CN107041727A - A kind of intelligent radio capsule and its control method - Google Patents
A kind of intelligent radio capsule and its control method Download PDFInfo
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- CN107041727A CN107041727A CN201710384289.5A CN201710384289A CN107041727A CN 107041727 A CN107041727 A CN 107041727A CN 201710384289 A CN201710384289 A CN 201710384289A CN 107041727 A CN107041727 A CN 107041727A
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- module
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- discharge
- intelligent radio
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/045—Control thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/065—Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0247—Pressure sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Optics & Photonics (AREA)
- Anesthesiology (AREA)
- Medicinal Chemistry (AREA)
- Human Computer Interaction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to intellectual drug technical field, specifically related to a kind of intelligent radio capsule and its control method, including hollow capsule shells, the first accommodating cavity and the second accommodating cavity are provided with the capsule shells, central processing module, power module, communication module and discharge module are provided with first accommodating cavity, provided with multiple powders and multiple electric discharge pointers in powder in second accommodating cavity, the capsule shells are provided with PH detection sensors；Position in the capsule shells corresponding to the second accommodating cavity is provided with multiple through holes；The powder includes the medicine in gel shell and gel shell.The present invention can be monitored and intervene to environment in intestines and stomach, according to the change of intestines and stomach intrinsic parameter, the automatic medicine for implementing precise location is delivered, and further drug releasing rate can be regulated and controled, with the effect realized preferably regulation gut flora or treat disease.
Description
Technical field
The invention belongs to intellectual drug field, and in particular to a kind of intelligent radio capsule and its control method.
Background technology
Constantly accelerate with the rhythm of life of people, all over the world because disappearing caused by operating pressure and dietary unbalance
Change the sick hair rate more and more higher corresponding to systemic disease.Simultaneously as intestines and stomach are joined directly together on physiological structure with anus, hold
It is vulnerable to the foreign matter and pathogenic infection of human external, so that clinically the sick hair rate of disorder of gastrointestinal tract is than other positions disease
The sick hair rate of disease is high.
There are many capsule endoscopes on existing market, intestines and stomach are carried out with detailed observation, to obtain biological tissue top layer
Deeper organizational information below, so that doctor is more effectively diagnosed, the pharmaceutical capsules also having can meet detection and medicine
Release, but need to realize by the magnetic field that outside large scale equipment is produced, and drug release rate can not be adjusted
Control.
The content of the invention
, can be to stomach the invention discloses a kind of intelligent radio capsule and its control method for defect of the prior art
Intestinal environment is monitored and intervened, according to the change of intestines and stomach intrinsic parameter, and the automatic medicine for implementing precise location is delivered, and
Further drug releasing rate can be regulated and controled, with the effect realized preferably regulation gut flora or treat disease.
Hold in a kind of intelligent radio capsule, including hollow capsule shells, the capsule shells provided with the first accommodating cavity and second
Put and central processing module, power module, communication module and discharge module are provided with chamber, first accommodating cavity, described second holds
Intracavitary is put provided with multiple powders and multiple electric discharge pointers in powder, the capsule shells are provided with PH detection sensors；Institute
State central processing module respectively with the power module, the communication module, the discharge module and the PH detection sensors
Electrical connection, the discharge module is electrically connected with the electric discharge pointer；Position in the capsule shells corresponding to the second accommodating cavity is set
There are multiple through holes；The powder includes the medicine in gel shell and gel shell.
Preferably, the capsule shells are provided with pressure sensor.
Preferably, the gel shell uses polyelectrolytes hydrogel.
Preferably, the capsule shells are provided with the power switch electrically connected with power module.
Preferably, the powder is at least one.
Preferably, the communication module uses bluetooth module.
Preferably, the power module is wireless charging module.
A kind of control method of intelligent radio capsule, comprises the following steps：
S1, sets PH first threshold as PH0, Second Threshold be PH1, pressure threshold is set as P0；
S2, the central processing module receives the outside liquid pH value of the PH detection sensors collection, receives the pressure
The pressure value of force snesor collection；
S3, judges the size of pH value, if the pH value is less than PH0, capsule described in the central processing module judges is from food
Road enters in stomach；
S4, judges the size of pH value, if the pH value is more than PH0, capsule described in the central processing module judges is from stomach
In enter duodenum；
S5, judges the size of pH value and the size of pressure value, and the central processing module sends difference according to judged result
The pulse control signal of frequency gives the discharge module, is discharged by the electric discharge pointer to the gel shell, by the medicine
Discharged out of described gel shell.
Preferably, the S5 is specially：
If the pH value is more than PH1And the pressure value is less than or equal to 40, the central processing module is to the electric discharge mould
Block sends the first pulse control signal, and the gel shell repid discharge is given by the electric discharge pointer, and the medicine coagulates from described
Quick release comes out in glue shell；
If the pH value is more than PH1And the pressure value is more than 40, the central processing module is sent out to the discharge module
Go out the second pulse control signal, give the gel shell low rates of discharge by the electric discharge pointer, the medicine is from the gel shell
Inside slowly release.
Preferably, the PH0For 4.5, the PH1For 7.0, the P0For 40.
The invention discloses a kind of intelligent radio capsule and its control method, environment in intestines and stomach can be monitored and be done
In advance, according to the change of intestines and stomach intrinsic parameter, the automatic medicine for implementing precise location is delivered, and can be further to drug releasing rate
Regulated and controled, with the effect realized preferably regulation gut flora or treat disease.
Brief description of the drawings
Fig. 1 is the sectional structure chart of intelligent radio capsule in the present embodiment；
Fig. 2 is the external structure of intelligent radio capsule in the present embodiment；
Fig. 3 is the circuit principle structure figure of intelligent radio capsule in the present embodiment；
Fig. 4 is the control method flow chart of intelligent radio capsule in the present embodiment.
Reference：
1- capsule shells, 2- power modules, 3- central processing modules, 4- communication modules, 5- discharge modules, 6- power switches,
7-PH detection sensors, 8- pressure sensors, 9- powders, 10- electric discharge pointers
Embodiment
The embodiment of technical solution of the present invention is described in detail below in conjunction with accompanying drawing.Following examples are only used for
Clearly illustrate technical scheme, therefore be intended only as example, and the protection of the present invention can not be limited with this
Scope.
Embodiment：
A kind of intelligent radio capsule, as shown in FIG. 1 to 3, including hollow capsule shells 1, provided with the in the capsule shells 1
Central processing module 3, power module 2, the and of communication module 4 are provided with one accommodating cavity and the second accommodating cavity, first accommodating cavity
Provided with multiple powders 9 and multiple electric discharge pointers 10 in powder 9, the capsule in discharge module 5, second accommodating cavity
Shell 1 is provided with PH detection sensors 7, pressure sensor 8 and the power switch 6 electrically connected with power module 2；The centre
Manage module 3 respectively with the power module 2, the communication module 4, the discharge module 5, the PH detection sensors 7, pressure
Sensor 8 and power switch 6 are electrically connected, and the discharge module 5 is electrically connected with the electric discharge pointer 10；It is right in the capsule shells 1
Multiple through holes should be provided with the position of the second accommodating cavity；The powder 9 includes the medicine in gel shell and gel shell.The gel
Shell uses polyelectrolytes hydrogel.
The intelligent radio capsule of the present embodiment can be monitored and intervene to environment in intestines and stomach, according to intestines and stomach intrinsic parameter
Change, the automatic medicine for implementing precise location is delivered, and further drug releasing rate can be regulated and controled, more preferable to realize
Regulation gut flora or treat disease effect.
The powder 9 is at least one.The power module 2 is wireless charging module.The communication module 4 uses bluetooth
Module.The bluetooth module is used to be communicated with external equipment, and the information transfer that intelligent radio capsule is gathered is set to outside
Standby, the external equipment can also remote control intelligent radio capsule.
Based on foregoing intelligent radio capsule, a kind of control method of intelligent radio capsule, as shown in figure 4, including
Following steps：
S1, sets PH first threshold as PH0, Second Threshold be PH1, pressure threshold is set as P0；
S2, the central processing module 3 receives the outside liquid pH value that the PH detection sensors 7 are gathered, and receives described
The pressure value of pressure sensor collection；
S3, judges the size of pH value, if the pH value is less than PH0, the central processing module 3 judges the capsule from food
Road enters in stomach；
S4, judges the size of pH value, if the pH value is more than PH0, the central processing module 3 judges the capsule from stomach
In enter duodenum；
S5, judges the size of pH value and the size of pressure value, and the central processing module sends difference according to judged result
The pulse control signal of frequency gives the discharge module, is discharged by the electric discharge pointer to the gel shell, by the medicine
Discharged out of described gel shell.
Preferably, the S5 is specially：
If the pH value is more than PH1And the pressure value is less than or equal to 40, the central processing module is to the electric discharge mould
Block sends the first pulse control signal, and the gel shell repid discharge is given by the electric discharge pointer, and the medicine coagulates from described
Quick release comes out in glue shell；
If the pH value is more than PH1And the pressure value is more than 40, the central processing module is sent out to the discharge module
Go out the second pulse control signal, give the gel shell low rates of discharge by the electric discharge pointer, the medicine is from the gel shell
Inside slowly release.
The gel shell in the present embodiment uses polyelectrolytes hydrogel, can be produced for the stimulation that voltage or electric current are given
Raw response, causes volume to change, after pressurization, and the rate of release of medicine is accelerated, and stops returning to before pressurization again after pressurization
Rate of release, thus control discharge module to be discharged to gel shell by the pulse control signal of different frequency, to control gel shell
The frequency of the first pulse control signal is higher than the frequency of the second pulse control signal in the rate of release of interior medicine, the present embodiment,
Thus the rate of release of medicine is faster.
PH described in the present embodiment0For 4.5, the PH1For 7.0, the P0For 40.Intelligent radio glue in the present embodiment
Capsule is after alimentary canal is entered, and PH detection sensors 7 are detected to PH in alimentary canal, and PH numerical value is gradually reduced by high step-down, when
When PH is less than 4.5, central processing module 3 judges that intelligent radio capsule is entered in stomach by esophagus according to feedback data；When intelligent nothing
After line capsule is passed through in stomach, PH numerical value is uprised by low, and when PH is more than 4.5, central processing module 3 judges intelligent radio capsule
Enter duodenum in stomach；Continue to raise when PH detection sensors 7 detect PH, when numerical value is more than 7.0, intelligent radio capsule
Positioned at small enteral, the central processing module 3 sends the first pulse signal to discharge module 5, by the pointer 10 that discharges to gel
Shell repid discharge, the medicine comes out from quick release in gel shell；Intelligent radio capsule moves to big enteral, the pressure of big enteral
Power be more than enteral pressure, when detect pH value more than 7.0 and the pressure value be more than 40mmHg when, it is described center processing mould
Block 3 sends the second pulse signal to discharge module 5, by the pointer 10 that discharges to gel shell low rates of discharge, and the medicine is from gel
Slowly released in shell.
The medicine such as probiotics, so it is possible to prevente effectively from probiotics is killed by hydrochloric acid in gastric juice, and is arrived at small with activated state
Intestines simultaneously play beneficial adjustment effect in small enteral.When pressure value is more than 40mmHg, central processing module 3 control medicine with
Low speed discharges medicine, so it is possible to prevente effectively from local intestinal hypertonia is to the adverse effect of probiotics.The present embodiment
Intelligent radio capsule quick release under the small intestine condition that relative pressure is smaller, low abundance flora is present can be made, in relative pressure
Slowly discharged under the colonic environment that higher, high abundance flora is present, realize automatic controllable of the medicine at varying environment and position
Release.PH and pressure data can be by Bluetooth transmissions to outside reception device in alimentary canal, and are passed further to high in the clouds and enter
Row big data is analyzed, and cloud computing result also in the release of different parts, and can adjust rate of release by feedback adjustment medicine in time.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to foregoing embodiments, it will be understood by those within the art that：It is still
Technical scheme described in foregoing embodiments can be modified, or which part or all technical characteristic are carried out
Equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technical side
The scope of case, it all should cover among the claim of the present invention and the scope of specification.
Claims (10)
1. a kind of intelligent radio capsule, it is characterised in that including hollow capsule shells, the first accommodating cavity is provided with the capsule shells
With the second accommodating cavity, first accommodating cavity is interior to be provided with central processing module, power module, communication module and discharge module, institute
State provided with multiple powders and multiple electric discharge pointers in powder in the second accommodating cavity, the capsule shells are detected provided with PH and passed
Sensor；The central processing module is detected with the power module, the communication module, the discharge module and the PH respectively
Sensor is electrically connected, and the discharge module is electrically connected with the electric discharge pointer；Corresponding to the second accommodating cavity in the capsule shells
Position is provided with multiple through holes；The powder includes the medicine in gel shell and gel shell.
2. a kind of intelligent radio capsule according to claim 1, it is characterised in that the capsule shells are provided with pressure sensing
Device.
3. a kind of intelligent radio capsule according to claim 1, it is characterised in that the gel shell is solidifying using polyelectrolyte
Glue.
4. a kind of intelligent radio capsule according to claim 1, it is characterised in that the capsule shells are provided with and power supply mould
The power switch of block electrical connection.
5. a kind of intelligent radio capsule according to claim 1, it is characterised in that the powder is at least one.
6. a kind of intelligent radio capsule according to claim 1, it is characterised in that the communication module uses bluetooth mould
Block.
7. a kind of intelligent radio capsule according to claim 1, it is characterised in that the power module is wireless charging mould
Block.
8. a kind of control method of intelligent radio capsule, it is characterised in that comprise the following steps：
S1, sets PH first threshold as PH0, Second Threshold be PH1, pressure threshold is set as P0；
S2, the central processing module receives the outside liquid pH value of the PH detection sensors collection, receives the pressure and passes
The pressure value of sensor collection；
S3, judges the size of pH value, if the pH value is less than PH0, capsule described in the central processing module judges from esophagus enter
In stomach；
S4, judges the size of pH value, if the pH value is more than PH0, capsule described in the central processing module judges enters in stomach
Duodenum；
S5, judges the size of pH value and the size of pressure value, and the central processing module sends different frequency according to judged result
Pulse control signal give the discharge module, gel shell electric discharge is given by the electric discharge pointer, by the medicine from institute
State and discharged in gel shell.
9. a kind of control method of intelligent radio capsule according to right 8, it is characterised in that the S5 is specially：
If the pH value is more than PH1And the pressure value is less than or equal to 40, the central processing module is sent to the discharge module
First pulse control signal, gives the gel shell repid discharge, the medicine is out of described gel shell by the electric discharge pointer
Quick release comes out；
If the pH value is more than PH1And the pressure value is more than 40, the central processing module sends second to the discharge module
Pulse control signal, gives the gel shell low rates of discharge, the medicine is slow out of described gel shell by the electric discharge pointer
Discharge.
10. a kind of control method of intelligent radio capsule according to right 8, it is characterised in that the PH0It is described for 4.5
PH1For 7.0, the P0For 40.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384289.5A CN107041727A (en) | 2017-05-26 | 2017-05-26 | A kind of intelligent radio capsule and its control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384289.5A CN107041727A (en) | 2017-05-26 | 2017-05-26 | A kind of intelligent radio capsule and its control method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107041727A true CN107041727A (en) | 2017-08-15 |
Family
ID=59547117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710384289.5A Pending CN107041727A (en) | 2017-05-26 | 2017-05-26 | A kind of intelligent radio capsule and its control method |
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Citations (9)
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| CN1774239A (en) * | 2003-01-29 | 2006-05-17 | 埃-皮尔制药公司 | Active drug delivery in the gastrointestinal tract |
| US20070071807A1 (en) * | 2005-09-28 | 2007-03-29 | Hidero Akiyama | Capsule-type drug-releasing device and capsule-type drug-releasing device system |
| CN1997421A (en) * | 2003-02-06 | 2007-07-11 | 安迪·沃尔夫 | Oral devices and methods for controlled drug delivery |
| CN101065161A (en) * | 2004-11-29 | 2007-10-31 | 皇家飞利浦电子股份有限公司 | Electronically controlled pill |
| CN101352343A (en) * | 2008-05-21 | 2009-01-28 | 重庆大学 | Intelligent medicine releasing capsule system for digestive canal and method |
| US20100063485A1 (en) * | 2006-09-08 | 2010-03-11 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a predefined quantity of a substance |
| CN103079453A (en) * | 2009-12-17 | 2013-05-01 | 梅迪梅特里科斯个性化药物传输私人有限公司 | Swallowable capsule for monitoring a condition |
| CN103381282A (en) * | 2012-05-02 | 2013-11-06 | 姜韫英 | Intelligent module for measuring pH value in drug release capsule |
| CN103785101A (en) * | 2014-02-19 | 2014-05-14 | 东南大学 | Electric field multi-pulse drug release device and manufacturing method and application thereof |
-
2017
- 2017-05-26 CN CN201710384289.5A patent/CN107041727A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1774239A (en) * | 2003-01-29 | 2006-05-17 | 埃-皮尔制药公司 | Active drug delivery in the gastrointestinal tract |
| CN1997421A (en) * | 2003-02-06 | 2007-07-11 | 安迪·沃尔夫 | Oral devices and methods for controlled drug delivery |
| CN101065161A (en) * | 2004-11-29 | 2007-10-31 | 皇家飞利浦电子股份有限公司 | Electronically controlled pill |
| US20070071807A1 (en) * | 2005-09-28 | 2007-03-29 | Hidero Akiyama | Capsule-type drug-releasing device and capsule-type drug-releasing device system |
| US20100063485A1 (en) * | 2006-09-08 | 2010-03-11 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a predefined quantity of a substance |
| CN101352343A (en) * | 2008-05-21 | 2009-01-28 | 重庆大学 | Intelligent medicine releasing capsule system for digestive canal and method |
| CN103079453A (en) * | 2009-12-17 | 2013-05-01 | 梅迪梅特里科斯个性化药物传输私人有限公司 | Swallowable capsule for monitoring a condition |
| CN103381282A (en) * | 2012-05-02 | 2013-11-06 | 姜韫英 | Intelligent module for measuring pH value in drug release capsule |
| CN103785101A (en) * | 2014-02-19 | 2014-05-14 | 东南大学 | Electric field multi-pulse drug release device and manufacturing method and application thereof |
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Application publication date: 20170815 |
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