CN107037034A - A kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth and method - Google Patents
A kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth and method Download PDFInfo
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- CN107037034A CN107037034A CN201710193331.5A CN201710193331A CN107037034A CN 107037034 A CN107037034 A CN 107037034A CN 201710193331 A CN201710193331 A CN 201710193331A CN 107037034 A CN107037034 A CN 107037034A
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
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Abstract
The invention discloses a kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth and method, the platform includes mobile phone, earphone cord, capacitation circuit and electrochemical luminescence reaction system；Earphone cord is connected with handset audio mouthful socket；Voltage drive is produced in audio port spigot by mobile phone, by applying voltage drive to electrochemical luminescence reaction system, so that reaction occurs and with luminescence phenomenon, the luminous intensity under dark field is caught and calculated using mobile phone camera, the final Concentration Testing realized to the testing sample in electrochemical luminescence reaction system；The present invention has the advantages that portable, miniaturization, stability are good, by the use of mobile phone as controlling, gives the platform for encouraging, analyzing and showing result, can greatly simplify the design of detection means, reduces cost, the portability of raising detection means.
Description
Technical field
The present invention relates to electrochemical luminescence detection technique, more particularly to a kind of electrochemistry hair excited based on handset audio mouth
Photoproduction detection platform and method.
Background technology
Electrochemiluminescence technology is a kind of very ripe analytical technology, and it has, and sensitivity is high, instrument and equipment is simple, result
The features such as easily observing, is widely used in field of biological detection.At present --- in combination with mobile phone, detection device is minimized, portable
Change, substantially increase the mobility and portability of detecting system, reduce R＆D costs.Also have not seen that document report is based on hand at present
The electrochemical luminescence detecting system of machine.Nicotine is a kind of liquid biological alkali, accounts for 98% of alkaloid total amount in tobacco.In addition,
Nicotine has hypertoxicity, can cause a variety of diseases such as human body apoplexy, renal failure and lung cancer.Atropine is then that one kind has
The alkaloid of medical value, available for spasm, organic agricultural chemicals poisoning and the treatment for the illness such as heartbeat is too slow.Therefore, realization pair
The sensitive determination of nicotine and atropine all has highly important value in the field such as clinical diagnosis and drugs analysis.
The content of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of electrochemistry excited based on handset audio mouth
Luminous biochemistry detection platform and method.
The purpose of the present invention is achieved through the following technical solutions：A kind of electrochemistry excited based on handset audio mouth
Luminous biochemistry detection platform, it includes mobile phone, earphone cord, capacitation circuit and electrochemical luminescence reaction system；The mobile phone includes
Audio port socket and camera；Earphone cord is connected with handset audio mouthful socket；It is divided into four root lines inside earphone cord, is respectively：
L channel line, R channel line, microphone lines and ground wire；Voltage drive, L channel line are produced in audio port spigot by mobile phone
Coil with ground wire with capacitation circuit is connected, and is used as the control source of capacitation circuit；The output of coil is sequentially connected by four
The rectifier bridge and voltage-regulator diode of FET composition, the output voltage and ground wire of voltage-regulator diode pass through two connecting lines and electricity
Chemiluminescence reaction system is connected, the voltage drive reacted as electrochemical luminescence；The electrochemical luminescence reaction system includes
Two panels ITO conductive electrodes and copper adhesive tape, ITO conductive electrode materials are that one layer of conductive tin indium oxide of attaching is thin on simple glass
Film；Testing sample is placed between two conducting surfaces of two panels ITO conductive electrodes.
Further, the interface of the mobile phone sets start button, driving frequency button, excitation density button and imaging area
Domain；By start button, audio port socket produces voltage drive；The frequency of voltage drive is adjusted by driving frequency button
Section；The intensity of voltage drive is adjusted by excitation density button；Being taken pictures by camera includes the picture of reaction
Imaging region.
Further, encouraged by mobile phone in the alternating voltage that audio port socket produces 1.8V, pass through L channel line and ground
Line, by 1:25 step-up coil is boosted, then the rectifier bridge being made up of FET by AC rectification into direct current,
Higher voltage drive is exported finally by voltage-regulator diode, the voltage drive of electrochemical luminescence reaction system is used as.
Further, by controlling the voltage drive intensity and driving frequency of handset audio mouthful anti-to regulate and control electrochemical luminescence
The voltage swing of system is answered, electrochemiluminescence assay is carried out to standard sample, and the result of detection is carried out to pair of luminous intensity
Than being optimal voltage by corresponding minimum voltage during luminous intensity maximum.
A kind of method that electrochemical luminescence biochemistry detection is carried out using above-mentioned platform, this method is comprised the following steps：
(1) examination criteria sample：Configure the standard sample solution of various concentrations gradient.
(2) luminous intensity values are obtained：Whole reaction system is placed under dark room conditions, standard sample is then dropped in into lower section
The conducting surface of ITO conductive electrodes, and contacted with the conducting surface of another ITO conductive electrode, due to the surface tension of solution, solution
Understand uniform fold ITO conductive electrodes and do not contacted between two plate electrodes；The voltage drive produced by mobile phone in audio port socket
By capacitation circuit amplification and act on electrochemical luminescence reaction system, reaction produce luminescence phenomenon caught by camera, and
Shown by mobile phone and calculate luminous intensity values；
(3) standard curve of standard sample concentration-luminous intensity is set up：Use electrochemical luminescence platform repeat step 2
Measurement process, until completing the measurement of the standard sample of all concentration gradients, obtains the luminous intensity values under various concentrations；Each
Concentration duplicate measurements several times, sets up the standard curve of standard sample concentration-luminous intensity.
(4) by the measurement process of solution repeat step 2 to be measured, luminous intensity is obtained, the standard for bringing step 3 foundation into is bent
Line, obtains the concentration of solution to be measured.
The present invention has the advantages that relative to existing electrochemical luminescence detecting system：The invention provides one kind
The electrochemical luminescence biochemistry detection platform excited based on handset audio mouth, can be achieved to biological agents such as nicotine, atropines
Detection.Using platform of the mobile terminal as device control, analysis and display, instead of traditional voltage drive applying mode,
The design and cost of detection means are enormously simplify, the portability of device is improved, overcomes that commercial apparatus are expensive, volume
It is huge, the shortcomings of be not easy to popularization and application.Electrochemiluminescence technology has sensitivity height, stable reaction, experimental design letter in itself
Single the features such as, its mobile terminal is used as with reference to mobile phone so that the present invention have using process it is simple, with low cost, be easy to carry
The advantages of.According to above advantage, platform of the invention can be widely used for the detection in terms of Electrochemiluminescence technology.
Brief description of the drawings
Fig. 1 is the showing interface figure of mobile phone used herein；
Fig. 2 is the general frame figure of electrochemical luminescence detecting system of the present invention；
Fig. 3 is each circuit module schematic diagram of capacitation circuit of the present invention；
Fig. 4 is each optimal value that mobile phone of the present invention produces voltage drive；
Fig. 5 is luminous intensity figure of the determinand tripropyl amine (TPA) of the present invention under various concentrations gradient；
Fig. 6 is the concentration linear gradient figure of tripropyl amine (TPA) of the present invention；
Fig. 7 is luminous intensity figure of the determinand nicotine of the present invention under various concentrations gradient；
Fig. 8 is the concentration linear gradient figure of nicotine of the present invention；
Fig. 9 is luminous intensity figure of the determinand atropine of the present invention under various concentrations gradient；
Figure 10 is the concentration linear gradient figure of atropine of the present invention；
In figure, mobile phone 1, earphone cord 2, capacitation circuit 3, connecting line 4, electrochemical luminescence system 5, solution to be measured 6, audio port
Socket 11, camera 12, imaging region 13, driving frequency button 14, excitation density button 15, start button 16, L channel line
21st, R channel line 22, microphone lines 23, ground wire 24, coil 31, p-type FET 32, N-type FET 33, voltage-regulator diode
34th, ITO conductive electrodes 51, copper adhesive tape 52, testing sample 53.
Embodiment
Below in conjunction with drawings and the specific embodiments, the present invention is described in detail, but is not the limitation present invention.
As shown in Figure 1, 2, a kind of electrochemical luminescence biochemistry detection excited based on handset audio mouth that the present invention is provided is put down
Platform, including：Mobile phone 1, earphone cord 2, capacitation circuit 3 and electrochemical luminescence reaction system 5；The mobile phone 1 includes audio port socket
11 and camera 12；Earphone cord 2 is connected with the audio port socket 11 of mobile phone 1；It is divided into four root lines inside earphone cord, is respectively：It is left
Sound channel line 21, R channel line 22, microphone lines 23 and ground wire 24；As shown in figure 3, being produced by mobile phone 1 at audio port socket 11
Raw voltage drive, L channel line 21 and ground wire 24 are connected with the coil 31 of capacitation circuit 3, and the voltage as capacitation circuit 3 is defeated
Enter；The output of coil 31 is sequentially connected the rectifier bridge being made up of four FETs and voltage-regulator diode 34, voltage-regulator diode 34
Output voltage and ground wire be connected by two connecting lines 4 with electrochemical luminescence reaction system 5, reacted as electrochemical luminescence
Voltage drive, four FETs include two p-type FETs 32 and two N-type FETs 33；The electrochemical luminescence
Reaction system 5 includes two panels ITO conductive electrodes 51 and copper adhesive tape 52, and the material of ITO conductive electrodes 51 is to attach one on simple glass
The conductive indium tin oxide films of layer；Testing sample 53 is placed between 51 two conducting surfaces of two panels ITO conductive electrodes.
Further, as shown in figure 1, the interface of the mobile phone 1 sets start button 16, driving frequency button 14, excitation
Intensity button 15 and imaging region 13；By start button 16, audio port socket 11 produces voltage drive；Pressed by driving frequency
The frequency of voltage drive is adjusted button 14；The intensity of voltage drive is adjusted by excitation density button 15；Pass through
Camera 12, which is taken pictures, includes the picture of reaction in imaging region 13.
Further, encouraged by mobile phone 1 in the alternating voltage that audio port socket 11 produces 1.8V, pass through L channel line 21
With ground wire 24, by 1:25 step-up coil 31 is boosted, then the rectifier bridge being made up of FET is by AC rectification
Into direct current, higher voltage drive is exported finally by voltage-regulator diode 34, the voltage of electrochemical luminescence reaction system 5 is used as
Excitation.
Further, by controlling the voltage drive intensity and driving frequency of the audio port of mobile phone 1 to regulate and control electrochemical luminescence
The voltage swing of reaction system 5, electrochemiluminescence assay is carried out to standard sample, and the result of detection is carried out into luminous intensity
Contrast, is optimal voltage by corresponding minimum voltage during luminous intensity maximum.
A kind of method that above-mentioned platform carries out electrochemical luminescence biochemistry detection, this method comprises the following steps：
(1) examination criteria sample：Configure the standard sample solution of various concentrations gradient.
(2) luminous intensity values are obtained：Whole reaction system is placed under dark room conditions, standard sample is then dropped in into lower section
The conducting surface of ITO conductive electrodes 51, and contacted with the conducting surface of another ITO conductive electrode 51, due to the surface tension of solution,
Solution is understood uniform fold ITO conductive electrodes 51 and not contacted between two plate electrodes；Produced by mobile phone 1 in audio port socket 11
Voltage drive passes through the amplification of capacitation circuit 3 and acts on electrochemical luminescence reaction system 5, and reaction produces luminescence phenomenon by imaging
First 12 catch, and are shown by mobile phone 1 and calculate luminous intensity values；
(3) standard curve of standard sample concentration-luminous intensity is set up：Use electrochemical luminescence platform repeat step 2
Measurement process, until completing the measurement of the standard sample of all concentration gradients, obtains the luminous intensity values under various concentrations；Each
Concentration duplicate measurements several times, sets up the standard curve of standard sample concentration-luminous intensity.
(4) by the measurement process of solution repeat step 2 to be measured, luminous intensity is obtained, the standard for bringing step 3 foundation into is bent
Line, obtains the concentration of solution to be measured.
Embodiment
It is respectively 5cm*3cm*0.7mm using the length, width and height of ITO conductive electrodes 51 in the present embodiment, it is flat using the present invention
The step of platform is detected to tripropyl amine (TPA), nicotine and atropine is as follows：
(1) software programming is carried out to mobile phone 1, realizes that audio port produces voltage drive, by being controlled to the interface of mobile phone 1
System, the frequency of voltage drive is adjusted by driving frequency button 14, by excitation density button 15 to voltage drive
Intensity is adjusted, and is taken pictures by camera 12 by the picture of reaction including in imaging region 13；
(2) handset audio mouth can produce 1.8V alternating voltage excitation, by L channel line 21 and ground wire 24, by 1:
25 step-up coil 31 is boosted, then the rectifier bridge being made up of FET 32,33 by AC rectification into direct current, most
Higher voltage drive is exported by voltage-regulator diode 34 afterwards, the voltage drive of electrochemical luminescence reaction system 5 is used as；
(3) determination of optimal voltage value：By controlling the voltage drive intensity and driving frequency of the audio port of mobile phone 1 to regulate and control
The voltage swing of electrochemical luminescence reaction system 5, electrochemiluminescence assay is carried out to standard sample, and the result of detection is carried out
The contrast of luminous intensity, is then optimal voltage by corresponding minimum voltage during luminous intensity maximum, as shown in Figure 4.
(4) examination criteria sample：7 of 0.1 μM, 1 μM, 5 μM, 10 μM, 10 μM, 50 μM, 100 μM, 1000 μM of configuration are dense
The standard sample solution of gradient is spent, whole reaction system is placed under dark room conditions, standard sample then is dropped in into lower section ITO leads
The conducting surface of electrode 51, and contacted with the conducting surface of another ITO conductive electrode 51, due to the surface tension of solution, solution
Understand uniform fold ITO conductive electrodes 51 and do not contacted between two plate electrodes；When the start button 16 for clicking on mobile phone interface, audio port
The voltage drive of generation passes through the amplification of capacitation circuit 3 and acts on electrochemical luminescence reaction system 5, and reaction produces luminescence phenomenon
Caught, and be calculated and be shown by mobile phone 1 by camera 12, such as Fig. 5, shown in 7,9；
(5) such as Fig. 6, shown in 8,10, the standard curve of standard sample concentration-luminous intensity is set up：Use electrochemical luminescence
The measurement process of platform repeat step 4, until completing the measurement of the standard sample of 7 concentration gradients, is obtained under various concentrations
Luminous intensity values；Each concentration duplicate measurements 5 times, wherein, the relation curve y=30.30 of tripropyl amine (TPA) concentration and luminous intensity ×
Relation curve y=30.92 × log (x)+14.54 of log (x)+34.30, nicotine concentration and luminous intensity, atropine concentration
With relation curve y=29.90 × log (x)+25.27 of luminous intensity；X is respectively the dense of tripropyl amine (TPA), nicotine and atropine
Degree, y is the gray value of luminous intensity；
(6) concentration of unknown tripropyl amine (TPA), nicotine solution and atropine solution is detected：By solution repeat step 4 to be measured
Measurement process, obtains luminous intensity, brings the curve equation of step 5 into, calculates the concentration for obtaining solution to be measured, realizes to 3 third
The Concentration Testing of amine, nicotine and atropine.
Claims (5)
1. a kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth, it is characterised in that it includes mobile phone
(1), earphone cord (2), capacitation circuit (3) and electrochemical luminescence reaction system (5)；The mobile phone (1) includes audio port socket
And camera (12) (11)；Earphone cord (2) is connected with mobile phone (1) audio port socket (11)；It is divided into four root lines inside earphone cord,
Respectively：L channel line (21), R channel line (22), microphone lines (23) and ground wire (24)；Inserted by mobile phone (1) in audio port
Mouth (11) place produces voltage drive, and L channel line (21) and ground wire (24) are connected with the coil (31) of capacitation circuit (3), as
The control source of capacitation circuit (3)；The output of coil (31) is sequentially connected the rectifier bridge being made up of four FETs and voltage stabilizing
Diode (34), the output voltage and ground wire of voltage-regulator diode (34) pass through two connecting lines (4) and electrochemical luminescence reaction system
System (5) is connected, the voltage drive reacted as electrochemical luminescence；The electrochemical luminescence reaction system (5) is led including two panels ITO
Electrode (51) and copper adhesive tape (52), ITO conductive electrodes (51) material are that one layer of conductive tin indium oxide is attached on simple glass
Film；Testing sample (53) is placed between (51) two conducting surfaces of two panels ITO conductive electrodes.
2. a kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth according to claim 1, it is special
Levy and be, the interface of the mobile phone (1) set start button (16), driving frequency button (14), excitation density button (15) and
Imaging region (13)；By start button (16), audio port socket (11) produces voltage drive；Pass through driving frequency button (14)
Frequency to voltage drive is adjusted；The intensity of voltage drive is adjusted by excitation density button (15)；By taking the photograph
Being taken pictures as head (12) includes the picture of reaction in imaging region (13).
3. a kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth according to claim 1, it is special
Levy and be, encouraged by mobile phone (1) in the alternating voltage that audio port socket (11) produces 1.8V, pass through L channel line (21) and ground
Line (24), by 1:25 step-up coil (31) is boosted, then the rectifier bridge being made up of FET is by AC rectification
Into direct current, higher voltage drive is exported finally by voltage-regulator diode (34), electrochemical luminescence reaction system (5) is used as
Voltage drive.
4. a kind of electrochemical luminescence biochemistry detection platform excited based on handset audio mouth according to claim 1, it is special
Levy and be, by controlling the voltage drive intensity and driving frequency of mobile phone (1) audio port to regulate and control electrochemical luminescence reaction system
(5) voltage swing, electrochemiluminescence assay is carried out to standard sample, and by the contrast of the result progress luminous intensity of detection,
It is optimal voltage by corresponding minimum voltage during luminous intensity maximum.
5. a kind of method that electrochemical luminescence biochemistry detection is carried out using platform described in claim 1, it is characterised in that this method
Comprise the following steps：
(1) examination criteria sample：Configure the standard sample solution of various concentrations gradient.
(2) luminous intensity values are obtained：Whole reaction system is placed under dark room conditions, standard sample is then dropped in into lower section ITO
The conducting surface of conductive electrode (51), and contacted with the conducting surface of another ITO conductive electrode (51), due to the surface of solution
Power, solution is understood uniform fold ITO conductive electrodes (51) and not contacted between two plate electrodes；By mobile phone (1) in audio port socket
(11) voltage drive produced passes through the amplification of capacitation circuit (3) and acts on electrochemical luminescence reaction system (5), and reaction is produced
Luminescence phenomenon is caught by camera (12), and is shown by mobile phone (1) and calculated luminous intensity values；
(3) standard curve of standard sample concentration-luminous intensity is set up：Use the measurement of electrochemical luminescence platform repeat step 2
Process, until completing the measurement of the standard sample of all concentration gradients, obtains the luminous intensity values under various concentrations；Each concentration
Duplicate measurements several times, sets up the standard curve of standard sample concentration-luminous intensity.
(4) by the measurement process of solution repeat step 2 to be measured, luminous intensity is obtained, the standard curve of step 3 foundation is brought into, obtains
To the concentration of solution to be measured.
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| CN111351781A (en) * | 2018-12-20 | 2020-06-30 | 麦德龙生物株式会社 | Electrochemiluminescence analysis apparatus and method of analyzing sample using the same |
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| CN107037034B (en) | 2019-08-16 |
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