CN107080804A - 一种治疗肾虚寒湿证的中药组合物 - Google Patents
一种治疗肾虚寒湿证的中药组合物 Download PDFInfo
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Abstract
本发明涉及一种中药组合物，具体的说涉及一种治疗肾虚寒湿证的中药组合物。所述中药组合物由下列重量份的原料粉碎、混合而成：淮小麦 25‑35，柴胡 5‑10，川牛膝8‑15，煅牡蛎25‑35，炒土鳖虫10‑20，酸枣仁10‑20，姜半夏8‑15，生地黄25‑35，牡丹皮25‑35，蒲公英25‑35，败酱草15‑25，木贼10‑20，茯苓10‑20，芦根15‑25，麦冬8‑15，陈皮8‑15。本发明的有益效果是：该组合物能使肾的经络气血运行畅通，辅以晨练，改善面色少华、神疲乏力和脉沉细的症状，针对性好，疗效显著，2‑3个月即可显著的改善。
Description
技术领域
本发明涉及一种中药组合物，具体的说涉及一种治疗肾虚寒湿证的中药组合物。
背景技术
肾虚寒湿证体征：腰部冷痛重着，转侧不利，渐渐加重，虽静卧亦不减或反加重，遇阴雨天疼痛加剧，口不渴，小便自利，苔白腻，脉沉而迟缓。肾虚寒湿证见于肾炎，风湿病，类风湿病，腰肌劳损；腰痛、痹证等病证中。肾虚寒湿证为临床常见证候，多因肾气虚加之久居湿冷之地，或涉水冒雨，劳汗当风，衣着湿冷导致寒湿内侵于肾，使肾之经络气血运行不畅而致。
肾虚寒湿证多见于病程长久，阴囊寒冷，皮肤增厚，坠胀不适，可有面色少华，神疲乏力，腰酸腿软，便溏，小便清长，苔白，脉沉细。目前缺乏针对肾虚寒湿证的对症调理中药，本发明旨在解决这一技术问题。
发明内容
本发明的目的在于解决现有技术中的不足，提供一种治疗肾虚寒湿证的中药组合物，该组合物能使肾的经络气血运行畅通，辅以晨练，改善面色少华、神疲乏力和脉沉细的症状，针对性好，疗效显著，2-3个月即可显著的改善。
本发明解决其技术问题所采用的技术方案是：
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 25-35，柴胡 5-10，川牛膝8-15，煅牡蛎25-35，
炒土鳖虫10-20，酸枣仁10-20，姜半夏8-15，生地黄25-35，
牡丹皮25-35，蒲公英25-35，败酱草15-25，木贼10-20，
茯苓10-20，芦根15-25，麦冬8-15，陈皮8-15。
淮小麦，【性味与归经】甘，平，入心经。【功效】养心安神。【临床应用】用于神志不宁，失眠等症。
柴胡, 【性味】味辛、苦，性微寒。【归经】归肝、胆、肺经。【功效】和解表里，疏肝解郁，升阳举陷，退热截疟。
川牛膝，【性味】味甘、微苦，性平。【归经】归肝、肾经。【功效】逐瘀通经，通利关节，利尿通淋。
煅牡蛎，【功效】收敛固涩，制酸止痛，重镇安神，软坚散结。
炒土鳖虫，【性味】味咸，性寒。【归经】归肝经。【功效】破血逐瘀，续筋接骨。
酸枣仁，【功效】养肝，宁心，安神，敛汗。
姜半夏，【性味】辛、温；有毒。【归经】归脾、胃、肺经。【功效】降逆止呕。用于呕吐反胃，胸脘痞闷，梅核气。
生地黄，【性味】甘苦，凉。【功效】治阴虚发热，消渴，吐血，衄血，血崩，***，胎动不安，阴伤便秘。
牡丹皮，【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功效】清热凉血，活血化瘀。
蒲公英，【性味】苦甘，寒。【归经】入肝、胃经。【功效】清热解毒，利尿散结。
败酱草，【性味】性凉，味辛、苦。【归经】入胃、大肠、肝经。【功效】清热解毒，祛瘀排脓。
木贼，【性味】甘苦，平。【归经】入肺、肝、胆经。【功效】疏风散热，解肌，退翳。
茯苓，【性味】味甘、淡，性平。【归经】归心、肺、脾、肾经。【功效】利水渗湿，健脾，宁心。
芦根，【性味】甘，寒。【归经】归肺经、胃经。【功效】清热生津，除烦，止呕，利尿。
麦冬，生津解渴、润肺止咳之效。
陈皮，【性味】味苦、辛，性温。【归经】归肺、脾经。【功效】理气健脾，燥湿化痰。
本发明的中药组合物配伍合理，作用迅速，起效快，口感好，病人容易接受，该组合物能使肾的经络气血运行畅通，辅以晨练，改善面色少华、神疲乏力和脉沉细的症状，针对性好，疗效显著，2-3个月即可显著的改善。
优选的，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 28-32，柴胡 6-8，川牛膝9-12，煅牡蛎25-30，
炒土鳖虫12-18，酸枣仁12-18，姜半夏8-12，生地黄28-32，
牡丹皮28-32，蒲公英28-32，败酱草15-20，木贼12-15，
茯苓12-18，芦根15-20，麦冬10-12，陈皮10-12。
优选的，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 30，柴胡 6，川牛膝10，煅牡蛎30，
炒土鳖虫15，酸枣仁15，姜半夏9，生地黄30，
牡丹皮30，蒲公英30，败酱草20，木贼15，
茯苓15，芦根20，麦冬10，陈皮10。
一种治疗肾虚寒湿证的中药组合物的制备方法，
（1）预煎煮：将配方量的煅牡蛎，加入适量的水，煎煮20min以上，
（2）煎煮：将配方量的淮小麦、柴胡 、川牛膝、炒土鳖虫、酸枣仁、姜半夏、生地黄、牡丹皮、蒲公英、败酱草、木贼、茯苓、芦根、麦冬和陈皮，用适量的水浸泡，步骤（1）预煎煮完成后，连料带水加入其中，继续煎煮30min-2h以上；
（3）过滤、灌装：煎煮完成后滤去药渣，加入药液质量分数0.05-0.1%的还原型谷胱甘肽和0.1-0.2%的水溶性葡聚糖，混合均匀，然后冷却至30-35℃趁热灌装即可，获得液态的治疗肾虚寒湿证的中药组合物。
本申请的发明人实践中发现，本发明的中药组合物煎煮后，8-10℃一般可以放置7天，存储时间再延长就会产生色变，杂质沉淀，液态的药液中大量活性成分会析出积聚，为了解决这一技术问题，本申请的发明人通过大量实践，发现添加适量的还原型谷胱甘肽和水溶性葡聚糖，能很好的解决这一技术问题，还原型谷胱甘肽具有良好的抗氧化性和抗色变性能，水溶性葡聚糖作为大分子，具有良好的水溶性、分散性和稳定性，起到稳定剂的作用，使得药液活性成分形成稳定的分散体系，避免积聚。大大延长药液的存储时间，8-10℃一般可以放置12天。
优选的，步骤（3）为过滤、浓缩、干燥和制剂：煎煮完成后滤去药渣，加入药液质量分数0.05-0.1%的还原型谷胱甘肽和0.1-0.2%的水溶性葡聚糖，混合均匀，然后经真空浓缩、干燥获得粉末，粉末灌注于胶囊中即可，获得胶囊型治疗肾虚寒湿证的中药组合物。本申请的发明人还发现，添加适量的谷胱甘肽和水溶性葡聚糖，在干燥获得中获得的粉末均一性更好，色泽浅，制得的胶囊吸收利用率高。
本发明的有益效果是：该组合物能使肾的经络气血运行畅通，辅以晨练，改善面色少华、神疲乏力和脉沉细的症状，针对性好，疗效显著，2-3个月即可显著的改善。
具体实施方式
下面通过具体实施例，对本发明的技术方案作进一步的具体说明。
实施例1：
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 25，柴胡 5，川牛膝8，煅牡蛎25，
炒土鳖虫10，酸枣仁10，姜半夏8，生地黄25，
牡丹皮25，蒲公英25，败酱草15，木贼10，
茯苓10，芦根15，麦冬8，陈皮8。
实施例2：
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 35，柴胡 10，川牛膝15，煅牡蛎35，
炒土鳖虫20，酸枣仁20，姜半夏15，生地黄35，
牡丹皮35，蒲公英35，败酱草25，木贼20，
茯苓20，芦根25，麦冬15，陈皮15。
实施例3：
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 28，柴胡 6，川牛膝9，煅牡蛎25，
炒土鳖虫12，酸枣仁12，姜半夏8，生地黄28，
牡丹皮28，蒲公英28，败酱草15，木贼12，
茯苓12，芦根15，麦冬10，陈皮10。
实施例1-3的中药组合物，其制备方法如下：
（1）预煎煮：将配方量的煅牡蛎，加入适量的水，煎煮20min以上，
（2）煎煮：将配方量的淮小麦、柴胡 、川牛膝、炒土鳖虫、酸枣仁、姜半夏、生地黄、牡丹皮、蒲公英、败酱草、木贼、茯苓、芦根、麦冬和陈皮，用适量的水浸泡，步骤（1）预煎煮完成后，连料带水加入其中，继续煎煮30min-2h以上；
（3）过滤、灌装：煎煮完成后滤去药渣，加入药液质量分数0.05%的还原型谷胱甘肽和0.2%的水溶性葡聚糖，混合均匀，然后冷却至30℃趁热灌装即可，获得液态的治疗肾虚寒湿证的中药组合物。
实施例4
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦32，柴胡 8，川牛膝12，煅牡蛎30，
炒土鳖虫18，酸枣仁18，姜半夏12，生地黄32，
牡丹皮32，蒲公英32，败酱草20，木贼15，
茯苓18，芦根20，麦冬12，陈皮12。
实施例5
一种治疗肾虚寒湿证的中药组合物，所述中药组合物由下列重量份的原料粉碎、混合而成：所述中药组合物由下列重量份的原料粉碎、混合而成：淮小麦 30，柴胡 6，川牛膝10，煅牡蛎30，
炒土鳖虫15，酸枣仁15，姜半夏9，生地黄30，
牡丹皮30，蒲公英30，败酱草20，木贼15，
茯苓15，芦根20，麦冬10，陈皮10。
实施例4-5的中药组合物，其制备方法如下：
（1）预煎煮：将配方量的煅牡蛎，加入适量的水，煎煮20min以上，
（2）煎煮：将配方量的淮小麦、柴胡 、川牛膝、炒土鳖虫、酸枣仁、姜半夏、生地黄、牡丹皮、蒲公英、败酱草、木贼、茯苓、芦根、麦冬和陈皮，用适量的水浸泡，步骤（1）预煎煮完成后，连料带水加入其中，继续煎煮30min-2h以上；
（3）为过滤、浓缩、干燥和制剂：煎煮完成后滤去药渣，加入药液质量分数0.1%的还原型谷胱甘肽和0.1%的水溶性葡聚糖，混合均匀，然后经真空浓缩、干燥获得粉末，粉末灌注于胶囊中即可，装填量15mg/粒，获得胶囊型治疗肾虚寒湿证的中药组合物。
本发明实施例1-3的中药组合物，早晚饭后热服，各120ml，本发明实施例4-5的中药组合物，早晚饭后开水冲服，各1粒，连续服用3个疗程（三个月），服药期间每天晨跑30-45min，辅助治疗。
临床试验：临床100例，复合肾虚寒湿证，均来源于门诊病例，年龄30-55岁，其中男性60例，女性40例，平均年龄43岁。随机分成五组，每组20例，按照上述方法分别使用实施例1-5的中药组合物，三个疗程后进行疗效评价。
疗效判断标准：以症状改变程度为疗效判定标准。
观察结果：临床治愈85例，有效12例，无效3例，总有效率97%。所有病例均无不良反应，治愈病例2年后回访复查，无复发。
下面以两例具体的病例进一步验证本发明的中药组合物。
病例1：谢某，男52岁，浙江瑞安某农民，该患者自2012年起阴囊寒冷，皮肤增厚，坠胀不适，面色少华，神疲乏力，腰酸腿软，便溏，小便清长，脉沉细，2014年8月开始口服实施例3的液态中药组合物，并辅以晨跑30min，一个月后明显改善，体力大增，面色微微红润，3个月后全部症状消失，面色红润，精神矍铄，大小便正常，2016年底回访，无复发症状。
病例2：顾某，男32岁，浙江温州某程序员，该患者自2013年起由于工作压力大，繁重的脑力劳动，睡眠浅，导致面色少华，神疲乏力，腰酸腿软，脉沉细，2014年10月开始口服实施例5的胶囊型中药组合物，并辅以晨跑45min，一个月后明显改善，体力大增，睡眠大大改善，睡眠过程中呼吸均匀，3个月后全部症状消失，面色红润，神气足，大小便正常，2016年底回访，无复发症状。
本发明的有益效果是：该组合物能使肾的经络气血运行畅通，辅以晨练，改善面色少华、神疲乏力和脉沉细的症状，针对性好，疗效显著，2-3个月即可显著的改善。
以上所述的实施例只是本发明的一种较佳的方案，并非对本发明作任何形式上的限制，在不超出权利要求所记载的技术方案的前提下还有其它的变体及改型。
Claims (5)
1.一种治疗肾虚寒湿证的中药组合物，其特征在于：所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 25-35，柴胡 5-10，川牛膝8-15，煅牡蛎25-35，
炒土鳖虫10-20，酸枣仁10-20，姜半夏8-15，生地黄25-35，
牡丹皮25-35，蒲公英25-35，败酱草15-25，木贼10-20，
茯苓10-20，芦根15-25，麦冬8-15，陈皮8-15。
2.根据权利要求1所述的治疗肾虚寒湿证的中药组合物，其特征在于：所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 28-32，柴胡 6-8，川牛膝9-12，煅牡蛎25-30，
炒土鳖虫12-18，酸枣仁12-18，姜半夏8-12，生地黄28-32，
牡丹皮28-32，蒲公英28-32，败酱草15-20，木贼12-15，
茯苓12-18，芦根15-20，麦冬10-12，陈皮10-12。
3.根据权利要求1所述的治疗肾虚寒湿证的中药组合物，其特征在于：所述中药组合物由下列重量份的原料粉碎、混合而成：
淮小麦 30，柴胡 6，川牛膝10，煅牡蛎30，
炒土鳖虫15，酸枣仁15，姜半夏9，生地黄30，
牡丹皮30，蒲公英30，败酱草20，木贼15，
茯苓15，芦根20，麦冬10，陈皮10。
4.一种权利要求1所述的治疗肾虚寒湿证的中药组合物的制备方法，其特征在于：
（1）预煎煮：将配方量的煅牡蛎，加入适量的水，煎煮20min以上，
（2）煎煮：将配方量的淮小麦、柴胡 、川牛膝、炒土鳖虫、酸枣仁、姜半夏、生地黄、牡丹皮、蒲公英、败酱草、木贼、茯苓、芦根、麦冬和陈皮，用适量的水浸泡，步骤（1）预煎煮完成后，连料带水加入其中，继续煎煮30min-2h以上；
（3）过滤、灌装：煎煮完成后滤去药渣，加入药液质量分数0.05-0.1%的还原型谷胱甘肽和0.1-0.2%的水溶性葡聚糖，混合均匀，然后冷却至30-35℃趁热灌装即可，获得液态的治疗肾虚寒湿证的中药组合物。
5.根据权利要求1所述的治疗肾虚寒湿证的中药组合物的制备方法，其特征在于：步骤（3）为过滤、浓缩、干燥和制剂：煎煮完成后滤去药渣，加入药液质量分数0.05-0.1%的还原型谷胱甘肽和0.1-0.2%的水溶性葡聚糖，混合均匀，然后经真空浓缩、干燥获得粉末，粉末灌注于胶囊中即可，获得胶囊型治疗肾虚寒湿证的中药组合物。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102559847A (zh) * | 2010-12-29 | 2012-07-11 | 中国科学院电子学研究所 | 一种生物发光试剂的热稳定剂 |
| CN104306498A (zh) * | 2014-11-05 | 2015-01-28 | 青岛恒波仪器有限公司 | 一种治疗妇女肾虚寒湿型带下的中药组合物及其制备方法 |
| CN104784614A (zh) * | 2015-03-26 | 2015-07-22 | 慕常松 | 一种治疗肾虚的中药组合物 |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102559847A (zh) * | 2010-12-29 | 2012-07-11 | 中国科学院电子学研究所 | 一种生物发光试剂的热稳定剂 |
| CN104306498A (zh) * | 2014-11-05 | 2015-01-28 | 青岛恒波仪器有限公司 | 一种治疗妇女肾虚寒湿型带下的中药组合物及其制备方法 |
| CN104784614A (zh) * | 2015-03-26 | 2015-07-22 | 慕常松 | 一种治疗肾虚的中药组合物 |
Non-Patent Citations (1)
| Title |
|---|
| 李蓉 等: "甜玉米胚乳中水溶性葡聚糖的结构与性质初探", 《食品工业科技》 * |
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