CN107095882A - A kind of water-soluble calcium particle and preparation method thereof - Google Patents
A kind of water-soluble calcium particle and preparation method thereof Download PDFInfo
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- CN107095882A CN107095882A CN201710214348.4A CN201710214348A CN107095882A CN 107095882 A CN107095882 A CN 107095882A CN 201710214348 A CN201710214348 A CN 201710214348A CN 107095882 A CN107095882 A CN 107095882A
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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Abstract
The present invention discloses a kind of water-soluble calcium particle and preparation method thereof, belongs to veterinary drug technical field, water-soluble calcium particle is made up of the supplementary material of following weight parts：Special 600~800 parts of oyster calcium carbonate, 400~600 parts of calcium monohydrogen phosphate, 700~900 parts of DEXTROSE ANHYDROUS, 1~3 part of catalase, 1~3 part of glucose oxidase, 5~7 parts of magnesium sulfate, 80~120 parts of zinc sulfate, 800~1000 parts of lactic acid, appropriate calcium carbonate, 700~900 parts of beta-cyclodextrin, 150~250 parts of oligosaccharide.Water-soluble calcium particle in the present invention is used as calcium supplement and calcium absorption accelerator, mainly the various problems caused by treatment livestock and poultry calcium deficiency and calcium absorption are not enough, and calcium content is more than 22% in water-soluble calcium particle in the present invention.
Description
Technical field
The present invention relates to veterinary drug technical field, more particularly to a kind of water-soluble calcium particle and preparation method thereof.
Background technology
Calcium is a kind of to the very important physiological activator of vital movement.Calcium ion is inherently important to blood clotting in animal body
Effect, the conduction to nerve, muscle excitement, nerve impulse plays an important role, and the maintenance of adhesion, cell membrane function to cell has
Important function, has activation to enzyme reaction, there is conclusive influence on the secretion of the incretory such as hypophysis, sexual gland, calcium from
Son is relevant with the function of the organ such as nerve, endocrine, breathing, circulation, digestion, reproductive system.
Calcium has following important physiological action：One is to form and maintain bone, the structure of tooth and composition miscible calcium pool bone
Calcium in bone and tooth accounts for the 99% of total amount, mainly exists with hydroxyapatite.Remaining in 1% half chelated with citric acid or with
Protein is combined, and second half is then present in outside soft tissue cells in liquid and blood with ionic condition, is miscible calcium pool.Miscible calcium pool
The calcium in dynamic equilibrium, i.e. bone is presented between skeletal calcium constantly to discharge in the presence of osteoclast into miscible calcium
Pond；And the calcium in miscible calcium pool is constantly deposited in bone, so that the calcium in bone is constantly able to supplement renewal, as bone
Update.Two be that the calcium ion that calcium can maintain the normal physiological condition of cell intracellular is cell to stimulating aitiogenic medium.
The regulation many important physiological functions of body jointly such as calcium and acceptor calcium, include the contraction of skeletal muscle and cardiac muscle, smooth muscle and non-
The maintenance of muscle cell activities and nervous excitation.Three be to participate in Blood Coagulation Process to be currently known at least 4 kinds vitamin K dependents
Calbindin participate in Blood Coagulation Process, i.e., be only possible to complete cascade reaction in the presence of calcium ion, finally make solubility
Fibrinogen is changed into fibrin, forms blood coagulation.Therefore, calcium has irreplaceable important function for animal.
Long term Animal calcium deficiency or calcium are insufficient, or lack and promote the vitaminAD (ostelin) of calcium uptake to occur
Acalcicosis, because calcium deficiency can induce a variety of diseases.The calcium preparation generally existing cost added in animal feed is high, content is low, inhale
The low problem of yield, and primarily as the calcium tonic of human body.Therefore, it is still anxious treat to develop safe and efficient feeding calcium tonic
One of the problem of solution.
The content of the invention
The invention provides a kind of water-soluble calcium particle and preparation method thereof, solve the existing calcium preparation for animal and inhale
Yield is low, the problem of effect of supplemented calcium is poor.
In order to solve the above technical problems, the technical scheme is that：
A kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special 600~800 parts of oyster calcium carbonate, phosphoric acid
400~600 parts of hydrogen calcium, 700~900 parts of DEXTROSE ANHYDROUS, 1~3 part of catalase, 1~3 part of glucose oxidase, sulfuric acid
It is 5~7 parts of magnesium, 80~120 parts of zinc sulfate, 800~1000 parts of lactic acid, appropriate calcium carbonate, 700~900 parts of cycloheptaamylose, oligomeric
150~250 parts of oligosaccharides.
Wherein it is preferred to, the enzyme activity force value of the catalase is 2000IU/g.
Wherein it is preferred to, the enzyme activity force value of the glucose oxidase is 2000IU/g.
Wherein it is preferred to, the molar concentration of the lactic acid is 6.45mol/L.
The present invention simultaneously provides a kind of preparation method of water-soluble calcium particle, comprises the following steps：
(1) take 3000 parts of purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Wherein it is preferred to, 0.8~1.2mm of particle size range of particle is made in the step (5).
Water-soluble calcium particle effect purposes in the present invention：Calcium supplement and calcium absorption accelerator.Mainly in treatment
Water-soluble calcium particle calcium content is more than 22% in various problems caused by livestock and poultry calcium deficiency and calcium absorption are not enough, the present invention.
Usage and dosage：
1st, treat：The molten water 600-1000kg of every bottle of 150g, freely drink for livestock and poultry.Prevention halves, and is used in conjunction 5-7 days.Severe
Also consumption can be increased.
2nd, spice is used, and complete diet pellet per ton adds 150-200 grams of this product, is used for a long time.
Beneficial effect of the present invention：
The water-soluble calcium grain dissolution of the present invention is rapid, animal absorptivity is high, the effect with strong bone, and can be with
Prevent animal due to various diseases caused by calcium deficiency.
For poultry：
1st, preventing and treating chicken, duck, goose, dove whole body skeleton bulking caused by calcium deficiency and be deficient in vitamin A, D, bone density reduction,
Generation can not stood, the disease such as limping, arthroncus deformation, paralysis.
2nd, can substantially increase egg size and eggshell hardness, improve eggshell and yolk color, effectively preventing and treating cage bird production check,
Soft egg, white lime-preserved egg, husky lime-preserved egg.
3rd, effectively preventing and treating " burnout syndrome of laying eggs ", the disease such as stretches, has difficult labour, paralyses after midnight sudden onset, two legs are stiff.
For domestic animal：
1st, cub is prevented and treated：Piglet, calf, pup, young rabbit rickets and rickets.
2nd, poultry is prevented and treated into：Sow, cow, bitch etc. are a large amount of calcareous due to gestation, lactation consumption, cannot such as mend in time
Fill, dam occur four limbs it is stiff, walk wave, body tremor, incoordination, lockjaw, yelp, twitching, severe patient paralysis,
That is " low blood calcium pathologic process ".
For milk cow：
1st, low blood calcium pathologic process：Cow grow up because gestation, galactopoiesis consumption are a large amount of calcareous, cannot such as supplement in time,
Lactation reduction occurs for cow, four limbs are stiff, walk and wave, body tremor, incoordination, lockjaw, yelp, twitching, seriously
Person paralyses.
2nd, parturient paresis：High yield cow converts bad, caused parturient paresis due to calcium absorption.
3rd, soft bone disease：Adult Bovine dysbolism disease, it is characterized in that lactation reduction, sclerotin soften, standing posture is abnormal, tail bone
Malabsorption and limping.
4th, calf is in newborn bone calcification process, appearance with digestive function it is disorderly, walk lamely and long bone flexural deformation etc.
The systemic mineral metabolism disease being characterized.
5th, allotriophagy：The foreign matters such as pad grass, soil, bone piece, hair that fecaluria polluted are eaten in happiness.
Embodiment
Below in conjunction with the specific embodiment of the invention, the technical scheme to the present invention carries out clear, complete description, institute
The example of description is only the section Example of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, sheet
Field those of ordinary skill, the every other embodiment obtained under the premise of creative work is not made, belongs to this hair
Bright protection domain.
In the following embodiments, the enzyme activity force value of catalase used is 2000IU/g, glucose oxidase used
Enzyme activity force value is 2000IU/g, and the molar concentration of lactic acid used is 6.45mol/L.
Embodiment 1
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
700g, calcium monohydrogen phosphate 500g, DEXTROSE ANHYDROUS 800g, catalase 2g, glucose oxidase 2g, magnesium sulfate 6g, zinc sulfate
100g, lactic acid 900g, appropriate calcium carbonate, cycloheptaamylose 800g, oligosaccharide 200g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000 parts of purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Embodiment 2
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
800g, calcium monohydrogen phosphate 400g, DEXTROSE ANHYDROUS 900g, catalase 1g, glucose oxidase 3g, magnesium sulfate 5g, zinc sulfate
120g, lactic acid 800g, appropriate calcium carbonate, cycloheptaamylose 900g, oligosaccharide 150g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000 parts of purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Embodiment 3
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
600g, calcium monohydrogen phosphate 600g, DEXTROSE ANHYDROUS 700g, catalase-3 g, glucose oxidase 1g, magnesium sulfate 7g, zinc sulfate
80g, lactic acid 1000g, appropriate calcium carbonate, cycloheptaamylose 700g, oligosaccharide 250g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000g purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Embodiment 4
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
650g, calcium monohydrogen phosphate 550g, DEXTROSE ANHYDROUS 750g, catalase 2.5g, glucose oxidase 1.5g, magnesium sulfate 5.5g,
Zinc sulfate 90g, lactic acid 950g, appropriate calcium carbonate, cycloheptaamylose 750g, oligosaccharide 220g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000g purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Embodiment 5
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
750g, calcium monohydrogen phosphate 450g, DEXTROSE ANHYDROUS 850g, catalase 2g, glucose oxidase 2.5g, magnesium sulfate 5.5g, sulphur
Sour zinc 110g, lactic acid 850g, appropriate calcium carbonate, cycloheptaamylose 850g, oligosaccharide 180g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000 parts of purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Embodiment 6
The present embodiment provides a kind of water-soluble calcium particle, is made up of the supplementary material of following weight parts：Special oyster calcium carbonate
620g, calcium monohydrogen phosphate 480g, DEXTROSE ANHYDROUS 880g, catalase 2g, glucose oxidase 2g, magnesium sulfate 6.5g, sulfuric acid
Zinc 110g, lactic acid 990g calcium carbonate are appropriate, cycloheptaamylose 810g, oligosaccharide 170g.
The preparation method of above-mentioned water-soluble calcium particle, comprises the following steps：
(1) take 3000 parts of purified waters be heated to after 35 DEG C add DEXTROSE ANHYDROUS be completely dissolved after add catalase and
Glucose oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide is mixed
Conjunction stirs, and is then pelletized on rotating pelletizer, toasts 3 hours, produces in 70 DEG C of baking ovens.
Application examples for young baby chicken
Choose 200 healthy, the Broiler chicks that body weight is approximate, chicken group be randomly divided into two groups, every group 100, be divided into control
Group and experimental group, the molten water 600-1000kg of water-soluble calcium particle 150g made from every bottle of above-described embodiment of experimental group 1, for chick certainly
By drinking, control group drinking pure, the nursing number of times of two groups of broiler chicken, feeding volume, nursing time all same, after continuously feeding 40 days
Two groups of broiler growth situation such as following tables：
| Experimental group | Control group | |
| Paralyse incidence of disease % | 1% | 5% |
| Chick beginning counterpoise g | 180g | 185g |
| Chick end counterpoise g | 902g | 812g |
It can be evident that from table, experimental group Broiler chicks occur after the drinking water that the continuous feeding present invention is provided
The probability of paralysis symptom is reduced, and weightening is obvious, is illustrated that this feed can strengthen chick constitution, is promoted skeleton development.
Application examples for weanling pig
Using weanling pig as subjects, selection average weight 7.5kg DLY three way cross piglet (gilt and goes
Gesture boar pig half and half) 150, according to science feeding experiment principle, test pig is randomly divided into two treatment groups, examination group and control
Group.The molten water 600-1000kg of water-soluble calcium particle 150g, freely drink for weanling pig made from every bottle of above-described embodiment of experimental group 1
With control group drinking pure.Pig house is carried out disinfection before experiment, test pig uses free choice feeding and drinking-water during group feeding, experiment,
Feeding management is carried out according to conventinal breeding and immunization protocol, experimental period is 35 days.Compared with control group, test group averagely increases day by day
Weight, feed intake and efficiency of feed utilization are all significantly higher than control group.Wherein, compared with control group, experimental group daily gain is improved
9.56%, calcium serum-concentration improves 36.56%.
Application examples for milk cow
Water-soluble calcium particle has been carried out to somewhere cattle farm morbidity high yield cow to test and evaluated.Before experiment
Milk cow can not droped to the ground, and all cases are betided after calving process or calving in 48h.Infected cattle performance is alert and resourceful, and diet is intended to subtract
Few, infected cattle is usually desired to get up, but its hind leg can not be fully extended.Above-mentioned infected cattle is randomly divided into two groups, experimental group and right
According to group.Molten 400~the 600kg of water of water-soluble calcium particle 150g, freely drink for infected cattle made from every bottle of above-described embodiment of experimental group 1
With control group drinking pure, experimental period is 30 days.The 100% infected cattle state of mind takes a turn for the better.82.6% infected cattle, 30 days after administration
It can stand, next day diet is normal.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (6)
1. a kind of water-soluble calcium particle, it is characterised in that be made up of the supplementary material of following weight parts：Special oyster calcium carbonate 600~
800 parts, 400~600 parts of calcium monohydrogen phosphate, 700~900 parts of DEXTROSE ANHYDROUS, 1~3 part of catalase, glucose oxidase 1
~3 parts, 5~7 parts of magnesium sulfate, 80~120 parts of zinc sulfate, 800~1000 parts of lactic acid, appropriate calcium carbonate, cycloheptaamylose 700~
900 parts, 150~250 parts of oligosaccharide.
2. a kind of water-soluble calcium particle according to claim 1, it is characterised in that：The enzyme activity force value of the catalase
For 2000IU/g.
3. a kind of water-soluble calcium particle according to claim 1, it is characterised in that：The enzyme activity of the glucose oxidase
It is worth for 2000IU/g.
4. a kind of water-soluble calcium particle according to claim 1, it is characterised in that：The molar concentration of the lactic acid is
6.45mol/L。
5. the preparation method of the water-soluble calcium particle described in a kind of any one of Claims 1 to 4, it is characterised in that including following step
Suddenly：
(1) 3000 parts of purified waters are taken to be heated to adding addition catalase and grape after DEXTROSE ANHYDROUS is completely dissolved after 35 DEG C
Carbohydrate oxidase, magnesium sulfate are reacted, insulated and stirred 45 minutes；
(2) calcium carbonate regulation pH value 4-4.5 is added, mixed material one is obtained；
(3) take oyster shell calcium, calcium monohydrogen phosphate and zinc sulfate to be put into 1000 DEG C of calcining compartment to calcine 15 hours；
(4) cooling is taken out, temperature adds lactic acid at 43 DEG C and stirred, reacted 45 minutes；
(5) mixed material one and mixed material two are added in agitator, cycloheptaamylose is added and oligosaccharide mixing is stirred
Mix uniform, then pelletized on rotating pelletizer, toast 3 hours, produce in 70 DEG C of baking ovens.
6. a kind of preparation method of water-soluble calcium particle according to claim 1, it is characterised in that：Step (5) system
Into 0.8~1.2mm of particle size range of particle.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828130B2 (en) * | 2000-05-23 | 2004-12-07 | Nec Partnership | Production of gluconate salts |
-
2017
- 2017-04-01 CN CN201710214348.4A patent/CN107095882A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828130B2 (en) * | 2000-05-23 | 2004-12-07 | Nec Partnership | Production of gluconate salts |
Non-Patent Citations (5)
| Title |
|---|
| 周红伟等: "酶法生产葡萄糖酸钙的新工艺", 《食品与发酵工业》 * |
| 周银龙: "由牡蝠壳制取离子化钙(活性钙)", 《天津药学》 * |
| 杨栩等: "以牡蛎壳为原料制备食品级乳酸钙", 《当代化工》 * |
| 洪鹏志等: "牡蛎壳制备活性钙", 《湛江海洋大学学报》 * |
| 赵景联等: "蛋壳制备乳酸钙的研究", 《现代化工》 * |
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