6: obtaining diastolic pressure.Measurement accuracy of the present invention is high and measurement is easy.
Description
Technical field
The present invention relates to blood pressure measurement technical field, specifically, it is related to a kind of based on the noninvasive of photoplethysmographic
Continuous BP measurement method.
Background technology
Blood pressure (Blood Pressure, BP) is as the important physiological health index of human body, and it can be such as cardiovascular disease
The Clinics and Practices of disease etc. provide important parameter foundation.
Existing blood pressure measurement can be divided into invasive blood pressure measurement and non-invasive blood pressure measures two major classes, wherein：Invasive blood pressure
Measurement needs to insert the main artery or heart of measurement object to detect blood pressure signal, measurement result by the conduit of pressure sensor
Precisely, but time length, high is required to testee and easily causes complication；Non-invasive blood pressure measurement is general by contacting people's body surface
Layer obtains characteristic signal and analyze and process obtaining blood pressure, and wound will not be brought to testee, therefore non-invasive measurement method is more suitable for
The demand of conventional blood pressure measurement.
The automatic continuous measurement of blood pressure medically has great practical significance, such as on clinical medicine to urgent patient and
Patient with severe symptoms in operation is required for carrying out the continuous monitoring of blood pressure, once so that the unexpected medical personnel of patient's appearance can
Effective rescue measure is taken in time.Existing such as Ke Shi auditions method, oscillographic method, angiosthenia method, volume-compensation method are noninvasive
Blood pressure measuring method is limited due to the factor such as being recovered by blood vessel elasticity, can not all be carried out blood pressure and continuously be monitored.
Volume pulsation wave being commonly based at present noninvasive continuous monitoring being carried out to the blood pressure of measurement object, this kind of method is main
It is to be realized by setting up the model of volume pulsation wave conduction time and blood pressure correlation.
The method for carrying out blood pressure measurement by volume pulsation wave conduction time mainly has two kinds：1st, while measuring electrocardio all the way
Signal and pulse wave signal, conduction time of the pulse wave from heart to measurement position is obtained according to the time difference of two signals；2、
Two-way is measured simultaneously apart from the different photoplethysmographic of heart, is calculated and obtained according to the time difference of two-way pulse wave characteristic point
Pulse wave translation time.Both approaches, which can unite, is classified as two point form measuring method, and measurement process is related to the multiple positions of human body, surveys
Complex operation is measured, is easily influenceed by measurement position and brings error.In addition, pulse wave translation time is in line with human body systolic pressure
Sexual intercourse, it is not good with human body diastolic pressure linear dependence, therefore human body diastolic pressure can not pass through pulse wave translation time well
Measure.
The content of the invention
Present disclosure is to provide a kind of noninvasive continuous BP measurement method based on photoplethysmographic, and it can
Overcome certain or some defects of prior art.
According to the noninvasive continuous BP measurement method based on photoplethysmographic of the present invention, it comprises the following steps：
Step 1: the volume pulsation wave of collection measurement object, after processing, obtains the digital volume arteries and veins of digital signal form
Fight ripple, the digital volume pulse wave time, c was represented to the mapping relations of amplitude with f (c)；
Step 2: maximum amplitude Hp, minimum amplitude Ht and the heart beat cycles T of digital volume pulse wave are extracted, according to
Formula " Aarea=∫ f (c) dc-Ht* C " obtains pulse waveform face of the digital volume pulse wave in a heart beat cycles T
Product Aarea, according to formula " Haυe=Ht+(Aarea/ C) " obtain pulse wave average amplitude Have；
Step 3: obtaining second-order differential volume pulsation wave by carrying out second-order differential computing to digital volume pulsation wave, carry
Take first rising fulcrum P1 and second of the second-order differential volume pulsation wave in a heart beat cycles T to rise fulcrum P2, enter
And pulse wave translation time PWTT is obtained, pulse wave translation time PWTT is between the first rising fulcrum P1 and the second rising fulcrum P2
Time difference；
Step 4: according to formulaObtain arteries and veins
Pressure difference DP, wherein, α is the coefficient related to blood vessel feature；
Step 5: systolic pressure SBP is obtained according to formula " SBP=aPWTT+b ", wherein, a and b are fitting coefficient；
Step 6: obtaining diastolic pressure, diastolic pressure is systolic pressure SBP and pulse pressure difference DP difference.
In the present invention, it is only necessary to gather single-point photoplethysmographic signal, you can preferably obtain systolic pressure SBP and relax
Pressure, so as to greatly reduce signal acquisition difficulty, preferably improve measurement comfort level, and forecast model result precision compared with
Height, so as to realize continuous blood pressure monitoring well.
Preferably, in step one, gathering the volume pulsation wave of measurement object to obtain simulation using photoelectric sensor
The simulation volume pulsation wave of signal form, carries out noise reduction, amplification and AD conversion to simulation volume pulsation wave afterwards and then obtains successively
Primary digital volume pulsation wave is taken, primary digital volume pulsation wave is filtered and corrected successively afterwards and then numeral appearance is obtained
Product pulse wave.So as to preferably lift the precision of final handled signal, and then greatly improve measurement accuracy.
Preferably, in step 2, using adaptive local extremum seeking method extract digital volume pulse wave most significantly
Value Hp, minimum amplitude Ht and heart beat cycles T.So as to preferably obtain digital volume pulse wave maximum amplitude Hp,
Minimum amplitude Ht and heart beat cycles T
Preferably, in step 3, extracting first using adaptive local extremum seeking method and rising on fulcrum P1 and second
Ascending branch point P2.Rise fulcrum P2 so as to preferably obtain the first rising fulcrum P1 and second.
Preferably, carrying out noise reduction, amplification and AD conversion successively to simulation volume pulsation wave using AFE4400.So as to
It is enough that preferably simulation volume pulsation wave signal is nursed one's health.
Brief description of the drawings
Fig. 1 be embodiment 1 in photoelectric sensor course of work schematic diagram；
Fig. 2 is oscillogram of the digital volume pulse wave in a heart beat cycles；
Fig. 3 is oscillogram of the second-order differential volume pulsation wave in a heart beat cycles.
Embodiment
To further appreciate that present disclosure, the present invention is described in detail in conjunction with the accompanying drawings and embodiments.It should be understood that
, embodiment be only the present invention is explained and and it is non-limiting.
Embodiment 1
A kind of noninvasive continuous BP measurement method based on photoplethysmographic is present embodiments provided, it can pass through
Photoplethysmographic obtains human body systolic pressure and human body diastolic pressure, so as to be obtained in noninvasive, convenient, accurate, continuous mode
Blood pressure measurement.
Noninvasive continuous BP measurement method in the present embodiment comprises the following steps：
Step 1: the volume pulsation wave of collection measurement object, after processing, obtains the digital volume arteries and veins of digital signal form
Fight ripple, the digital volume pulse wave time, c was represented to the mapping relations of amplitude with f (c)；
With reference to shown in Fig. 1, adopted at the finger tips 200 that the measurement object of a photoelectric sensor 100 is used in the present embodiment
Collect the volume pulsation wave of measurement object, photoelectric sensor 100 includes infrared emitter 110, red emission source 120 and opto-electronic receiver
Pipe 130；Wherein, infrared emitter 110 to the launch wavelength of finger tips 200 be 810nm measuring beam, red emission source 120
To the measuring beam that the launch wavelength of finger tips 200 is 600nm, photoelectric receiving tube 130 receives two measuring beams through finger end
Optical signal after the absorption of end 200 is so as to obtain the simulation volume pulsation wave of analog signal form；Afterwards using AFE4400 to simulation
Volume pulsation wave carries out noise reduction, across resistance amplification and AD conversion, so as to obtain primary digital volume pulsation wave successively；Afterwards, will be just
The digital volume pulsation wave of level is sent into a MCU, carries out 0.1Hz~30Hz band to primary digital volume pulsation wave in the MCU
Pass filter, and signal correction is carried out using existing mathematical Morphology Algorithm, and then drifting baseline is removed, so as to obtain signal to noise ratio
High, feature clearly digital volume pulse wave；
Step 2: using existing adaptive local extremum seeking method extract digital volume pulse wave maximum amplitude Hp,
Minimum amplitude Ht and heart beat cycles T, according to formula " Aarea=∫ f (c) dc-Ht* C " obtains digital volume pulse wave at one
Pulse waveform area Aarea in heart beat cycles T, according to formula " Haυe=Ht+(Aarea/ C) " obtain pulse wave be averaged
Amplitude Have；
As shown in Fig. 2 being oscillograms of the digital volume pulse wave f (c) in a heart beat cycles T；The present embodiment
In, extract the time interval of two neighboring pulse wave (multiple continuous pulse waves are included in digital volume pulse wave) main ripple crest
As heart beat cycles T, make the maximum of pulse wave in a heart beat cycles T as maximum amplitude Hp, minimum value
For minimum amplitude Ht；Pulse waveform area Aarea is obtained by integral operation afterwards, and then obtains pulse wave average amplitude
Have；
Step 3: obtaining second-order differential volume pulsation wave by carrying out second-order differential computing to digital volume pulsation wave, adopt
First of second-order differential volume pulsation wave in a heart beat cycles T is extracted with existing adaptive local extremum seeking method
Rise fulcrum P1 and second and rise fulcrum P2, and then obtain pulse wave translation time PWTT, pulse wave translation time PWTT is the
One rises the time difference between the rising fulcrums of fulcrum P1 and second P2；
As shown in figure 3, the oscillogram for second-order differential volume pulsation wave in a heart beat cycles T；The present embodiment
In, the first rising fulcrum P1 and the second rising fulcrum P2 are burst out and flowed back with the blood because of caused by heartbeat and set up connection
System, so that the time interval between the first rising fulcrum P1 and the second rising fulcrum P2 is put out to being transferred to as blood from heart
The pulse wave translation time PWTT of end finger capillary；
Step 4: according to formulaObtain pulse pressure
Poor DP, wherein, α is the coefficient related to blood vessel feature；
In the present embodiment, according to Lambert-Beer's law association detection light intensity and the relation and human finger pulse blood of output voltage
The change of pressure-volume product and the relation of blood pressure, obtain pulse pressure difference DP and maximum amplitude Hp, minimum amplitude Ht, pulse wave average amplitude Have
Relation with pulse waveform area Aarea isWherein
α is the fitting coefficient relevant with blood vessel characteristic parameter；Using pulse pressure difference DP as dependent variable, with maximum amplitude Hp, minimum amplitude Ht, arteries and veins
Ripple average amplitude Have and pulse waveform area Aarea and the blood vessel PARAMETER ALPHA of fighting are independent variable, you can obtain formulaAnd then can preferably obtain pulse pressure difference DP's
Forecast model；It is worth noting that, blood vessel PARAMETER ALPHA is progressively obtained through repeatedly fitting, i.e., pulse pressure difference DP is also through multiple
It is fitted and progressively obtains；
Step 5: systolic pressure SBP is obtained according to formula " SBP=aPWTT+b ", wherein, a and b are fitting coefficient；
In the present embodiment, because systolic pressure SBP and pulse wave translation time PWTT are linear, therefore with systolic pressure
SBP is dependent variable, using pulse wave translation time PWTT as independent variable, and carries out regression analysis and can set up the pre- of systolic pressure SBP
Survey model, i.e. " SBP=aPWTT+b "；Wherein, fitting coefficient a and b can be obtained by being progressively fitted；
Step 6: obtaining diastolic pressure, diastolic pressure is systolic pressure SBP and pulse pressure difference DP difference.
In the present embodiment, diastolic pressure can be accurately obtained using difference and calculating (systolic pressure SBP- pulse pressure difference DP).
By the method provided in the present embodiment, the systolic pressure SBP of measurement object more can be accurately continuously acquired
And diastolic pressure, and can be analyzed by correlation analysis and Bland-Altman, checking this method is in terms of blood pressure is measured
Precision, and then corresponding measurement model is improved.
Method in the present embodiment, it is only necessary to gather single-point photoplethysmographic signal, you can preferably obtain and shrink
SBP and diastolic pressure are pressed, so that greatly reduce signal acquisition difficulty, preferably improve measurement comfort level, and forecast model
As a result precision is higher, so as to realize continuous blood pressure monitoring well.
Schematical above that the present invention and embodiments thereof are described, the description does not have restricted, institute in accompanying drawing
What is shown is also one of embodiments of the present invention, and actual structure is not limited thereto.So, if the common skill of this area
Art personnel are enlightened by it, without departing from the spirit of the invention, are designed and the technical scheme without creative
Similar frame mode and embodiment, all should belong to protection scope of the present invention.
Claims (5)
1. the noninvasive continuous BP measurement method based on photoplethysmographic, it comprises the following steps：
Step 1: the volume pulsation wave of collection measurement object, after processing, obtains the digital volume pulse of digital signal form
Ripple, the digital volume pulse wave time, c was represented to the mapping relations of amplitude with f (c)；
Step 2: maximum amplitude Hp, minimum amplitude Ht and the heart beat cycles T of digital volume pulse wave are extracted, according to formula
“Aarea=∫ f (c) dc-Ht* C " obtains pulse waveform area of the digital volume pulse wave in a heart beat cycles T
Aarea, according to formula " Haυe=Ht+(Aarea/ C) " obtain pulse wave average amplitude Have；
Step 3: obtaining second-order differential volume pulsation wave by carrying out second-order differential computing to digital volume pulsation wave, two are extracted
First rising fulcrum P1 and second of the rank differential volume pulsation wave in a heart beat cycles T rises fulcrum P2, and then obtains
Take pulse wave translation time PWTT, pulse wave translation time PWTT be first rise fulcrum P1 and second rise between fulcrum P2 when
Between it is poor；
Step 4: according to formulaObtain pulse pressure difference
DP, wherein, α is the coefficient related to blood vessel feature；
Step 5: systolic pressure SBP is obtained according to formula " SBP=aPWTT+b ", wherein, a and b are fitting coefficient；
Step 6: obtaining diastolic pressure, diastolic pressure is systolic pressure SBP and pulse pressure difference DP difference.
2. the noninvasive continuous BP measurement method according to claim 1 based on photoplethysmographic, it is characterised in that：
In step one, gather the volume pulsation wave of measurement object to obtain the simulation volume of analog signal form using photoelectric sensor
Pulse wave, carries out noise reduction, amplification and AD conversion to simulation volume pulsation wave afterwards and then obtains primary digital volume pulsation successively
Ripple, is filtered and corrects successively to primary digital volume pulsation wave afterwards and then obtain digital volume pulse wave.
3. the noninvasive continuous BP measurement method according to claim 1 based on photoplethysmographic, it is characterised in that：
In step 2, using adaptive local extremum seeking method extract digital volume pulse wave maximum amplitude Hp, minimum amplitude Ht and
Heart beat cycles T.
4. the noninvasive continuous BP measurement method according to claim 1 based on photoplethysmographic, it is characterised in that：
In step 3, extract first using adaptive local extremum seeking method and rise the rising fulcrums of fulcrum P1 and second P2.
5. the noninvasive continuous BP measurement method according to claim 2 based on photoplethysmographic, it is characterised in that：
Noise reduction, amplification and AD conversion are carried out using AFE4400 successively to simulation volume pulsation wave.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549639A (en) * | 2017-09-26 | 2019-04-02 | 郑昕 | A kind of pulse wave pressure and blood pressure measurement device and measurement method |
| CN110367959A (en) * | 2019-07-18 | 2019-10-25 | 上海海事大学 | A kind of blood pressure measuring device based on pulse wave phase difference and pulse wave characteristic parameters |
| CN110403579A (en) * | 2018-04-28 | 2019-11-05 | 深圳市大耳马科技有限公司 | A kind of pulse transit parameter measurement system and method |
| CN110403580A (en) * | 2018-04-28 | 2019-11-05 | 深圳市大耳马科技有限公司 | A kind of pulse transit measurement method of parameters and pulse transit parameter processing device |
| CN110638435A (en) * | 2018-06-27 | 2020-01-03 | 深圳市大耳马科技有限公司 | Heart physiological parameter measuring method, device, terminal and computer storage medium |
| CN112336326A (en) * | 2020-10-21 | 2021-02-09 | 华南师范大学 | Volume pulse wave signal processing method, blood pressure measuring device, and storage medium |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549639A (en) * | 2017-09-26 | 2019-04-02 | 郑昕 | A kind of pulse wave pressure and blood pressure measurement device and measurement method |
| CN110403579A (en) * | 2018-04-28 | 2019-11-05 | 深圳市大耳马科技有限公司 | A kind of pulse transit parameter measurement system and method |
| CN110403580A (en) * | 2018-04-28 | 2019-11-05 | 深圳市大耳马科技有限公司 | A kind of pulse transit measurement method of parameters and pulse transit parameter processing device |
| CN110638435A (en) * | 2018-06-27 | 2020-01-03 | 深圳市大耳马科技有限公司 | Heart physiological parameter measuring method, device, terminal and computer storage medium |
| CN110367959A (en) * | 2019-07-18 | 2019-10-25 | 上海海事大学 | A kind of blood pressure measuring device based on pulse wave phase difference and pulse wave characteristic parameters |
| CN112336326A (en) * | 2020-10-21 | 2021-02-09 | 华南师范大学 | Volume pulse wave signal processing method, blood pressure measuring device, and storage medium |
| CN112336326B (en) * | 2020-10-21 | 2023-09-05 | 华南师范大学 | Volume pulse wave signal processing method, blood pressure measuring device, and storage medium |
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Application publication date: 20170915 |